公开(公告)号：US07012127B1

公开(公告)日：2006-03-14

申请号：US09588525

申请日：2000-06-06

申请人： Manuel de Jesús Araña Rosainz ,  Glay Chinea Santiago ,  Maribel Guerra Vallespi ,  Osvaldo Reyes Acosta

发明人： Manuel de Jesús Araña Rosainz ,  Glay Chinea Santiago ,  Maribel Guerra Vallespi ,  Osvaldo Reyes Acosta

IPC分类号： C07K14/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention relates to analogues of peptides from lipopolysaccharide-binding protein (LBP) region whose primary sequence have been substituted at particular amino acid sites to obtain effective binding to, and neutralization of, lipopolysaccharide (LPS).

摘要翻译： 本发明涉及来自脂多糖结合蛋白（LBP）区域的肽类似物，其一级序列已在特定氨基酸位点被取代，以获得对脂多糖（LPS）的有效结合和中和。

公开(公告)号：US06383488B1

公开(公告)日：2002-05-07

申请号：US09341833

申请日：1999-10-14

申请人： Susana Vazquez Ramudo ,  Guadalupe Guzman Tirado ,  Gerardo Enrique Guillen Nieto ,  Orlando Luis Pardo Lazo ,  Glay Chinea Santiago ,  Ana Beatriz Perez Diaz ,  Maritza Pupo Antunez ,  Rosmari Rodriguez Roche ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Perez ,  Gabriel Padron Palomares ,  Maylin Alvarez Vera ,  Luis Morier Diaz ,  Omaida Perez Insuita ,  Jose Luis Pelegrino Martinez De La Cotera

发明人： Susana Vazquez Ramudo ,  Guadalupe Guzman Tirado ,  Gerardo Enrique Guillen Nieto ,  Orlando Luis Pardo Lazo ,  Glay Chinea Santiago ,  Ana Beatriz Perez Diaz ,  Maritza Pupo Antunez ,  Rosmari Rodriguez Roche ,  Osvaldo Reyes Acosta ,  Hilda Elisa Garay Perez ,  Gabriel Padron Palomares ,  Maylin Alvarez Vera ,  Luis Morier Diaz ,  Omaida Perez Insuita ,  Jose Luis Pelegrino Martinez De La Cotera

IPC分类号： A61K3912

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C12N2770/24122 ,  G01N2333/18 ,  Y02A50/386

摘要： The present invention relates to five synthetic peptides of pre-M/M protein of Dengue-2 virus, corresponding to amino acid sequences 3-31, 45-67, 57-92, 69-93 and 103-124. The anti-peptide immune response was evaluated in mice. Recombinant fusion proteins were also obtained, including regions of pre-M/M protein. The presence of B cell epitopes in both mice and humans was demonstrated in the pre-M/M protein peptides. Peptides 3-31 and 103-124 elicited neutralizing antibodies against the four serotypes of Dengue virus. Virus-specific proliferative responses were demonstrated in mice immunized with non-conjugated peptides 3-31 and 57-92. Mice immunized with conjugated peptides 3-31, 57-92, and 69-93 were protected when they were challenged with Dengue-2 virus. Thus, the presence of sequential epitopes in Pre-M/M protein of Dengue-2 virus was demonstrated, as well as their relevance in the immune response against this flavivirus.

摘要翻译： 本发明涉及对应于氨基酸序列3-31,45-67,57-92,69-93和103-124的五种登革热-2病毒前M / M蛋白的合成肽。 在小鼠中评估抗肽免疫应答。 还获得了重组融合蛋白，包括前M / M蛋白的区域。 在M-M蛋白肽前体中证实了小鼠和人体中B细胞表位的存在。 肽3-31和103-124引发针对登革热病毒的四种血清型的中和抗体。 在用非结合肽3-31和57-92免疫的小鼠中证明病毒特异性增殖应答。 当用登革热-2病毒攻击时，用缀合肽3-31,57-92和69-93免疫的小鼠被保护。 因此，证实了登革2型病毒的Pre-M / M蛋白中序列表位的存在，以及它们在针对该黄病毒的免疫应答中的相关性。

