公开(公告)号：US20090054822A1

公开(公告)日：2009-02-26

申请号：US12174742

申请日：2008-07-17

申请人： Tomoya Murakami ,  Masahiro Toyoda ,  Akari Agata

发明人： Tomoya Murakami ,  Masahiro Toyoda ,  Akari Agata

IPC分类号： A61M1/14

CPC分类号： A61M1/3653 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3658

摘要： A blood purification apparatus that can make the specific peak to be imparted to the blood more distinct, and therefore can detect blood recirculation reliably and precisely, is presented. It contains a blood circuit route, a blood pump, a dialyzer, dialysate introduction and discharge lines, a duplex pump, a pressurizing pump, a blood concentration means, and detection means that detect the specific peak imparted by the blood concentration means. The blood concentration means is configured to have an atmosphere release line, the tip of which is open to the atmosphere, that extends from between the pressurizing pump and the duplex pump in the dialysate discharge line, and to have an electromagnetic valve that can open or close the atmosphere release line. The electromagnetic valve opens the atmosphere release line to impart the specific peak by rapidly concentrating the blood flowing in the dialyzer for a short period of time.

摘要翻译： 可以使血液净化装置能够使特定的峰值赋予血液更加清晰，因此可以可靠且精确地检测血液循环。 它包含血液回路，血液泵，透析器，透析液引入和排出管线，双相泵，加压泵，血液浓缩装置和检测由血液浓度装置赋予的特定峰值的检测装置。 血液浓度装置被配置为具有气体释放管线，其顶端向大气开放，其从透析液排出管线中的加压泵和双相泵之间延伸，并且具有能够打开的电磁阀或 关闭气氛释放线。 电磁阀打开大气释放线，以通过快速浓缩在透析器中流动的血液短时间来赋予特定峰值。

公开(公告)号：US07473371B2

公开(公告)日：2009-01-06

申请号：US11104947

申请日：2005-04-13

申请人： Nikolai M. Krivitski ,  David R. MacGibbon

发明人： Nikolai M. Krivitski ,  David R. MacGibbon

IPC分类号： A61B5/026 ,  A61B5/0275 ,  A61B8/06

CPC分类号： A61M1/3653 ,  A61B5/0275 ,  A61M1/16 ,  A61M1/3655 ,  A61M1/3658 ,  A61M1/3663 ,  A61M1/3669 ,  A61M1/367

摘要： The measurement of blood flow in a dialysis shunt is obtained by injection of an indicator material into a venous line leading from dialysis equipment to the shunt. The blood flow in an arterial line leading from the shunt at a location downstream of the venous line to the dialysis equipment is monitored by an arterial line sensor for the presence of the indicator material. A detector connected to the sensor provides a dilution curve in response to the presence of the indicator material and the blood flow in the shunt is calculated from the area under the dilution curve. The locations of the arterial and venous lines in the shunt can be reversed to obtain a measurement of blood recirculation from the venous line into the arterial line.

摘要翻译： 通过将指示剂材料注射到从透析设备引导到分流器的静脉管线中，可以测量透析分流器中的血流量。 通过动脉线传感器监测从静脉线下游位置到分离设备的分流处的动脉线中的血液流动，以指示物质的存在。 连接到传感器的检测器响应于指示剂材料的存在而提供稀释曲线，并且根据稀释曲线下的面积计算分流器中的血流量。 分流器中的动脉和静脉线的位置可以反转，以获得从静脉线进入动脉线的血液再循环的测量。

公开(公告)号：US20080208102A1

公开(公告)日：2008-08-28

申请号：US12115160

申请日：2008-05-05

申请人： Lennart Jonsson ,  Mattias Holmer ,  Per Hansson

发明人： Lennart Jonsson ,  Mattias Holmer ,  Per Hansson

IPC分类号： A61M1/14

CPC分类号： A61M1/367 ,  A61M1/3658 ,  A61M39/223 ,  Y10T137/87249

摘要： It is disclosed a circuit for extracorporeal blood treatment in which a flow-inverting device is interposed between a blood treatment unit and a blood pump placed on an artery branch connected with a vascular access of a patient. The flow-inverting device allows the blood flow within the filtering unit to be kept unchanged even following an inverted circulation in the patient-side artery and vein branches controlled by the blood pump.

