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20 条记录 (耗时 0.038 秒)

    Chip for optical analysis
    11.
    发明授权
    Chip for optical analysis 有权
    芯片用于光学分析

    公开(公告)号：US08859267B2

    公开(公告)日：2014-10-14

    申请号：US12304112

    申请日：2007-06-11

    申请人： Michiko Seyama ,  Serge Camou ,  Yuzuru Iwasaki ,  Toru Miura ,  Jyunichi Takahashi ,  Tsuneyuki Haga ,  Tsutomu Horiuchi

    发明人： Michiko Seyama ,  Serge Camou ,  Yuzuru Iwasaki ,  Toru Miura ,  Jyunichi Takahashi ,  Tsuneyuki Haga ,  Tsutomu Horiuchi

    IPC分类号： C12M1/40 ,  G01N21/01 ,  B01L3/00 ,  G01N21/55

    CPC分类号： G01N33/54373 ,  B01L3/502715 ,  B01L2200/148 ,  B01L2300/0645 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2400/084 ,  G01N21/553

    摘要： The present invention relates to a chip for optical analysis. In particular, the present invention relates to an optical sensor handling a liquid sample, which is a chip for analysis that can be used for selectively measuring a biologically-relevant substance or a chemical substance such as an environmental pollutant or a health affecting substance in a liquid to be measured. The chip for optical analysis of the present invention is characterized in that (1) an adsorption region (filter region) is provided between a sample introduction section and the observation section in a passage of the chip for analysis, (2) a bypass passage is provided in the passage (main passage) of the chip for analysis, and a time lag is generated between samples passed through the main passage and passed through a bypass passage, and (3) a measurement region and a reference region are provided in the observation section of the chip for analysis. In the present invention, the aspects (1) to (3) can be achieved individually or two or more thereof can be combined.

    摘要翻译： 本发明涉及一种用于光学分析的芯片。 特别地，本发明涉及一种处理液体样品的光学传感器，该液体样品是可用于选择性地测量生物相关物质或化学物质如环境污染物质或健康影响物质的分析用芯片 要测量的液体 本发明的光学分析用芯片的特征在于，（1）在用于分析的芯片的通路中，在样品导入部和观察部之间设置有吸附区域（滤波区域），（2）旁路通路 设置在用于分析的芯片的通道（主通道）中，并且在通过主通道并穿过旁路通道的样品之间产生时间延迟，并且（3）在观察中提供测量区域和参考区域 芯片部分进行分析。 在本发明中，方面（1）〜（3）可以单独实现，也可以组合2个以上。

    Sensor element for SPR measurement
    15.
    发明授权
    Sensor element for SPR measurement 有权
    用于SPR测量的传感器元件

    公开(公告)号：US08916389B2

    公开(公告)日：2014-12-23

    申请号：US12303693

    申请日：2007-06-26

    申请人： Yuzuru Iwasaki ,  Michiko Seyama ,  Toru Miura ,  Tsutomu Horiuchi ,  Tsuneyuki Haga ,  Serge Camou

    发明人： Yuzuru Iwasaki ,  Michiko Seyama ,  Toru Miura ,  Tsutomu Horiuchi ,  Tsuneyuki Haga ,  Serge Camou

    IPC分类号： G01N33/553 ,  G01N33/53 ,  G01N33/52 ,  G01N21/55 ,  G01N33/543 ,  G01N33/544

    CPC分类号： G01N21/553 ,  G01N33/53 ,  G01N33/543 ,  G01N33/54373 ,  G01N33/553 ,  Y10T436/2575

    摘要： An object of the present invention is to provide an element for SPR measurement without the need of a mechanical solution-sending mechanism. The scope of the present invention is defined by a sensor element for surface plasmon resonance (SPR) measurement utilizing an SPR effect, wherein the sensor element comprises a transparent substrate, a gold thin film formed on at least a part of the transparent substrate, and a thin film with affinity for a sample provided on the transparent substrate having the gold thin film formed on at least a part thereof, and the thin film with affinity for a sample has a measurement region (region A), a sample introduction section (region B) and a sample absorption section (region C) provided with the region A therebetween, the region A is provided with a sample measurement section containing a molecule-recognizing film, an introduction port is formed on the film with affinity for a sample in the region B, an absorption pad is provided on the film with affinity for a sample in the region C so that the whole region C should be covered, and a point in the region B, a point in the region A, and a point in the region C exist in one straight line on the thin film with affinity for a sample.