公开(公告)号：US20140206621A1

公开(公告)日：2014-07-24

申请号：US14075276

申请日：2013-11-08

申请人： Maribel Guerra Vallespi ,  Julio Raúl Fernández Massó ,  Alexis Musacchio Lasa ,  Jeovanis Gil Valdés ,  Osvaldo Reyes Acosta ,  Brizaida Maylin Oliva Argüelles

发明人： Maribel Guerra Vallespi ,  Julio Raúl Fernández Massó ,  Alexis Musacchio Lasa ,  Jeovanis Gil Valdés ,  Osvaldo Reyes Acosta ,  Brizaida Maylin Oliva Argüelles

IPC分类号： C12N15/11 ,  C07K7/08

CPC分类号： C12N15/11 ,  A61K31/505 ,  A61K31/513 ,  A61K33/24 ,  A61K38/10 ,  A61K38/1767 ,  A61K45/06 ,  A61K48/00 ,  C07K7/08 ,  G01N33/574 ,  A61K2300/00

摘要： This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.

摘要翻译： 本发明描述了通过增加与降低或阻断癌细胞增殖相关的COMMD1蛋白的核定位来治疗癌症的方法。 本发明还涉及在制造用于癌症治疗的药物中增加COMMD1蛋白的核定位的试剂的用途。 这些试剂可以是其他化合物中的肽或蛋白质。 本发明还涉及来自序列HARIKPTFRRLKWKKYKGKFW的肽的优化，以增加蛋白质COMMD的核定位，从而提高该肽的抗肿瘤效果。

公开(公告)号：US07736638B2

公开(公告)日：2010-06-15

申请号：US11662844

申请日：2005-09-16

申请人： Alicia Santos Savio ,  Ania Cabrales Rico ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Celia Aurora Arrieta Aguero ,  Silvio Ernesto Perea Rodriguez

发明人： Alicia Santos Savio ,  Ania Cabrales Rico ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Celia Aurora Arrieta Aguero ,  Silvio Ernesto Perea Rodriguez

IPC分类号： A61K38/20 ,  C12N15/06 ,  C07K14/54 ,  C12N5/02 ,  C12P21/02

CPC分类号： C07K14/5443 ,  A61K38/00 ,  A61K39/00 ,  C07K16/244

摘要： Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor a subunit (IL15Rα) and TNFα-mediated apoptosis.Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15Rα expression is associated to the disease progression.

摘要翻译： 本发明涉及分子药理学分支，特别是涉及能够抑制IL-15生物活性，类似物或模拟这些肽的白细胞介素-15序列（IL-15）的肽。 在本发明中，显示肽结合IL15受体a亚基（IL15Rα）和TNFα介导的细胞凋亡后，抑制IL-15诱导的T细胞增殖。 此外，本发明涉及该肽用于治疗其中异常IL-15或IL-15Rα表达与疾病进展相关的几种病症的用途。

公开(公告)号：US20130224313A1

公开(公告)日：2013-08-29

申请号：US13700286

申请日：2011-05-31

申请人： Maribel Guerra Vallespi ,  Julio Raúl Fernández Massó ,  Alexis Musacchio Lasa ,  Jeovanis Gil Valdés ,  Osvaldo Reyes Acosta ,  Brizaida Maylin Oliva Argüelles

发明人： Maribel Guerra Vallespi ,  Julio Raúl Fernández Massó ,  Alexis Musacchio Lasa ,  Jeovanis Gil Valdés ,  Osvaldo Reyes Acosta ,  Brizaida Maylin Oliva Argüelles

IPC分类号： A61K38/10 ,  A61K31/513 ,  A61K33/24 ,  G01N33/574 ,  A61K48/00 ,  C07K7/08

CPC分类号： C12N15/11 ,  A61K31/505 ,  A61K31/513 ,  A61K33/24 ,  A61K38/10 ,  A61K38/1767 ,  A61K45/06 ,  A61K48/00 ,  C07K7/08 ,  G01N33/574 ,  A61K2300/00

摘要： This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.

