公开(公告)号：US09597103B2

公开(公告)日：2017-03-21

申请号：US14941276

申请日：2015-11-13

Applicant: University of Washington through its Center for Commercialization

Inventor： Michael Bailey ,  John Kucewicz ,  Barbrina Dunmire ,  Neil Owen ,  Bryan Cunitz

IPC: A61N7/02 ,  A61B17/225 ,  A61B8/08 ,  A61N7/00 ,  A61B6/03 ,  A61B6/00 ,  A61B5/055 ,  A61B17/22 ,  G01S7/52 ,  G01S15/89 ,  A61B5/00

CPC classification number: A61B17/225 ,  A61B5/055 ,  A61B5/7232 ,  A61B6/03 ,  A61B6/485 ,  A61B8/085 ,  A61B8/488 ,  A61B17/2256 ,  A61B2017/22005 ,  A61B2090/378 ,  A61N7/00 ,  A61N2007/0004 ,  A61N2007/0052 ,  A61N2007/0082 ,  G01S7/52071 ,  G01S15/899

Abstract: Described herein are methods and apparatus for detecting stones by ultrasound, in which the ultrasound reflections from a stone are preferentially selected and accentuated relative to the ultrasound reflections from blood or tissue. Also described herein are methods and apparatus for applying pushing ultrasound to in vivo stones or other objects, to facilitate the removal of such in vivo objects.

公开(公告)号：US20160287909A1

公开(公告)日：2016-10-06

申请号：US14777949

申请日：2014-03-28

Applicant: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION ,  THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： Adam Maxwell ,  Ryan Hsi ,  Thomas Lendvay ,  Pasquale Casale ,  Michael Bailey

IPC: A61N7/00 ,  A61B8/00 ,  A61B8/08

CPC classification number: A61N7/00 ,  A61B8/0866 ,  A61B8/44 ,  A61B8/4444 ,  A61B2090/3784 ,  A61N7/02 ,  A61N2007/006 ,  A61N2007/0065 ,  A61N2007/0078 ,  A61N2007/0086

Abstract: Methods for diagnosing a pathologic tissue membrane, as well as a focused ultrasound apparatus and methods of treatment are disclosed to perform ureterocele puncture noninvasively using focused ultrasound-generated cavitation or boiling bubbles to controllably erode a hole through the tissue. An example ultrasound apparatus may include (a) a therapy transducer having a treatment surface, wherein the therapy transducer comprises a plurality of electrically isolated sections, (b) at least one concave acoustic lens defining a therapy aperture in the treatment surface of the therapy transducer, (c) an imaging aperture defined by either the treatment surface of the therapy transducer or by the at least one concave acoustic lens and (d) an ultrasound imaging probe axially aligned with a central axis of the therapy aperture.

Abstract translation: 公开了用于诊断病理组织膜的方法，以及聚焦超声装置和治疗方法，使用聚焦超声产生的空化或沸腾气泡非侵入性地执行输尿管穿刺，以可控地侵蚀通过组织的孔。 示例性超声装置可以包括（a）具有治疗表面的治疗换能器，其中所述治疗换能器包括多个电隔离部分，（b）至少一个凹面声透镜，其在治疗传感器的治疗表面中限定治疗孔 ，（c）由治疗换能器的治疗表面或至少一个凹面声透镜所定义的成像孔和（d）与治疗孔的中心轴线轴向对准的超声成像探针。

公开(公告)号：US20140081174A1

公开(公告)日：2014-03-20

申请号：US13966535

申请日：2013-08-14

Applicant: University of Washington Through Its Center for Commercialization

Inventor： Neil Owen ,  Michael Bailey ,  Oleg Sapozhinikov

IPC: A61B17/225 ,  A61B5/00 ,  A61B7/04

CPC classification number: A61B17/22004 ,  A61B5/05 ,  A61B5/06 ,  A61B5/4848 ,  A61B7/00 ,  A61B7/04 ,  A61B8/00 ,  A61B8/0833 ,  A61B8/085 ,  A61B8/13 ,  A61B17/22012 ,  A61B17/22029 ,  A61B17/225 ,  A61B17/2255 ,  A61B17/2256 ,  A61B2017/22011 ,  A61N7/00 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0052 ,  G06T7/0012 ,  G06T7/0016 ,  G10K11/35 ,  G10K15/04

Abstract: During shock wave therapy, a determination is made that a kidney stone has begun to fracture, and then a progress of its fragmentation is assessed. This determination can reduce the number of shock waves used to disintegrate kidney stones, and thereby reduce dose-dependent tissue damage. The identification of fracture is possible through the detection and analysis of resonant acoustic scattering, which is the radiation caused by reverberations within a stone particle that is struck by a shock wave. The scattering frequency can provide both an indication that the kidney stone has fragmented, and an indication of the relative sizes of the fragments. Related concepts employ displacement measurements of kidney stones/fragments to provide both an indication that the kidney stone has fragmented, and an indication of the relative sizes of the fragments. Such techniques can be combined with vibro-acoustography based gating that better targets the stone.

Abstract translation: 在冲击波治疗期间，确定肾结石已经开始断裂，然后评估其破碎进展。 这种测定可以减少用于分解肾结石的冲击波的数量，从而减少剂量依赖性组织损伤。 通过检测和分析谐振声散射可以确定断裂，该共振声散射是由受冲击波撞击的石颗粒内的混响引起的辐射。 散射频率可以提供肾结石已经碎裂的指示，以及片段的相对大小的指示。 相关概念使用肾结石/碎片的位移测量来提供肾结石已经分裂的指征，以及碎片的相对大小的指示。 这种技术可以与更好地瞄准石头的基于振动 - 声学的门控相结合。