公开(公告)号：US20140029002A1

公开(公告)日：2014-01-30

申请号：US13561561

申请日：2012-07-30

Applicant: Shih-Yuan Wang ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Gary Gibson ,  Huei Pei Kuo ,  Zhang-Lin Zhou ,  Steven J. Barcelo ,  Ansoon Kim ,  R Stanley Williams

Inventor： Shih-Yuan Wang ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Gary Gibson ,  Huei Pei Kuo ,  Zhang-Lin Zhou ,  Steven J. Barcelo ,  Ansoon Kim ,  R Stanley Williams

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y15/00

Abstract: A sensor for surface enhanced Raman spectroscopy (SERS) sensor includes surfaces and an actuator to adjust an intersurface spacing between the surfaces to contain an analyte and allow the analyte to be released from containment.

Abstract translation: 用于表面增强拉曼光谱（SERS）传感器的传感器包括表面和致动器，以调节表面之间的表面间隔，以包含分析物并允许分析物从容纳物释放。

公开(公告)号：US08048377B1

公开(公告)日：2011-11-01

申请号：US10795730

申请日：2004-03-08

Applicant: Zhang-Lin Zhou ,  Zhiyong Li ,  Sean Xiao-An Zhang

Inventor： Zhang-Lin Zhou ,  Zhiyong Li ,  Sean Xiao-An Zhang

IPC: G01N27/00 ,  C12M1/00 ,  G01N21/75

CPC classification number: G01N33/54373 ,  B82Y15/00 ,  B82Y30/00 ,  Y10S977/70 ,  Y10S977/742 ,  Y10S977/745 ,  Y10S977/842

Abstract: The present invention is drawn toward a chemical or biological sensor that can comprise a semi-conducting nanowire and a chemical or biological sensing molecule tethered to the semi-conducting nanowire through a spacer group including a hydrophilic reactive group. In one embodiment, the semi-conducting nanowire can be part of an array of like or similar semi-conducting nanowires. Electrical leads can provide an electrical current to the array, and a signal measurement apparatus can be electrically coupled to the array, and can be configured for detecting changes in the electrical current of the array.

Abstract translation: 本发明涉及化学或生物传感器，其可以包括通过包括亲水反应性基团的间隔基团连接到半导体纳米线的半导体纳米线和化学或生物传感分子。 在一个实施例中，半导体纳米线可以是类似或类似的半导体纳米线阵列的一部分。 电引线可以向阵列提供电流，并且信号测量装置可以电耦合到阵列，并且可以被配置为检测阵列的电流的变化。

公开(公告)号：US07780841B2

公开(公告)日：2010-08-24

申请号：US11059258

申请日：2005-02-15

Applicant: Sean Xiao-An Zhang ,  Zhiyong Li ,  Zhang-Lin Zhou ,  William M. Tong ,  R. Stanley Williams ,  Yong Chen

Inventor： Sean Xiao-An Zhang ,  Zhiyong Li ,  Zhang-Lin Zhou ,  William M. Tong ,  R. Stanley Williams ,  Yong Chen

IPC: G01N27/327

CPC classification number: G01N33/5308 ,  G01N33/5438 ,  G01N2430/00

Abstract: A sensor array for sensing at least one of chemical moieties and biological moieties is provided. The sensor array comprises a plurality of working electrodes electrically associated with a reference electrode, each working electrode in combination with the reference electrode forming a transducer. Each working electrode is provided with a coating of a sensing element comprised of an ionizable moiety and a functional group sensitive to one of the chemical and/or biological moieties.

Abstract translation: 提供了用于感测化学部分和生物部分中的至少一个的传感器阵列。 传感器阵列包括与参考电极电连接的多个工作电极，每个工作电极与参考电极组合形成换能器。 每个工作电极设置有由可电离部分和对化学和/或生物部分之一敏感的官能团组成的感测元件的涂层。

公开(公告)号：US10520440B2

公开(公告)日：2019-12-31

申请号：US14377524

申请日：2012-02-08

Applicant: Devin Alexander Mourey ,  James William Stasiak ,  James Elmer Abbott, Jr. ,  Zhiyong Li

Inventor： Devin Alexander Mourey ,  James William Stasiak ,  James Elmer Abbott, Jr. ,  Zhiyong Li

IPC: G01J3/44 ,  G01N21/65

Abstract: Molecule sensing apparatus. The apparatus has first and second chambers, an input port extending into the first chamber, a fluid channel extending from the first chamber to the second chamber, and a surface-enhanced substrate in the second chamber.

