公开(公告)号：US07388202B2

公开(公告)日：2008-06-17

申请号：US11256656

申请日：2005-10-21

Applicant: Bernhard B. Sterling ,  W. Dale Hall ,  Kenneth G. Witte ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Bernhard B. Sterling ,  W. Dale Hall ,  Kenneth G. Witte ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: G01J1/00 ,  G01N21/35

CPC classification number: G01N21/274 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/1495 ,  A61B2560/0223 ,  A61M5/14212 ,  A61M2230/20 ,  G01N21/35 ,  G01N35/00693 ,  G01N35/00712 ,  G01N2201/1215 ,  G01N2201/127

Abstract: A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.

Abstract translation: 描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。 该方法减少了在存在干扰物的情况下分析物浓度的误差。 该方法包括使用对具有已知分析物范围和干扰化合物浓度的大群体获得的一组测量。 从可能或可能不是其中一个群体的样本测量中，可能存在干扰物被识别，并且计算校准向量。

公开(公告)号：US6001064A

公开(公告)日：1999-12-14

申请号：US929957

申请日：1997-09-15

Applicant: Kurt Peter Weckstrom

Inventor： Kurt Peter Weckstrom

IPC: G01N11/00 ,  G01N21/35 ,  A61B5/00

CPC classification number: G01N11/00 ,  G01N21/3504 ,  G01N2201/1215

Abstract: A measuring device for determining the concentration of such gas components from a gas mixture, which includes collision dilation of the absorption lines constituting the absorption spectral bands for measuring objects. The device comprises a non-dispersive concentration measuring sensor (20), which includes: a measuring chamber (6) containing a gas mixture to be analyzed; a radiation source (17) for emitting over a wavelength range which includes an absorption spectral band used in concentration determination; a detector (18) receiving radiation that has passed through the measuring chamber and for producing a first signal (7) therefrom; as well as an optical bandpass filter (16) positioned between the detector and the radiation source. The measuring device further comprises a second measuring sensor (4) for identifying the viscosity or some other viscosity-related feature of a gas mixture to be analyzed and for producing a second signal (9). Both signals (7, 9) are delivered to a calculating unit (8), which uses at least a second signal for performing the corrections required for the first signal. In addition, the device is provided with a display means (10).

Abstract translation: 一种用于确定来自气体混合物的这种气体组分的浓度的测量装置，其包括构成用于测量物体的吸收光谱带的吸收线的碰撞扩张。 该装置包括非分散浓度测量传感器（20），其包括：包含要分析的气体混合物的测量室（6）; 用于在包括用于浓度测定的吸收光谱带的波长范围内发射的辐射源（17）; 接收已经通过测量室的辐射并从其产生第一信号（7）的检测器（18）; 以及位于检测器和辐射源之间的光学带通滤波器（16）。 测量装置还包括用于识别要分析的气体混合物的粘度或某些其它与粘度有关的特征并用于产生第二信号的第二测量传感器（4）。 两个信号（7,9）被传送到计算单元（8），该计算单元使用至少第二信号来执行第一信号所需的校正。 此外，该装置设置有显示装置（10）。

公开(公告)号：US5379238A

公开(公告)日：1995-01-03

申请号：US923029

申请日：1992-07-30

Applicant: Edward W. Stark

Inventor： Edward W. Stark

IPC: G01J3/28 ,  G01N21/35 ,  G06F17/00 ,  G06F17/10 ,  A61B5/00 ,  G06G7/48 ,  G06F15/42

CPC classification number: G06F17/10 ,  G01N21/359 ,  G01J2003/2843 ,  G01N2201/1215

Abstract: A method and apparatus for the determination of spectral samples is disclosed wherein spectral measurements are taken, normalization of the spectral measurements takes place, and a bilinear modeling is performed to extract spectral data. Once this data is derived, the interference quantitization levels are determined using multiple linear regression analysis, and are then removed from the sample readings in order to determine a more precise level of analyte spectra, such as analyte levels of glucose in serum or whole blood.

Abstract translation: 公开了用于确定光谱样本的方法和装置，其中进行光谱测量，进行光谱测量的归一化，并且执行双线性建模以提取光谱数据。 一旦得到这些数据，就可以使用多重线性回归分析来确定干扰量化水平，然后从样本读数中去除干扰量化水平，以便确定更精确的分析物光谱水平，如血清或全血中葡萄糖的分析物水平。

公开(公告)号：US4928015A

公开(公告)日：1990-05-22

申请号：US252960

申请日：1988-10-03

Applicant: James W. Butler ,  Thomas J. Korniski ,  Alex D. Colvin

Inventor： James W. Butler ,  Thomas J. Korniski ,  Alex D. Colvin

IPC: G01J3/28 ,  G01J3/453 ,  G01N1/28 ,  G01N1/38 ,  G01N21/35 ,  G01N33/00

CPC classification number: G01N33/0016 ,  G01J3/453 ,  G01N21/3504 ,  G01J2003/2866 ,  G01N1/38 ,  G01N2001/383 ,  G01N2001/388 ,  G01N2021/3595 ,  G01N2201/1215

