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公开(公告)号：US5494931A
公开(公告)日：1996-02-27
申请号：US350436
申请日：1994-12-06
申请人： Walter P. Cullen , John P. Dirlam , Hiroshi Maeda , Junsuke Tone
发明人： Walter P. Cullen , John P. Dirlam , Hiroshi Maeda , Junsuke Tone
IPC分类号： A23K1/16 , A23K1/17 , A23K1/18 , A61K31/35 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/00 , A61P33/02 , C07D493/10 , C07H17/04 , C07H19/01 , C12P17/18 , C12P19/44 , C12P19/60 , C12R1/03 , C07D309/10
CPC分类号： C07H19/01 , A23K20/195 , A23K50/30 , C12P17/181 , C12P19/445 , C12R1/01
摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 55080. This novel antibiotic is useful as an anticoccidial in poultry, in the prevention and treatment of swine dysentery and as a growth promotant in cattle and swine.
摘要翻译： 通过X射线晶体学建立的结构的酸性多环醚抗生素是通过发酵一种新型微生物Actinomadura sp。 ATCC 55080.这种新型抗生素可用作家禽中的抗球虫，预防和治疗猪痢疾以及作为牛和猪的生长促进剂。
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12.发明授权Acidic polycyclic ether antibiotic having an anticoccidial and growth promotant activity 失效具有抗球虫和生长促进活性的酸性多环醚抗生素
公开(公告)号：US5298524A
公开(公告)日：1994-03-29
申请号：US655440
申请日：1992-03-27
申请人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
发明人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
CPC分类号： C07H19/01 , A23K20/195 , A23K50/30 , C12P17/18 , C12P19/44 , Y10S435/825
摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53764. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
摘要翻译： PCT No.PCT / US88 / 01954 Sec。 371日期：1992年3月27日 102（e）1992年3月27日PCT PCT。1988年6月9日。具有通过X射线晶体学建立的结构的酸性多环醚抗生素通过新型微生物Actinomadura sp。 ATCC 53764.这种新型抗生素可用作鸡的抗球虫病，预防或治疗猪痢疾，以及作为牛和猪的生长促进剂。
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13.发明授权Acidic polycyclic ether useful as an anticoccidial agent and as a growth promotant 失效酸性聚合物有效地作为抗焦虑剂和作为生长促进剂
公开(公告)号：US5147858A
公开(公告)日：1992-09-15
申请号：US487947
申请日：1990-04-16
申请人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
发明人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
IPC分类号： C12P19/00 , A23K1/16 , A23K1/17 , A61K31/35 , A61K31/70 , A61K31/7028 , A61K31/7042 , A61K31/7048 , A61P31/00 , A61P33/02 , C07D493/10 , C07H7/06 , C07H15/04 , C07H17/04 , C07H19/01 , C12N1/20 , C12P17/06 , C12P19/60 , C12R1/03
CPC分类号： C07H19/01 , A23K20/195 , Y10S435/825
摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53676. This novel antibiotic is useful as an anticoccidial in chickens and as a growth promotant in cattle and swine.
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14.发明授权
公开(公告)号：US4908316A
公开(公告)日：1990-03-13
申请号：US161630
申请日：1988-02-29
IPC分类号： C07D407/14 , C12P17/16 , C12P19/44
CPC分类号： C07D407/14 , C12P17/16 , C12P19/44 , Y10S435/886
摘要： An antibiotic has been isolated from fermentation of a new Streptomyces culture. The new ionophore is active as an antibacterial and anticoccidial agent.
摘要翻译： 已经从新的链霉菌培养物的发酵中分离出抗生素。 新型离子载体作为抗菌和抗球虫剂具有活性。
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公开(公告)号：US4746650A
公开(公告)日：1988-05-24
申请号：US747613
申请日：1985-06-21
申请人： Walter P. Cullen , Hiroshi Maeda , John C. Ruddock , Junsuke Tone
发明人： Walter P. Cullen , Hiroshi Maeda , John C. Ruddock , Junsuke Tone
IPC分类号： A23K20/195 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/00 , A61P31/04 , A61P33/02 , C07H17/04 , C07H19/01 , C12P17/18 , C12P19/44 , C12P19/60 , C12R1/03 , A61K31/71 , A23G3/00
CPC分类号： C07H19/01 , C12P19/44 , C12P19/60 , C12R1/03 , Y10S435/825
摘要： A new acidic polycyclic ether antibiotic UK-58,852 has the formula: ##STR1## wherein R and R.sup.1 are both hydrogen, and can be prepared by the submerged aerobic propagation in aqueous nutrient media of Actinomadura sp. ATCC 39697. The antibiotic and its cationic salts are active against a variety of microorganisms and are effective in controlling coccidiosis, enteritis, swine dysentery and theileriosis as well as being effective in promotion of growth and/or improving efficiency of feed utilization in swine and ruminants. Two minor components, wherein R is H and R.sup.1 is CH.sub.3 and wherein R and R.sup.1 are both CH.sub.3, have also been isolated from the fermentation.
