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    Medical device ECG marker for use in compressed data stream
    11.
    发明授权
    Medical device ECG marker for use in compressed data stream 有权

    公开(公告)号：US07016721B2

    公开(公告)日：2006-03-21

    申请号：US09975621

    申请日：2001-10-10

    申请人： Brian B. Lee ,  Michael R. Kane

    发明人： Brian B. Lee ,  Michael R. Kane

    IPC分类号： A61B5/0432

    CPC分类号： A61B5/0006 ,  A61B5/0031 ,  A61B5/0456 ,  A61B5/7203 ,  A61B5/7232 ,  A61B5/7285 ,  A61N1/3718

    摘要： Triggers and noise should be available as information in recorded electrograms in memories of implantable medical devices. Particularly where the recording of electrogram data is done in the far field, there will be considerable noise and the interpretation of ECG's reproduced from such recorded data will benefit from the storing of information regarding contemporaneous noise. By storing contemporaneous trigger data and noise data directly in the ECG data, recordings of the ECG data become more useful for physician use when played back through an external display system with minimal loss of ECG data, since out of range values are employed for the noise and trigger information and this non-ECG data is limited in size to no longer than individual point values of the ECG signal.

    System and method for deriving a virtual ECG or EGM signal
    12.
    发明授权
    System and method for deriving a virtual ECG or EGM signal 有权
    用于导出虚拟ECG或EGM信号的系统和方法

    公开(公告)号：US06505067B1

    公开(公告)日：2003-01-07

    申请号：US09721275

    申请日：2000-11-22

    申请人： Brian B. Lee ,  Eric J. Panken ,  James D. Reinke

    发明人： Brian B. Lee ,  Eric J. Panken ,  James D. Reinke

    IPC分类号： A61B50402

    CPC分类号： A61B5/04011 ,  A61B5/0402 ,  G06F19/00

    摘要： A system and method for obtaining a virtual physiologic voltage signal between a first predetermined point in a second selected point in the body is disclosed. At least three electrodes are used to measure two voltage signals S1 and S2 in a body. In one embodiment, the signal S1 is measured between a first electrode and a common electrode, and the signal S2 is measured between a second electrode and the common electrode. A selected point within the body may be chosen to define a pair of virtual electrodes existing between this selected point and the common electrode. An approximation of the voltage signal S as could be measured between electrodes positioned at these virtual electrode locations may be derived as a function of S1, S2, and &thgr;, wherein &thgr; is the angle between the directional vector U1 for the signal S1 and the directional vector U for the signal S. According to the inventive system and method, the signal value for S is also dependent on the distances between the electrode pairs, on the angle &bgr; between directional vectors U1 and U2, and on the distance between the virtual electrodes. The current invention may be utilized with electrodes that are positioned either externally on the surface of, or implanted within, a body. According to one aspect of the invention, a user may employ a user interface to select the values of &thgr;, &bgr;, and the electrode spacings. Alternatively, ones of these parameters may be predetermined by the system. In another embodiment, the system could derive the signal S over a predetermined range of values for the angle &thgr;. The system may then select the angle of &thgr; resulting in the derived signal S that exhibits a desired waveform morphology.

    摘要翻译： 公开了一种用于在身体的第二选定点中的第一预定点之间获得虚拟生理电压信号的系统和方法。 使用至少三个电极来测量身体中的两个电压信号S1和S2。 在一个实施例中，在第一电极和公共电极之间测量信号S1，并且在第二电极和公共电极之间测量信号S2。 可以选择体内的选定点以限定存在于该选定点和公共电极之间的一对虚拟电极。 可以在位于这些虚拟电极位置的电极之间测量的电压信号S的近似作为S1，S2和θ的函数导出，其中θ是信号S1的方向矢量U1与方向 信号S的矢量U根据本发明的系统和方法，S的信号值也取决于在方向矢量U1和U2之间的角度β上的电极对之间的距离，以及虚拟电极之间的距离 。 本发明可以与位于体外表面或植入体内的电极一起使用。 根据本发明的一个方面，用户可以使用用户界面来选择θ，β和电极间距的值。 或者，这些参数中的一个可以由系统预先确定。 在另一个实施例中，系统可以在角度θ的预定值范围内导出信号S. 然后，系统可以选择θ的角度，导致出现所需波形形态的导出信号S.

