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    MOLECULAR DIAGNOSTIC SYSTEM BASED ON EVANESCENT ILLUMINATION AND FLUORESCENCE
    12.
    发明申请
    MOLECULAR DIAGNOSTIC SYSTEM BASED ON EVANESCENT ILLUMINATION AND FLUORESCENCE 有权
    基于历史照明和荧光的分子诊断系统

    公开(公告)号：US20100320397A1

    公开(公告)日：2010-12-23

    申请号：US12864910

    申请日：2009-01-26

    申请人： Marius Iosif Boamfa ,  Maarten Marinus Johannes Wilhelmus Van Herpen ,  Derk Jan Wilfred Klunder

    发明人： Marius Iosif Boamfa ,  Maarten Marinus Johannes Wilhelmus Van Herpen ,  Derk Jan Wilfred Klunder

    IPC分类号： G01N21/64 ,  G01N21/55

    CPC分类号： G01N21/648

    摘要： An illumination detection system comprises an excitation radiation source and associated radiation processing arrangement, and a focusing arrangement for focusing the excitation radiation from the radiation processing arrangement onto an analysis region of a sample. A radiation collection arrangement collects radiation from the analysis region of the sample resulting from the excitation, and a detector detects the collected radiation. The focused excitation radiation comprises an excitation line which is evanescent in the sample. This combines the advantages of line scanning (reduced analysis time) and evanescent excitation (reduced background signal) and therewith enables increased measurement speed and precision for point of care application.

    摘要翻译： 照明检测系统包括激发辐射源和相关联的辐射处理装置，以及用于将来自辐射处理装置的激发辐射聚焦到样品的分析区域上的聚焦装置。 辐射收集装置从由激发产生的样品的分析区域收集辐射，并且检测器检测收集的辐射。 聚焦的激发辐射包括在样品中消逝的激发线。 这结合了线扫描的优点（减少的分析时间）和ev逝激发（降低的背景信号），并且因此可以提高点护理应用的测量速度和精度。

    OPTICAL SYSTEM FOR MAPPING SIGNAL LIGHT ONTO A DETECTOR
    15.
    发明申请
    OPTICAL SYSTEM FOR MAPPING SIGNAL LIGHT ONTO A DETECTOR 失效
    用于将信号光映射到探测器的光学系统

    公开(公告)号：US20100140464A1

    公开(公告)日：2010-06-10

    申请号：US11909638

    申请日：2006-03-27

    申请人： Marcello Balistreri ,  Derk Jan Wilfred Klunder ,  Maarten Van Herpen

    发明人： Marcello Balistreri ,  Derk Jan Wilfred Klunder ,  Maarten Van Herpen

    IPC分类号： H01L31/0232 ,  G02B27/42 ,  G02B5/18 ,  G02B27/44

    CPC分类号： G01N21/645 ,  G02B27/0037 ,  G02B27/4205 ,  G02B27/4277

    摘要： The invention relates to an optical system that particularly allows an improved detection of signal light propagating from a light source (1) through a flat glass substrate (11). SC-modes of this signal light that would normally be totally internally reflected at the backside (10) of the substrate (11) are coupled out by a first diffractive optical element DOE (21). To map all signal light leaving the substrate (11) onto a single target location (51), a focusing lens (31) and a second DOE (41) are disposed in the optical path behind the substrate (11). The DOEs (21, 41) may for example be a ID sinusoidal grating or a 2D blaze grating. The optical system may particularly be applied in an investigation apparatus for detecting multiple spots of a fluorescent sample material.

    摘要翻译： 本发明涉及一种特别允许改进从光源（1）通过平板玻璃基板（11）传播的信号光的检测的光学系统。 通常在基板（11）的背面（10）处内部反射的该信号光的SC模式由第一衍射光学元件DOE（21）耦合出来。 为了将离开基板（11）的所有信号光映射到单个目标位置（51）上，在基板（11）后面的光路中设置聚焦透镜（31）和第二DOE（41）。 DOE（21,41）可以例如是ID正弦光栅或2D火焰光栅。 光学系统可以特别应用于用于检测荧光样品材料的多个点的检查装置中。

