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公开(公告)号：US20090191587A1
公开(公告)日：2009-07-30
申请号：US12300926
申请日：2007-05-16
申请人： Yasunori Chiba , Yoshifumi Jigami , Kosuke Kuroda , Kazuo Kobayashi , Kimihisa Ichikawa , Koichi Nonaka , Takeshi Suzuki
发明人： Yasunori Chiba , Yoshifumi Jigami , Kosuke Kuroda , Kazuo Kobayashi , Kimihisa Ichikawa , Koichi Nonaka , Takeshi Suzuki
CPC分类号： C07K16/2875 , C07K16/00
摘要： This invention provides a means for enabling high-level secretory production of proteins, in particular proteins having complicated structures such as antibodies, in host cells such as yeast cells. The invention also provides transformed yeast cells having the activated HAC1 gene and the RRBP1 gene and a method for enabling high-level secretory production of foreign proteins using such transformed host cells by inhibiting O-sugar chain formation indigenous to host cells such as yeast cells.
摘要翻译： 本发明提供了一种用于在宿主细胞如酵母细胞中进行蛋白质，特别是具有复杂结构如蛋白质的蛋白质的高水平分泌生产的方法。 本发明还提供具有活化的HAC1基因和RRBP1基因的转化的酵母细胞，以及通过抑制宿主细胞如酵母细胞本身的O-糖链形成，使用这种转化的宿主细胞能够高水平分泌外源蛋白质的方法。
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公开(公告)号：US07565723B2
公开(公告)日：2009-07-28
申请号：US11083953
申请日：2005-03-21
申请人： Hiroto Sugahara , Kazuo Kobayashi , Motohiro Yasui , Jun Akedo , Sou Baba
发明人： Hiroto Sugahara , Kazuo Kobayashi , Motohiro Yasui , Jun Akedo , Sou Baba
IPC分类号： H01L41/22
CPC分类号： B41J2/14233 , B41J2/161 , B41J2/1623 , B41J2/1626 , B41J2/1631 , B41J2/1642 , B41J2/1643 , B41J2/1645 , B41J2/1646 , H01L41/0805 , H01L41/314 , H01L41/319 , Y10T29/42 , Y10T29/49005 , Y10T29/49007 , Y10T29/49128 , Y10T29/4913 , Y10T29/49401
摘要： A piezoelectric material layer is easily formed on a partial region of the substrate surface. By forming a different hardness material layer that has a different hardness from that of the substrate in the form of a pattern on the surface of the substrate, a film-deposition permitting region A to which particles of a piezoelectric material in a carrier gas adhere in a form of a film and a film-deposition inhibiting region B which inhibits the formation of a film are provided. Further, when a carrier gas containing particles of a piezoelectric material are ejected onto the surface of the substrate by means of AD, a film-like piezoelectric material layer is formed as a result of the adhesion of the particles in the film-deposition permitting region A. As a result, the piezoelectric material layer can be formed easily in a partial region of the surface of the substrate.
摘要翻译： 在基板表面的部分区域上容易形成压电材料层。 通过在基板的表面上形成与图案形式的基板的硬度不同的不同的硬度材料层，载体气体中的压电材料的粒子粘附在其上的成膜允许区域A 提供了抑制膜形成的膜形式和膜沉积抑制区域B. 此外，当通过AD将含有压电材料的颗粒的载气喷射到基板的表面上时，由于颗粒在成膜允许区域中的粘附而形成膜状的压电材料层 因此，可以在基板的表面的部分区域容易地形成压电体层。
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13.发明申请公开(公告)号：US20090115822A1
公开(公告)日：2009-05-07
申请号：US12343793
申请日：2008-12-24
申请人： Hiroto Sugahara , Kazuo Kobayashi
发明人： Hiroto Sugahara , Kazuo Kobayashi
IPC分类号： B41J2/045 , H01L41/047
CPC分类号： H01L41/0475 , B41J2/045 , B41J2/14233 , B41J2/161 , B41J2/1623 , B41J2/164 , B41J2/1642 , B41J2/1643 , B41J2/1646 , B41J2002/14266 , B41J2002/14491 , H01L41/09 , H01L41/0973 , H01L41/314 , Y10T29/42 , Y10T29/49147 , Y10T29/49155
摘要： A piezoelectric actuator includes a metallic vibration plate, an insulating layer, a plurality of individual electrodes, a piezoelectric layer and a common electrode. The insulating layer is formed on the top surface of the vibration plate. The individual electrodes are formed on the top surface of the insulating layer. The piezoelectric layer is formed on the top surfaces of the individual electrodes. The common electrode is formed on the top surface of the piezoelectric layer over the individual electrodes. A plurality of terminals and a plurality of wirings are formed on the top surface of the insulating layer. Each of the terminals is associated with one of the individual electrodes. Each of the wirings connects one of the individual electrodes and the associated terminal.