    Medical device ECG marker for use in compressed data system
    13.
    发明授权
    Medical device ECG marker for use in compressed data system 有权
    用于压缩数据系统的医疗设备心电图标记

    公开(公告)号：US06347245B1

    公开(公告)日：2002-02-12

    申请号：US09353277

    申请日：1999-07-14

    申请人： Brian B. Lee ,  Michael R. Kane

    发明人： Brian B. Lee ,  Michael R. Kane

    IPC分类号： A61B50432

    CPC分类号： A61B5/0006 ,  A61B5/0031 ,  A61B5/0456 ,  A61B5/7203 ,  A61B5/7232 ,  A61B5/7285 ,  A61N1/3718

    摘要： A system for recording trigger events and noise in conjunction with the recording of physiological signals is provided for use in an implantable medical device. In one embodiment, recorded trigger and noise data is provided for display to a physician along with reconstructed ECG data to facilitate interpretation of the ECG signal. In one embodiment, digitized ECG samples that are outside of a predetermined range are discarded during the sampling process so that one or more ranges of encoded values are available for use in encoding noise and trigger information. This non-physiologic data may be limited in size to individual point values of the ECG signal.

    摘要翻译： 提供了用于记录触发事件和噪声以及生理信号记录的系统，用于可植入医疗装置。 在一个实施例中，记录的触发和噪声数据被提供用于与重建的ECG数据一起显示给医师以便于ECG信号的解读。 在一个实施例中，在采样过程中丢弃在预定范围之外的数字化ECG样本，使得编码值的一个或多个范围可用于编码噪声和触发信息。 该非生理数据的大小可能受到ECG信号的各个点值的限制。

    ELECTRODE SHAPES AND POSITIONS FOR REDUCING LOSS OF CONTACT IN AN IMPLANTABLE ECG RECORDER
    14.
    发明申请
    ELECTRODE SHAPES AND POSITIONS FOR REDUCING LOSS OF CONTACT IN AN IMPLANTABLE ECG RECORDER 审中-公开
    电极形状和位置，用于减少可移植ECG记录仪中的接触损失

    公开(公告)号：US20120108993A1

    公开(公告)日：2012-05-03

    申请号：US13282167

    申请日：2011-10-26

    申请人： Charles R. Gordon ,  Brian B. Lee ,  Michael W. Barror

    发明人： Charles R. Gordon ,  Brian B. Lee ,  Michael W. Barror

    IPC分类号： A61B5/042

    CPC分类号： A61B5/0422 ,  A61B5/0006 ,  A61B5/076 ,  A61B5/6861 ,  A61B2560/0406

    摘要： An improved design for subcutaneous monitors that addresses the problem caused by bubbles of air may remain in the pocket in which the device is implanted. As implantable monitors and their associated electrodes are reduced in size, these bubbles may in some cases cover one or both electrodes, interfering with sensing of the ECG signal. The invention addresses this problem by configuring the electrodes to increase the pressure of the electrodes against the tissue above the electrodes relative to the pressures exerted by the adjacent outer facing surfaces of the device.

    摘要翻译： 用于解决由空气气泡引起的问题的皮下监测器的改进设计可以保留在装置植入的口袋中。 随着植入式监护仪及其相关电极的尺寸减小，这些气泡在某些情况下可能会覆盖一个或两个电极，从而干扰ECG信号的感测。 本发明通过配置电极来相对于由相邻的面向外部的表面施加的压力来配置电极以增加电极对电极上方的组织的压力来解决这个问题。

    Method and apparatus for atrial fibrillation detection based on ventricular cycle lengths
    15.
    发明授权
    Method and apparatus for atrial fibrillation detection based on ventricular cycle lengths 有权
    基于心室周期长度的心房颤动检测方法和装置

    公开(公告)号：US07634310B2

    公开(公告)日：2009-12-15

    申请号：US11554275

    申请日：2006-10-30

    申请人： Brian B. Lee ,  Eric J. Panken

    发明人： Brian B. Lee ,  Eric J. Panken

    IPC分类号： A61B5/024

    CPC分类号： A61B5/046 ,  A61B5/02405 ,  A61N1/3621 ,  A61N1/3925 ,  A61N1/395

    摘要： A method and apparatus for detecting atrial arrhythmias include acquiring a cardiac signal comprising R-waves. Differences between pairs of consecutive R-R intervals occurring during a first time interval are computed from the cardiac signal. An atrial arrhythmia is detected subsequent to the first time interval in response to the computed differences. Storage of the cardiac signal is triggered in response to the atrial arrhythmia detection.