Abstract: A method is disclosed of making an on-line gas analysis of a multicomponent gas emission flow by (a) continuously sequestering a sample flow from the gas emission flow, which sample flow may be filtered to substantially eliminate solid or liquid particles, diluted to lower its dew point to below room temperature, and changed in either temperature and/or pressure to be substantially the same in temperature and pressure as that of gases used to create reference transmission frequency spectral data employed in step (d); (b) continuously irradiating the sample flow with an electromagnetic radiation beam while modulating the amplitude of infrared frequencies in the audio frequency range of the beam, either prior to or immediately subsequent to irradiation of the sample flow, to produce electromagnetic signals having discernible amplitude variations resulting from spectral interference patterns; (c) detecting and collecting the signals at a sufficiently high rate to substantially completely distinguish between adjacent spectral pattern amplitude peaks without mutual spectral interference and to permit analysis of the signals in real time; and (d) analyzing the signals in real time by (i) mathematically manipulating the signals in accordance with Beer's Law to create reformed background-corrected data, and (ii) applying reference transmission frequency spectral data to the reformed data for each suspected gaseous component to give a linear quantitative measure of the presence of each and every suspected gas component in the gas emission flow.

Abstract translation: 公开了一种通过以下方法来进行多组分气体排放流的在线气体分析：（a）从气体排放流中连续隔离样品流，该样品流可被过滤以基本上消除固体或液体颗粒，稀释至较低 其露点低于室温，并且在温度和/或压力下变化为与用于产生步骤（d）中使用的参考透射频谱数据的气体的温度和压力基本相同; （b）在对样品流的照射之前或紧随其后的同时调制光束的音频范围内的红外频率的幅度，同时用电磁辐射束连续照射样品流，以产生具有可辨别的幅度变化的电磁信号 由光谱干涉图形引起; （c）以足够高的速率检测和收集信号，以基本上完​​全区分没有相互频谱干扰的相邻频谱图幅度峰值，并允许实时分析信号; 和（d）通过（i）根据“啤酒定律”数学地操纵信号以实时地分析信号，以产生经改良的背景校正数据，以及（ii）将参考传输频谱数据应用于每个可疑气体组分的重整数据 对气体排放流中每个可疑气体成分的存在进行线性定量测量。

公开(公告)号：US4829183A

公开(公告)日：1989-05-09

申请号：US96169

申请日：1987-09-11

Applicant: Edward A. McClatchie ,  Kevin G. Williams

Inventor： Edward A. McClatchie ,  Kevin G. Williams

IPC: G01N21/31 ,  G01N21/35

CPC classification number: G01N21/3504 ,  G01N2021/3137 ,  G01N2021/3166 ,  G01N2201/1215

Abstract: A non-dispersive infrared gas analyzer is disclosed that accurately measures the concentration levels of a plurality of gases within a gas mixture. The analyzer includes first and second sample cells and is utilized advantageously for the measurement of NO.sub.x and hydrocarbon gas present in the exhaust of an automobile engine. The gas mixture of the exhaust is chilled before entering the first sample cell to remove a substantial amount of the water vapor from that sample cell to facilitate measurement of the NO.sub.x gas. The second sample cell receives the gas mixtue in an unchilled state to allow for accurate measurement of the hydrocarbon gas. The analyzer includes processors which are utilized to further correct the NO.sub.x measurement and which also interact with each other to provide an output data stream that is representative of the concentration levels of the gases that are being analyzed.

Abstract translation: 公开了一种非分散红外线气体分析仪，其精确地测量气体混合物内的多种气体的浓度水平。 分析仪包括第一和第二样品池，并且有利地用于测量存在于汽车发动机的排气中的NOx和烃气体。 排气的气体混合物在进入第一样品池之前被冷却以从该样品池中除去大量的水蒸汽，以便于测量NOx气体。 第二个样品池接收处于非烧结状态的气体混合物，以准确测量烃类气体。 分析仪包括用于进一步校正NOx测量并且彼此相互作用以提供表示正在分析的气体的浓度水平的输出数据流的处理器。

