公开(公告)号：US20210246560A1

公开(公告)日：2021-08-12

申请号：US17272765

申请日：2020-06-04

Applicant: CHEMICAL DENSHI CO., LTD. ,  Tokushima University

Inventor： Shoichi YAMADA ,  Toshio HYUGA ,  Hisao NEMOTO

IPC: C23F11/12 ,  C07D319/06 ,  C07D317/20 ,  C07C327/22 ,  C23F11/16

Abstract: The objective of the present invention is to provide a hydrophilic metal surface treatment agent by which a water-repellent property can be given to a metal surface with suppressing a corrosion and a discolorment of the metal, a method for treating a surface of a metal by using the hydrophilic metal surface treatment agent, a synthetic intermediate compound of a branched glycerol derivative as an active ingredient of the hydrophilic metal surface treatment agent, and a method for efficiently producing the synthetic intermediate compound. The hydrophilic metal surface treatment agent of the present invention is characterized in comprising the branched glycerol derivative represented by the following formula (I) as an active ingredient. wherein R1 is a hydrocarbon group having a carbon number of 10 or more and 30 or less, X is S or a carbonyl group, Y is an n +1 valent linker group, n is an integer of 1 or more and 5 or less.

公开(公告)号：US10928303B2

公开(公告)日：2021-02-23

申请号：US16320002

申请日：2017-07-25

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro Deguchi ,  Takashi Fukawa ,  Taiki Hattori ,  Masaaki Nagase ,  Kazuteru Tanaka ,  Kouji Nishino ,  Nobukazu Ikeda

IPC: G01N21/59 ,  G01N21/05 ,  G01N21/03 ,  G01N21/33

Abstract: A concentration measuring device includes a measuring cell having a flow passage and a translucent window, a light source for emitting light to the measuring cell through the window, a reflective member for reflecting light propagating through the measuring cell to the window, a light detector for detecting the light exiting from the window, a calculation part for calculating the concentration of the fluid on the basis of a detection signal from the light detector, and an optical device for guiding the light from the light source to the window and guiding the light from the window to the light detector.

公开(公告)号：US20190271636A1

公开(公告)日：2019-09-05

申请号：US16320002

申请日：2017-07-25

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro DEGUCHI ,  Takashi FUKAWA ,  Taiki HATTORI ,  Masaaki NAGASE ,  Kazuteru TANAKA ,  Kouji NISHINO ,  Nobukazu IKEDA

IPC: G01N21/05 ,  G01N21/59 ,  G01N21/03

Abstract: A concentration measuring device includes a measuring cell having a flow passage and a translucent window, a light source for emitting light to the measuring cell through the window, a reflective member for reflecting light propagating through the measuring cell to the window, a light detector for detecting the light exiting from the window, a calculation part for calculating the concentration of the fluid on the basis of a detection signal from the light detector, and an optical device for guiding the light from the light source to the window and guiding the light from the window to the light detector.

公开(公告)号：US10324029B2

公开(公告)日：2019-06-18

申请号：US15748261

申请日：2016-08-09

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro Deguchi ,  Masaaki Nagase ,  Michio Yamaji ,  Nobukazu Ikeda ,  Kouji Nishino ,  Masayoshi Kawashima ,  Kazuteru Tanaka

IPC: G01N21/31 ,  G01N21/33 ,  G01J3/42 ,  G01N21/59 ,  G01N21/27 ,  G01J3/10 ,  G01J3/28 ,  G01J3/433 ,  G01J3/02 ,  G01N21/3504 ,  G01J1/42

Abstract: A concentration measurement device including at least one light source; a measurement cell for containing a fluid to be measured; a splitter for dividing light from the light source into incident light being incident into the measurement cell and non-incident light not being incident into the measurement cell; a transmitted-light detector for detecting transmitted light that is the incident light having passed through the measurement cell; a non-incident light detector for detecting the non-incident light; and an arithmetic part for correcting a detection signal of the transmitted-light detector using a detection signal of the non-incident light detector.

公开(公告)号：US20180217054A1

公开(公告)日：2018-08-02

申请号：US15748264

申请日：2016-08-09

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro DEGUCHI ,  Masaaki NAGASE ,  Michio YAMAJI ,  Nobukazu IKEDA ,  Kouji NISHINO ,  Masayoshi KAWASHIMA ,  Kazuteru TANAKA

IPC: G01N21/31 ,  G01N21/59 ,  G01J3/42 ,  G01J3/10

CPC classification number: G01N21/3103 ,  G01J3/10 ,  G01J3/42 ,  G01N21/33 ,  G01N21/3504 ,  G01N21/59 ,  G01N2021/157 ,  G01N2021/3133 ,  G01N2201/0627 ,  G01N2201/08 ,  G01N2201/1211

Abstract: A concentration measurement device for measuring the concentration of a measured fluid within a measurement cell by detecting transmitted light that has passed through the measurement cell having a light incidence window and a light emission window disposed opposing to each other, comprising a reflected-light detector for detecting reflected light of the light incidence window.

公开(公告)号：US20180064073A1

公开(公告)日：2018-03-08

申请号：US15551791

申请日：2016-02-18

Applicant: Masakazu HASHIMOTO ,  Tokushima University ,  BEX Co., Ltd.