    摘要翻译： 本发明的目的是提供一种用于SPR测量的元件，而不需要机械解决方案发送机构。 本发明的范围由用于利用SPR效应的表面等离子体共振（SPR）测量的传感器元件限定，其中传感器元件包括透明基板，形成在透明基板的至少一部分上的金薄膜，以及 对在其至少部分形成有金薄膜的透明基板上提供的样品具有亲和性的薄膜，对样品具有亲和性的薄膜具有测量区域（区域A），样品导入部（区域 B）和在其间设置有区域A的样品吸收部（区域C），区域A设置有包含分子识别膜的样品测定部，在膜上形成有对样品的亲和性的引入口 区域B中，在膜C上提供吸收垫，对区域C中的样品具有亲和性，使得应该覆盖整个区域C，并且区域B中的点，区域A中的点和 区域C中的点在样品的亲和性上存在于薄膜上的一条直线上。

    CHIP FOR OPTICAL ANALYSIS
    16.
    发明申请
    CHIP FOR OPTICAL ANALYSIS 有权
    芯片用于光学分析

    公开(公告)号：US20100248351A1

    公开(公告)日：2010-09-30

    申请号：US12304112

    申请日：2007-06-11

    申请人： Michiko Seyama ,  Serge Camou ,  Yuzuru Iwasaki ,  Toru Miura ,  Jyunichi Takahashi ,  Tsuneyuki Haga ,  Tsutomu Horiuchi

    发明人： Michiko Seyama ,  Serge Camou ,  Yuzuru Iwasaki ,  Toru Miura ,  Jyunichi Takahashi ,  Tsuneyuki Haga ,  Tsutomu Horiuchi

    IPC分类号： C12M1/40 ,  G01N21/01

    CPC分类号： G01N33/54373 ,  B01L3/502715 ,  B01L2200/148 ,  B01L2300/0645 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2400/084 ,  G01N21/553

    摘要： The present invention relates to a chip for optical analysis. In particular, the present invention relates to an optical sensor handling a liquid sample, which is a chip for analysis that can be used for selectively measuring a biologically-relevant substance or a chemical substance such as an environmental pollutant or a health affecting substance in a liquid to be measured. The chip for optical analysis of the present invention is characterized in that (1) an adsorption region (filter region) is provided between a sample introduction section and the observation section in a passage of the chip for analysis, (2) a bypass passage is provided in the passage (main passage) of the chip for analysis, and a time lag is generated between samples passed through the main passage and passed through a bypass passage, and (3) a measurement region and a reference region are provided in the observation section of the chip for analysis. In the present invention, the aspects (1) to (3) can be achieved individually or two or more thereof can be combined.

    摘要翻译： 本发明涉及一种用于光学分析的芯片。 特别地，本发明涉及一种处理液体样品的光学传感器，该液体样品是可用于选择性地测量生物相关物质或化学物质如环境污染物质或健康影响物质的分析用芯片 要测量的液体 本发明的光学分析用芯片的特征在于，（1）在用于分析的芯片的通路中，在样品导入部和观察部之间设置有吸附区域（滤波区域），（2）旁路通路 设置在用于分析的芯片的通道（主通道）中，并且在通过主通道并穿过旁路通道的样品之间产生时间延迟，并且（3）在观察中提供测量区域和参考区域 芯片部分进行分析。 在本发明中，方面（1）〜（3）可以单独实现，也可以组合2个以上。

    Surface plasmon resonance measuring device, sample cell, and measuring method
    17.
    发明授权
    Surface plasmon resonance measuring device, sample cell, and measuring method 有权
    表面等离子体共振测量装置，样品池和测量方法

