公开(公告)号：US07670822B2

公开(公告)日：2010-03-02

申请号：US12212767

申请日：2008-09-18

申请人： Sergey Vasilievich Smirnov ,  Natalia Nikolaevna Samsonova ,  Tomohiro Kodera ,  Kazuhiko Matsui

发明人： Sergey Vasilievich Smirnov ,  Natalia Nikolaevna Samsonova ,  Tomohiro Kodera ,  Kazuhiko Matsui

IPC分类号： C07H21/04 ,  C12N9/88

CPC分类号： C12N9/88 ,  C12P13/06

摘要： A novel aldolase is described. 4-hydroxy-3-methyl-2-keto-pentanoic acid, which is useful as an intermediate in the synthesis of 4-hydroxy-L-isoleucine, may be synthesized from acetaldehyde and α-ketobutyric acid using a novel aldolase, which is derived from the genus Arthrobacter.

摘要翻译： 描述了一种新的醛缩酶。 可用于合成4-羟基-L-异亮氨酸的中间体的4-羟基-3-甲基-2-酮戊酸可以使用新的醛缩酶由乙醛和α-酮丁酸合成，其是 衍生自节杆菌属。

公开(公告)号：US20120107884A1

公开(公告)日：2012-05-03

申请号：US13344200

申请日：2012-01-05

申请人： Tomohiro Kodera ,  Sergey Vasilievich Smirnov ,  Natalia Nikolaevna Samsonova ,  Veronika Aleksandrovna Kotliarova ,  Natalia Yurievna Rushkevich ,  Yury Ivanovich Kozlov ,  Vitaly Grigorievich Paraskevov ,  Sakayu Shimizu ,  Jun Ogawa ,  Makoto Hibi

发明人： Tomohiro Kodera ,  Sergey Vasilievich Smirnov ,  Natalia Nikolaevna Samsonova ,  Veronika Aleksandrovna Kotliarova ,  Natalia Yurievna Rushkevich ,  Yury Ivanovich Kozlov ,  Vitaly Grigorievich Paraskevov ,  Sakayu Shimizu ,  Jun Ogawa ,  Makoto Hibi

IPC分类号： C12P13/06

CPC分类号： C12N9/0069 ,  C12P13/06

摘要： A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.

摘要翻译： 提供了一种来自苏云金芽孢杆菌的高活性L-异亮氨酸双加氧酶。 在L-异亮氨酸双加氧酶存在下，通过使L-异亮氨酸在水性溶剂中反应，并分离（2S，3R，4S） - 还提供了4-羟基-L-异亮氨酸。

公开(公告)号：US07947315B2

公开(公告)日：2011-05-24

申请号：US11777601

申请日：2007-07-13

申请人： Tomohiro Kodera ,  Hiroyuki Nakagoshi ,  Noriko Miwa ,  Nami Nakamura ,  Hidehiko Wakabayashi

发明人： Tomohiro Kodera ,  Hiroyuki Nakagoshi ,  Noriko Miwa ,  Nami Nakamura ,  Hidehiko Wakabayashi

IPC分类号： A23C9/12

CPC分类号： A23C9/1275 ,  A23C9/1216 ,  A23C19/0328 ,  A23C19/0688 ,  C12Y305/01

摘要： The present invention provides a dairy product with smooth oral sensation and suppressed acidic taste and bitter taste and a method for manufacturing the same, wherein a protein deamidating enzyme is added to raw milk to act on the milk protein in the raw milk.

摘要翻译： 本发明提供一种具有口感平滑，酸味和酸味苦味的乳制品及其制造方法，其中将蛋白质脱酰胺酶加入生奶中作用于生奶中的乳蛋白质。

公开(公告)号：US20110070270A1

公开(公告)日：2011-03-24

申请号：US12899045

申请日：2010-10-06

申请人： Tomohiro Kodera ,  Yuzuru Eto ,  Yoshinori Mine

发明人： Tomohiro Kodera ,  Yuzuru Eto ,  Yoshinori Mine

IPC分类号： A61K38/05 ,  A61K31/13 ,  A61P35/00 ,  A61P37/04 ,  A61P1/00 ,  A61P1/12 ,  A61P37/08

CPC分类号： A61K31/132 ,  A23L33/10 ,  A23L33/18 ,  A61K31/135 ,  A61K38/03 ,  A61K38/17 ,  Y02A50/473

摘要： An immunostimulating agent, which can stimulate immunity effectively, is described. The immunostimulating agent contains an active ingredient including a calcium receptor activator such as γ-Glu-X-Gly [wherein X represents an amino acid or a derivative thereof other than Cys], γ-Glu-Val-Y [wherein Y represents an amino acid or a derivative thereof], γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Met, γ-Glu-Thr, γ-Glu-Val, γ-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, γ-Glu-Met(O), γ-Glu-γ-Glu-Val, γ-Glu-Val-NH2, γ-Glu-Val-ol, γ-Glu-Ser, γ-Glu-Tau, γ-Glu-Cys(S-Me)(O), γ-Glu-Leu, γ-Glu-Ile, γ-Glu-t-Leu, γ-Glu-Cys(S-Me), a cation having a valency of 2 or more, protamine, polylysine, spermine, spermidine, putrescine, cinacalcet, a cinacalcet analogue compound, and a salt of any one of the aforementioned components.

