公开(公告)号：US20060268267A1

公开(公告)日：2006-11-30

申请号：US11399032

申请日：2006-04-06

Applicant: Thomas Voigt ,  David Tuschel ,  John Maier

Inventor： Thomas Voigt ,  David Tuschel ,  John Maier

IPC: G01J3/44

CPC classification number: G01N21/6456 ,  G01J3/12 ,  G01J3/1256 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/1269 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/65

Abstract: A system and method for detecting dynamic changes that occur in a sample between a first time interval and a second time interval using a series of at least first and second sequential chemical images of the sample. During the first time interval: (i) the sample is illuminated with a plurality of photons to thereby produce photons scattered or emitted by the sample; (ii) a two-dimensional array of detection elements is used to simultaneously detect scattered or emitted photons in a first predetermined wavelength band from different locations on or within the sample; and (iii) the two-dimensional array of detection elements is thereafter used one or more further times to simultaneously detect scattered or emitted photons in one or more further predetermined wavelength band(s) from different locations on or within the sample. The outputs of the two-dimensional array of detection elements during the first time interval are then combined to generate the first chemical image of the sample. The process is repeated during the second time interval to generate the second chemical image of the sample. Dynamic changes occurring in the sample between the first time interval and the second time interval are detected based on one or more differences between the first and second chemical images.

Abstract translation: 一种系统和方法，用于使用所述样本的至少第一和第二顺序化学图像的一系列来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。 在第一时间间隔期间：（i）样品用多个光子照射，从而产生样品散射或发射的光子; （ii）检测元件的二维阵列用于同时从样品上或样品内的不同位置检测来自第一预定波长带的散射或发射的光子; 然后，（iii）检测元件的二维阵列此后再被使用一次或多次，以同时检测来自样品上或样品内的不同位置的一个或多个另外的预定波长带中的散射或发射的光子。 然后组合在第一时间间隔期间检测元件的二维阵列的输出以产生样本的第一化学图像。 该过程在第二时间间隔期间重复以产生样品的第二化学图像。 基于第一和第二化学图像之间的一个或多个差异来检测在第一时间间隔和第二时间间隔之间在样本中发生的动态变化。

公开(公告)号：US20060256426A1

公开(公告)日：2006-11-16

申请号：US11416392

申请日：2006-05-03

Applicant: Ralf Wolleschensky

Inventor： Ralf Wolleschensky

IPC: G02F1/33

CPC classification number: G02B27/283 ,  G01J3/0224 ,  G01J3/1256 ,  G01J3/4406 ,  G01J3/447 ,  G01N21/6445 ,  G01N21/6458 ,  G02B21/002 ,  G02B21/0068

Abstract: Device for controlling light radiation, which is excited in a specimen and/or which is backscattered and/or reflected and which contains one or more wavelengths, at a plurality of light outlets, wherein a separation of the light radiation into differently polarized components is carried out; and the components of the excitation radiation and/or detection radiation are affected in their polarization by means of a preferably birefringent, preferably acousto-optic or electro-optic medium, which changes the ordinary and extraordinary refractive index.

公开(公告)号：US20060167347A1

公开(公告)日：2006-07-27

申请号：US10532669

申请日：2003-09-25

Applicant: Kexin Xu ,  Yiwen Ma ,  Renda Wang

Inventor： Kexin Xu ,  Yiwen Ma ,  Renda Wang

IPC: A61B5/00

CPC classification number: A61B5/0059 ,  G01J3/10 ,  G01J3/1256 ,  G01N21/359 ,  G01N2021/3144

Abstract: The present invention discloses a spectral measurement method via continuous light source and discrete light source, and a measurement instrument for non-invasive detection of human body tissue components. Said instrument includes an incident unit, a probe, a receiving unit and a data processing unit. Said composite spectral measurement method improves or strengthens the output light intensity at the wavelength that carries information of the target component within human body. It enables the spectral detection in the whole wavelength range, and thus significantly enhances the SNR of the detecting system. In the non-invasive detection instrument, light from both the continuous light source and discrete light source can be firstly selectively light-split by AOTF, or AOTF conducts light-splitting for the continuous light source, while the discrete light source LD is controlled by a spatial chopper. When data of the spectral curves achieved from said continuous light source and discrete light source are processed, data acquired under different measuring modes can be compared.