    公开(公告)号：US08355135B2

    公开(公告)日：2013-01-15

    申请号：US12812219

    申请日：2009-01-16

    申请人： Yuzuru Iwasaki ,  Tsutomu Horiuchi ,  Michiko Seyama ,  Toru Miura ,  Tsuneyuki Haga ,  Tsuyoshi Hayashi

    发明人： Yuzuru Iwasaki ,  Tsutomu Horiuchi ,  Michiko Seyama ,  Toru Miura ,  Tsuneyuki Haga ,  Tsuyoshi Hayashi

    IPC分类号： G01N21/55 ,  H03M1/22

    CPC分类号： G01N35/00732 ,  G01N21/553

    摘要： A surface plasmon resonance measuring device includes a light source (2) which irradiates, with condensed light, a sample cell (10) having the characteristic structure of the reflectance of light that is formed in advance as a code from at least either of a substance film to be measured and a substance film different from the substance film to be measured, from a surface opposite to one on which the substance film to be measured is immobilized to a metal thin film, a CCD camera (5) which detects light reflected by the sample cell (10), and a data processing device (6) which extracts the identification code of the sample cell (10) from the feature of an image sensed by the camera (5).

    摘要翻译： 一种表面等离子体共振测量装置，包括：光源（2），其以冷凝光照射具有预先形成的光的反射率的特征结构的样品池（10），该样品池作为代码从至少一种物质 将被测量的膜和与被测定物质膜相反的表面与被测定物质膜不同的物质膜固定在金属薄膜上，CCD照相机（5），其检测由 所述采样单元（10）以及从所述照相机（5）感测到的图像的特征提取所述样本单元（10）的识别码的数据处理装置（6）。

    SURFACE PLASMON RESONANCE MEASURING DEVICE, SAMPLE CELL, AND MEASURING METHOD
    18.
    发明申请
    SURFACE PLASMON RESONANCE MEASURING DEVICE, SAMPLE CELL, AND MEASURING METHOD 有权
    表面等离子体共振测量装置，样品池和测量方法

    公开(公告)号：US20100284013A1

    公开(公告)日：2010-11-11

    申请号：US12812219

    申请日：2009-01-16

    申请人： Yuzuru Iwasaki ,  Tsutomu Horiuchi ,  Michiko Seyama ,  Toru Miura ,  Tsuneyuki Haga ,  Tsuyoshi Hayashi

    发明人： Yuzuru Iwasaki ,  Tsutomu Horiuchi ,  Michiko Seyama ,  Toru Miura ,  Tsuneyuki Haga ,  Tsuyoshi Hayashi

    IPC分类号： G01N21/55 ,  G01N21/01

    CPC分类号： G01N35/00732 ,  G01N21/553

    摘要： A surface plasmon resonance measuring device includes a light source (2) which irradiates, with condensed light, a sample cell (10) having the characteristic structure of the reflectance of light that is formed in advance as a code from at least either of a substance film to be measured and a substance film different from the substance film to be measured, from a surface opposite to one on which the substance film to be measured is immobilized to a metal thin film, a CCD camera (5) which detects light reflected by the sample cell (10), and a data processing device (6) which extracts the identification code of the sample cell (10) from the feature of an image sensed by the camera (5).

    摘要翻译： 一种表面等离子体共振测量装置，包括：光源（2），其以冷凝光照射具有预先形成的光的反射率的特征结构的样品池（10），该样品池作为代码从至少一种物质 将被测量的膜和与被测定物质膜相反的表面与被测定物质膜不同的物质膜固定在金属薄膜上，CCD照相机（5），其检测由 所述采样单元（10）以及从所述照相机（5）感测到的图像的特征提取所述样本单元（10）的识别码的数据处理装置（6）。

    FLOW CELL
    19.
    发明申请
    FLOW CELL 有权
    流通池

    公开(公告)号：US20100296972A1

    公开(公告)日：2010-11-25

    申请号：US12864222

    申请日：2009-01-30

    申请人： Toru Miura ,  Tsutomu Horiuchi ,  Yuzuru Iwasaki ,  Michiko Seyama

    发明人： Toru Miura ,  Tsutomu Horiuchi ,  Yuzuru Iwasaki ,  Michiko Seyama

    IPC分类号： G01N21/05

    CPC分类号： G01N21/05 ,  B01L3/502707 ,  B01L3/50273 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/086 ,  F04B19/006 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2021/056 ,  Y10T137/2224 ,  Y10T137/85978 ,  Y10T436/2575

