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221 条记录 (耗时 0.057 秒)

    Heterocyclic compounds and their uses
    11.
    发明授权
    Heterocyclic compounds and their uses 有权
    杂环化合物及其用途

    公开(公告)号：US08901135B2

    公开(公告)日：2014-12-02

    申请号：US13468234

    申请日：2012-05-10

    申请人： Yi Chen ,  Timothy D. Cushing ,  Jason A. Duquette ,  Felix Gonzalez Lopez De Turiso ,  Xiaolin Hao ,  Xiao He ,  Brian Lucas ,  Lawrence R. McGee ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

    发明人： Yi Chen ,  Timothy D. Cushing ,  Jason A. Duquette ,  Felix Gonzalez Lopez De Turiso ,  Xiaolin Hao ,  Xiao He ,  Brian Lucas ,  Lawrence R. McGee ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

    IPC分类号： C07D487/04 ,  C07D473/34 ,  C07D473/30

    CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D473/30 ,  C07D473/34

    摘要： Substituted bicyclic heteroaryls having the following formula where the variables are as defined herein, and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110□ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

    摘要翻译： 具有下式的取代的双环杂芳基，其中变量如本文所定义，以及含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣， 包括但不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血， 包括所有形式的超敏反应的过敏症状本发明还使得能够治疗依赖于p110□活性或与p110□活性相关的癌症的方法，包括但不限于白血病，例如急性骨髓性白血病（AML）Myelo-dysplastic sy （MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病（CML）T细胞急性淋巴细胞性白血病（T-ALL）B细胞急性淋巴细胞性白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和 实体肿瘤，如乳腺癌。

    Method and device for storing and reading/writing composite document
    14.
    发明授权
    Method and device for storing and reading/writing composite document 有权
    用于存储和读写复合文件的方法和装置

    公开(公告)号：US08788784B2

    公开(公告)日：2014-07-22

    申请号：US13537950

    申请日：2012-06-29

    申请人： Libo Deng ,  Yi Chen

    发明人： Libo Deng ,  Yi Chen

    IPC分类号： G06F12/02

    CPC分类号： G06F17/30011

    摘要： A method and device for storing and reading/writing a composite document are disclosed. The method includes: an initial storing area is pre-allocated for an inner controlling stream of the composite document and the initial storing area is continuous sectors or sector clusters; the inner controlling stream is stored in the initial storing area. The patches of a user data stream and the inner controlling stream in the composite document are reduced using the method or device. Correspondingly, pre-allocating storing area makes the probability of continuously storing the user data stream and the inner controlling stream in the composite document increased. The I/O can be optimized by introducing a strategy of reading cache and writing in a batch size, which can improve the efficiency of reading and writing.

    摘要翻译： 公开了一种用于存储和读取/写入复合文档的方法和装置。 该方法包括：为复合文档的内部控制流预分配初始存储区域，初始存储区域是连续扇区或扇区簇; 内部控制流存储在初始存储区域中。 使用方法或装置减少用户数据流的补丁和复合文档中的内部控制流。 相应地，预分配存储区域使得在复合文档中连续存储用户数据流和内部控制流的概率增加。 可以通过引入以批量读取缓存和写入的策略来优化I / O，从而提高读写效率。

    Camptothecin derivatives and their use
    15.
    发明授权
    Camptothecin derivatives and their use 有权
    喜树碱衍生物及其用途

    公开(公告)号：US08685997B2

    公开(公告)日：2014-04-01

    申请号：US12282397

    申请日：2007-01-17

    申请人： Wei Lu ,  Jian Ding ,  Heyong Gao ,  Liping Lin ,  Yi Chen

    发明人： Wei Lu ,  Jian Ding ,  Heyong Gao ,  Liping Lin ,  Yi Chen

    IPC分类号： A61K31/44 ,  C07D471/00

    CPC分类号： C07D491/22

    摘要： New camptothecin derivatives with the following structure of the formula (I), their use and the pharmaceutical compositions containing the same. The compounds of the present invention have good anti-tumor activities and good solubility in water, and can be used in development of medicines.

    摘要翻译： 具有以下结构式（I）的新的喜树碱衍生物，它们的用途和含有它们的药物组合物。 本发明化合物具有良好的抗肿瘤活性和在水中的良好溶解性，可用于药物的开发。

    METHOD OF FORMING AN ARRAY OF NANOSTRUCTURES
    17.
    发明申请
    METHOD OF FORMING AN ARRAY OF NANOSTRUCTURES 有权
    形成纳米结构阵列的方法

    公开(公告)号：US20130298977A1

    公开(公告)日：2013-11-14

    申请号：US13882631

    申请日：2011-10-31

    申请人： Yi Chen ,  G. Logan Liu

    发明人： Yi Chen ,  G. Logan Liu

    IPC分类号： H01L21/02 ,  H01L31/0352 ,  H01L29/06

    CPC分类号： H01L21/02612 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  H01L29/0665 ,  H01L31/02363 ,  H01L31/035209 ,  H01L31/035227 ,  H01L31/1804 ,  Y02E10/547 ,  Y02P70/521

    摘要： A method of forming an array of nanostructures includes forming a plurality of seed points on a surface of a substrate, and growing masks from the seed points to create masked regions of the substrate underlying the masks. A remainder of the substrate comprises an unmasked region. Each mask and masked region increase in size with growth time while the unmasked region of the substrate decreases in size. During the growing, the unmasked region is etched to remove material from the substrate in a depth direction, and, simultaneously, unetched structures are formed from the masked regions of the substrate underlying the masks. Each of the unetched structures has a lateral size that increases with depth.

    摘要翻译： 形成纳米结构阵列的方法包括在衬底的表面上形成多个种子点，以及从种子点生长掩模以产生掩模下面的衬底的掩蔽区域。 衬底的其余部分包括未掩模区域。 每个掩模和掩模区域随着生长时间而增大，而衬底的未掩模区域的尺寸减小。 在生长期间，蚀刻未掩模区域以在深度方向上从衬底去除材料，并且同时从掩模下面的衬底的掩蔽区域形成未蚀刻的结构。 每个未蚀刻的结构具有随深度增加的横向尺寸。