Abstract translation: 本发明公开了一种通过连续光源和离散光源的光谱测量方法，以及用于非侵入式检测人体组织成分的测量仪器。 所述仪器包括入射单元，探测器，接收单元和数据处理单元。 所述复合光谱测量方法改善或加强了携带人体内目标成分信息的波长处的输出光强度。 它能够在整个波长范围内进行光谱检测，从而显着提高检测系统的信噪比。 在非侵入式检测仪器中，来自连续光源和离散光源的光可以首先被AOTF选择性地光分裂，或者AOTF对连续光源进行光分裂，而离散光源LD由 空中砍刀 当从所述连续光源和离散光源获得的光谱曲线的数据被处理时，可以比较在不同测量模式下获得的数据。

公开(公告)号：US20060061761A1

公开(公告)日：2006-03-23

申请号：US11227432

申请日：2005-09-16

Applicant: Qun Li ,  Sean Wang

Inventor： Qun Li ,  Sean Wang

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/65 ,  G01J3/1256 ,  G01J3/4338 ,  G01J3/44 ,  G01J2001/4242 ,  G01N21/658

Abstract: A fluorescence subtracted Raman spectroscopy apparatus uses a wavelength modulated tunable filter as the spectrometer. The wavelength modulation results in an amplitude modulation on the detected optical signal. By using a frequency selective detection technique, the Raman signal is amplified and extracted from the fluorescence background.

公开(公告)号：US20060018002A1

公开(公告)日：2006-01-26

申请号：US10896175

申请日：2004-07-22

Applicant: Narsingh Singh

Inventor： Narsingh Singh

IPC: G02F1/11

CPC classification number: G02F1/33 ,  G01J3/1256 ,  G02F1/116

Abstract: Acoustic-optic devices which use a crystal of tellurium into which is launched acoustic shear waves by a lithium niobate transducer in accordance with an input RF signal. Tellurium used in the devices exhibits a figure of merit in the range of around 5,000 to 10,000.

公开(公告)号：US20060001870A1

公开(公告)日：2006-01-05

申请号：US10882082

申请日：2004-06-30

Applicant: Thomas Voigt ,  David Tuschel ,  John Maier

Inventor： Thomas Voigt ,  David Tuschel ,  John Maier

IPC: G01J3/44

CPC classification number: G01N21/6456 ,  G01J3/12 ,  G01J3/1256 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/44 ,  G01J2003/1269 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/65

Abstract: A system and method for detecting dynamic changes that occur in a sample between a first time interval and a second time interval using a series of at least first and second sequential chemical images of the sample. During the first time interval: (i) the sample is illuminated with a plurality of photons to thereby produce photons scattered or emitted by the sample; (ii) a two-dimensional array of detection elements is used to simultaneously detect scattered or emitted photons in a first predetermined wavelength band from different locations on or within the sample; and (iii) the two-dimensional array of detection elements is thereafter used one or more further times to simultaneously detect scattered or emitted photons in one or more further predetermined wavelength band(s) from different locations on or within the sample. The outputs of the two-dimensional array of detection elements during the first time interval are then combined to generate the first chemical image of the sample. The process is repeated during the second time interval to generate the second chemical image of the sample. Dynamic changes occurring in the sample between the first time interval and the second time interval are detected based on one or more differences between the first and second chemical images.

公开(公告)号：US20040169854A1

公开(公告)日：2004-09-02

申请号：US10376965

申请日：2003-02-28

Inventor： Tuan Vo-Dinh ,  Alan Wintenberg

IPC: G01N021/64 ,  G01N021/65

CPC classification number: G01J3/44 ,  G01J3/1256 ,  G01J3/2889 ,  G01N21/65 ,  G01N21/658 ,  G01N2021/656

Abstract: A scanning tunable detection system and related method for analyzing samples includes a source of time varying excitation signals and a tunable optical filter for selectively transmitting time-varying optical signals emanated from a sample following irradiation with the time varying excitation signals. A detector is provided for converting the time-varying optical signals to electrical detection signals. The system can identify components in a sample using phase sensitive or time sensitive detection. A slew scan mode can be used to permit slow scanning through spectral regions rich in information but quickly in regions without such information.