摘要翻译： 本发明描述了通过增加与降低或阻断癌细胞增殖相关的COMMD1蛋白的核定位来治疗癌症的方法。 本发明还涉及在制造用于癌症治疗的药物中增加COMMD1蛋白的核定位的试剂的用途。 这些试剂可以是其他化合物中的肽或蛋白质。 本发明还涉及来自序列HARIKPTFRRLKWKKYKGKFW的肽的优化，以增加蛋白质COMMD的核定位，从而提高该肽的抗肿瘤效果。

公开(公告)号：US08729226B2

公开(公告)日：2014-05-20

申请号：US13700286

申请日：2011-05-31

申请人： Maribel Guerra Vallespi ,  Julio Raúl Fernández Massó ,  Alexis Musacchio Lasa ,  Jeovanis Gil Valdés ,  Osvaldo Reyes Acosta ,  Brizaida Maylin Oliva Argüelles

发明人： Maribel Guerra Vallespi ,  Julio Raúl Fernández Massó ,  Alexis Musacchio Lasa ,  Jeovanis Gil Valdés ,  Osvaldo Reyes Acosta ,  Brizaida Maylin Oliva Argüelles

IPC分类号： A61K38/00

CPC分类号： C12N15/11 ,  A61K31/505 ,  A61K31/513 ,  A61K33/24 ,  A61K38/10 ,  A61K38/1767 ,  A61K45/06 ,  A61K48/00 ,  C07K7/08 ,  G01N33/574 ,  A61K2300/00

摘要： This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.

摘要翻译： 本发明描述了通过增加与降低或阻断癌细胞增殖相关的COMMD1蛋白的核定位来治疗癌症的方法。 本发明还涉及在制造用于癌症治疗的药物中增加COMMD1蛋白的核定位的试剂的用途。 这些试剂可以是其他化合物中的肽或蛋白质。 本发明还涉及来自序列HARIKPTFRRLKWKKYKGKFW的肽的优化，以增加蛋白质COMMD的核定位，从而提高该肽的抗肿瘤效果。

公开(公告)号：US09205128B2

公开(公告)日：2015-12-08

申请号：US13637845

申请日：2011-04-01

申请人： Celia Berta Fernandez Ortega ,  Anna Caridys Ramírez Suárez ,  Dionne Casillas Casanova ,  Taimi Emelia Paneque Guerrero ,  Raimundo Ubieta Gómez ,  Marta Dubed Echevarria ,  Leonor Margarita Navea Leyva ,  Lila Rosa Castellanos Serra ,  Carlos Antonio Duarte Cano ,  Viviana Falcón Cama ,  Osvaldo Reyes Acosta

发明人： Celia Berta Fernandez Ortega ,  Anna Caridys Ramírez Suárez ,  Dionne Casillas Casanova ,  Taimi Emelia Paneque Guerrero ,  Raimundo Ubieta Gómez ,  Marta Dubed Echevarria ,  Leonor Margarita Navea Leyva ,  Lila Rosa Castellanos Serra ,  Carlos Antonio Duarte Cano ,  Viviana Falcón Cama ,  Osvaldo Reyes Acosta

IPC分类号： A61K38/10 ,  C12N5/0783 ,  A61K31/713 ,  A61K31/19 ,  A61K38/17 ,  A61K45/06 ,  A61K31/7105 ,  A61K31/5575 ,  C07K14/47 ,  C12N15/113

CPC分类号： A61K38/10 ,  A61K31/19 ,  A61K31/5575 ,  A61K31/7105 ,  A61K31/713 ,  A61K38/1709 ,  A61K38/1748 ,  A61K45/06 ,  C07K14/47 ,  C07K14/4741 ,  C12N5/0636 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/1132 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/31

摘要： The present invention describes a method to inhibit replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, more precisely the proteins forming the intermediate cytoskeletal filaments, wherein the said proteins are vimentin and/or keratin-10. The replication of the virus is inhibited in human cells by intervening in the structure of these proteins. The present invention is also related to the use of agents, which comprise peptides and/or interfering RNA and/or lipidic compounds, said agents producing a negative modulation or alteration of the cytoskeleton to prevent or to treat the HIV infection. The invention provides means and methods for altering the cytoskeleton/filament structure of cells, as a result of which the infection of human cells by HIV is disturbed and can even be completely inhibited. The cytoskeleton is altered by reducing the amount of vimentin and/or keratin (e.g. by transcriptional control using interfering RNA) or by using peptides that disrupt the cytoskeleton.

