摘要:
The invention relates to substituted aryl-sulphonylglycine derivatives of general formula (I) wherein the groups Ra to Rf, A and Z are defined as in the specification and claims, which are suitable for preparing a pharmaceutical composition for the treatment of metabolic disorders, particularly type 1 or type 2 diabetes mellitus.
摘要:
A compound of formula 1′ wherein: V is —CH2—, —NH—, or —O—; Ra and Rb are each independently hydrogen, C1-4-alkyl, or halogen-C1-4-alkyl, or Ra and Rb together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R1 and R1′ are each independently hydrogen, C1-6-alkyl, C3-6-cycloalkyl, halogen-C1-6-alkyl, halogen-C3-6-cycloalkyl, or C1-6-alkylene-C3-6-cycloalkyl, or R1 and R1′ together are a C2-5-alkylene bridge wherein one or more hydrogen atoms are optionally replaced by halogen; R2, R2′, R2″, and R′″ are each independently hydrogen, C1-6-alkyl, halogen-C1-6-alkylene, OH, HO—C1-6-alkylene, —O—C1-6-alkyl, C6-10-aryl, C6-10-aryl-C1-4-alkylene, C6-10-aryl-C1-6-alkylene-O, COOH, COOC1-6-alkyl, O—C1-6-alkylene-COOH, O—C1-6-alkylene-COOC1-6-alkyl, NHSO2—C1-6-alkyl, CN, NH2, NH—C1-6-alkyl, N(C1-6-alkyl)2, NO2, S—C1-6-alkyl, SO2—C1-6-alkyl, SO—C1-6-alkyl, O(CO)C1-6-alkyl, COC1-6-alkyl, NHCOC1-6-alkyl, or halogen; and n is 0, 1, or 2, or an optical isomer thereof, or a corresponding acid addition salt thereof with a pharmacologically acceptable acid, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
摘要:
The present invention relates to compounds of formula 1 wherein the groups X, Ra, Rb, R1, R1′, R2, R2′, R2″, R2′″, V and n may have the meanings given in the claims and in the specification, and the use thereof as pharmaceutical compositions, particularly for the treatment of inflammatory and obstructive respiratory complaints.
摘要翻译:本发明涉及式1的化合物,其中基团X,R a,R b,R 1,R 1, R 2,R 2,R 2,R“2”,R“2”,R“2” ,V和n可以具有权利要求书和说明书中给出的含义,以及其作为药物组合物的用途,特别是用于治疗炎性和阻塞性呼吸道疾病。
摘要:
The invention relates to the use of pteridines for the treatment of inflammatory and obstructive respiratory complaints, preferably asthma or COPD, as well as pharmaceutical compositions containing these compounds.
摘要:
A hand tool case holding device includes: a holding device housing, a case accommodating area, and at least one charging coil, which is provided for the purpose of transferring energy into the case accommodating area in a direction perpendicular to a charging surface of the holding device housing. The holding device housing has a case support surface, which is provided for the purpose of causing a support force at least essentially parallel to the charging surface.
摘要:
A device for the inductive transmission of electrical energy, having at least one induction coil which is connected, or connectible, to a consumer and/or to a rechargeable battery, and having a communications device, which encompasses at least one control unit and is configured to modulate the load of the induction coil. It is provided that the communications device has a DC converter, whose output is connected or connectible to the consumer/the battery, and whose input is connected to the induction coil, the control unit controlling the DC converter for a load modulation.
摘要:
A method for charging a battery, in particular a lithium ion battery, be performing the following: charging the battery using a constant charging current in a first phase, charging the battery using a constant charging voltage in a subsequent second phase, ending the charging as a function of a specifiable boundary value of the charging current in the second phase. In this context, the following operations are provided: comparing a guide voltage specified for setting the constant voltage to at least one stored switch-off value determined as a function of the boundary value, and ending the charging when the guide voltage reaches the switch-off value. Also described is a device for charging the battery.
摘要:
A hand tool case holding device includes at least one charging coil, a case accommodating area and a holding device housing, which includes a first outer side facing toward the case accommodating area. The holding device housing includes at least one second outer side, (a) which, in at least one operating state, faces toward the case accommodating area, (b) which is aligned essentially perpendicularly to the first outer side, and (c) on which the charging coil is situated.
摘要:
A system having a hand tool battery, a hand tool case which has at least one inductive charge receiving area which is provided for storing a hand tool battery which is inserted into the inductive charge receiving area at least partially in close proximity to at least one wall of the hand tool case, and having at least one latent heat storage unit which is provided for influencing at least a temperature of the at least one hand tool battery.
摘要:
Compounds of the formula I wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and X are defined as described in the specification, which are bradykinin B1 antagonists, and their use as medicaments.