公开(公告)号：US20100233033A1

公开(公告)日：2010-09-16

申请号：US12303943

申请日：2007-06-26

申请人： Tsutomu Horiuchi ,  Toru Miura ,  Yuzuru Iwasaki ,  Jyunichi Takahashi ,  Katsuyoshi Hayashi ,  Tsuneyuki Haga ,  Michiko Seyama ,  Serge Camou

发明人： Tsutomu Horiuchi ,  Toru Miura ,  Yuzuru Iwasaki ,  Jyunichi Takahashi ,  Katsuyoshi Hayashi ,  Tsuneyuki Haga ,  Michiko Seyama ,  Serge Camou

IPC分类号： G01N35/08 ,  B05D3/02 ,  B32B37/12 ,  B44C1/22 ,  B01L3/00 ,  B81B1/00

CPC分类号： G01N35/1095 ,  B01L3/502707 ,  B01L3/502761 ,  B01L2200/0673 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0406

摘要： An object of the invention is to provide various flow cells and a method for manufacturing the same, in which formation of a groove on a substrate and formation of components such as an electrode, auxiliary parts such as a pump are not necessary. The inventive flow cells are capable of realize complicated chemical analysis or synthesis or the like. A channel of a porous member provided on a sample-incompatible substrate is formed; the porous member is composed of an air non-contact region having a network structure and an air contact region covering the air non-contact region and having a lower pore density than the air non-contact region; in which a capillary force to be generated within the porous member is a drive force for pumping a liquid.

摘要翻译： 本发明的目的是提供各种流动池及其制造方法，其中不需要在基板上形成凹槽并形成诸如电极的部件，诸如泵的辅助部件。 本发明的流动池能够实现复杂的化学分析或合成等。 形成设置在样品不相容基板上的多孔构件的通道; 多孔构件由具有网状结构的空气非接触区域和覆盖空气非接触区域的空气接触区域构成，并且具有比空气非接触区域低的孔密度; 其中在多孔构件内产生的毛细管力是泵送液体的驱动力。

公开(公告)号：US08647589B2

公开(公告)日：2014-02-11

申请号：US13554380

申请日：2012-07-20

申请人： Tsutomu Horiuchi ,  Toru Miura ,  Yuzuru Iwasaki ,  Jyunichi Takahashi ,  Katsuyoshi Hayashi ,  Tsuneyuki Haga ,  Michiko Seyama ,  Serge Camou

发明人： Tsutomu Horiuchi ,  Toru Miura ,  Yuzuru Iwasaki ,  Jyunichi Takahashi ,  Katsuyoshi Hayashi ,  Tsuneyuki Haga ,  Michiko Seyama ,  Serge Camou

IPC分类号： B01L3/00

CPC分类号： G01N35/1095 ,  B01L3/502707 ,  B01L3/502761 ,  B01L2200/0673 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0406

摘要： An object of the invention is to provide various flow cells and a method for manufacturing the same, in which formation of a groove on a substrate and formation of components such as an electrode, auxiliary parts such as a pump are not necessary. The inventive flow cells are capable of realize complicated chemical analysis or synthesis or the like. A channel of a porous member provided on a sample-incompatible substrate is formed; the porous member is composed of an air non-contact region having a network structure and an air contact region covering the air non-contact region and having a lower pore density than the air non-contact region; in which a capillary force to be generated within the porous member is a drive force for pumping a liquid.

摘要翻译： 本发明的目的是提供各种流动池及其制造方法，其中不需要在基板上形成凹槽并形成诸如电极的部件，诸如泵的辅助部件。 本发明的流动池能够实现复杂的化学分析或合成等。 形成设置在样品不相容基板上的多孔构件的通道; 多孔构件由具有网状结构的空气非接触区域和覆盖空气非接触区域的空气接触区域构成，并且具有比空气非接触区域低的孔密度; 其中在多孔构件内产生的毛细管力是泵送液体的驱动力。

公开(公告)号：US20120288421A1

公开(公告)日：2012-11-15

申请号：US13554380

申请日：2012-07-20

申请人： Tsutomu Horiuchi ,  Toru Miura ,  Yuzuru Iwasaki ,  Jyunichi Takahashi ,  Katsuyoshi Hayashi ,  Tsuneyuki Haga ,  Michiko Seyama ,  Serge Camou

