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公开(公告)号：US20130217129A1
公开(公告)日：2013-08-22
申请号：US13842324
申请日：2013-03-15
申请人： Allergan, Inc.
发明人： Gail K. Naughton , David L. Horwitz , Mark Applegate , Joan Zeltinger , Jonathan Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
IPC分类号： C12N5/071
CPC分类号： A23L33/10 , A23V2002/00 , A61K8/02 , A61K8/0208 , A61K8/64 , A61K8/65 , A61K8/985 , A61K9/0014 , A61K35/33 , A61K35/35 , A61K35/36 , A61K35/50 , A61K38/18 , A61K38/1825 , A61K38/39 , A61K45/06 , A61K2800/86 , A61K2800/91 , A61L31/044 , A61L31/047 , A61L31/16 , A61L2300/414 , A61L2430/36 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C12N5/0603 , C12N5/0606 , C12N5/0625 , C12N5/0629 , C12N5/0656 , C12N5/069 , C12N2502/1323 , C12P21/00 , A61K2300/00
摘要： Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, or formulated with a salve or ointment for topical applications. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.
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公开(公告)号：US20100267103A1
公开(公告)日：2010-10-21
申请号：US12745890
申请日：2008-05-19
申请人： Sin-Kyu Kim , Jin-Sung Kim
发明人： Sin-Kyu Kim , Jin-Sung Kim
CPC分类号： A61K8/985
摘要： A method of fermenting animal horny substance, which includes a step of fermenting the mixture of animal horny substance and rice straw in order to ferment animal horny substance by using rice straw, so that not only water-soluble effective components in animal horny substance but also non-water-soluble effective components can be ingested.
摘要翻译： 一种发酵动物角质物质的方法，其包括发酵动物角质物质和稻草混合物的步骤，以通过使用稻草发酵动物角质物质，使得不仅水溶性有效成分在动物角质物质中而且 可以摄取非水溶性有效成分。
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13.发明授权公开(公告)号：US07807188B2
公开(公告)日：2010-10-05
申请号：US10512933
申请日：2003-05-02
IPC分类号： A61K9/00
CPC分类号： A61Q19/007 , A61K8/11 , A61K8/14 , A61K8/982 , A61K8/985 , A61K2800/413 , A61Q17/00 , A61Q19/00
摘要： A composition and a method of producing a composition which simulates hydration, cleansing and other properties of native vernix. The composition contains hydrated synthetic cells in a lipid matrix to provide rheological properties which are substantially similar to those of native vernix, and may also contain proteins. In one embodiment, the composition contains cubosomes/water with up to 30% protein and about 5% lipid to about 30% lipid. The composition may be used to cleanse newborn skin, compromised skin surfaces, as well as normal skin, to provide hydration/barrier function, and other applications.
摘要翻译： 一种组合物和一种制备模拟水合，清洁和其它天然植物性质的组合物的方法。 组合物在脂质基质中含有水合的合成细胞，以提供基本上类似于天然叶绿体的流变学性质，并且还可以含有蛋白质。 在一个实施方案中，组合物含有具有高达30％蛋白质和约5％脂质至约30％脂质的cub体/水。 该组合物可用于清洁新生皮肤，损伤的皮肤表面以及正常皮肤，以提供水合/屏障功能以及其它应用。
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公开(公告)号：US20090202654A1
公开(公告)日：2009-08-13
申请号：US12097132
申请日：2006-12-14
申请人： Andrew J. Nixon
发明人： Andrew J. Nixon
CPC分类号： A61K8/985 , A61K9/0014 , A61K35/33 , A61K35/36 , A61Q19/08
摘要： The invention is directed compositions containing growth agents synthesized from cultured cells from skin. Skin cells such as keratinocytes and dermal fibroblasts are cultured in vitro in cell medium and in the course of culture the cultured cells synthesize and secrete agents into the cell medium. The medium containing agents are collected and incorporated into pharmaceutical or cosmetic preparations to treat an individual. The preparation is applied and has a rejuvenating effect on the cells and tissue.
