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1.发明授权Analogues of lipopolysaccharide-binding protein (LBP)-derived peptides that efficiently neutralize lipopolysaccharides (LPS) 失效类脂多糖结合蛋白（LBP）衍生的肽，有效中和脂多糖（LPS）公开(公告)号：US07012127B1
公开(公告)日：2006-03-14
申请号：US09588525
申请日：2000-06-06
申请人： Manuel de Jesús Araña Rosainz , Glay Chinea Santiago , Maribel Guerra Vallespi , Osvaldo Reyes Acosta
发明人： Manuel de Jesús Araña Rosainz , Glay Chinea Santiago , Maribel Guerra Vallespi , Osvaldo Reyes Acosta
摘要： The present invention relates to analogues of peptides from lipopolysaccharide-binding protein (LBP) region whose primary sequence have been substituted at particular amino acid sites to obtain effective binding to, and neutralization of, lipopolysaccharide (LPS).
摘要翻译： 本发明涉及来自脂多糖结合蛋白（LBP）区域的肽类似物，其一级序列已在特定氨基酸位点被取代，以获得对脂多糖（LPS）的有效结合和中和。
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2.发明授权Cell penetrating peptides and its use fused to biomolecules with therapeutic action 有权细胞穿透肽及其使用与具有治疗作用的生物分子融合公开(公告)号：US08673313B2
公开(公告)日：2014-03-18
申请号：US12671335
申请日：2008-07-31
申请人： Isis del Carmen Torrens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
发明人： Isis del Carmen Torrens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
CPC分类号： A61K39/12 , A61K2039/585 , A61K2039/6031 , C12N2710/20034
摘要： The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen-exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.
摘要翻译： 本发明涉及使用新的细胞穿透肽（CPP），特别涉及蛋白鲎抗脂蛋白（LALF）的区域32-51及其类似物。 本发明涉及包含与具有治疗学性质的生物分子相关联的这些肽的组合物。 本发明由组合物组成，包括生物分子的共价融合，在该人乳头状瘤病毒抗原（HPV）与这些CPP之间，用于诱导对HPV和HPV蛋白抗原呈递细胞（包括HPV相关肿瘤）的有效免疫细胞应答。 所提及的组合物可用作制药工业中用于人类治疗用途的疫苗。
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公开(公告)号：US20140206621A1
公开(公告)日：2014-07-24
申请号：US14075276
申请日：2013-11-08
申请人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
发明人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
CPC分类号： C12N15/11 , A61K31/505 , A61K31/513 , A61K33/24 , A61K38/10 , A61K38/1767 , A61K45/06 , A61K48/00 , C07K7/08 , G01N33/574 , A61K2300/00
摘要： This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.
摘要翻译： 本发明描述了通过增加与降低或阻断癌细胞增殖相关的COMMD1蛋白的核定位来治疗癌症的方法。 本发明还涉及在制造用于癌症治疗的药物中增加COMMD1蛋白的核定位的试剂的用途。 这些试剂可以是其他化合物中的肽或蛋白质。 本发明还涉及来自序列HARIKPTFRRLKWKKYKGKFW的肽的优化，以增加蛋白质COMMD的核定位，从而提高该肽的抗肿瘤效果。
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公开(公告)号：US20130224313A1
公开(公告)日：2013-08-29
申请号：US13700286
申请日：2011-05-31
申请人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
发明人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
IPC分类号： A61K38/10 , A61K31/513 , A61K33/24 , G01N33/574 , A61K48/00 , C07K7/08
CPC分类号： C12N15/11 , A61K31/505 , A61K31/513 , A61K33/24 , A61K38/10 , A61K38/1767 , A61K45/06 , A61K48/00 , C07K7/08 , G01N33/574 , A61K2300/00
摘要： This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.