公开(公告)号：US4370553A

公开(公告)日：1983-01-25

申请号：US165250

申请日：1980-07-02

Applicant: Roy A. Waycaster ,  William T. Baker ,  Jerry D. Bidle

Inventor： Roy A. Waycaster ,  William T. Baker ,  Jerry D. Bidle

IPC: G01N21/03 ,  G01N21/35 ,  G01J1/04

CPC classification number: G01N21/3504 ,  G01N21/03 ,  G01N2201/1215

Abstract: A gas analyzer for performing gas analysis on a sample gas containing contaminants which normally interfere with the operation of the analyzer is disclosed comprising a source of radiant energy; means for directing radiant energy through a sample gas; a disposable gas cell; a detector for receiving radiant energy; and a circuit for analyzing the output of the detector and indicating the concentration of predetermined constituents in the sample gas. The gas cell comprises a disposable sample gas cell having a sample enclosure for containing a sample gas volume; sample windows defining a portion of a sample gas optical path extending from the source of radiant energy through the sample gas volume to the detector; an inlet for supplying sample gas to the sample gas volume and an outlet for exhausting sample gas from the sample gas volume. The disposable sample cell is provided with inlet and exhaust manifolds having cross-sectional areas that minimize dead space and insure laminar flow, minimizing stagnant areas. Specifically, the cross-sectional areas of the inlet and outlet manifolds are relatively constant, the cross-sectional area of the outlet being larger than the cross-sectional area of the inlet, and the inlet and outlet manifolds vary in cross-sectional shape from elongate shapes proximate the windows to a shape having roughly equilateral dimensions distal to the windows. The analyzer and the gas cell are provided with a number of inter-related features that make the analyzer self aligning and eliminates the necessity of recalibrating the analyzer each time a sample cell is replaced.

Abstract translation: 公开了一种用于对通常干扰分析仪的操作的污染物的样品气体进行气体分析的气体分析仪，其包括辐射能源; 用于通过样品气体引导辐射能的装置; 一次性气室; 用于接收辐射能的检测器; 以及用于分析检测器的输出并指示样品气体中预定成分的浓度的电路。 气室包括具有用于容纳样品气体体积的样品外壳的一次性样品气室; 样本窗口，其限定从辐射源通过样本气体体积延伸到检测器的样品气体光路的一部分; 用于将样品气体供应到样品气体体积的入口和用于从样品气体体积排出样品气体的出口。 一次性样品池设有入口和排气歧管，其具有使死区最小化并确保层流的横截面积，从而最小化停滞区域。 具体来说，入口歧管和出口歧管的横截面面积相对恒定，出口的横截面面积大于入口的横截面面积，而入口和出口歧管的横截面积从 靠近窗户的细长形状具有远离窗户的大致等边尺寸的形状。 分析仪和气室配备有多个相互关联的特征，使分析仪自动对准，并且每次更换样品池时都不需要重新校准分析仪。

公开(公告)号：US09546902B2

公开(公告)日：2017-01-17

申请号：US14662307

申请日：2015-03-19

Applicant: Servomex Group Limited

Inventor： Richard P. Kovacich ,  Bahram Alizadeh ,  Ian C. Gaskin ,  James D. Hobby ,  Martin Lopez

IPC: G01N21/00 ,  G01J3/02 ,  G01J3/10 ,  G01J3/433 ,  G01N21/39 ,  G01N21/27 ,  G01J3/42

CPC classification number: G01J3/027 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/433 ,  G01J2003/423 ,  G01N21/274 ,  G01N21/39 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/121 ,  G01N2201/1215

Abstract: A method and system for correcting the effect of intensity fluctuations of the transmitted light in an absorption spectroscopy system used for the detection or measurement of chemical species in a medium, whereby one or more modulation bursts are imposed onto a light beam that passes through the medium. This burst signal may be obtained by modulating the bias current of a tunable diode laser, and the modulation burst signal may be optimally at the second harmonic of the modulation frequency of a wavelength modulated beam to allow usage of the same signal path processing used for the spectroscopic detection of the measurand for a second harmonic detection system. The burst signal can be controlled using a smooth window function to minimise the effects of non-linear perturbations that are inherent in tunable diode laser wavelength modulation spectroscopy systems, of optical interference fringes (etalons) and of the residual light absorption by background chemical species or the measurand at the wavelength coinciding with the modulation burst.

Abstract translation: 一种用于校正用于检测或测量介质中的化学物质的吸收光谱系统中的透射光的强度波动的影响的方法和系统，由此一个或多个调制脉冲串被施加到通过介质的光束 。 可以通过调制可调二极管激光器的偏置电流来获得该脉冲串信号，并且调制脉冲串信号可以在波长调制波束的调制频率的二次谐波处最佳地进行，以允许使用与 用于二次谐波检测系统的被测量的光谱检测。 可以使用平滑窗函数来控制突发信号，以最小化可调谐二极管激光波长调制光谱系统固有的非线性扰动，光学干涉条纹（标准具）和背景化学物质的残余光吸收的影响， 在波长上的被测量与调制脉冲串一致。