摘要翻译： 公开了一种用于体外血液处理的电路，其中流动反转装置插入在血液处理单元和放置在与患者的血管通路连接的动脉分支上的血液泵之间。 即使在由血泵控制的患者侧动脉和静脉分支中的倒置循环之后，流动反转装置也能够使过滤单元内的血液流量保持不变。

公开(公告)号：US20080015487A1

公开(公告)日：2008-01-17

申请号：US11829261

申请日：2007-07-27

申请人： Balazs Szamosfalvi ,  Stanley Frinak ,  Jerry Yee

发明人： Balazs Szamosfalvi ,  Stanley Frinak ,  Jerry Yee

IPC分类号： A61M1/16

CPC分类号： A61M1/3672 ,  A61M1/3406 ,  A61M1/3413 ,  A61M1/3434 ,  A61M1/3437 ,  A61M1/3441 ,  A61M1/3455 ,  A61M1/3458 ,  A61M1/3609 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3658 ,  A61M1/3675 ,  A61M2202/0486 ,  A61M2205/3306

摘要： The present invention includes a comprehensive replacement fluid system and method for the delivery of regional citrate anticoagulation (RCA) to extracorporeal blood circuits, wherein the system may include an online clearance monitor (OCM) and a circuit effluent online sensor system (OSS) for the continuous determination of patient plasma content of ultrafilterable solutes.

摘要翻译： 本发明包括用于向体外血液回路输送局部柠檬酸抗凝（RCA）的综合替代液体系统和方法，其中所述系统可以包括在线间隙监测器（OCM）和用于 连续测定超滤溶质的患者血浆含量。

公开(公告)号：US07297280B2

公开(公告)日：2007-11-20

申请号：US10871319

申请日：2004-06-18

申请人： Nikolai M. Krivitski ,  David R. MacGibbon

发明人： Nikolai M. Krivitski ,  David R. MacGibbon

IPC分类号： A61B5/026 ,  A61B5/0275 ,  A61B8/06

CPC分类号： A61M1/3653 ,  A61B5/0275 ,  A61M1/16 ,  A61M1/3655 ,  A61M1/3658 ,  A61M1/3663 ,  A61M1/3669 ,  A61M1/367

摘要： The measurement of blood flow in a dialysis shunt is obtained by injection of an indicator material into a venous line leading from dialysis equipment to the shunt. The blood flow in an arterial line leading from the shunt at a location downstream of the venous line to the dialysis equipment is monitored by an arterial line sensor for the presence of the indicator material. A detector connected to the sensor provides a dilution curve in response to the presence of the indicator material and the blood flow in the shunt is calculated from the area under the dilution curve. The locations of the arterial and venous lines in the shunt can be reversed to obtain a measurement of blood recirculation from the venous line into the arterial line.

摘要翻译： 通过将指示剂材料注射到从透析设备引导到分流器的静脉管线中，可以测量透析分流器中的血流量。 通过动脉线传感器监测从静脉线下游位置到分离设备的分流处的动脉线中的血液流动，以指示物质的存在。 连接到传感器的检测器响应于指示剂材料的存在而提供稀释曲线，并且根据稀释曲线下的面积计算分流器中的血流量。 分流器中的动脉和静脉线的位置可以反转，以获得从静脉线进入动脉线的血液再循环的测量。

公开(公告)号：US20050051496A1

公开(公告)日：2005-03-10

申请号：US10871319

申请日：2004-06-18

申请人： Nikolai Krivitski ,  David MacGibbon

发明人： Nikolai Krivitski ,  David MacGibbon

IPC分类号： A61B5/0275 ,  A61M1/16 ,  A61M1/36 ,  A61B5/026 ,  A61M31/00

CPC分类号： A61M1/3653 ,  A61B5/0275 ,  A61M1/16 ,  A61M1/3655 ,  A61M1/3658 ,  A61M1/3663 ,  A61M1/3669 ,  A61M1/367

摘要： The measurement of blood flow in a dialysis shunt is obtained by injection of an indicator material into a venous line leading from dialysis equipment to the shunt. The blood flow in an arterial line leading from the shunt at a location downstream of the venous line to the dialysis equipment is monitored by an arterial line sensor for the presence of the indicator material. A detector connected to the sensor provides a dilution curve in response to the presence of the indicator material and the blood flow in the shunt is calculated from the area under the dilution curve. The locations of the arterial and venous lines in the shunt can be reversed to obtain a measurement of blood recirculation from the venous line into the arterial line.

