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11.发明申请Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds 有权HIV蛋白酶抑制剂化合物的膦酸酯类似物的细胞积累公开(公告)号：US20050209197A1
公开(公告)日：2005-09-22
申请号：US10423496
申请日：2003-04-25
申请人： Murty Arimilli , Mark Becker , Clifford Bryant , James Chen , Xiaowu Chen , Azar Dastgah , Maria Fardis , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard Mackman , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Williams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang
发明人： Murty Arimilli , Mark Becker , Clifford Bryant , James Chen , Xiaowu Chen , Azar Dastgah , Maria Fardis , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard Mackman , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Williams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang
IPC分类号： C12N9/99 , A61K31/4155 , A61K31/66 , A61K31/665 , A61K31/675 , A61P31/18 , A61P43/00 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/48 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F20060101 , C07F9/02 , C07F9/38 , C07F9/40 , C07F9/44 , C07F9/58 , C07F9/62 , C07F9/645 , C07F9/6506 , C07F9/6509 , C07F9/6512 , C07F9/653 , C07F9/6533 , C07F9/655 , C07F9/6558 , C07F9/6561 , C07F9/6584 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C12Q1/70 , G01N33/04 , G01N33/50
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/58 , C07F9/645 , C07F9/6506 , C07F9/650905 , C07F9/650947 , C07F9/6512 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
摘要翻译： 公开了具有用作治疗剂和其它工业目的的具有HIV蛋白酶抑制性质的膦酸酯取代的化合物。 组合物抑制HIV蛋白酶活性和/或可用于治疗AIDS和其它抗病毒感染以及用于检测HIV蛋白酶的测定。
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公开(公告)号：US07803788B2
公开(公告)日：2010-09-28
申请号：US12110829
申请日：2008-04-28
申请人： Mark W. Becker , Harlan H. Chapman , Tomas Cihlar , Eugene J. Eisenberg , Gong-Xin He , Michael R. Kernan , William A. Lee , Ernest J. Prisbe , John C. Rohloff , Mark L. Sparacino
发明人： Mark W. Becker , Harlan H. Chapman , Tomas Cihlar , Eugene J. Eisenberg , Gong-Xin He , Michael R. Kernan , William A. Lee , Ernest J. Prisbe , John C. Rohloff , Mark L. Sparacino
IPC分类号： A61K31/675 , A61P31/12
CPC分类号： C07H19/10 , C07F9/65616 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/5011
摘要： A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
摘要翻译： 一种新的方法导致鉴定用于逆转录病毒或肝炎病毒治疗的PMPA的新型混合酯酰胺化物，包括具有如本文所定义的取代基的结构（5a）的化合物。 提供这些新化合物在药学上可接受的赋形剂中的组合物及其在治疗和预防中的用途。
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公开(公告)号：US20080227754A1
公开(公告)日：2008-09-18
申请号：US12110829
申请日：2008-04-28
申请人： Mark W. Becker , Harlan H. Chapman , Tomas Cihlar , Eugene J. Eisenberg , Gong-Xin He , Michael R. Kernan , William A. Lee , Ernest J. Prisbe , John C. Rohloff , Mark L. Sparacino
发明人： Mark W. Becker , Harlan H. Chapman , Tomas Cihlar , Eugene J. Eisenberg , Gong-Xin He , Michael R. Kernan , William A. Lee , Ernest J. Prisbe , John C. Rohloff , Mark L. Sparacino
IPC分类号： A61K31/675 , A61P31/12
CPC分类号： C07H19/10 , C07F9/65616 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/5011
摘要： A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
摘要翻译： 一种新的方法导致鉴定用于逆转录病毒或肝炎病毒治疗的PMPA的新型混合酯酰胺化物，包括具有如本文所定义的取代基的结构（5a）的化合物。 提供这些新化合物在药学上可接受的赋形剂中的组合物及其在治疗和预防中的用途。
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公开(公告)号：US07390791B2
公开(公告)日：2008-06-24
申请号：US10798692
申请日：2004-03-11
申请人： Mark W. Becker , Harlan H. Chapman , Tomas Cihlar , Eugene J. Eisenberg , Gong-Xin He , Michael R. Kernan , William A. Lee , Ernest J. Prisbe , John C. Rohloff , Mark L. Sparacino
发明人： Mark W. Becker , Harlan H. Chapman , Tomas Cihlar , Eugene J. Eisenberg , Gong-Xin He , Michael R. Kernan , William A. Lee , Ernest J. Prisbe , John C. Rohloff , Mark L. Sparacino
IPC分类号： A01N43/48 , A61K3/1675 , C07F9/6512
CPC分类号： C07H19/10 , C07F9/65616 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/5011
摘要： A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
摘要翻译： 一种新的方法导致鉴定用于逆转录病毒或肝炎病毒治疗的PMPA的新型混合酯酰胺化物，包括具有如本文所定义的取代基的结构（5a）的化合物。 提供这些新化合物在药学上可接受的赋形剂中的组合物及其在治疗和预防中的用途。
