公开(公告)号：US09120777B2

公开(公告)日：2015-09-01

申请号：US14525593

申请日：2014-10-28

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Asato Kina ,  Hideki Hirose ,  Takeshi Yamasaki ,  Tohru Yamashita ,  Yoichi Nishikawa

IPC: C07D401/12 ,  C07D211/86 ,  C07D239/22

CPC classification number: C07D401/12 ,  C07D211/86 ,  C07D239/22 ,  C07D401/04 ,  C07D401/14

Abstract: A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent the prophylaxis or treatment of diabetes mellitus are provided.

Abstract translation: 提供具有SSTR5拮抗作用的化合物和该化合物作为药物的用途。 具体地，由下式表示的化合物或其盐，其中每个符号如本文所定义，或其盐，包含该化合物或其盐的药物，以及该化合物或其盐的用途作为预防或治疗 提供糖尿病。

公开(公告)号：US11498898B2

公开(公告)日：2022-11-15

申请号：US17021701

申请日：2020-09-15

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi Ikemoto ,  Hideya Mizufune ,  Toshiaki Nagata ,  Takeshi Yamasaki

IPC: C07D207/337 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D401/12 ,  C07D207/30 ,  C07D207/48

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

公开(公告)号：US20210070705A1

公开(公告)日：2021-03-11

申请号：US17021701

申请日：2020-09-15

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi Ikemoto ,  Misayo Sera ,  Naohiro Fukuda ,  Hideya Mizufune ,  Toshiaki Nagata ,  Takeshi Yamasaki

IPC: C07D207/337 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D401/12 ,  C07D207/30 ,  C07D207/48

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

公开(公告)号：US10173977B2

公开(公告)日：2019-01-08

申请号：US14994360

申请日：2016-01-13

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Tomomi Ikemoto ,  Hideya Mizufune ,  Toshiaki Nagata ,  Misayo Sera ,  Naohiro Fukuda ,  Takeshi Yamasaki

IPC: C07D207/337 ,  C07D207/333 ,  C07D207/34 ,  C07D207/36 ,  C07D401/12 ,  C07D207/30 ,  C07D207/48

Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.

公开(公告)号：US20160237087A1

公开(公告)日：2016-08-18

申请号：US15139531

申请日：2016-04-27

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Hideki Hirose ,  Takeshi Yamasaki ,  Tohru Yamashita ,  Asato Kina ,  Yoichi Nishikawa

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent for the prophylaxis or treatment of diabetes mellitus are provided.

Abstract translation: 提供具有SSTR5拮抗作用的化合物和该化合物作为药物的用途。 具体地，由下式表示的化合物或其盐，其中每个符号如本文所定义，或其盐，包含该化合物或其盐的药物，以及该化合物或其盐作为预防或治疗剂的用途 的糖尿病。

公开(公告)号：US09382188B2

公开(公告)日：2016-07-05

申请号：US14377953

申请日：2013-02-12

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Seiji Miwatashi ,  Hideo Suzuki ,  Tomohiro Okawa ,  Yasufumi Miyamoto ,  Takeshi Yamasaki ,  Yuko Hitomi ,  Yasuhiro Hirata ,  Akito Shibuya

IPC: C07C59/135 ,  C07D405/14 ,  C07C255/46 ,  C07D309/06 ,  C07D231/12 ,  C07D333/38 ,  C07D401/12 ,  C07D239/26 ,  C07D239/34 ,  C07C317/44 ,  C07C229/34 ,  C07C233/47 ,  C07D271/10 ,  C07D277/24 ,  C07C255/37 ,  C07D285/12 ,  C07D213/30 ,  C07D213/55 ,  C07D213/64 ,  C07D213/65 ,  C07D213/68 ,  C07D213/69 ,  C07C59/68 ,  C07C59/70 ,  C07C59/72 ,  C07D213/12 ,  C07C309/65 ,  C07C309/66 ,  C07C311/21 ,  C07C323/56 ,  C07C235/34 ,  C07C255/41

CPC classification number: C07C59/135 ,  C07C59/68 ,  C07C59/70 ,  C07C59/72 ,  C07C229/34 ,  C07C233/47 ,  C07C235/34 ,  C07C255/37 ,  C07C255/41 ,  C07C255/46 ,  C07C309/65 ,  C07C309/66 ,  C07C311/21 ,  C07C317/44 ,  C07C323/56 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07D213/12 ,  C07D213/30 ,  C07D213/55 ,  C07D213/64 ,  C07D213/65 ,  C07D213/68 ,  C07D213/69 ,  C07D231/12 ,  C07D239/26 ,  C07D239/34 ,  C07D271/10 ,  C07D277/24 ,  C07D285/12 ,  C07D309/06 ,  C07D333/38 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D405/14

Abstract: Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.

公开(公告)号：US20150099777A1

公开(公告)日：2015-04-09

申请号：US14505907

申请日：2014-10-03

Applicant: Takeda Pharmaceutical Company Limited

Inventor： Shizuo Kasai ,  Hideki Hirose ,  Takeshi Yamasaki ,  Tohru Yamashita ,  Asato Kina ,  Yoichi Nishikawa

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: A compound having an SSTR5 antagonist action and use of the compound as a medicament are provided. Specifically, a compound represented by the following formula: wherein each symbol is as defined herein, or a salt thereof, a medicament comprising the compound or a salt thereof, and use of the compound or a salt thereof as an agent for the prophylaxis or treatment of diabetes mellitus are provided.

Abstract translation: 提供具有SSTR5拮抗作用的化合物和该化合物作为药物的用途。 具体地，由下式表示的化合物或其盐，其中每个符号如本文所定义，或其盐，包含该化合物或其盐的药物，以及该化合物或其盐作为预防或治疗剂的用途 的糖尿病。

公开(公告)号：US20150045378A1

公开(公告)日：2015-02-12

申请号：US14377951

申请日：2013-02-12

Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Inventor： Seiji Miwatashi ,  Hideo Suzuki ,  Tomohiro Okawa ,  Yasufumi Miyamoto ,  Takeshi Yamasaki ,  Yuko Hitomi ,  Yasuhiro Hirata

IPC: C07D213/64 ,  C07D403/12 ,  C07D405/14 ,  C07D401/12 ,  C07D213/55

CPC classification number: C07D213/64 ,  C07D213/30 ,  C07D213/55 ,  C07D213/68 ,  C07D213/69 ,  C07D239/34 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14

Abstract: Provided is an aromatic ring compound having a GPR40 agonist activity. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity, and is useful as an agent for the prophylaxis or treatment of diabetes and the like.

Abstract translation: 提供具有GPR40激动剂活性的芳环化合物。 由式（I）表示的化合物：其中每个符号如说明书所述，或其盐具有GPR40激动剂活性，并且可用作预防或治疗糖尿病等的药剂。