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公开(公告)号:US08273890B2
公开(公告)日:2012-09-25
申请号:US12667093
申请日:2008-06-26
申请人: Thomas Stengel , Mathias Schmidt , Steffen Weinbrenner , Alexander Weber , Petra Gimmnich , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Thomas Maier , Beate Schmidt , Florian Dehmel
发明人: Thomas Stengel , Mathias Schmidt , Steffen Weinbrenner , Alexander Weber , Petra Gimmnich , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Thomas Maier , Beate Schmidt , Florian Dehmel
IPC分类号: C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02 , A61K31/44
CPC分类号: C07D471/04
摘要: The invention relates to thiophene-imidazopyridine compounds according to formula (I), wherein the substituents and symbols are as defined in the description. The compounds are inhibitors of PIk1.
摘要翻译: 本发明涉及式(I)的噻吩 - 咪唑并吡啶化合物,其中取代基和符号如说明书中所定义。 这些化合物是PIk1的抑制剂。
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12.
公开(公告)号:US20110021494A1
公开(公告)日:2011-01-27
申请号:US12678806
申请日:2008-09-19
申请人: Thomas Maier , Thomas Beckers , Thomas Baer , Matthias Vennemann , Volker Gekeler , Astrid Zimmermann , Petra Gimmnich , Kamlesh Padiya , Hemant Joshi , Uday Joshi , Mahindra Makhija , Dipak Harel
发明人: Thomas Maier , Thomas Beckers , Thomas Baer , Matthias Vennemann , Volker Gekeler , Astrid Zimmermann , Petra Gimmnich , Kamlesh Padiya , Hemant Joshi , Uday Joshi , Mahindra Makhija , Dipak Harel
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/437 , A61K31/4355 , C07D471/04 , C07D513/04 , C07D498/04 , A61P29/00 , A61K31/4365 , A61P35/04 , A61P37/00
CPC分类号: C07D513/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要: The compounds of formula (I), wherein ring D and ring E together form a fused ring system selected from formula (II), (III), (IV), (V), (VI), (VII), and the salts of these compounds are novel, effective inhibitors of histone deacetylases.
摘要翻译: 式(I)化合物,其中环D和环E一起形成选自式(II),(III),(IV),(V),(VI),(VII) 的这些化合物是组蛋白脱乙酰酶的新颖有效的抑制剂。
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公开(公告)号:US20110044938A1
公开(公告)日:2011-02-24
申请号:US12377539
申请日:2007-08-15
申请人: Bjorn Bartels , Mathias Schmidt , Klaus Pekari , Thomas Beckers , Astrid Zimmermann , Volker Gekeler
发明人: Bjorn Bartels , Mathias Schmidt , Klaus Pekari , Thomas Beckers , Astrid Zimmermann , Volker Gekeler
IPC分类号: A61K31/381 , C07D409/14 , C07D409/12 , C07D333/68 , C07D413/12 , C07D413/14 , A61K31/444 , A61K31/4436 , A61K31/5377 , A61K31/4178 , A61K31/4545 , A61K31/661 , A61K31/675 , A61K33/24 , A61K31/437 , A61K31/704 , A61K31/513 , A61K31/44 , A61K31/404 , A61K31/517 , A61K39/395 , A61K38/20 , A61P35/00 , A61P35/02
CPC分类号: C07D333/68 , C07D409/12 , C07D409/14
摘要: Compounds of a certain formula I, in which Ra and Rb have the meanings indicated in the description, are novel effective compounds with anti-proliferative and apoptosis inducing activity.
摘要翻译: 其中Ra和Rb具有说明书中所示含义的某种式I化合物是具有抗增殖和凋亡诱导活性的新型有效化合物。
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公开(公告)号:US08614218B2
公开(公告)日:2013-12-24
申请号:US12731880
申请日:2010-03-25
申请人: Swen Hölder , Matthias Vennemann , Gerrit Beneke , Armin Zülch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
发明人: Swen Hölder , Matthias Vennemann , Gerrit Beneke , Armin Zülch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
IPC分类号: A01N43/90 , A61K31/519 , C07D487/00
CPC分类号: C07D487/04
摘要: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.
摘要翻译: 式(I)化合物其互变异构体或立体异构体或其盐,其中环B和其稠合的嘧啶,R4,R5,R6和R7具有在说明书和权利要求书中给出的含义,是有效的 Pi3K / Akt途径的抑制剂。
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公开(公告)号:US20090137607A1
公开(公告)日:2009-05-28
申请号:US12191703
申请日:2008-08-14
申请人: Swen Holder , Matthias Vennemann , Gerrit Beneke , Armin Zulch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
发明人: Swen Holder , Matthias Vennemann , Gerrit Beneke , Armin Zulch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
IPC分类号: A61K31/497 , C07D487/02 , A61K31/519 , A61P35/00
CPC分类号: C07D487/04
摘要: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.