摘要翻译： 通过将指示剂材料注射到从透析设备引导到分流器的静脉管线中，可以测量透析分流器中的血流量。 通过动脉线传感器监测从静脉线下游位置到分离设备的分流处的动脉线中的血液流动，以指示物质的存在。 连接到传感器的检测器响应于指示剂材料的存在而提供稀释曲线，并且根据稀释曲线下的面积计算分流器中的血流量。 分流器中的动脉和静脉线的位置可以反转，以获得从静脉线进入动脉线的血液再循环的测量。

公开(公告)号：US20030167030A1

公开(公告)日：2003-09-04

申请号：US10372470

申请日：2003-02-21

申请人： The Regents of the University of Michigan

发明人： William F. Weitzel ,  Jonathan M. Rubin ,  Joseph M. Messana

IPC分类号： A61M005/00

CPC分类号： A61M1/3663 ,  A61M1/3658

摘要： A system and method are provided for determining the performance of a vessel, such as a hemodialysis access, which communicates blood between two locations of a patient. A conduit, such as an external dialysis circuit or an intravascular catheter, is provided in fluid communication with the vessel, and has a diversion point for diverting blood from the vessel into the conduit. The system further includes means for determining a flow rate of the diverted blood through the conduit. A first sensor in communication with the vessel generates at least one signal that is a function of a blood flow rate in the vessel downstream from the diversion point, wherein the downstream flow rate depends on the determined conduit flow rate and the performance of the vessel can be determined based on the signal. In addition, a processor can be provided in communication with the first sensor for determining a flow rate in the vessel upstream from the diversion point from the signal and the conduit flow rate. In a preferred embodiment, the first sensor is an ultrasonic sensor, and the at least one signal represents a time-averaged mean Doppler velocity of blood flow. Still further, additional sensors may be employed to provide a measure of the upstream flow rate as well as the conduit flow rate.

摘要翻译： 提供了一种系统和方法，用于确定在患者的两个位置之间传送血液的血管的血液透析进入的血管的性能。 提供与容器流体连通的导管，例如外部透析回路或血管内导管，并具有用于将血液从血管转移到导管中的转移点。 该系统还包括用于确定通过导管的转运血液的流量的装置。 与容器连通的第一传感器产生至少一个信号，该信号是从转向点下游的血管中的血液流速的函数，其中下游流速取决于确定的导管流速和容器的性能 根据信号确定。 此外，可以提供与第一传感器通信的处理器，用于从信号和导管流量确定从转向点上游的容器中的流量。 在优选实施例中，第一传感器是超声波传感器，并且所述至少一个信号表示血流的时间平均平均多普勒速度。 此外，可以使用附加的传感器来提供上游流量以及导管流量的量度。

公开(公告)号：US20030138348A1

公开(公告)日：2003-07-24

申请号：US10051465

申请日：2002-01-18

发明人： David Bell ,  William J. Schnell ,  David S. Utterberg

IPC分类号： A61M001/34 ,  A61M037/00

CPC分类号： A61M1/367 ,  A61M1/3658 ,  A61M39/223 ,  A61M39/28

摘要： A tubular set portion for circulating blood between a patient and an extracorporeal blood treatment device. The set portion comprises: an arterial tube for conveying blood from a patient toward the blood treatment device; a venous tube for conveying blood from the blood treatment device back towards the patient; and a pair of spaced, transverse tubes that each connect between the arterial tube and the venous tube, each of the tubes being capable of clamp sealing. The arterial and venous tubes are clamp sealable between the spaced, transverse tubes. Flow reversal on the patient's side of this device is possible by appropriate clamping of two opposed tube sections of the rectangular array which may be formed by the joined tube sections, while flow remains unchanged on the side of the tubular set portion that is connected to the extracorporeal blood treatment device.

摘要翻译： 一种用于在患者和体外血液处理装置之间循环血液的管状固定部分。 设置部分包括：用于将血液从患者输送到血液处理装置的动脉管; 用于将血液从血液处理装置输送回患者的静脉管; 以及一对间隔开的横向管，每个管连接在动脉管和静脉管之间，每个管能够夹紧密封。 动脉和静脉管可夹紧在间隔开的横向管之间。 可以通过适当地夹紧矩形阵列的两个相对的管部分，这可以由连接的管部分形成，而在该装置的患者侧的流动逆转可以在连接到管状部分的管状部分的一侧保持不变 体外血液处理装置。