摘要翻译： 本发明描述了通过增加与降低或阻断癌细胞增殖相关的COMMD1蛋白的核定位来治疗癌症的方法。 本发明还涉及在制造用于癌症治疗的药物中增加COMMD1蛋白的核定位的试剂的用途。 这些试剂可以是其他化合物中的肽或蛋白质。 本发明还涉及来自序列HARIKPTFRRLKWKKYKGKFW的肽的优化，以增加蛋白质COMMD的核定位，从而提高该肽的抗肿瘤效果。
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5.发明申请CELL PENETRATING PEPTIDES AND ITS USE FUSED TO BIOMOLECULES WITH THERAPEUTIC ACTION 有权细胞穿刺肽及其用于治疗生物分子的用途公开(公告)号：US20120135021A1
公开(公告)日：2012-05-31
申请号：US12671335
申请日：2008-07-31
申请人： Isis del Carmen Torens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
发明人： Isis del Carmen Torens Madrazo , Maribel Guerra Vallespi , Milaid Granadillo Rodriguez , Osvaldo Reyes Acosta , Boris Ernesto Acevedo Castro
CPC分类号： A61K39/12 , A61K2039/585 , A61K2039/6031 , C12N2710/20034
摘要： The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein Limulus antilipopolisacárido (LALF) and its analogous. This invention refers to compositions containing these peptides associated to biomolecules with therapeutics properties. This invention consist of compositions comprise the covalent fusion of biomolecules, between this human papillomavirus antigens (HPV) to these CPP for induce a potent immune cellular responses against HPV and HPV protein antigen-exhibiting cells including HPV-associated tumors. The referred compositions are applicable in the pharmaceutical industry as vaccine for therapeutic use in human.
摘要翻译： 本发明涉及使用新的细胞穿透肽（CPP），特别涉及蛋白鲎抗脂蛋白（LALF）的区域32-51及其类似物。 本发明涉及包含与具有治疗学性质的生物分子相关联的这些肽的组合物。 本发明由组合物组成，包括生物分子的共价融合，在该人乳头状瘤病毒抗原（HPV）与这些CPP之间，用于诱导对HPV和HPV蛋白抗原呈递细胞（包括HPV相关肿瘤）的有效免疫细胞应答。 所提及的组合物可用作制药工业中用于人类治疗用途的疫苗。
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公开(公告)号：US20090221508A1
公开(公告)日：2009-09-03
申请号：US12278990
申请日：2007-02-23
申请人： Maribel Guerra Vallespi , Isis del Carmen Torrrens Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Gerardo Enrique Guillen Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gomez
发明人： Maribel Guerra Vallespi , Isis del Carmen Torrrens Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Gerardo Enrique Guillen Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gomez
CPC分类号： C07K14/43509 , A61K38/00
摘要： The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKKYKGKFW, showing aminoacids substitutions, these peptides unable to bind to the lipopolysaccharide and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.
摘要翻译： 本发明涉及来自序列HYRIKPTFRRLKWKKYKGKFW的肽的开发，显示出氨基酸取代，这些肽不能结合脂多糖并具有抗肿瘤和免疫调节能力。 单独或组合的这些肽可用于治疗癌症，并且与常规疗法协同作用。
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公开(公告)号：US08729226B2
公开(公告)日：2014-05-20
申请号：US13700286
申请日：2011-05-31
申请人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
发明人： Maribel Guerra Vallespi , Julio Raúl Fernández Massó , Alexis Musacchio Lasa , Jeovanis Gil Valdés , Osvaldo Reyes Acosta , Brizaida Maylin Oliva Argüelles
IPC分类号： A61K38/00
CPC分类号： C12N15/11 , A61K31/505 , A61K31/513 , A61K33/24 , A61K38/10 , A61K38/1767 , A61K45/06 , A61K48/00 , C07K7/08 , G01N33/574 , A61K2300/00
摘要： This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.
摘要翻译： 本发明描述了通过增加与降低或阻断癌细胞增殖相关的COMMD1蛋白的核定位来治疗癌症的方法。 本发明还涉及在制造用于癌症治疗的药物中增加COMMD1蛋白的核定位的试剂的用途。 这些试剂可以是其他化合物中的肽或蛋白质。 本发明还涉及来自序列HARIKPTFRRLKWKKYKGKFW的肽的优化，以增加蛋白质COMMD的核定位，从而提高该肽的抗肿瘤效果。
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公开(公告)号：US08283324B2
公开(公告)日：2012-10-09
申请号：US12278990
申请日：2007-02-23
申请人： Maribel Guerra Vallespi , Isis del Carmen Torréns Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Gerardo Enrique Guillén Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gómez
发明人： Maribel Guerra Vallespi , Isis del Carmen Torréns Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Gerardo Enrique Guillén Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gómez
CPC分类号： C07K14/43509 , A61K38/00
摘要： The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKYKGKFW (SEQ ID NO.: 13), showing amino acid substitutions, these peptides unable to bind to the lipopolysaccharides and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.