    摘要翻译： 用于检测心房心律失常的方法和装置包括获取包括R波的心脏信号。 从心脏信号计算在第一时间间隔期间发生的连续R-R间隔对之间的差异。 响应于所计算的差异，在第一时间间隔之后检测心房心律失常。 响应于心房心律失常检测触发心脏信号的存储。

    Noise rejection for monitoring ECG's
    16.
    发明授权
    Noise rejection for monitoring ECG's 有权
    监测心电图的噪声抑制

    公开(公告)号：US06236882B1

    公开(公告)日：2001-05-22

    申请号：US09353167

    申请日：1999-07-14

    申请人： Brian B. Lee ,  Michael R. Kane ,  Gregg Turi

    发明人： Brian B. Lee ,  Michael R. Kane ,  Gregg Turi

    IPC分类号： A61B50402

    CPC分类号： A61B5/0402 ,  A61B5/0432 ,  A61B5/0456 ,  A61B5/7203 ,  A61B5/7232

    摘要： An implantable medical device which preferably has a segmented looping memory for storing triggered physiologic events also has autotriggers to record the ECGs and any other relevant physiologic signals occurring during triggering events. The problem is that in the far field R-wave sensing is difficult because of noise. Denial and extensible accommodation periods are introduced into the R-wave sensing registration for triggering data storage. If the event is sensed during an accommodation period the sense will not add an R-wave sense to the trigger's count of R-waves. It may cause resetting of the trigger count in some circumstnaces. Typical triggering events may include arrhythmia's and syncopal events. Preferably the device can function without a microprocessor. An outside device or other patient activated manual trigger may be included. Auto triggers and manually set triggers may be of different sizes. Electrode spacing can be critical. Additional sensors may be provided to the device. Preferred communications with the device is through telemetry such as is used for pacemakers and other implanted devices.

    摘要翻译： 优选地具有用于存储触发的生理事件的分段循环存储器的可植入医疗装置还具有记录ECG的自动触发器以及在触发事件期间发生的任何其它相关生理信号。 问题在于，在远场R波传感由于噪声困难。 拒绝和可延伸的住宿期被引入到R波感测注册中以触发数据存储。 如果在住宿期间感测到事件，感觉不会在触发器的R波数量上增加R波感。 在某些情况下可能会导致触发计数的重置。 典型的触发事件可能包括心律失常和晕厥事件。 优选地，该装置可以在没有微处理器的情况下工作。 可以包括外部设备或其他患者激活的手动触发器。 自动触发器和手动设置触发器可能具有不同的大小。 电极间距可能很重要。 可以向设备提供附加的传感器。 与设备的首选通信是通过诸如用于起搏器和其他植入设备的遥测。

    Minimally invasive implantable device for monitoring physiologic events
    17.
    发明授权
    Minimally invasive implantable device for monitoring physiologic events 失效
    用于监测生理事件的微创植入式装置

    公开(公告)号：US5987352A

    公开(公告)日：1999-11-16

    申请号：US33678

    申请日：1998-03-03

    申请人： George J. Klein ,  Dwight H. Warkentin ,  Kenneth M. Riff ,  Brian B. Lee ,  James K. Carney ,  Gregg Turi ,  Anthony J. Varrichio

    发明人： George J. Klein ,  Dwight H. Warkentin ,  Kenneth M. Riff ,  Brian B. Lee ,  James K. Carney ,  Gregg Turi ,  Anthony J. Varrichio

    IPC分类号： A61B5/0492 ,  A61B5/0404 ,  A61B5/0408 ,  A61B5/0478 ,  A61N1/375 ,  A61B5/0402

    CPC分类号： A61N1/375

    摘要： A minimally invasive implant, means for insertion, and description of how to most efficiently use it are described n several embodiments. This implant preferably has a segmented looping memory for storing triggered physiologic events. Preferred events for setting autotriggers to record physiologic signals occurring during events include arrhythmias and syncopal events. Preferably the device can function without a microprocessor. An outside device or other patient activated manual trigger is included. Auto triggers and manually set triggers may be of different sizes. The preferred physiologic events are ECG signals. Electrode spacing can be critical. Additional sensors may be provided to the device. Preferred communications with the device is through telemetry such as is used for pacemakers and other implanted devices.