发明人： Tsutomu Horiuchi ,  Toru Miura ,  Yuzuru Iwasaki ,  Jyunichi Takahashi ,  Katsuyoshi Hayashi ,  Tsuneyuki Haga ,  Michiko Seyama ,  Serge Camou

IPC分类号： B01L3/00

CPC分类号： G01N35/1095 ,  B01L3/502707 ,  B01L3/502761 ,  B01L2200/0673 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0406

摘要： An object of the invention is to provide various flow cells and a method for manufacturing the same, in which formation of a groove on a substrate and formation of components such as an electrode, auxiliary parts such as a pump are not necessary. The inventive flow cells are capable of realize complicated chemical analysis or synthesis or the like. A channel of a porous member provided on a sample-incompatible substrate is formed; the porous member is composed of an air non-contact region having a network structure and an air contact region covering the air non-contact region and having a lower pore density than the air non-contact region; in which a capillary force to be generated within the porous member is a drive force for pumping a liquid.

摘要翻译： 本发明的目的是提供各种流动池及其制造方法，其中不需要在基板上形成凹槽并形成诸如电极的部件，诸如泵的辅助部件。 本发明的流动池能够实现复杂的化学分析或合成等。 形成设置在样品不相容基板上的多孔构件的通道; 多孔构件由具有网状结构的空气非接触区域和覆盖空气非接触区域的空气接触区域构成，并且具有比空气非接触区域低的孔密度; 其中在多孔构件内产生的毛细管力是泵送液体的驱动力。

公开(公告)号：US08859267B2

公开(公告)日：2014-10-14

申请号：US12304112

申请日：2007-06-11

申请人： Michiko Seyama ,  Serge Camou ,  Yuzuru Iwasaki ,  Toru Miura ,  Jyunichi Takahashi ,  Tsuneyuki Haga ,  Tsutomu Horiuchi

发明人： Michiko Seyama ,  Serge Camou ,  Yuzuru Iwasaki ,  Toru Miura ,  Jyunichi Takahashi ,  Tsuneyuki Haga ,  Tsutomu Horiuchi

IPC分类号： C12M1/40 ,  G01N21/01 ,  B01L3/00 ,  G01N21/55

CPC分类号： G01N33/54373 ,  B01L3/502715 ,  B01L2200/148 ,  B01L2300/0645 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2400/084 ,  G01N21/553

摘要： The present invention relates to a chip for optical analysis. In particular, the present invention relates to an optical sensor handling a liquid sample, which is a chip for analysis that can be used for selectively measuring a biologically-relevant substance or a chemical substance such as an environmental pollutant or a health affecting substance in a liquid to be measured. The chip for optical analysis of the present invention is characterized in that (1) an adsorption region (filter region) is provided between a sample introduction section and the observation section in a passage of the chip for analysis, (2) a bypass passage is provided in the passage (main passage) of the chip for analysis, and a time lag is generated between samples passed through the main passage and passed through a bypass passage, and (3) a measurement region and a reference region are provided in the observation section of the chip for analysis. In the present invention, the aspects (1) to (3) can be achieved individually or two or more thereof can be combined.

摘要翻译： 本发明涉及一种用于光学分析的芯片。 特别地，本发明涉及一种处理液体样品的光学传感器，该液体样品是可用于选择性地测量生物相关物质或化学物质如环境污染物质或健康影响物质的分析用芯片 要测量的液体 本发明的光学分析用芯片的特征在于，（1）在用于分析的芯片的通路中，在样品导入部和观察部之间设置有吸附区域（滤波区域），（2）旁路通路 设置在用于分析的芯片的通道（主通道）中，并且在通过主通道并穿过旁路通道的样品之间产生时间延迟，并且（3）在观察中提供测量区域和参考区域 芯片部分进行分析。 在本发明中，方面（1）〜（3）可以单独实现，也可以组合2个以上。

公开(公告)号：US20100248351A1

公开(公告)日：2010-09-30

申请号：US12304112

申请日：2007-06-11

申请人： Michiko Seyama ,  Serge Camou ,  Yuzuru Iwasaki ,  Toru Miura ,  Jyunichi Takahashi ,  Tsuneyuki Haga ,  Tsutomu Horiuchi