摘要翻译： 描述了可以有效地刺激免疫的免疫刺激剂。 免疫刺激剂含有包括钙受体活化剂如γ-Glu-X-Gly [其中X表示除Cys]以外的氨基酸或其衍生物的活性成分，γ-Glu-Val-Y [其中Y表示氨基 酸或其衍生物]，γ-Glu-Ala，γ-Glu-Gly，γ-Glu-Met，γ-Glu-Thr，γ-Glu-Val，γ-Glu-Orn，Asp-Gly，Cys-Gly ，Cys-Met，Glu-Cys，Gly-Cys，Leu-Asp，γ-Glu-Met（O），γ-Glu-γ-Glu-Val，γ-Glu-Val-NH2，γ-Glu-Val- （S-Me）（O），γ-Glu-Leu，γ-Glu-Ile，γ-Glu-t-Leu，γ- Glu-Cys（S-Me），2价以上的阳离子，鱼精蛋白，聚赖氨酸，精胺，亚精胺，腐胺，西那卡塞，西那卡塞类似物化合物和上述成分中的任一种的盐。

公开(公告)号：US20100323058A1

公开(公告)日：2010-12-23

申请号：US12862892

申请日：2010-08-25

申请人： Akiko MARUYAMA ,  Hiroaki Sato ,  Tomohiro Kodera

发明人： Akiko MARUYAMA ,  Hiroaki Sato ,  Tomohiro Kodera

IPC分类号： A23L1/325 ,  A23J3/34

CPC分类号： A23K10/22 ,  A23L17/65 ,  A23L17/70 ,  C12Y203/02013

摘要： In the process of producing a fish paste product, adding a defined amount of a transglutaminase and ascorbic acid or a related compound thereof are added to material surimi can suppress changes in the physical properties of nerimi during the process of producing a fish paste product and a fish paste product having a preferable firmness and elasticity can be obtained even in the case of reducing the amount of material surimi.

摘要翻译： 在制造鱼浆制品的过程中，向食品中添加规定量的转谷氨酰胺酶和抗坏血酸或其相关化合物可以抑制鱼酱产品的制造过程中的nerimi的物理性质的变化， 即使在减少材料量的情况下也可以获得具有优选的坚实性和弹性的鱼浆制品。

公开(公告)号：US20090104659A1

公开(公告)日：2009-04-23

申请号：US12212767

申请日：2008-09-18

申请人： Sergey Vasilievich Smirnov ,  Natalia Nikolaevna Samsonova ,  Tomohiro Kodera ,  Kazuhiko Matsui

发明人： Sergey Vasilievich Smirnov ,  Natalia Nikolaevna Samsonova ,  Tomohiro Kodera ,  Kazuhiko Matsui

IPC分类号： C12N9/00 ,  C07H21/04 ,  C12N15/63 ,  C12N1/20 ,  C12P21/06

CPC分类号： C12N9/88 ,  C12P13/06

摘要： A novel aldolase is described. 4-hydroxy-3-methyl-2-keto-pentanoic acid, which is useful as an intermediate in the synthesis of 4-hydroxy-L-isoleucine, may be synthesized from acetaldehyde and α-ketobutyric acid using a novel aldolase, which is derived from the genus Arthrobacter.

摘要翻译： 描述了一种新的醛缩酶。 可用作合成4-羟基-L-异亮氨酸的中间体的4-羟基-3-甲基-2-酮 - 戊酸可以使用新的醛缩酶，由乙醛和α-酮丁酸合成，其是 衍生自节杆菌属。

公开(公告)号：US08367382B2

公开(公告)日：2013-02-05

申请号：US13344200

申请日：2012-01-05

申请人： Tomohiro Kodera ,  Sergey Vasilievich Smirnov ,  Natalia Nikolaevna Samsonova ,  Veronika Aleksandrovna Kotliarova ,  Natalia Yurievna Rushkevich ,  Sakayu Shimizu ,  Jun Ogawa ,  Makoto Hibi ,  Vitaly Grigorievich Paraskevov

发明人： Tomohiro Kodera ,  Sergey Vasilievich Smirnov ,  Natalia Nikolaevna Samsonova ,  Veronika Aleksandrovna Kotliarova ,  Natalia Yurievna Rushkevich ,  Yury Ivanovich Kozlov ,  Sakayu Shimizu ,  Jun Ogawa ,  Makoto Hibi

IPC分类号： C12P13/06 ,  C12P21/06 ,  C12P21/04 ,  C12N9/02 ,  C12N1/20 ,  C12N15/00 ,  C12Q1/26 ,  C07H21/04

CPC分类号： C12N9/0069 ,  C12P13/06

摘要： A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.