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公开(公告)号：US08354421B2
公开(公告)日：2013-01-15
申请号：US12215264
申请日：2008-06-26
申请人： Gong-Xin He , Choung U. Kim , Michael L. Mitchell , Lianhong Xu
发明人： Gong-Xin He , Choung U. Kim , Michael L. Mitchell , Lianhong Xu
IPC分类号： A61K31/505 , C07F9/09 , C07D239/08
CPC分类号： C07D239/54
摘要： The invention is related to compounds of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，酯和/或膦酸盐，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法。
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公开(公告)号：US20090075939A1
公开(公告)日：2009-03-19
申请号：US12215264
申请日：2008-06-26
申请人： Gong-Xin He , Choung U. Kim , Michael L. Mitchell , Lianhong Xu
发明人： Gong-Xin He , Choung U. Kim , Michael L. Mitchell , Lianhong Xu
IPC分类号： A61K31/675 , C07D413/12 , A61K31/5377 , A61P31/18 , A61K31/505 , C07D239/10
CPC分类号： C07D239/54
摘要： The invention is related to compounds of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物，酯和/或膦酸盐，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法。
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公开(公告)号：US20050159392A1
公开(公告)日：2005-07-21
申请号：US11031228
申请日：2005-01-06
申请人： Mark Becker , Harlan Chapman , Tomas Cihlar , Eugene Eisenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino
发明人： Mark Becker , Harlan Chapman , Tomas Cihlar , Eugene Eisenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino
IPC分类号： A61K31/664 , A61K31/675 , A61P31/12 , A61P31/18 , A61P35/00 , C07F9/6561 , C07H19/10 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： C07H19/10 , C07F9/65616 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/5011
摘要： A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
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公开(公告)号：US20050124584A1
公开(公告)日：2005-06-09
申请号：US11031251
申请日：2005-01-06
申请人： Mark Becker , Harlan Chapman , Tomas Cihlar , Eugene Eisenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino
发明人： Mark Becker , Harlan Chapman , Tomas Cihlar , Eugene Eisenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino
IPC分类号： A61K31/664 , A61K31/675 , A61P31/12 , A61P31/18 , A61P35/00 , C07F9/6561 , C07H19/10 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： C07H19/10 , C07F9/65616 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/5011
摘要： A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
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19.发明申请公开(公告)号：US20070190523A1
公开(公告)日：2007-08-16
申请号：US10554287
申请日：2003-11-06
申请人： Gabriel Birkus , James Chen , Xiaowu Chen , Tomas Cihlar , Eugene Eisenberg , Marcos Hatada , Gong-Xin He , Choung Kim , William Lee , Martin McDermott , Sundaramoorthi Swaminathan
发明人： Gabriel Birkus , James Chen , Xiaowu Chen , Tomas Cihlar , Eugene Eisenberg , Marcos Hatada , Gong-Xin He , Choung Kim , William Lee , Martin McDermott , Sundaramoorthi Swaminathan
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/58 , C07F9/645 , C07F9/6506 , C07F9/650905 , C07F9/650947 , C07F9/6512 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： The invention relates to methods and compositions for identifying compounds having therapeutic activity against human immunodeficiency virus (HIV).
摘要翻译： 本发明涉及用于鉴定具有针对人类免疫缺陷病毒（HIV）的治疗活性的化合物的方法和组合物。
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20.发明申请Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same 审中-公开膦酸酯核苷酸类似物的前体药物及其制备方法公开(公告)号：US20060024659A1
公开(公告)日：2006-02-02
申请号：US10785497
申请日：2004-02-24
申请人： Mark Becker , Harlan Chapman , Tomas Cihlar , Eugene Eisenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino
发明人： Mark Becker , Harlan Chapman , Tomas Cihlar , Eugene Eisenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino
CPC分类号： C07H19/10 , C07F9/65616 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/5011
摘要： A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
摘要翻译： 一种新的方法导致鉴定用于逆转录病毒或肝炎病毒治疗的PMPA的新型混合酯酰胺化物，包括具有如本文所定义的取代基的结构（5a）的化合物。 提供这些新化合物在药学上可接受的赋形剂中的组合物及其在治疗和预防中的用途。
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