发明人： Michiko Seyama ,  Serge Camou ,  Yuzuru Iwasaki ,  Toru Miura ,  Jyunichi Takahashi ,  Tsuneyuki Haga ,  Tsutomu Horiuchi

IPC分类号： C12M1/40 ,  G01N21/01

CPC分类号： G01N33/54373 ,  B01L3/502715 ,  B01L2200/148 ,  B01L2300/0645 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2400/084 ,  G01N21/553

摘要： The present invention relates to a chip for optical analysis. In particular, the present invention relates to an optical sensor handling a liquid sample, which is a chip for analysis that can be used for selectively measuring a biologically-relevant substance or a chemical substance such as an environmental pollutant or a health affecting substance in a liquid to be measured. The chip for optical analysis of the present invention is characterized in that (1) an adsorption region (filter region) is provided between a sample introduction section and the observation section in a passage of the chip for analysis, (2) a bypass passage is provided in the passage (main passage) of the chip for analysis, and a time lag is generated between samples passed through the main passage and passed through a bypass passage, and (3) a measurement region and a reference region are provided in the observation section of the chip for analysis. In the present invention, the aspects (1) to (3) can be achieved individually or two or more thereof can be combined.

摘要翻译： 本发明涉及一种用于光学分析的芯片。 特别地，本发明涉及一种处理液体样品的光学传感器，该液体样品是可用于选择性地测量生物相关物质或化学物质如环境污染物质或健康影响物质的分析用芯片 要测量的液体 本发明的光学分析用芯片的特征在于，（1）在用于分析的芯片的通路中，在样品导入部和观察部之间设置有吸附区域（滤波区域），（2）旁路通路 设置在用于分析的芯片的通道（主通道）中，并且在通过主通道并穿过旁路通道的样品之间产生时间延迟，并且（3）在观察中提供测量区域和参考区域 芯片部分进行分析。 在本发明中，方面（1）〜（3）可以单独实现，也可以组合2个以上。

公开(公告)号：US20100233028A1

公开(公告)日：2010-09-16

申请号：US12303693

申请日：2007-06-26

申请人： Yuzuru Iwasaki ,  Michiko Seyama ,  Toru Miura ,  Tsutomu Horiuchi ,  Tsuneyuki Haga ,  Serge Camou

发明人： Yuzuru Iwasaki ,  Michiko Seyama ,  Toru Miura ,  Tsutomu Horiuchi ,  Tsuneyuki Haga ,  Serge Camou

IPC分类号： G01N30/00

CPC分类号： G01N21/553 ,  G01N33/53 ,  G01N33/543 ,  G01N33/54373 ,  G01N33/553 ,  Y10T436/2575

摘要： An object of the present invention is to provide an element for SPR measurement without the need of a mechanical solution-sending mechanism. The scope of the present invention is defined by a sensor element for surface plasmon resonance (SPR) measurement utilizing an SPR effect, wherein the sensor element comprises a transparent substrate, a gold thin film formed on at least a part of the transparent substrate, and a thin film with affinity for a sample provided on the transparent substrate having the gold thin film formed on at least a part thereof, and the thin film with affinity for a sample has a measurement region (region A), a sample introduction section (region B) and a sample absorption section (region C) provided with the region A therebetween, the region A is provided with a sample measurement section containing a molecule-recognizing film, an introduction port is formed on the film with affinity for a sample in the region B, an absorption pad is provided on the film with affinity for a sample in the region C so that the whole region C should be covered, and a point in the region B, a point in the region A, and a point in the region C exist in one straight line on the thin film with affinity for a sample.

摘要翻译： 本发明的目的是提供一种用于SPR测量的元件，而不需要机械解决方案发送机构。 本发明的范围由用于利用SPR效应的表面等离子体共振（SPR）测量的传感器元件限定，其中传感器元件包括透明基板，形成在透明基板的至少一部分上的金薄膜，以及 对在其至少部分形成有金薄膜的透明基板上提供的样品具有亲和性的薄膜，对样品具有亲和性的薄膜具有测量区域（区域A），样品导入部（区域 B）和在其间设置有区域A的样品吸收部（区域C），区域A设置有包含分子识别膜的样品测定部，在膜上形成有对样品的亲和性的引入口 区域B中，在膜C上提供吸收垫，对区域C中的样品具有亲和性，使得应该覆盖整个区域C，并且区域B中的点，区域A中的点和 区域C中的点在样品的亲和性上存在于薄膜上的一条直线上。