摘要翻译： 本发明涉及来自序列HYRIKPTFRRLKWKYKGKFW（SEQ ID NO：13）的肽的开发，显示氨基酸取代，这些肽不能结合脂多糖并具有抗肿瘤和免疫调节能力。 单独或组合的这些肽可用于治疗癌症，并且与常规疗法协同作用。
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公开(公告)号：US09375459B2
公开(公告)日：2016-06-28
申请号：US14005855
申请日：2012-03-21
申请人： María del Carmen Abrahantes Pérez , Glay Chinea Santiago , Eduardo Martínez Diaz , Hilda Elisa Garay Pérez , Osvaldo Reyes Acosta , Ernesto Lopez Mola , Cruz Matilde Lopez Abad , Sonia Gonzalez Blanco
发明人： María del Carmen Abrahantes Pérez , Glay Chinea Santiago , Eduardo Martínez Diaz , Hilda Elisa Garay Pérez , Osvaldo Reyes Acosta , Ernesto Lopez Mola , Cruz Matilde Lopez Abad , Sonia Gonzalez Blanco
IPC分类号： A61K38/12 , A61K31/4025 , A61K45/06 , C07K7/64 , C07K7/06 , C07K7/08 , A61K47/48 , A61K38/00 , A61K9/00 , A61K9/127 , A61K9/50
CPC分类号： A61K38/12 , A61K9/0019 , A61K9/127 , A61K9/5031 , A61K31/4025 , A61K38/00 , A61K45/06 , A61K47/60 , C07K7/06 , C07K7/08 , C07K7/64
摘要： The present invention comprises cyclic peptides bearing antitumor and antiangiogenic properties, as well as their corresponding pharmaceutically-suitable salts and also pharmaceutical compositions containing it. These cyclic peptides are used to prepare medicines for human and/or veterinary therapeutics, and additionally in diagnosis. These compounds can be used to detect, monitor and/or control a range of cellular proliferation-related disorders, such as oncological diseases and undesired angiogenesis. Moreover, they can be included as part of controlled release systems, and used more precisely in the field of nanobiotechnology, either because of their self-assembly capacity or as part of other systems.
摘要翻译： 本发明包括具有抗肿瘤和抗血管生成特性的环肽，以及它们相应的药学上合适的盐以及含有它的药物组合物。 这些环肽用于制备用于人和/或兽医治疗剂的药物，另外用于诊断。 这些化合物可用于检测，监测和/或控制一系列细胞增殖相关疾病，例如肿瘤疾病和不期望的血管生成。 此外，它们可以作为控制释放系统的一部分进行纳入，并且在纳米生物技术领域更加精确地使用，无论是由于其自组装能力还是作为其他系统的一部分。
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10.发明申请公开(公告)号：US20110212105A1
公开(公告)日：2011-09-01
申请号：US12298808
申请日：2007-04-26
申请人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martín Dunn , Mónica Sarría Núñez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sánchez Puente , Vladimir Armando Besada Pérez , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramón Padrón Palomares , Luis Javier González López
发明人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martín Dunn , Mónica Sarría Núñez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sánchez Puente , Vladimir Armando Besada Pérez , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramón Padrón Palomares , Luis Javier González López
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70596 , C07K14/8107 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
摘要翻译： 本发明涉及一种基于干扰病毒包膜蛋白与细胞受体的直接相互作用或其通过载体蛋白与所述细胞受体的间接相互作用而阻断登革热病毒感染细胞的方法，以及相关的 用途; 其中所述细胞受体是α-2巨球蛋白受体，也称为低密度受体相关蛋白或CD91，所述载体蛋白是人α-2巨球蛋白。
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