公开(公告)号：US09709538B2

公开(公告)日：2017-07-18

申请号：US14239330

申请日：2011-09-30

Applicant: Wei Wu ,  Zhiyong Li ,  Ansoon Kim ,  Min Hu ,  Michael Josef Stuke

Inventor： Wei Wu ,  Zhiyong Li ,  Ansoon Kim ,  Min Hu ,  Michael Josef Stuke

IPC: G01N31/22 ,  G01N21/64 ,  G01N21/65 ,  B01L3/00 ,  B82Y15/00

CPC classification number: G01N31/22 ,  B01L3/5085 ,  B01L3/50853 ,  B01L2200/141 ,  B01L2300/0636 ,  B01L2300/069 ,  B01L2300/0819 ,  B82Y15/00 ,  G01N21/648 ,  G01N21/658 ,  G01N2201/0227 ,  G01N2201/023 ,  Y10T436/25

Abstract: Devices to detect a substance and methods of producing such a device are disclosed. An example device to detect a substance includes a housing defining an externally accessible chamber and a seal to enclose at least a portion of the chamber. The example device also includes a substrate includes nanoparticles positioned within the chamber. The nanoparticles to react to the substance when exposed thereto. The example device also includes a non-analytic solution within the chamber to protect the nanoparticles from premature exposure.

公开(公告)号：US09678013B2

公开(公告)日：2017-06-13

申请号：US14394295

申请日：2012-04-20

Applicant: Alexandre M. Bratkovski ,  Zhiyong Li ,  Wei Wu ,  Min Hu ,  R. Stanley Williams ,  Ansoon Kim

Inventor： Alexandre M. Bratkovski ,  Zhiyong Li ,  Wei Wu ,  Min Hu ,  R. Stanley Williams ,  Ansoon Kim

IPC: G01N21/01 ,  G01N21/65 ,  G01N35/00 ,  B01L3/00 ,  G01N21/64

CPC classification number: G01N21/658 ,  B01L3/5088 ,  B01L2300/0627 ,  B01L2300/0819 ,  B01L2300/161 ,  G01N21/648 ,  G01N35/00009 ,  G01N2035/00019

Abstract: Examples of integrated sensors are disclosed herein. An example of an integrated sensor includes a substrate and a sensing member formed on a surface of the substrate. The sensing member includes collapsible signal amplifying structures and an area surrounding the collapsible signal amplifying structures that enables self-positioning of droplets exposed thereto toward the collapsible signal amplifying structures.

公开(公告)号：US09592001B2

公开(公告)日：2017-03-14

申请号：US14406601

申请日：2012-07-29

Applicant: Steven Barcelo ,  Zhiyong Li ,  Ansoon Kim ,  Gary Gibson

Inventor： Steven Barcelo ,  Zhiyong Li ,  Ansoon Kim ,  Gary Gibson

IPC: G01J3/44 ,  A61B5/1459 ,  G01N21/65 ,  A61B5/00

CPC classification number: A61B5/1459 ,  A61B5/0075 ,  A61B5/6862 ,  G01N21/658

Abstract: An implantable nanosensor includes a stent to be implanted inside a fluid conduit. The stent has a well in a surface of the stent. The implantable nanosensor further includes a nanoscale-patterned sensing substrate disposed in the well. The nanoscale-patterned sensing substrate is to produce an optical scattering response signal indicative of a presence of an analyte in a fluid carried by the fluid conduit when interrogated by an optical stimulus signal.