公开(公告)号：US08916389B2

公开(公告)日：2014-12-23

申请号：US12303693

申请日：2007-06-26

申请人： Yuzuru Iwasaki ,  Michiko Seyama ,  Toru Miura ,  Tsutomu Horiuchi ,  Tsuneyuki Haga ,  Serge Camou

发明人： Yuzuru Iwasaki ,  Michiko Seyama ,  Toru Miura ,  Tsutomu Horiuchi ,  Tsuneyuki Haga ,  Serge Camou

IPC分类号： G01N33/553 ,  G01N33/53 ,  G01N33/52 ,  G01N21/55 ,  G01N33/543 ,  G01N33/544

CPC分类号： G01N21/553 ,  G01N33/53 ,  G01N33/543 ,  G01N33/54373 ,  G01N33/553 ,  Y10T436/2575

摘要： An object of the present invention is to provide an element for SPR measurement without the need of a mechanical solution-sending mechanism. The scope of the present invention is defined by a sensor element for surface plasmon resonance (SPR) measurement utilizing an SPR effect, wherein the sensor element comprises a transparent substrate, a gold thin film formed on at least a part of the transparent substrate, and a thin film with affinity for a sample provided on the transparent substrate having the gold thin film formed on at least a part thereof, and the thin film with affinity for a sample has a measurement region (region A), a sample introduction section (region B) and a sample absorption section (region C) provided with the region A therebetween, the region A is provided with a sample measurement section containing a molecule-recognizing film, an introduction port is formed on the film with affinity for a sample in the region B, an absorption pad is provided on the film with affinity for a sample in the region C so that the whole region C should be covered, and a point in the region B, a point in the region A, and a point in the region C exist in one straight line on the thin film with affinity for a sample.

摘要翻译： 本发明的目的是提供一种用于SPR测量的元件，而不需要机械解决方案发送机构。 本发明的范围由用于利用SPR效应的表面等离子体共振（SPR）测量的传感器元件限定，其中传感器元件包括透明基板，形成在透明基板的至少一部分上的金薄膜，以及 对在其至少部分形成有金薄膜的透明基板上提供的样品具有亲和性的薄膜，对样品具有亲和性的薄膜具有测量区域（区域A），样品导入部（区域 B）和在其间设置有区域A的样品吸收部（区域C），区域A设置有包含分子识别膜的样品测定部，在膜上形成有对样品的亲和性的引入口 区域B中，在膜C上提供吸收垫，对区域C中的样品具有亲和性，使得应该覆盖整个区域C，并且区域B中的点，区域A中的点和 区域C中的点在样品的亲和性上存在于薄膜上的一条直线上。

公开(公告)号：US08263025B2

公开(公告)日：2012-09-11

申请号：US12864854

申请日：2009-01-30

申请人： Toru Miura ,  Tsutomu Horiuchi ,  Yuzuru Iwasaki ,  Michiko Seyama ,  Serge Camou ,  Tsuyoshi Hayashi ,  Jun-ichi Takahashi

发明人： Toru Miura ,  Tsutomu Horiuchi ,  Yuzuru Iwasaki ,  Michiko Seyama ,  Serge Camou ,  Tsuyoshi Hayashi ,  Jun-ichi Takahashi

IPC分类号： G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC分类号： G01N21/05 ,  B01L3/502707 ,  B01L3/50273 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0851 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/082 ,  B01L2400/086 ,  F04B19/006 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2021/056 ,  Y10T137/85978

摘要： Ends (134a-1) of projections (134a) do not contact a first substrate (11), forming a gap between the ends (134a-1) and the first substrate (11). The internal capacity of a suction pump (17) can be increased by an amount by which the projections (134a) are shortened, compared to a conventional structure in which pillars are formed to connect the ceiling and bottom of the cavity of a capillary pump. The capacity of the suction pump (17) can be increased without enlarging the planar shape. Further, the ends (134a-1) of the projections (134a) do not contact the first substrate (11), forming a gap between them. An impurity can pass through the gap, and clogging of the inside of the suction pump (17) with the impurity can be prevented, realizing a stable operation.