摘要翻译： 压电致动器包括金属振动板，绝缘层，多个单独电极，压电层和公共电极。 绝缘层形成在振动板的顶表面上。 各个电极形成在绝缘层的顶表面上。 压电层形成在各个电极的顶表面上。 公共电极形成在各个电极上的压电层的顶表面上。 多个端子和多个布线形成在绝缘层的顶表面上。 每个端子与单个电极中的一个相关联。 每个布线连接单个电极中的一个和相关联的端子。
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公开(公告)号：US20090068702A1
公开(公告)日：2009-03-12
申请号：US11678678
申请日：2007-02-26
申请人： Yasunori CHIBA , Kou Amano , Yoshifumi Jigami , Kazuo Kobayashi
发明人： Yasunori CHIBA , Kou Amano , Yoshifumi Jigami , Kazuo Kobayashi
CPC分类号： C12P21/005 , C12N9/1051
摘要： The present invention relates to a means for generating a mucin-type glycopeptide or glycoprotein on a large scale in yeast. Specifically, the invention relates to a method which comprises introducing into a yeast at least one selected from the group consisting of a gene encoding UDP-GalNAc synthetase, a gene encoding UDP-GalNAc transporter, and a gene encoding polypeptide:O-GalNAc transferase, and, if desired, a gene encoding a mucin-type glycopeptide; and producing a mucin-type glycoprotein having O-GalNAc by use of the yeast.
摘要翻译： 本发明涉及在酵母中大规模生产粘蛋白型糖肽或糖蛋白的方法。 具体地，本发明涉及一种方法，其包括向酵母中引入选自编码UDP-GalNAc合成酶的基因，编码UDP-GalNAc转运蛋白的基因和编码多肽O-GalNAc转移酶的基因中的至少一种， 如果需要，编码粘蛋白型糖肽的基因; 并通过使用酵母生产具有O-GalNAc的粘蛋白型糖蛋白。
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公开(公告)号：US20090065922A1
公开(公告)日：2009-03-12
申请号：US12235734
申请日：2008-09-23
IPC分类号： H01L23/02
CPC分类号： H01L23/3135 , H01L23/3128 , H01L23/49575 , H01L24/48 , H01L24/49 , H01L25/0652 , H01L25/0657 , H01L2224/05554 , H01L2224/32145 , H01L2224/48091 , H01L2224/48247 , H01L2224/49175 , H01L2225/0651 , H01L2225/06513 , H01L2225/0652 , H01L2225/06572 , H01L2225/06582 , H01L2225/06596 , H01L2924/00014 , H01L2924/01004 , H01L2924/10161 , H01L2924/15311 , H01L2924/181 , H01L2924/00 , H01L2924/00012 , H01L2224/45099 , H01L2224/45015 , H01L2924/207
摘要： A semiconductor chip mounted interposer (60) is configured by executing wire bonding between a semiconductor chip (50) and an interposer (20), in which terminals (21) that connect to terminals (51) of the chip (50) and separate terminals (22) are formed, on the upper face of the interposer (20). A semiconductor chip (30) is mounted to the top face of a package substrate (10), the interposer (60) is adhered to the upper portion of the chip (30), and wire bonding is executed between the terminals (22) and terminals (11′). When configuring a semiconductor device with a plurality of semiconductor chips combined into one package in this manner, KGD (Known-Good-Die) can easily be guaranteed for each semiconductor chip, and semiconductor devices can be fabricated with a high yield of good units. Also, the semiconductor chips can be used as-is, without restricting the position, pitch, signal arrangement, or the like, of their terminals.