    MULTI-SPOT INVESTIGATION APPARATUS
    16.
    发明申请
    MULTI-SPOT INVESTIGATION APPARATUS 审中-公开
    多点调查装置

    公开(公告)号：US20100051788A1

    公开(公告)日：2010-03-04

    申请号：US11721392

    申请日：2005-12-13

    申请人： Derk Jan Wilfred Klunder ,  Maarten Van Herpen ,  Marcello Balistreri ,  Menno Prins

    发明人： Derk Jan Wilfred Klunder ,  Maarten Van Herpen ,  Marcello Balistreri ,  Menno Prins

    IPC分类号： G01J1/58 ,  H01J40/02 ,  G01N21/00

    CPC分类号： G01N21/645 ,  B01L3/5085 ,  G01N21/6452 ,  G01N2201/0635

    摘要： The invention relates to a method and an apparatus for the investigation of a sample material that is stored in the sample chamber (303) of a storage unit (300). A multi-spot generator MSG (100) and a transmission section (200) generate an array of sample light spots (501) within the sample chamber. Input light (504) that leaves the storage unit (300) in forward direction is mapped onto a CCD array (401) and measured as reference. Moreover, fluorescence light (500) that is stimulated in the sample chamber (303) is measured by a second CCD array which is disposed perpendicular to the optical path of the input light (504).

    摘要翻译： 本发明涉及一种用于研究存储在存储单元（300）的样品室（303）中的样品材料的方法和装置。 多点发生器MSG（100）和透射部分（200）在样品室内产生样品光点阵列（501）。 将存储单元（300）向前移动的输入光（504）映射到CCD阵列（401）上并作为参考进行测量。 此外，通过垂直于输入光（504）的光路设置的第二CCD阵列来测量在样品室（303）中被刺激的荧光（500）。

    Imaging Apparatus for Combined Temperature and Luminescence Spatial Imaging of an Object
    18.
    发明申请
    Imaging Apparatus for Combined Temperature and Luminescence Spatial Imaging of an Object 审中-公开
    用于物体的组合温度和发光空间成像的成像装置

    公开(公告)号：US20090194693A1

    公开(公告)日：2009-08-06

    申请号：US12301642

    申请日：2007-05-14

    申请人： Derk Jan Wilfred Klunder ,  Aleksey Kolesnychenko

    发明人： Derk Jan Wilfred Klunder ,  Aleksey Kolesnychenko

    IPC分类号： G01N21/64 ,  G01N21/76

    CPC分类号： G01N21/6456 ,  G01N21/6428 ,  G01N21/76

    摘要： An imaging apparatus is disclosed for combined temperature and luminescence spatial imaging of an object (1), such as a bio-array for detection of biological molecules. Light (5) is separated into a first (10) and a second (20) optical path, where the first optical path (10) guides infrared (IR), and the second optical path (20) guides luminescence light, preferably fluorescence light, from the object (1). Image intensifying means (30) converts infrared light (10a) in the first optical path into intensified light (10b), preferably visible light. Photo detection means (100) are arranged for spatial imaging of the object (1), the photo detection means being arranged for alternately receiving light from the first (10) and the second (20) optical path. Processing means (200) are capable of combining a temperature image (11) with a luminescence image (21) so as to obtain a combined image (25) of the object with a direct spatial correspondence between the two images. For bio-arrays this provides many advantages in relation to combined imaging of an array, whereupon numerous probe molecules are located.

    摘要翻译： 公开了用于物体（1）的组合温度和发光空间成像的成像装置，例如用于检测生物分子的生物阵列。 光（5）被分离为第一光路（10）和第二光路（20），其中第一光路（10）引导红外（IR），第二光路（20）引导发光，优选荧光 ，从对象（1）。 图像增强装置（30）将第一光路中的红外光（10a）转换成强光（10b），优选可见光。 照片检测装置（100）布置成用于物体（1）的空间成像，光检测装置被布置成交替地接收来自第一光（10）和第（20）光路的光。 处理装置（200）能够将温度图像（11）与发光图像（21）组合，从而以两个图像之间的直接空间对应来获得对象的组合图像（25）。 对于生物阵列，这提供了与阵列的组合成像相关的许多优点，因此存在许多探针分子。