摘要翻译： 本发明描述了通过负面调节或改变细胞骨架，更精确地形成中间细胞骨架细丝的蛋白质来抑制人免疫缺陷病毒（HIV）复制的方法，其中所述蛋白质是波形蛋白和/或角蛋白-10。 通过介入这些蛋白质的结构，人类细胞中病毒的复制被抑制。 本发明还涉及包含肽和/或干扰RNA和/或脂质化合物的试剂的用途，所述试剂产生细胞骨架的负调节或改变以预防或治疗HIV感染。 本发明提供用于改变细胞的细胞骨架/细丝结构的方法和方法，其结果是HIV的人细胞感染被干扰并且甚至可以被完全抑制。 通过减少波形蛋白和/或角蛋白的量（例如通过使用干扰RNA的转录控制）或通过使用破坏细胞骨架的肽来改变细胞骨架。

公开(公告)号：US20110250196A1

公开(公告)日：2011-10-13

申请号：US13121915

申请日：2009-09-30

申请人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

发明人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P37/04 ,  A61K39/00

CPC分类号： A61K39/0011 ,  A61K38/09 ,  A61K39/0006 ,  A61K47/48261 ,  A61K47/4833 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/585 ,  A61K2039/6037 ,  A61K2300/00

摘要： A pharmaceutical composition using natural gonadotropin-releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule; in one case by its carboxyl extreme and in the other case by the amino terminal extreme, thus eliciting a faster and more potent immunological response against the endogenous GnRH hormone. This finally leads to the ablation of the GnRH and consequently of the rest of the involved hormones in the stream GnRH/LH-FSH/Testosterone-(estrogens). An advantage of this formulation consists on facilitating the exposition to the immune system of a greater number of epitopes of the GnRH or its mimetics, minimizing thus the steric hindrance produced by the carriers. This invention has a direct application in the castration of pets and animals of economic interest, in the control of human fertility as well as in the treatment of hormone-sensitive tumors, such as that of the prostate, the breast, ovary, the endometry, testicles, hypophysis, salivary glands and other kinds of human tumors.

摘要翻译： 使用天然促性腺激素释放激素（GnRH）和/或其一些模拟肽的药物组合物，其不明显地被其氨基或羧基末端与载体分子结合; 在一种情况下其羧基末端，另一种情况下由氨基末端极端，从而引发对内源GnRH激素的更快更有效的免疫应答。 这最终导致消化GnRH，从而导致流GnRH / LH-FSH /睾酮（雌激素）中涉及的其他激素的消融。 该制剂的优点在于促进免疫系统暴露于更多数量的GnRH或其模拟物的表位，从而最小化载体产生的空间位阻。 本发明直接应用于经济兴趣的宠物和动物的阉割，控制人的生育能力以及治疗激素敏感性肿瘤，如前列腺，乳腺，卵巢， 睾丸，垂体，唾液腺等多种人体肿瘤。

公开(公告)号：US08999931B2

公开(公告)日：2015-04-07

申请号：US13121915

申请日：2009-09-30

申请人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

发明人： Jesus Arturo Junco Barranco ,  Osvaldo Reyes Acosta ,  Eddy Emilio Bover Fuentes ,  Franklin Fuentes Aguilar ,  Eulogio Pimentel Vazquez ,  Roberto Basulto Baker ,  Gerardo Enrique Guillen Nieto ,  Yovisleidys Lopez Saez ,  Hilda Elisa Garay Perez ,  Lesvia Calzada Aguilera ,  Maria Castro Santana ,  Niurka Oneysi Arteaga More ,  Luis Alberto Aguero Barrocal