摘要翻译： 半导体芯片安装插入件（60）通过在半导体芯片（50）和插入件（20）之间执行引线键合而构成，其中连接到芯片（50）的端子（51）的端子（21）和分离的端子 （22）形成在插入件（20）的上表面上。 半导体芯片（30）安装在封装基板（10）的顶面上，插入件（60）粘接到芯片（30）的上部，并且在端子（22）和 端子（11'）。 当以这种方式配置具有组合成一个封装的多个半导体芯片的半导体器件时，可以容易地保证每个半导体芯片的KGD（Known-Good-Die），并且可以以高产量的良好单元制造半导体器件。 此外，半导体芯片可以原样使用，而不限制其端子的位置，间距，信号布置等。
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公开(公告)号：US07290867B2
公开(公告)日：2007-11-06
申请号：US10876531
申请日：2004-06-28
申请人： Kazuo Kobayashi , Chikamasa Hattori
发明人： Kazuo Kobayashi , Chikamasa Hattori
IPC分类号： B41J2/045
CPC分类号： B41J2/14209 , B41J2/14233 , B41J2002/14225 , B41J2002/14266 , B41J2002/14491
摘要： A liquid delivering apparatus including: at least one piezoelectric element; a plurality of electrodes which generate an electric field for deforming the at least one piezoelectric element; a drive circuit which supplies a drive voltage to the plurality of electrodes; a plurality of liquid chambers which store liquid, the liquid being given pressure by deformation of the at least one piezoelectric element, so that the liquid is delivered from the plurality of liquid chambers to an exterior of the apparatus; and an insulating sheet and a plurality of wires which connect the plurality of electrodes to the drive circuit, the plurality of electrodes and the plurality of wires being formed on the insulating sheet.
摘要翻译： 一种液体输送装置，包括：至少一个压电元件; 多个电极，其产生使所述至少一个压电元件变形的电场; 向所述多个电极提供驱动电压的驱动电路; 存储液体的多个液体室，所述液体通过所述至少一个压电元件的变形被施加压力，使得所述液体从所述多个液体室输送到所述设备的外部; 以及绝缘片和将多个电极连接到驱动电路的多条电线，多个电极和多条电线形成在绝缘片上。
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公开(公告)号：US20070216735A1
公开(公告)日：2007-09-20
申请号：US11717869
申请日：2007-03-14
申请人： Kazuo Kobayashi , Hiroyuki Ishikawa
发明人： Kazuo Kobayashi , Hiroyuki Ishikawa
IPC分类号： B41J2/045
CPC分类号： B41J2/14233 , B41J2002/14491
摘要： An ink-jet head includes a channel unit which includes a plurality of pressure chambers, a vibration plate stacked on the channel unit, and a piezoelectric material layer arranged on the vibration plate. The piezoelectric material layer includes a first portion functioning as a piezoelectric actuator, and a second portion functioning as a piezoelectric transformer which amplifies a driving signal to be supplied to the piezoelectric actuator. Accordingly, it is possible to realize a small-size ink-jet head with a built-in piezoelectric amplifier.