公开(公告)号：US20140067282A1

公开(公告)日：2014-03-06

申请号：US14013788

申请日：2013-08-29

Applicant: SICK AG

Inventor： Thomas BEYER ,  Julian EDLER

IPC: G01N21/25

CPC classification number: G01N21/255 ,  G01J3/28 ,  G01J3/433 ,  G01N21/274 ,  G01N21/3504 ,  G01N21/39 ,  G01N2021/399 ,  G01N2201/0691 ,  G01N2201/1211 ,  G01N2201/1215 ,  G01N2201/1218

Abstract: A method of determining a concentration of a gas in a sample and/or of the composition of a gas by means of a spectrometer includes measuring an absorption signal of the gas as a function of the wavelength. The wavelength substantially continuously runs through a wavelength range and is superimposed by a harmonic wavelength modulation, wherein the influence of the wavelength modulation on the absorption signal via the light source modulation properties and the detection properties of the spectrometer is dependent on the device properties of the respective spectrometer. The method includes converting the absorption signal into at least one first derivative signal; deriving a gas concentration measurement parameter from the first derivative signal; determining the concentration and/or composition of the gas from at least the gas concentration measurement parameter and from a calibration function compensating for influences of state variables of the gas and of the spectrometer properties.

Abstract translation: 通过光谱仪测定样品和/或气体组成中的气体的浓度的方法包括测量作为波长的函数的气体的吸收信号。 波长基本上连续地穿过波长范围并通过谐波波长调制叠加，其中波长调制对吸收信号的影响经由光源调制性质和光谱仪的检测特性取决于器件的性质 各自的光谱仪。 该方法包括将吸收信号转换成至少一个一阶导数信号; 从一阶导数信号导出气体浓度测量参数; 从至少气体浓度测量参数和补偿气体的状态变量和光谱仪性质的影响的校准函数确定气体的浓度和/或组成。

公开(公告)号：US20110093215A1

公开(公告)日：2011-04-21

申请号：US12911666

申请日：2010-10-25

Applicant: Xin Zhou ,  Xiang Liu ,  Alfred Feitisch ,  Gregory M. Sanger

Inventor： Xin Zhou ,  Xiang Liu ,  Alfred Feitisch ,  Gregory M. Sanger

IPC: G06F19/00 ,  G01N21/25

CPC classification number: G01N21/3504 ,  G01N2021/3545 ,  G01N2021/399 ,  G01N2201/1215

Abstract: A differential absorption spectrum for a reactive gas in a gas mixture can be generated for sample absorption data by subtracting background absorption data set from the sample absorption data. The background absorption data can be characteristic of absorption characteristics of the background composition in a laser light scan range that includes a target wavelength. The differential absorption spectrum can be converted to a measured concentration of the reactive gas using calibration data. A determination can be made whether the background composition has substantially changed relative to the background absorption data, and new background absorption data can be used if the background composition has substantially changed. Related systems, apparatus, methods, and/or articles are also described.

Abstract translation: 可以通过从样品吸收数据中减去设置的背景吸收数据，为样品吸收数据产生气体混合物中的反应气体的差分吸收光谱。 背景吸收数据可以是包括目标波长的激光扫描范围中背景组合物的吸收特性的特征。 使用校准数据可以将差示吸收光谱转换为测量的反应气体浓度。 可以确定背景组合物是否相对于背景吸收数据基本上改变，并且如果背景组合物已经基本上改变，则可以使用新的背景吸收数据。 还描述了相关系统，装置，方法和/或制品。

公开(公告)号：US20100221762A1

公开(公告)日：2010-09-02

申请号：US12573821

申请日：2009-10-05

Applicant: Bernhard B. Sterling ,  W. Dale Hall ,  Kenneth G. Witte ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Bernhard B. Sterling ,  W. Dale Hall ,  Kenneth G. Witte ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: C12Q1/58 ,  G06F19/00 ,  C12Q1/54 ,  C12Q1/02 ,  C12Q1/24

CPC classification number: G01N21/274 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/1495 ,  A61B2560/0223 ,  A61M5/14212 ,  A61M2230/20 ,  G01N21/35 ,  G01N35/00693 ,  G01N35/00712 ,  G01N2201/1215 ,  G01N2201/127

Abstract: A method and apparatus are described that permit an analyte concentration to be estimated from a measurement in the presence of compounds that interfere with the measurement. The method reduces the error in the analyte concentration in the presence of interferents. The method includes the use of a set of measurements obtained for a large population having a range of known analyte and interfering compound concentrations. From a sample measurement, which may or may not be one of the population, likely present interferents are identified, and a calibration vector is calculated.

Abstract translation: 描述了允许在干扰测量的化合物存在下从测量估计分析物浓度的方法和装置。 该方法减少了在存在干扰物的情况下分析物浓度的误差。 该方法包括使用对具有已知分析物范围和干扰化合物浓度的大群体获得的一组测量。 从可能或可能不是其中一个群体的样本测量中，可能存在干扰物被识别，并且计算校准向量。