摘要翻译： 一种新的酸性多环醚抗生素UK-58,852具有以下分子式：其中R和R1都是氢，并且可以通过在放线菌属的水性营养培养基中浸没需氧繁殖来制备。 抗生素及其阳离子盐对各种微生物有活性，有效控制球虫病，肠炎，猪痢疾和腹膜炎，以及有效促进生长和/或提高猪和反刍动物饲料利用效率 。 从发酵中也分离出两个次要组分，其中R为H且R 1为CH 3，并且其中R和R 1均为CH 3。
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公开(公告)号：US4625041A
公开(公告)日：1986-11-25
申请号：US770472
申请日：1985-08-29
IPC分类号： A23K20/195 , C07H19/01 , C12P19/44 , C12P19/60 , C07D309/10
CPC分类号： C07H19/01 , A23K20/195 , C12P19/445 , C12P19/60 , C12R1/465
摘要： A new acidic polycyclic ether antibiotic, CP-63,517, having the formula: ##STR1## and cationic salts thereof produced by submerged aerobic propagation of Streptomyces endus subsp. aureus, ATCC-39574, a new strain of microorganism isolated from a soil sample in Japan, a process for producing this antibiotic and methods for its use to improve feed utilization, promote growth of cattle and swine and to control coccidiosis.
摘要翻译： 一种新的酸性多环醚抗生素CP-63,517，具有下式：其中通过唾液链霉菌（Streptomyces endus subsp。）的浸没有氧繁殖产生的阳离子盐。 金黄色葡萄球菌ATCC-39574是从日本土壤样品中分离的新菌株，该抗生素的生产方法及其用于改善饲料利用，促进牛和猪生长以及控制球虫病的方法。
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17.发明授权
公开(公告)号：US4543334A
公开(公告)日：1985-09-24
申请号：US562784
申请日：1983-12-16
CPC分类号： C07H17/08 , C12P19/62 , C12R1/465 , Y10S435/886
摘要： An antibiotic complex, consisting of one major and two minor components, has been isolated from fermentation of a new Streptomyces culture. The components from the complex are three new macrolides which are active as antibacterial agents against certain gram-negative and gram-positive microorganisms.
摘要翻译： 由一种主要和两个次要组分组成的抗生素复合物已经从新的链霉菌培养物的发酵中分离出来。 来自该复合物的组分是三种新的大环内酯类，其作为针对某些革兰氏阴性和革兰氏阳性微生物的抗菌剂是有活性的。
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18.发明授权
公开(公告)号：US5965445A
公开(公告)日：1999-10-12
申请号：US849552
申请日：1992-03-11
申请人： Walter P. Cullen , John P. Dirlam , Hiroshi Maeda , Junsuke Tone
发明人： Walter P. Cullen , John P. Dirlam , Hiroshi Maeda , Junsuke Tone
CPC分类号： C07H15/04 , C07H19/01 , Y10S435/886
摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces sp. ATCC 55028. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, as a growth promotant in cattle and swine, and as an anthelmintic in mammals, particularly in dogs, cats, sheep, cattle and swine.
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19.发明授权Process for producing acidic polycyclic ether antibiotic having anticoccidial and growth promant activity with Actinomadura 失效用放线菌制备具有抗球虫和生长促进活性的酸性多环醚抗生素的方法
公开(公告)号：US5478735A
公开(公告)日：1995-12-26
申请号：US301748
申请日：1994-09-06
申请人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
发明人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
CPC分类号： C07H19/01 , A23K20/195 , A23K50/30 , C12P17/18 , C12P19/44 , Y10S435/825
摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Actinomadura sp. ATCC 53764. This novel antibiotic is useful as an anticoccidial in chickens, in the prevention or treatment of swine dysentery, and as a growth promotant in cattle and swine.
摘要翻译： 通过X射线晶体学建立的结构的酸性多环醚抗生素是通过发酵一种新型微生物Actinomadura sp。 ATCC 53764.这种新型抗生素可用作鸡的抗球虫病，预防或治疗猪痢疾，以及作为牛和猪的生长促进剂。
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20.发明授权Acidic polycyclic ether useful as an anticoccidial agent and as a growth promotant 失效酸性多环醚可用作抗球虫剂和作为生长促进剂
公开(公告)号：US5206263A
公开(公告)日：1993-04-27
申请号：US438506
申请日：1989-12-05
申请人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
发明人： John P. Dirlam , Walter P. Cullen , Hiroshi Maeda , Junsuke Tone
IPC分类号： A23K20/195 , C07H19/01 , C12P17/18
CPC分类号： C07H19/01 , A23K20/195 , C12P17/181 , Y10S435/886 , Y10S435/898
摘要： An acidic polycyclic ether antibiotic, having structure established by X-ray crystallography, is formed by fermentation of a novel microorganism, Streptomyces hygroscopicus ATCC 53626. This novel antibiotic is useful as an anticoccidial in chickens and as a growth promotant in cattle and swine.
摘要翻译： PCT No.PCT / US87 / 01487第 371日期1989年12月5日第 102（e）1989年12月5日PCT PCT。1987年6月24日。具有通过X射线晶体学建立的结构的酸性多环醚抗生素是通过发酵一种新型微生物，吸水链霉菌ATCC 53626形成的。这种新型抗生素 作为鸡和猪的生长促进剂在鸡中起抗球虫作用。
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