公开(公告)号：US06575927B1

公开(公告)日：2003-06-10

申请号：US09310673

申请日：1999-05-12

申请人： William F. Weitzel ,  Jonathan M. Rubin ,  Joseph M. Messana

发明人： William F. Weitzel ,  Jonathan M. Rubin ,  Joseph M. Messana

IPC分类号： A61M500

CPC分类号： A61M1/3663 ,  A61M1/3658

摘要： A system and method are provided for determining the performance of a vessel, such as a hemodialysis access, which communicates blood between two locations of a patient. A conduit, such as an external dialysis circuit or an intravascular catheter, is provided in fluid communication with the vessel, and has a diversion point for diverting blood from the vessel into the conduit. The system further includes means for determining a flow rate of the diverted blood through the conduit. A first sensor in communication with the vessel generates at least one signal that is a function of a blood flow rate in the vessel downstream from the diversion point, wherein the downstream flow rate depends on the determined conduit flow rate and the performance of the vessel can be determined based on the signal. In addition, a processor can be provided in communication with the first sensor for determining a flow rate in the vessel upstream from the diversion point from the signal and the conduit flow rate. In a preferred embodiment, the first sensor is an ultrasonic sensor, and the at least one signal represents a time-averaged mean Doppler velocity of blood flow. Still further, additional sensors may be employed to provide a measure of the upstream flow rate as well as the conduit flow rate.

摘要翻译： 提供了一种系统和方法，用于确定在患者的两个位置之间传送血液的血管的血液透析进入的血管的性能。 提供与容器流体连通的导管，例如外部透析回路或血管内导管，并具有用于将血液从血管转移到导管中的转移点。 该系统还包括用于确定通过导管的转运血液的流量的装置。 与容器连通的第一传感器产生至少一个信号，该信号是从转向点下游的血管中的血液流速的函数，其中下游流速取决于确定的导管流速和容器的性能 根据信号确定。 此外，可以提供与第一传感器通信的处理器，用于从信号和导管流量确定从转向点上游的容器中的流量。 在优选实施例中，第一传感器是超声波传感器，并且所述至少一个信号表示血流的时间平均平均多普勒速度。 此外，可以使用附加的传感器来提供上游流量以及导管流量的量度。

公开(公告)号：US5830365A

公开(公告)日：1998-11-03

申请号：US687752

申请日：1996-07-25

申请人： Daniel Schneditz

发明人： Daniel Schneditz

IPC分类号： A61M1/34 ,  A61M1/36 ,  B01D17/12 ,  B01D61/32 ,  G01F5/00

CPC分类号： A61M1/3653 ,  A61M1/3427 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3621 ,  A61M1/3658 ,  A61M1/3663 ,  G01N2291/02809 ,  G01N2291/02881 ,  Y10S210/929

摘要： The invention relates to a means for determining hemodynamic parameters, such as cardiopulmonary recirculation, fistula flow and cardiac minute output during an extracorporeal blood treatment, in which blood is conducted to a dialyzer (3) by way of arterial branch (8, 8') of extracorporeal path (2) which is fluidly connected to a segment (9, 12) of a fistula (10), then returned by way of venous branch (11, 11') of the extracorporeal path which is fluidly connected to the other segment (12, 9) of the fistula. The hemodynamic parameters are determined by two recirculation fraction measurements taken in quick succession and which are performed automatically by the apparatus before and after the blood flow is reversed. In a computer-memory unit (22) cardiopulmonary recirculation is calculated based on the recirculation fraction during normal blood flow together with the recirculation fraction during reversed blood flow. To determine the recirculation fraction the concentration of an indicator solution is altered in venous branch (11, 11') of the extracorporeal path and the change in concentration of indicator solution resulting from recirculation in arterial branch (8, 8') of extracorporeal path (2) is recorded. In a preferred embodiment of the present invention indicator solution in the form of a predetermined amount of dialyzate is infused into the extracorporeal path by back filtration.

摘要翻译： 本发明涉及一种用于在体外血液处理期间确定血液动力学参数（例如心肺再循环，瘘流量和心脏分钟输出）的装置，其中通过动脉分支（8,8'）将血液传导到透析器（3） 流体地连接到瘘管（10）的段（9,12）的体外路径（2），然后通过流体连接到另一段的体外路径的静脉分支（11,11'）返回 （12,9）的瘘管。 血液动力学参数通过快速连续进行的两次循环分数测量来确定，并且在血流反转之前和之后由装置自动执行。 在计算机存储单元（22）中，基于正常血流中的再循环分数以及反向血流中的再循环分数，计算心肺再循环。 为了确定再循环分数，在体外路径的静脉分支（11,11'）中改变指示剂溶液的浓度以及由体外路径的动脉分支（8,8'）中再循环引起的指示剂溶液浓度的变化（ 2）被记录。 在本发明的优选实施方案中，通过反过滤将预定量的透析液形式的指示剂溶液注入体外路径。