摘要翻译： 本发明涉及含有从皮肤培养的细胞合成的生长剂的组合物。 皮肤细胞如角质形成细胞和真皮成纤维细胞在细胞培养基中体外培养，培养过程中培养的细胞合成并将细胞分泌到细胞培养基中。 收集含有培养基的试剂，并将其并入药物或化妆品制剂中以治疗个体。 应用制剂，对细胞和组织具有恢复活力。
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公开(公告)号：US20080241101A1
公开(公告)日：2008-10-02
申请号：US12155285
申请日：2008-06-02
申请人： Satoshi Amano , Yuki Ogura , Yukiko Matsunaga , Takanari Tsuda , Yukari Aoyama , Nobuyoshi Koga
发明人： Satoshi Amano , Yuki Ogura , Yukiko Matsunaga , Takanari Tsuda , Yukari Aoyama , Nobuyoshi Koga
CPC分类号： A61K8/64 , A61K8/553 , A61K8/97 , A61K8/985 , A61K2800/782 , A61Q1/02 , A61Q19/00 , A61Q19/08
摘要： The invention provides an epidermal basement membrane structure formation accelerating preparation and a skin external preparation comprising a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane. It also provides, as a means for producing artificial skin having an adequately formed basement membrane, an artificial skin-forming medium which comprises a serine protease inhibitor, and optionally an accelerator of production of extracellular matrix protein components of the epidermal basement membrane and a matrix metalloprotease inhibitor, as well as a method for producing the same.
摘要翻译： 本发明提供了一种表皮基底膜结构形成促进制剂和皮肤外用制剂，其包含丝氨酸蛋白酶抑制剂和任选的表皮基底膜细胞外基质蛋白组分产生促进剂。 它还提供了用于生产具有充分形成的基底膜的人造皮肤的手段，人造皮肤形成培养基包括丝氨酸蛋白酶抑制剂和任选的表皮基底膜的细胞外基质蛋白组分的产生促进剂和基质 金属蛋白酶抑制剂，以及其制备方法。
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公开(公告)号：US20060058238A1
公开(公告)日：2006-03-16
申请号：US11226558
申请日：2005-09-14
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K8/64 , A61K8/985 , A61K38/014 , A61K45/06 , A61Q17/04 , A61Q19/00 , A61Q19/08
摘要： The present invention provides methods and compositions designed for treating a subject suffering from skin conditions, disorders or diseases. The compositions include fetal skin cell proteins obtained from fetal skin cells after induced cell lysis.
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17.发明申请Compositions and methods for inducing new hair follicle formation and hair growth in a desired orientation 审中-公开用于诱导新毛囊形成和按期望取向的毛发生长的组合物和方法公开(公告)号：US20030198646A1
公开(公告)日：2003-10-23
申请号：US10123984
申请日：2002-04-17
发明人： Kurt Stricker Stenn
IPC分类号： A61K039/00
摘要： The present invention relates to compositions and methods for inducing hair follicle formation and subsequent hair growth in a mammal in a cosmetically acceptable orientation. The method further comprises implanting papilla cells or growth factors under or in contact with the epidermal layer with a vehicle to direct growth of the epidermis and thus the formation of nascent hair follicles. The vehicle is removed after hair follicle formation has begun. The present invention further comprises an apparatus for the packaging and delivery of papilla cells.
摘要翻译： 本发明涉及用于在化妆品可接受的取向中诱导哺乳动物毛囊形成和随后毛发生长的组合物和方法。 该方法还包括将乳头细胞或生长因子与表皮层接触或与表皮层接触，以引导表皮的生长，从而形成新生毛囊。 在毛囊形成开始后，移除载体。 本发明还包括用于包装和递送乳头细胞的装置。
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公开(公告)号：US6113932A
公开(公告)日：2000-09-05
申请号：US257008
申请日：1999-02-25
IPC分类号： A61F13/49 , A61F13/00 , A61F13/15 , A61F13/472 , A61K8/00 , A61K8/29 , A61K8/35 , A61K8/37 , A61K8/44 , A61K8/49 , A61K8/72 , A61K8/96 , A61K8/98 , A61K9/70 , A61K35/50 , A61L15/00 , A61L15/16 , A61L15/34 , A61L15/40 , A61L26/00 , A61P17/00 , A61Q19/00 , A01N25/35
CPC分类号： A61K8/29 , A61K8/35 , A61K8/37 , A61K8/445 , A61K8/4946 , A61K8/72 , A61K8/982 , A61K8/985 , A61K9/7015 , A61L15/34 , A61L15/40 , A61L26/0057 , A61Q17/00 , A61Q19/00
摘要： A composition consisting essentially of vernix for a skin curative and skin protectant effect and a method of producing. A natural or synthetic vernix is dispersed in a film-forming amount in a biocompatable liquid such as dimethylsulfoxide, amniotic fluid and/or pulmonary surfactant to form a film. The film may be applied to a growing layer of epithelial cells either directly or supported on a substrate such as a wound dressing, a diaper, or a feminine hygiene product.
