Camptothecin derivatives and their use
    1.
    发明授权
    Camptothecin derivatives and their use 有权
    喜树碱衍生物及其用途

    公开(公告)号:US08685997B2

    公开(公告)日:2014-04-01

    申请号:US12282397

    申请日:2007-01-17

    IPC分类号: A61K31/44 C07D471/00

    CPC分类号: C07D491/22

    摘要: New camptothecin derivatives with the following structure of the formula (I), their use and the pharmaceutical compositions containing the same. The compounds of the present invention have good anti-tumor activities and good solubility in water, and can be used in development of medicines.

    摘要翻译: 具有以下结构式(I)的新的喜树碱衍生物,它们的用途和含有它们的药物组合物。 本发明化合物具有良好的抗肿瘤活性和在水中的良好溶解性,可用于药物的开发。

    CAMPTOTHECIN DERIVATIVES AND THEIR USE
    2.
    发明申请
    CAMPTOTHECIN DERIVATIVES AND THEIR USE 有权
    CAMPTOTHECIN衍生物及其用途

    公开(公告)号:US20090325996A1

    公开(公告)日:2009-12-31

    申请号:US12282397

    申请日:2007-01-17

    CPC分类号: C07D491/22

    摘要: New camptothecin derivatives with the following structure of the formula (I), their use and the pharmaceutical compositions containing the same. The compounds of the present invention have good anti-tumor activities and good solubility in water, and can be used in development of medicines.

    摘要翻译: 具有以下结构式(I)的新的喜树碱衍生物,它们的用途和含有它们的药物组合物。 本发明化合物具有良好的抗肿瘤活性和在水中的良好溶解性,可用于药物的开发。

    Non-volatile solid state resistive switching devices

    公开(公告)号:US10134985B2

    公开(公告)日:2018-11-20

    申请号:US11875541

    申请日:2007-10-19

    申请人: Wei Lu Sung Hyun Jo

    发明人: Wei Lu Sung Hyun Jo

    IPC分类号: H01L47/00 H01L45/00 H01L27/24

    摘要: Non-crystalline silicon non-volatile resistive switching devices include a metal electrode, a non-crystalline silicon layer and a planar doped silicon electrode. An electrical signal applied to the metal electrode drives metal ions from the metal electrode into the non-crystalline silicon layer to form a conducting filament from the metal electrode to the planar doped silicon electrode to alter a resistance of the non-crystalline silicon layer. Another electrical signal applied to the metal electrode removes at least some of the metal ions forming the conducting filament from the non-crystalline silicon layer to further alter the resistance of the non-crystalline silicon layer.

    Solvent-based methods for production of graphene nanoribbons
    8.
    发明授权
    Solvent-based methods for production of graphene nanoribbons 有权
    用于生产石墨烯纳米带的基于溶剂的方法

    公开(公告)号:US09493355B2

    公开(公告)日:2016-11-15

    申请号:US14345016

    申请日:2012-09-14

    摘要: The present invention provides methods of preparing functionalized graphene nanoribbons. Such methods include: (1) exposing a plurality of carbon nanotubes (CNTs) to an alkali metal source in the presence of an aprotic solvent to open them; and (2) exposing the opened CNTs to an electrophile to form functionalized graphene nanoribbons (GNRs). The methods may also include a step of exposing the opened CNTs to a protic solvent to quench any reactive species on them. Additional methods include preparing unfunctionalized GNRs by: (1) exposing a plurality of CNTs to an alkali metal source in the presence of an aprotic solvent to open them; and (2) exposing the opened CNTs to a protic solvent to form unfunctionalized GNRs.

    摘要翻译: 本发明提供了制备官能化石墨烯纳米带的方法。 这些方法包括:(1)在非质子溶剂的存在下将多个碳纳米管(CNT)暴露于碱金属源以将其打开; 和(2)将开放的CNT暴露于亲电子试剂以形成官能化的石墨烯纳米带(GNR)。 所述方法还可以包括将开放的CNT暴露于质子溶剂以淬灭其上的任何反应性物质的步骤。 另外的方法包括:通过以下步骤制备未官能化的GNR:(1)在非质子溶剂存在下将多个CNT暴露于碱金属源以打开它们; 和(2)将开放的CNT暴露于质子溶剂以形成未官能化的GNR。

    METHODS AND APPARATUS FOR INDIVIDUALLY OPTIMIZING UNIFORM CONTRAST ENHANCEMENTS IN COMPUTED TOMOGRAPHY IMAGING
    9.
    发明申请
    METHODS AND APPARATUS FOR INDIVIDUALLY OPTIMIZING UNIFORM CONTRAST ENHANCEMENTS IN COMPUTED TOMOGRAPHY IMAGING 有权
    在计算机图像成像中单独优化均匀对比增强的方法和装置

    公开(公告)号:US20150324979A1

    公开(公告)日:2015-11-12

    申请号:US14710052

    申请日:2015-05-12

    IPC分类号: G06T7/00 G06T11/00

    摘要: A method is provided for optimizing a contrast injection function for CT imaging. The method includes injecting, with an injector pump, a test bolus of a contrast agent into a subject. The method also includes computing, on a processor, an impulse enhancement function. The method also includes determining, on a processor, a target enhancement function for a region of interest. The method also includes determining, with a processor, a plurality of parameters for a functional form for a contrast injection function in a time domain. The method also includes determining for the contrast injection function a constraint. The method also includes determining, with a processor, particular values for the plurality of parameters, which satisfy the constraint and minimize a difference between a value of an enhancement function and the target enhancement function computed in the time domain at discrete time periods without use of a Fourier transform.

    摘要翻译: 提供了一种用于优化CT成像的造影剂注射功能的方法。 该方法包括用注射器泵将造影剂的测试团注入受试者。 该方法还包括在处理器上计算脉冲增强功能。 该方法还包括在处理器上确定感兴趣区域的目标增强功能。 该方法还包括使用处理器确定用于时域中的对比度注入功能的功能形式的多个参数。 该方法还包括确定对比度注入功能的约束。 该方法还包括使用处理器确定满足约束的多个参数的特定值,并且使离散时间段内在增强函数的值和在时域中计算的目标增强函数之间的差最小化,而不使用 傅立叶变换。

    Content associative caching method for web applications
    10.
    发明授权
    Content associative caching method for web applications 有权
    Web应用程序的内容关联缓存方法

    公开(公告)号:US08793307B2

    公开(公告)日:2014-07-29

    申请号:US12695996

    申请日:2010-01-28

    IPC分类号: G06F15/16

    CPC分类号: H04L67/2842

    摘要: A cache logically disposed in a communication path between a client and a server receives a request for a content item and, in response thereto, requests from the server header information concerning the content item and an initial portion of data that makes up the content item. The cache then computes a first hashing value from the header information and a second hashing value from the initial portion of data. A content identifier is created by combining the first hashing value and the second hashing value. Using the content identifier, the cache determines whether a copy of the content item is stored by the cache; and, if so provides same to the client. Otherwise, the cache requests the content item from the server and, upon receipt thereof, provides it to the client.

    摘要翻译: 逻辑上设置在客户端和服务器之间的通信路径中的高速缓存器接收对内容项目的请求,并响应于此,来自服务器的关于内容项目的信息的请求以及组成内容项的数据的初始部分。 然后,高速缓存从头信息计算第一散列值,并从数据的初始部分计算第二哈希值。 通过组合第一哈希值和第二散列值来创建内容标识符。 使用内容标识符,缓存确定高速缓存是否存储内容项的副本; 如果是这样,给客户端一样。 否则,高速缓存从服务器请求内容项,并在接收到该内容时将其提供给客户端。