摘要翻译: 式(I)化合物其互变异构体或立体异构体或其盐,其中环B和其稠合的嘧啶,R4,R5,R6和R7具有在说明书和权利要求书中给出的含义,是有效的 Pi3K / Akt途径的抑制剂。
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公开(公告)号:US07776864B2
公开(公告)日:2010-08-17
申请号:US12191703
申请日:2008-08-14
申请人: Swen Hölder , Matthias Vennemann , Gerrit Beneke , Armin Zülch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
发明人: Swen Hölder , Matthias Vennemann , Gerrit Beneke , Armin Zülch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
IPC分类号: A61K31/4965 , A61K31/505 , A61K31/519 , A61K31/445 , C07D471/04 , C07D471/22 , C07D487/00 , C07D491/00 , C07D403/00 , C07D239/02 , A01N43/54 , A01N43/90 , A01N43/40
CPC分类号: C07D487/04
摘要: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.
摘要翻译: 式(I)化合物其互变异构体或立体异构体或其盐,其中环B和其稠合的嘧啶,R4,R5,R6和R7具有在说明书和权利要求书中给出的含义,是有效的 Pi3K / Akt途径的抑制剂。
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公开(公告)号:US20100184782A1
公开(公告)日:2010-07-22
申请号:US12731880
申请日:2010-03-25
申请人: Swen Hölder , Matthias Vennemann , Gerrit Beneke , Armin Zülch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
发明人: Swen Hölder , Matthias Vennemann , Gerrit Beneke , Armin Zülch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
IPC分类号: A61K31/519 , A61P35/00 , A61P35/02
CPC分类号: C07D487/04
摘要: Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.
摘要翻译: 式(I)化合物其互变异构体或立体异构体或其盐,其中环B和其稠合的嘧啶,R4,R5,R6和R7具有在说明书和权利要求书中给出的含义,是有效的 Pi3K / Akt途径的抑制剂。
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公开(公告)号:US09073913B2
公开(公告)日:2015-07-07
申请号:US12934228
申请日:2009-03-23
申请人: Volker Gekeler , Thomas Maier , Astrid Zimmermann , Hans-Peter Hofmann , Sanjeev A. Kulkarni , Anil P. Jagtap , Ganesh S. Chaure
发明人: Volker Gekeler , Thomas Maier , Astrid Zimmermann , Hans-Peter Hofmann , Sanjeev A. Kulkarni , Anil P. Jagtap , Ganesh S. Chaure
IPC分类号: A61K31/44 , C07D471/04
CPC分类号: C07D471/04 , A61K31/4745 , C07D453/04 , Y02A50/409 , Y02A50/414
摘要: Imidazoquinolines of formula I that contain substituted amine or amide functionality at 1-position and that are effective as Toll like Receptor 7 activators are disclosed. These compounds are useful as anticancer agents.
摘要翻译: 公开了在1-位含有取代的胺或酰胺官能团并且作为Toll样受体7激活剂有效的式I的咪唑并喹啉。 这些化合物可用作抗癌剂。
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公开(公告)号:US20110245289A1
公开(公告)日:2011-10-06
申请号:US12934228
申请日:2009-03-23
申请人: Volker Gekeler , Thomas Maier , Astrid Zimmermann , Hans-Peter Hofmann , Sanjeev Kulkarni , Anil Jagtap , Ganesh Chaure
发明人: Volker Gekeler , Thomas Maier , Astrid Zimmermann , Hans-Peter Hofmann , Sanjeev Kulkarni , Anil Jagtap , Ganesh Chaure
IPC分类号: A61K31/4745 , C07D471/04 , A61P31/12 , A61P35/00
CPC分类号: C07D471/04 , A61K31/4745 , C07D453/04 , Y02A50/409 , Y02A50/414
摘要: Imidazoquinolines of formula I that contain substituted amine or amide functionality at 1-position and that are effective as Toll like Receptor 7 activators are disclosed. These compounds are useful as anticancer agents.
摘要翻译: 公开了在1-位含有取代的胺或酰胺官能团并且作为Toll样受体7激活剂有效的式I的咪唑并喹啉。 这些化合物可用作抗癌剂。
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公开(公告)号:US08530493B2
公开(公告)日:2013-09-10
申请号:US12280424
申请日:2007-02-21
IPC分类号: A61K31/435 , A61K31/44 , A61K31/41 , A61K31/40
CPC分类号: C07D471/14
摘要: Compounds of a certain formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings indicated in the description, are effective compounds with anti-proliferative and/or apoptosis inducing activity.
摘要翻译: 其中R1,R2,R3,R4,R5和R6具有说明书中所示含义的某种式I化合物是具有抗增殖和/或凋亡诱导活性的有效化合物。
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