    摘要： A measurement fluidic channel (17) is formed at almost the center of a flow cell (1). In general, the measurement region of a measurement apparatus is set to focus on almost the center of a measurement chip. When the flow cell (1) is mounted in the measurement apparatus, the focus of the measurement region is positioned just above the measurement fluidic channel (17). The measurement apparatus can more reliably measure a sample solution flowing through the measurement fluidic channel (17). A suction pump (18) is formed in regions around the measurement fluidic channel (17). When the flow cell has the same planar shape as a conventional one, the amount of sample solution which can be supplied can be increased, compared to a conventional structure in which components are formed in line. The time during which a sample solution flows through the fluidic channel can be prolonged, the amount of sample solution can be increased, and the measurement time can also be prolonged. A sample solution flowing through the fluidic channel can be measured more reliably.

    摘要翻译： 测量流体通道（17）形成在流动池（1）的几乎中心处。 通常，测量装置的测量区域被设置为聚焦在测量芯片的几乎中心。 当流量池（1）安装在测量装置中时，测量区域的焦点位于测量流体通道（17）的正上方。 测量装置可以更可靠地测量流过测量流体通道（17）的样品溶液。 在测量流体通道（17）周围的区域中形成抽吸泵（18）。 当流动池具有与常规流动池相同的平面形状时，与其中部件形成在一起的常规结构相比，可以提高可供应的样品溶液的量。 样品溶液流过流体通道的时间可以延长，可以增加样品溶液的量，并且还可以延长测量时间。 可以更可靠地测量流过流体通道的样品溶液。

    Flow cell
    20.
    发明授权
    Flow cell 有权
    流通池

    公开(公告)号：US08241589B2

    公开(公告)日：2012-08-14

    申请号：US12864222

    申请日：2009-01-30

    申请人： Toru Miura ,  Tsutomu Horiuchi ,  Yuzuru Iwasaki ,  Michiko Seyama

    发明人： Toru Miura ,  Tsutomu Horiuchi ,  Yuzuru Iwasaki ,  Michiko Seyama

    IPC分类号： G01N21/05 ,  G01N21/11

    CPC分类号： G01N21/05 ,  B01L3/502707 ,  B01L3/50273 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/086 ,  F04B19/006 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2021/056 ,  Y10T137/2224 ,  Y10T137/85978 ,  Y10T436/2575

    摘要： A measurement fluidic channel (17) is formed at almost the center of a flow cell (1). In general, the measurement region of a measurement apparatus is set to focus on almost the center of a measurement chip. When the flow cell (1) is mounted in the measurement apparatus, the focus of the measurement region is positioned just above the measurement fluidic channel (17). The measurement apparatus can more reliably measure a sample solution flowing through the measurement fluidic channel (17). A suction pump (18) is formed in regions around the measurement fluidic channel (17). When the flow cell has the same planar shape as a conventional one, the amount of sample solution which can be supplied can be increased, compared to a conventional structure in which components are formed in line. The time during which a sample solution flows through the fluidic channel can be prolonged, the amount of sample solution can be increased, and the measurement time can also be prolonged. A sample solution flowing through the fluidic channel can be measured more reliably.

    摘要翻译： 测量流体通道（17）形成在流动池（1）的几乎中心处。 通常，测量装置的测量区域被设置为聚焦在测量芯片的几乎中心。 当流量池（1）安装在测量装置中时，测量区域的焦点位于测量流体通道（17）的正上方。 测量装置可以更可靠地测量流过测量流体通道（17）的样品溶液。 在测量流体通道（17）周围的区域中形成抽吸泵（18）。 当流动池具有与常规流动池相同的平面形状时，与其中部件形成在一起的常规结构相比，可以提高可供应的样品溶液的量。 样品溶液流过流体通道的时间可以延长，可以增加样品溶液的量，并且还可以延长测量时间。 可以更可靠地测量流过流体通道的样品溶液。