摘要翻译： 喷墨头包括通道单元，其包括多个压力室，堆叠在通道单元上的振动板和布置在振动板上的压电材料层。 压电材料层包括用作压电致动器的第一部分和用作放大要供应到压电致动器的驱动信号的压电变压器的第二部分。 因此，可以实现具有内置压电放大器的小尺寸喷墨头。
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公开(公告)号：US07249413B2
公开(公告)日：2007-07-31
申请号：US10874321
申请日：2004-06-24
CPC分类号： B41J2/1623 , B41J2/14209 , B41J2/1609 , B41J2/1626 , B41J2002/14217 , B41J2002/14225 , B41J2002/14306 , B41J2002/14459 , B41J2202/20 , Y10T29/42 , Y10T29/49144 , Y10T29/49149 , Y10T29/49401
摘要： A method of manufacturing an ink jet printing head includes: forming a first laminated structure by laminating at least two metal plates having a hole formed thereon and fixing the metal plates to one another by metal-metal junction, and by laminating a plurality of thin plate members having a hole formed thereon, the thin plate members including the metal plates, and fixing the thin plate members to one another; forming a second laminated structure that includes at least a part of a common ink chamber, by laminating a plurality of thin plate members having a hole formed thereon and fixing the thin plate members to one another; and fixing the first laminated structure and the second laminated structure to each other while laminating the first laminated structure and the second laminated structure on each other.
摘要翻译： 一种制造喷墨打印头的方法包括：通过层压至少两个具有形成在其上的孔的金属板并通过金属 - 金属接合将金属板彼此固定，并且通过层叠多个薄板来形成第一层压结构 具有形成在其上的孔的构件，所述薄板构件包括所述金属板，并且将所述薄板构件彼此固定; 通过层叠多个形成有孔的薄板构件并将薄板构件彼此固定，形成包括公共墨室的至少一部分的第二层压结构; 以及将所述第一层压结构和所述第二层叠结构彼此层叠，将所述第一层叠结构和所述第二层叠结构彼此固定。
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公开(公告)号：US20070154641A1
公开(公告)日：2007-07-05
申请号：US11648442
申请日：2006-12-29
申请人： Kazuo Kobayashi
发明人： Kazuo Kobayashi
CPC分类号： C23C24/04 , C23C4/01 , H01L28/55 , H01L41/1876 , H01L41/314 , H01L41/331
摘要： Ultra-fine particles are jetted from a nozzle to be deposited on a substrate via a mask which is plate-shaped and in which an opening pattern is formed, thereby forming on the substrate a thin film having a shape corresponding to the opening pattern. The mask has a first area, a second area which surrounds the first area and defines an opening between the first area and the second area, and a bridge portion connecting the first and second areas. The bridge portion is formed at a position away from the bottom surface of the mask. By using this mask, a thin film having a pattern including an independent non-film formation area can be formed.
摘要翻译： 从喷嘴喷射超细颗粒，通过板状的掩模将其沉积在基板上，形成开口图案，从而在基板上形成具有与开口图案对应的形状的薄膜。 掩模具有第一区域，第二区域围绕第一区域并且限定第一区域和第二区域之间的开口，以及连接第一区域和第二区域的桥接部分。 桥接部形成在远离掩模的底面的位置。 通过使用该掩模，可以形成具有独立的非成膜区域的图案的薄膜。
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20.发明授权公开(公告)号：US07221547B2
公开(公告)日：2007-05-22
申请号：US10465820
申请日：2003-06-19
IPC分类号： G11B5/127
CPC分类号： B82Y25/00 , B82Y10/00 , G01R33/093 , G11B5/012 , G11B5/3143 , G11B5/3903 , G11B5/3909 , G11B2005/3996 , H01F10/3254 , H01F10/3268 , H01F10/3295 , H01L43/08
摘要： A magnetoresistive effect element is a compound lamination including a first anti-ferromagnetic layer, a first fixed magnetic layer, a tunnel insulation layer, a free magnetic layer, a non-magnetic metal layer, a second fixed magnetic layer, and a second anti-ferromagnetic layer such that a TMR element and a SVMR element are formed, sharing the free magnetic layer.
摘要翻译： 磁阻效应元件是包括第一反铁磁层，第一固定磁性层，隧道绝缘层，自由磁性层，非磁性金属层，第二固定磁性层和第二抗铁磁性层的复合层压体， 铁磁层，使得形成TMR元件和SVMR元件，共享自由磁性层。
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