公开(公告)号：US20120115203A1

公开(公告)日：2012-05-10

申请号：US13344110

申请日：2012-01-05

申请人： Tomohiro Kodera ,  Sergey Vasilievich Smirnov ,  Natalia Nikolaevna Samsonova ,  Veronika Aleksandrovna Kotliarova ,  Natalia Yurievna Rushkevich ,  Yury Ivanovich Kozlov ,  Sakayu Shimizu ,  Jun Ogawa ,  Makoto Hibi ,  Vitaly Grigorievich Paraskevov

发明人： Tomohiro Kodera ,  Sergey Vasilievich Smirnov ,  Natalia Nikolaevna Samsonova ,  Veronika Aleksandrovna Kotliarova ,  Natalia Yurievna Rushkevich ,  Yury Ivanovich Kozlov ,  Sakayu Shimizu ,  Jun Ogawa ,  Makoto Hibi ,  Vitaly Grigorievich Paraskevov

IPC分类号： C12N9/02 ,  C12N1/15 ,  C12N1/21 ,  C12N15/53 ,  C12N15/63

CPC分类号： C12N9/0069 ,  C12P13/06

摘要： A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.

公开(公告)号：US08114651B2

公开(公告)日：2012-02-14

申请号：US12412823

申请日：2009-03-27

申请人： Tomohiro Kodera ,  Sergey Vasilievich Smirnov ,  Natalia Nikolaevna Samsonova ,  Veronika Aleksandrovna Kotliarova ,  Natalia Yurievna Rushkevich ,  Yury Ivanovich Kozlov ,  Vitaly Grigorievich Paraskevov, legal representative ,  Sakayu Shimizu ,  Jun Ogawa ,  Makoto Hibi

发明人： Tomohiro Kodera ,  Sergey Vasilievich Smirnov ,  Natalia Nikolaevna Samsonova ,  Veronika Aleksandrovna Kotliarova ,  Natalia Yurievna Rushkevich ,  Yury Ivanovich Kozlov ,  Sakayu Shimizu ,  Jun Ogawa ,  Makoto Hibi

IPC分类号： C12N9/02 ,  C12N15/00 ,  C12P21/04

CPC分类号： C12N9/0069 ,  C12P13/06

摘要： A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.

摘要翻译： 提供了一种来自苏云金芽孢杆菌的高活性L-异亮氨酸双加氧酶。 在L-异亮氨酸双加氧酶存在下，通过使L-异亮氨酸在水性溶剂中反应，并分离（2S，3R，4S） - 还提供了4-羟基-L-异亮氨酸。

公开(公告)号：US20090275092A1

公开(公告)日：2009-11-05

申请号：US12412823

申请日：2009-03-27

申请人： Tomohiro Kodera ,  Sergey Vasilievich Smirnov ,  Natalia Nikolaevna Samsonova ,  Veronika Aleksandrovna Kotliarova ,  Natalia Yurievna Rushkevich ,  Yury Ivanovich Kozlov ,  Vitaly Grigorlevich Paraskevov ,  Sakayu Shimizu ,  Jun Ogawa ,  Makoto Hibi

发明人： Tomohiro Kodera ,  Sergey Vasilievich Smirnov ,  Natalia Nikolaevna Samsonova ,  Veronika Aleksandrovna Kotliarova ,  Natalia Yurievna Rushkevich ,  Yury Ivanovich Kozlov ,  Vitaly Grigorlevich Paraskevov ,  Sakayu Shimizu ,  Jun Ogawa ,  Makoto Hibi

IPC分类号： C12P13/06 ,  C12N9/02 ,  C07H21/04 ,  C12N1/00 ,  C07K14/00

CPC分类号： C12N9/0069 ,  C12P13/06

摘要： A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is also provided.

摘要翻译： 提供了一种来自苏云金芽孢杆菌的高活性L-异亮氨酸双加氧酶。 在L-异亮氨酸双加氧酶存在下，通过使L-异亮氨酸在水性溶剂中反应，并分离（2S，3R，4S） - 还提供了4-羟基-L-异亮氨酸。