Abstract translation: 可植入纳米传感器包括待植入流体导管内的支架。 支架在支架表面有一个井。 可植入纳米传感器还包括设置在井中的纳米级图案感测基片。 纳米级图案化感测衬底将产生光学散射响应信号，该信号指示由光学刺激信号询问时由流体导管携带的流体中分析物的存在。

公开(公告)号：US09310306B2

公开(公告)日：2016-04-12

申请号：US14006436

申请日：2011-03-24

Applicant: Zhiyong Li ,  Ivan Naumov ,  Farzad Parvaresh

Inventor： Zhiyong Li ,  Ivan Naumov ,  Farzad Parvaresh

IPC: G01J3/44 ,  G01N21/65 ,  B05D3/00

CPC classification number: G01N21/65 ,  B05D3/007 ,  G01N21/658

Abstract: An apparatus for use in sensing applications includes a substrate and a plurality of clusters arranged in an aperiodic configuration on the substrate, wherein each of the plurality of clusters is formed of a plurality of Raman-active material nano-particles, and wherein each of the Raman-active material nano-particles is positioned in a substantially ordered configuration with respect to each other in each of the respective plurality of clusters.

Abstract translation: 用于感测应用的装置包括基板和在基板上以非周期配置布置的多个簇，其中多个簇中的每一个由多个拉曼活性材料纳米颗粒形成，并且其中 拉曼活性材料纳米颗粒在相应的多个簇中的每一个中相对于彼此定位成基本排列的构型。

公开(公告)号：US09001324B2

公开(公告)日：2015-04-07

申请号：US13810982

申请日：2010-07-30

Applicant: Zhiyong Li ,  Min Hu ,  Wei Wu

Inventor： Zhiyong Li ,  Min Hu ,  Wei Wu

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: A surface enhanced Raman spectroscopy (SERS) probe apparatus and a method of SERS probing employ Raman-active surfaces of a plurality of nanoscale field concentrator (NFC) structures at a terminal end of an optical fiber. The SERS probe apparatus includes an optical fiber having an optical path and a terminal end that terminates the optical path. The SERS probe apparatus further includes a plurality of NFC structures and nanoparticles on surfaces of the plurality of NFC structures. First ends of the NFC structures are adjacent to the terminal end of optical fiber. The nanoparticles are Raman active to an analyte.

Abstract translation: 表面增强拉曼光谱（SERS）探针装置和SERS探测的方法在光纤的末端使用多个纳米尺度场集中器（NFC）结构的拉曼活性表面。 SERS探针装置包括具有光路的光纤和终止光路的终端。 SERS探针装置还包括在多个NFC结构的表面上的多个NFC结构和纳米颗粒。 NFC结构的第一端与光纤的终端相邻。 纳米颗粒是对分析物有活性的拉曼。

公开(公告)号：US09000411B2

公开(公告)日：2015-04-07

申请号：US13130799

申请日：2009-01-06

Applicant: Zhiyong Li ,  Alexandre M. Bratkovski ,  Jianhua Yang

Inventor： Zhiyong Li ,  Alexandre M. Bratkovski ,  Jianhua Yang

IPC: H01L45/00 ,  H01L27/24 ,  H01L29/06 ,  G11C11/00 ,  B82Y10/00

CPC classification number: H01L29/0665 ,  B82Y10/00 ,  H01L27/2472 ,  H01L29/0673 ,  H01L29/068 ,  H01L45/08 ,  H01L45/1233 ,  H01L45/146 ,  H01L45/147

Abstract: Various embodiments of the present invention are direct to nanoscale, reconfigurable, two-terminal memristor devices. In one aspect, a device (400) includes an active region (402) for controlling the flow of charge carriers between a first electrode (104) and a second electrode (106). The active region is disposed between the first electrode and the second electrode and includes a storage material. Excess mobile oxygen ions formed within the active region are stored in the storage material by applying a first voltage.

Abstract translation: 本发明的各种实施例直接涉及纳米尺度，可重新配置的两端忆阻器件。 一方面，装置（400）包括用于控制第一电极（104）和第二电极（106）之间的电荷载流子的有源区（402）。 有源区域设置在第一电极和第二电极之间，并且包括存储材料。 通过施加第一电压，在活性区域内形成的多余的移动氧离子被储存在存储材料中。