Abstract translation: 用于分析样本的扫描可调检测系统和相关方法包括时变激励信号源和可调谐光学滤波器，用于选择性地传输随时间变化的激发信号照射后从样品发出的时变光信号。 提供了用于将时变光信号转换为电检测信号的检测器。 该系统可以使用相敏或时间敏感检测来识别样品中的成分。 可以使用旋转扫描模式来允许在没有这种信息的区域中快速扫描富含信息的频谱区域，但是快速地扫描。

公开(公告)号：US20030102433A1

公开(公告)日：2003-06-05

申请号：US10342480

申请日：2003-01-15

Inventor： Emil W. Ciurczak ,  Kevin C. Bynum

IPC: G02B005/30 ,  G02B005/32 ,  B29C039/22 ,  B29C039/02

CPC classification number: G01N21/35 ,  G01J1/0455 ,  G01J1/4228 ,  G01J3/0243 ,  G01J3/10 ,  G01J3/12 ,  G01J3/1256 ,  G01J3/2803 ,  G01J2003/123 ,  G01J2003/1243 ,  G01J2003/1828 ,  G01J2003/2866 ,  G01N21/359 ,  G01N21/59

Abstract: A hemispherical detector comprising a plurality of photodetectors arranged in a substantially contiguous array, the array being substantially in the shape of a half-sphere, the half-sphere defining a closed end and an open end, the open end defining a substantially circular face. Also provided is a method for constructing a hemispherical detector comprising the steps of making a press mold of the desired shape of the hemispherical detector, pouring a material into the press mold to form a cast, finishing the cast to remove any defects, coating the cast with a coating material, and attaching a plurality of photodetectors to the cast.

公开(公告)号：US20020185608A1

公开(公告)日：2002-12-12

申请号：US10158909

申请日：2002-06-03

Inventor： Manfred Wieser

IPC: G01N021/64

CPC classification number: G01J3/4406 ,  G01J3/1256 ,  G01J3/42 ,  G01N21/253 ,  G01N21/645 ,  G01N2021/6482

Abstract: The invention relates to a method and measuring device for determining at least one luminescence, fluorescence, or absorption parameter of a sample, including an excitation light source supplying the excitation radiation directed onto the sample, a detector unit for detection of the emission radiation (i.e., the radiation to be measured) given off by the sample, and an acousto-optical tunable filter (AOTF) being provided in the radiation path of the excitation radiation and/or in the radiation path of the emission radiation. The ultrasonic oscillations of the acousto-optical filter are excited by a high-frequency oscillator, which is furnished with a unit for amplitude modulation in the form of a rectangular, Gaussian, Hann, or Hamming window, thus providing an optical switch with switching times in the nullsec range.

Abstract translation: 本发明涉及一种用于确定样品的至少一种发光，荧光或吸收参数的方法和测量装置，包括提供引导到样品上的激发辐射的激发光源，用于检测发射辐射的检测器单元（即 ，待测量的辐射），以及在激发辐射的辐射路径和/或发射辐射的辐射路径中提供的声光可调谐滤波器（AOTF）。 声光滤波器的超声波振荡由高频振荡器激励，高频振荡器配备有以矩形，高斯，汉斯或汉明窗形式进行幅度调制的单元，从而提供具有切换时间的光学开关 在音乐范围内。

公开(公告)号：US20020131042A1

公开(公告)日：2002-09-19

申请号：US09938483

申请日：2001-08-27

Applicant: FUJITSU LIMITED

Inventor： Takeo Iwama

IPC: G01J003/28

CPC classification number: G01J9/0246 ,  G01J3/1256 ,  G01J3/2803

Abstract: In an optical spectrum analyzer comprising a spectrograph and a photodevice array, and an optical spectrum detecting method, a wavelength deviation, from an assigned wavelength, of a light detected by a photodevice array which detects a wavelength of a diffraction light or a non-diffraction light from an acoustooptic device, is detected and a feedback control to a diffraction angle of the acoustooptic device is performed. Also, without using a feedback control, an exit light and a diffraction light from the acoustooptic device are respectively received by two photodevice arrays and the photodevices are arranged in order to mutually compensate gaps between the photodevices, whereby a center of each photodevice is similarly made coincide with a peak of an optical beam to be received.

Abstract translation: 在包括光谱仪和光器件阵列以及光谱检测方法的光谱分析仪中，从检测衍射光的波长的光器件阵列检测到的光的波长偏差，或非衍射 检测来自声光装置的光，并执行对声光装置的衍射角的反馈控制。 此外，不使用反馈控制，来自声光装置的出射光和衍射光分别由两个光器件阵列接收，并且设置光器件以相互补偿光器件之间的间隙，由此类似地制造每个光器件的中心 与要接收的光束的峰值一致。