Inventor： Masakazu Hashimoto ,  Tatsuya Takemoto

IPC: A01K67/027 ,  C12N15/09 ,  C12N9/16

CPC classification number: A01K67/0275 ,  A01K67/027 ,  C12N9/16 ,  C12N15/09

Abstract: The disclosure relates to a method of introducing mRNA encoding Cas9 protein (Cas9 mRNA) into a mammalian embryo, comprising the steps of; (a) placing a mixture of the mammalian embryo and a solution comprising Cas9 mRNA in the gap between a pair of electrodes, and (b) applying a voltage to the electrodes for a voltage application duration, wherein the voltage and the voltage application duration achieve the efficiency of mRNA introduction (R) higher than the minimum required efficiency of mRNA introduction (Rmin) that is calculated on the basis of the concentration of Cas9 mRNA (ng/μl).

公开(公告)号：US09725490B2

公开(公告)日：2017-08-08

申请号：US14235666

申请日：2012-07-27

Applicant: Toyomasa Katagiri ,  Takuya Tsunoda

Inventor： Toyomasa Katagiri ,  Takuya Tsunoda

IPC: C07K7/06 ,  C07K7/04 ,  C07K14/47 ,  G01N33/50 ,  G01N33/574 ,  C12N9/48 ,  A61K31/138 ,  A61K38/17 ,  A61K38/00

CPC classification number: C07K14/4705 ,  A61K31/138 ,  A61K38/00 ,  A61K38/1709 ,  C12N9/485 ,  G01N33/5011 ,  G01N33/57484 ,  G01N2333/4704 ,  G01N2333/95 ,  G01N2500/02

Abstract: Provided is a novel cancer-treating agent which can be used as a novel choice for the treatment of cancer. Specifically provided are: a peptide that inhibits binding of ERAP1 polypeptide to PHB2 polypeptide, which comprises a binding site of the ERAP1 polypeptide to the PHB2 polypeptide, and a pharmaceutical composition comprising the peptide. In addition, provided is a method for screening a drug candidate for treating and/or preventing cancer using inhibition of the binding of the ERAP1 polypeptide to PP1α polypeptide, PKA polypeptide or PKB polypeptide as an index.

公开(公告)号：US20170199117A1

公开(公告)日：2017-07-13

申请号：US15321398

申请日：2015-07-23

Applicant: TOKUSHIMA UNIVERSITY ,  FUJIKIN INCORPORATED

Inventor： Yoshihiro DEGUCHI ,  Masaaki NAGASE ,  Nobukazu IKEDA ,  Michio YAMAJI ,  Tadayuki YAKUSHIJIN

IPC: G01N21/27 ,  G01N21/15 ,  G01N21/05

CPC classification number: G01N21/27 ,  G01N21/05 ,  G01N21/15 ,  G01N2021/151 ,  G01N2201/08

Abstract: An inline concentration measurement device comprises: a measurement cell main body with a gas flow path formed; a light incident part with a window member connected to the main body; and a light receiving part with a window member connected to the main body, wherein the gas flow path includes a gas flow path for an optical path extending straight between the window members of the light incident part and the light receiving part, a first communication part making a gas inlet formed in the main body communicate with the gas flow path part for the optical path, and a second communication part making a gas outlet formed in the main body communicate with the gas flow path part for the optical path, and the first communication part obliquely extends from the gas inlet towards the window member of the light incident part.

公开(公告)号：US20240327828A1

公开(公告)日：2024-10-03

申请号：US18743751

申请日：2024-06-14

Applicant: Tokushima University

Inventor： Keishi Osakabe ,  Yuriko Osakabe

IPC: C12N15/11 ,  C12N9/22 ,  C12N15/10

CPC classification number: C12N15/111 ,  C12N9/22 ,  C12N15/102 ,  C12N2310/20

Abstract: Provided is a method for targeting a target nucleotide sequence. The method includes introducing, into a cell: (i) CRISPR type I-D related proteins Cas5d, Cas6d, and Cas7d, or nucleic acids encoding these proteins; and (ii) a guide RNA which includes a sequence complementary to said target nucleotide sequence and common repetitive sequences derived from CRISPR gene locus before and after said complementary sequence, or a DNA encoding said guide RNA.

公开(公告)号：US12064460B2

公开(公告)日：2024-08-20

申请号：US16964142

申请日：2019-01-25

Applicant: TOKUSHIMA UNIVERSITY ,  JICHI MEDICAL UNIVERSITY ,  GENE THERAPY RESEARCH INSTITUTION CO., LTD.

Inventor： Kohji Itoh ,  Daisuke Tsuji ,  Shinichi Muramatsu ,  Katsuhito Asai

IPC: A61K35/76 ,  A61P25/28 ,  C12N7/00

CPC classification number: A61K35/76 ,  A61P25/28 ,  C12N7/00 ,  C12N2750/14121 ,  C12N2750/14143 ,  C12N2750/14171

Abstract: According to a conventional method for treatment of Sandhoff disease and Tay-Sachs disease comprising administering a modified β-subunit to a patient in the form of a protein, it is necessary that administration be performed frequently. This invention relates to a recombinant adeno-associated virus virion comprising: capsomere comprising a protein capable of forming a virus virion; and a polynucleotide packaged in the capsomere comprising a promoter sequence and nucleotide sequences operably linked to the promoter sequence encoding a first amino acid sequence derived from the amino acid sequence of the β-subunit of wild-type human β-hexosaminidase composed of amino acids 55 to 556 in the sequence as shown in SEQ ID NO: 28 by substitution of amino acids 312 to 318 with glycine, serine, glutamic acid, proline, serine, glycine, and threonine in that order and a second amino acid sequence, which is an amino acid sequence of a signal peptide linked to the N terminus of the first amino acid.