    摘要翻译： 在几个实施例中描述了微创植入物，用于插入的手段和如何最有效地使用它的描述。 该植入物优选地具有用于存储触发的生理事件的分段循环存储器。 设置自动跟踪器记录事件中发生的生理信号的首选事件包括心律失常和晕厥事件。 优选地，该装置可以在没有微处理器的情况下工作。 包括外部设备或其他患者激活的手动触发器。 自动触发器和手动设置触发器可能具有不同的大小。 优选的生理事件是ECG信号。 电极间距可能很重要。 可以向设备提供附加的传感器。 与设备的首选通信是通过诸如用于起搏器和其他植入设备的遥测。

    Implantable capacitive absolute pressure and temperature monitor system
    18.
    发明授权
    Implantable capacitive absolute pressure and temperature monitor system 失效
    可植入电容绝对压力和温度监控系统

    公开(公告)号：US5535752A

    公开(公告)日：1996-07-16

    申请号：US394860

    申请日：1995-02-27

    申请人： Louis E. Halperin ,  Brian B. Lee ,  Glenn M. Roline ,  Anthony J. Varrichio

    发明人： Louis E. Halperin ,  Brian B. Lee ,  Glenn M. Roline ,  Anthony J. Varrichio

    IPC分类号： A61B5/00 ,  A61B5/01 ,  A61B5/0215 ,  A61N1/08 ,  A61N1/365 ,  A61N1/362

    CPC分类号： A61B5/0215 ,  A61N1/08 ,  A61N1/3655 ,  A61N1/36564 ,  A61B2560/0257 ,  Y10S977/90 ,  Y10S977/905

    摘要： A capacitive pressure and temperature sensing system for providing signals representative of the magnitude of body fluid absolute pressure at a selected site and ambient operating conditions, including body temperature, at the site. An implantable lead having a sensor module formed in its distal end is coupled to a monitor that powers a sensor circuit in the sensor module and demodulates and stores absolute pressure and temperature data derived from signals generated by the sensor circuit. The sensor module is formed with a pickoff capacitor that changes capacitance with pressure changes and a reference capacitor that is relatively insensitive to pressure changes. The sensor circuit provides charge current that changes with temperature variation at the implant site, alternately charges and discharges the two capacitors, and provides timing pulses having distinguishable parameters at the end of each charge cycle that are transmitted to the demodulator. The demodulator detects and synchronizes the timing pulses and derives pressure and temperature analog voltage values representative of the intervals between the timing pulses which are digitized and stored in the monitor. The monitor may also be coupled with other sensors for measuring and storing related patient body parameters, e.g. blood gas, EGM, and patient activity.

    摘要翻译： 一种电容式压力和温度感测系统，用于提供代表在现场的所选位置和环境操作条件（包括体温）的体液绝对压力的大小的信号。 具有形成在其远端的传感器模块的可植入引线被耦合到对传感器模块中的传感器电路供电的监视器，并且解调并存储由传感器电路产生的信号导出的绝对压力和温度数据。 传感器模块形成有一个传感器电容器，可以改变压力变化的电容和对压力变化相对不敏感的参考电容。 传感器电路提供随着植入部位温度变化而变化的充电电流，交替地对两个电容器进行充电和放电，并且在每个充电周期结束时提供定时脉冲，其在每个充电周期结束时被传送到解调器。 解调器检测并同步定时脉冲，并导出代表数字化和存储在监视器中的定时脉冲之间的间隔的压力和温度模拟电压值。 监视器还可以与其他传感器耦合，用于测量和存储相关的患者身体参数，例如， 血气，EGM和患者活动。