摘要翻译： 基本上由vernix组成的用于皮肤疗效和皮肤保护作用的组合物和生产方法。 在生物相容性液体如二甲基亚砜，羊水和/或肺表面活性剂中以天然或合成的紫色分散成膜形成量以形成膜。 该膜可以直接或者支撑在诸如伤口敷料，尿布或女性卫生产品的基底上的上皮细胞生长层上。
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公开(公告)号：US5882660A
公开(公告)日：1999-03-16
申请号：US794719
申请日：1997-02-03
IPC分类号： A61K8/00 , A61K8/31 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/44 , A61K8/63 , A61K8/67 , A61K8/72 , A61K8/73 , A61K8/86 , A61K8/92 , A61K8/97 , A61K8/98 , A61Q5/00 , A61Q19/00 , A61Q19/08 , A61Q19/10 , A61Q90/00 , C11D3/18 , C11D3/20 , C11D3/38 , A61K7/48
CPC分类号： A61K8/31 , A61K8/342 , A61K8/361 , A61K8/63 , A61K8/671 , A61K8/731 , A61K8/737 , A61K8/86 , A61K8/97 , A61K8/985 , A61Q19/00 , A61Q19/10 , A61K2800/5426 , Y10S514/844 , Y10S514/845 , Y10S514/846
摘要： A personal care composition in the form of an aqueous liquid comprises:i) a lipid composition comprising two components D and E, where D is a molecule having one long hydrocarbon chain and a hydrophillic head group and E is a material which comprises at least one of a compound selected from 3.beta.-sterol; squalane; squalane; saponins or sapogenins of the plant steroid or triterpenoid type; di and tri terpenes such as phytol, retinol and amyrin; and mixtures thereof, wherein D and E are respectively present at levels within the range 0.1 to 10 wt % and 0.2 a to 12 wt % based on the total composition;ii) a surface active agent selected from anionic, nonionic, cationic, zwitterionic, amphoteric surface active agents, soap and mixtures thereof; andiii) a deposition aid; andthe composition is substantially free of a molecule having at least two hydrocarbon chains and a polar head group which satisfies the relationship ##EQU1## where V is the volume of the hydrocarbon chainsI.sub.c is the critical length of the hydrocarbon chains anda.sub.o is the optimum area of the polar head group.The composition may in the form of for example a shower gel or facial cleanser which is temporarily applied to the skin before being removed such as wiping or rinsing it from the skin.
摘要翻译： 水性液体形式的个人护理组合物包括：i）包含两种组分D和E的脂质组合物，其中D是具有一个长烃链和亲水性头基的分子，E是包含至少一种 的选自3β-甾醇的化合物; 角鲨烷 角鲨烷 植物类固醇或三萜类皂甙或皂甙元; 二萜和三萜，如植醇，视黄醇和氨in; 和其混合物，其中D和E分别以基于总组合物的0.1至10重量％和0.2重量至12重量％的范围内的水平存在; ii）选自阴离子，非离子，阳离子，两性离子，两性表面活性剂，皂及其混合物的表面活性剂; 和iii）沉积助剂; 并且所述组合物基本上不含具有至少两个烃链和极性头基团的分子，其满足关系式（I）其中V是烃链的体积Ic是烃链的临界长度，ao 是极地头组的最佳面积。 组合物可以是例如沐浴露或面部清洁剂的形式，其在被去除之前临时施用于皮肤，例如从皮肤擦拭或冲洗皮肤。
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公开(公告)号：US5053229A
公开(公告)日：1991-10-01
申请号：US300217
申请日：1989-01-24
IPC分类号： A61K8/96 , A61K8/00 , A61K8/06 , A61K8/34 , A61K8/92 , A61K8/98 , A61K31/00 , A61K35/36 , A61Q19/00
摘要： Novel cosmetic compositions comprising a lipid derived from horny cells can enhance a moisture retention ability of the horny layer and are useful for remedy of dry skin. When the lipid is used in combination with surface active agents, the above effect is enhanced.The cosmetic compositions may take any preparations such as creams, milky lotions, beauty wash, rouges, foundations, hair tonics and the like.
摘要翻译： 包含衍生自角质细胞的脂质的新型化妆品组合物可以增强角质层的保湿能力，并且可用于补救干性皮肤。 当脂质与表面活性剂组合使用时，上述效果得到提高。 化妆品组合物可以采取任何制剂，例如乳膏，乳液，美容洗涤剂，水果，地基，发质等。
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