摘要翻译： 突起（134a）的端部（134a-1）不接触第一基板（11），在端部（134a-1）和第一基板（11）之间形成间隙。 与形成有用于连接毛细管泵的空腔的顶部和底部的柱的常规结构相比，抽吸泵（17）的内部容量可以增加突起（134a）缩短的量。 可以增加抽吸泵（17）的容量，而不会扩大平面形状。 此外，突起（134a）的端部（134a-1）不与第一基板（11）接触，在它们之间形成间隙。 杂质可以通过间隙，并且可以防止吸入泵17的内部与杂质的堵塞，实现稳定的操作。

公开(公告)号：US20100307617A1

公开(公告)日：2010-12-09

申请号：US12864854

申请日：2009-01-30

申请人： Toru Miura ,  Tsutomu Horiuchi ,  Yuzuru Iwasaki ,  Michiko Seyama ,  Serge Camou ,  Tsuyoshi Hayashi ,  Jun-ichi Takahashi

发明人： Toru Miura ,  Tsutomu Horiuchi ,  Yuzuru Iwasaki ,  Michiko Seyama ,  Serge Camou ,  Tsuyoshi Hayashi ,  Jun-ichi Takahashi

IPC分类号： F15D1/00

CPC分类号： G01N21/05 ,  B01L3/502707 ,  B01L3/50273 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0851 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/082 ,  B01L2400/086 ,  F04B19/006 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2021/056 ,  Y10T137/85978

摘要： Ends (134a-1) of projections (134a) do not contact a first substrate (11), forming a gap between the ends (134a-1) and the first substrate (11). The internal capacity of a suction pump (17) can be increased by an amount by which the projections (134a) are shortened, compared to a conventional structure in which pillars are formed to connect the ceiling and bottom of the cavity of a capillary pump. The capacity of the suction pump (17) can be increased without enlarging the planar shape. Further, the ends (134a-1) of the projections (134a) do not contact the first substrate (11), forming a gap between them. An impurity can pass through the gap, and clogging of the inside of the suction pump (17) with the impurity can be prevented, realizing a stable operation.

摘要翻译： 突起（134a）的端部（134a-1）不接触第一基板（11），在端部（134a-1）和第一基板（11）之间形成间隙。 与形成有用于连接毛细管泵的空腔的顶部和底部的柱的常规结构相比，抽吸泵（17）的内部容量可以增加突起（134a）缩短的量。 可以增加抽吸泵（17）的容量，而不会扩大平面形状。 此外，突起（134a）的端部（134a-1）不与第一基板（11）接触，在它们之间形成间隙。 杂质可以通过间隙，并且可以防止吸入泵17的内部与杂质的堵塞，实现稳定的操作。

公开(公告)号：US20110070655A1

公开(公告)日：2011-03-24

申请号：US12993298

申请日：2009-05-26

申请人： Tsutomu Horiuchi ,  Toru Miura ,  YUzuru Iwasaki ,  Michiko Seyama ,  Tsuyoshi Hayashi ,  Jun-Ichi Takahashi ,  Tsuneyuki Haga

发明人： Tsutomu Horiuchi ,  Toru Miura ,  YUzuru Iwasaki ,  Michiko Seyama ,  Tsuyoshi Hayashi ,  Jun-Ichi Takahashi ,  Tsuneyuki Haga

IPC分类号： G01N1/28

CPC分类号： G01N21/05 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L2200/0621 ,  B01L2200/148 ,  B01L2200/16 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0694 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2035/1039

摘要： A flow cell includes: a flow channel through which a sample solution flows; an inlet section which communicates with the flow channel and to which the sample solution is supplied; a transfer section which includes a plurality of opening sections, one end side of which communicates with the flow channel and an other side of which opens to outside air, and which communicates with the flow channel, and draws in and guides the sample solution supplied into the inlet section to the flow channel; a detecting section which faces the sample solution in the flow channel; and a sealing member which unsealably seals at least either one of the opening section or the inlet section.

摘要翻译： 流动池包括：样品溶液流过的流动通道; 入口部分，其与所述流动通道连通并且供应所述样品溶液; 转移部，其包括多个开口部，其一端侧与流路连通，另一侧与外部空气连通，与流路连通，吸入并引导供给的样品溶液 流道的入口部分; 检测部，其面向流路中的样品溶液; 以及密封构件，其不分封地密封所述开口部或所述入口部中的至少一个。