IPC分类号： A61K38/09 ,  A61K47/48 ,  A61K39/00

CPC分类号： A61K39/0011 ,  A61K38/09 ,  A61K39/0006 ,  A61K47/48261 ,  A61K47/4833 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/585 ,  A61K2039/6037 ,  A61K2300/00

摘要： A pharmaceutical composition using natural gonadotropin-releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule; in one case by its carboxyl extreme and in the other case by the amino terminal extreme, thus eliciting a faster and more potent immunological response against the endogenous GnRH hormone. This finally leads to the ablation of the GnRH and consequently of the rest of the involved hormones in the stream GnRH/LH-FSH/Testosterone-(estrogens). An advantage of this formulation consists on facilitating the exposition to the immune system of a greater number of epitopes of the GnRH or its mimetics, minimizing thus the steric hindrance produced by the carriers. This invention has a direct application in the castration of pets and animals of economic interest, in the control of human fertility as well as in the treatment of hormone-sensitive tumors, such as that of the prostate, the breast, ovary, the endometry, testicles, hypophysis, salivary glands and other kinds of human tumors.

摘要翻译： 使用天然促性腺激素释放激素（GnRH）和/或其一些模拟肽的药物组合物，其不明显地被其氨基或羧基末端与载体分子结合; 在一种情况下其羧基末端，另一种情况下由氨基末端极端，从而引发对内源GnRH激素的更快更有效的免疫应答。 这最终导致消化GnRH，从而导致流GnRH / LH-FSH /睾酮（雌激素）中涉及的其他激素的消融。 该制剂的优点在于促进免疫系统暴露于更多数量的GnRH或其模拟物的表位，从而最小化载体产生的空间位阻。 本发明直接应用于经济兴趣的宠物和动物的阉割，控制人的生育能力以及治疗激素敏感性肿瘤，如前列腺，乳腺，卵巢， 睾丸，垂体，唾液腺等多种人体肿瘤。

公开(公告)号：US08431524B2

公开(公告)日：2013-04-30

申请号：US13120855

申请日：2009-09-30

申请人： Alicia Santos Savio ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Hilda Elisa Garay Perez ,  Yunier Rodriguez Alvarez ,  Gerardo Enríque Guillen Nieto

发明人： Alicia Santos Savio ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Hilda Elisa Garay Perez ,  Yunier Rodriguez Alvarez ,  Gerardo Enríque Guillen Nieto

IPC分类号： A61K38/04 ,  C12Q1/68

CPC分类号： C07K14/5443 ,  A61K38/00

摘要： The present invention is related to the field of molecular immunology, particularly to a peptide derived from the sequence of interleukine-15 (IL-15), wherein said peptide was optimized to inhibit the biological activity of this molecule. In the present invention, it is shown that this peptide inhibits IL-15-induced T cell proliferation, Tumor Necrosis Factor α (TNFα) induction and the expression of IL-8 and IL-6 by the IL-15 receptor α subunit (IL-15Rα), all these effects mediated by the binding of the peptide to the IL-15Rα. The invention is also related to the use of the peptide to treat pathologies where the abnormal expression of IL-15 or IL-15Rα is related to the course of the disease, such as rheumatoid arthritis (RA) and prostate cancer.

摘要翻译： 本发明涉及分子免疫学领域，特别涉及衍生自白介素-15（IL-15）序列的肽，其中所述肽被优化以抑制该分子的生物学活性。 在本发明中，显示该肽抑制IL-15诱导的T细胞增殖，肿瘤坏死因子α（TNFalpha）诱导和IL-8受体α亚基（IL）的IL-8和IL-6的表达 -15Rα），所有这些作用由肽与IL-15Rα的结合介导。 本发明还涉及使用肽来治疗其中IL-15或IL-15Rα异常表达与疾病进程如类风湿性关节炎（RA）和前列腺癌相关的病理学。