摘要:
Biocompatible fluorocarbon compositions are provided which may be used for the delivery of bioactive agents to the pulmonary air passages of a patient. Preferred compositions comprise a fluorocarbon liquid carrier having a bioactive agent in a solid or immiscible liquid form distributed therein. The disclosed compositions allow for the selective delivery of bioactive agents in conjunction with liquid lavage and liquid ventilation for the treatment of ARDS and other pulmonary disorders.
摘要:
The amount of breathable liquid eliminated from a mammal through volatilization in the lungs and/or through skin transpiration is detected by measuring the amount of saturation of the expiratory gas by vapors or the breathable liquid. Instantaneous saturation values are employed to gauge the amount of interaction in the lungs between the breathable liquid and respiratory gas flowing therein and to control selected feedback operations to maintain the maximum possible amount of interaction therebetween. The saturation level of expiratory gas is also employed to optimize operating parameters or a system for recovering the breathable liquid from the expiratory gas, directly from the patient, or from a gas or liquid ventilator. The saturation level or expiratory gas is also employed to perform functional residual capacity studies and to correct for errors in conventional functional residual capacity measurements performed while a patient undergoes partial liquid ventilation. When breathable liquid is employed as a blood substitute, the quantification or the loss of the breathable liquid from volatilization and transpiration helps to determine when to replenish the breathable liquid in the bloodstream. Vapors of one form of breathable liquid, perfluorocarbon, are employed to determine the functional residual capacity of a mammal's lung.
摘要:
This invention relates to the combination of a number of pieces of separate functioning apparatus in order to accomplish the combined purposes of producing medical grade oxygen from air, saturating an inert isotonic liquid with the oxygen, adjusting the temperature of the oxygen saturated liquid to a predetermined temperature, injecting the oxygen saturated liquid into the bottom of the animal lung(s) cavity, circulating the liquid up through the lung(s) cavity by removal of the carbon dioxide saturated liquid at the top of the lung(s) cavity along with displaced from the lung(s) cavity non-miscible, aqueous liquid; separation of nonmiscible liquid, filtering of isotonic liquid for particulate removal, heat sterilization of isotonic liquid as well as stripping of remaining absorbed gases, particularly carbon dioxide (CO.sub.2), cooling and temperature adjusting of isotonic liquid to predetermined desired temperature, and return of isotonic liquid to saturator for resaturation with oxygen and repeat cycle use. Remaining isotonic liquid in the lung(s) cavity, at end of treatment is removed by inverting animal sufficiently to raise the influent tube at bottom of lung(s) cavity above effluent tube and inflating lung(s) cavity with medical grade oxygen gas.
摘要:
The aeration of specific inert, nonmagnetic liquids, under superatmospheric pressure, and ambient temperature, increases both the oxygen and nitrogen solubility of the liquid. Filtered, sterilized air, within a controlled temperature range is dissolved under superatmospheric pressure in the nonmagnetic liquid. The liquid pregnant with both oxygen and nitrogen is then passed through a high intensity electromagnet which paramagnetically separates the oxygen from the liquid. The collected oxygen gas is pressurized for storage and later use, or used as produced. The oxygen stripped nonmagnetic liquid, still pregnant with nonparamagnetic nitrogen is reduced to sub or atmospheric pressure which releases the nitrogen gas to atmosphere. The gases stripped nonmagnetic liquid is then returned for recycle use.
摘要:
A dispenser (1) comprises a can (2) and body (3). The can is an aluminum extrusion with a valve crimped into its mouth, the valve having an outlet spout (4). The crimped region (5) of the can surrounding the valve has a lesser diameter than the can has through the main part (6) of its length. The body has a mouthpiece (11) with a pivotal cover (12) drivingly connected to a cam (13). This bears on the underside of junction member (14), into a socket (15) of which the spout 4 fits. A breath actuated dose release mechanism (16) is provided. The body has a tubular section (7) for receiving the necked down region (5) of the can. A printed paper label (21) is wrapped around the joint between the body and the can to unite the can to the body in position such that when the cover is opened, a dose is dispensed by the cam (13) lifting the junction member and depressing the spout.
摘要:
A dispenser (1) comprises a can (2) and body (3). The can is an aluminum extrusion with a valve crimped into its mouth, the valve having an outlet spout (4). The crimped region (5) of the can surrounding the valve has a lesser diameter than the can has through the main part (6) of its length. The body has a mouthpiece (11) with a pivotal cover (12) drivingly connected to a cam (13). This bears on the underside of junction member (14), into a socket (15) of which the spout 4 fits. A breath actuated dose release mechanism (16) is provided. The body has a tubular section (7) for receiving the necked down region (5) of the can. A printed paper label (21) is wrapped around the joint between the body and the can to unite the can to the body in position such that when the cover is opened, a dose is dispensed by the cam (13) lifting the junction member and depressing the spout.
摘要:
Methods of delivering a therapeutic or diagnostic agent in a perfluorochemical liquid carrier are provided. In preferred embodiments, the disclosed methods use compositions in the form of an emulsion or a dispersion for delivery of a biological agent to the pulmonary air passages.
摘要:
In respiratory care with liquids, the patient is connected to a liquid apparatus and a ventilator for supplying and removing a treatment liquid and a breathing gas respectively to/from the patient. The exchange of gases between the breathing gas and the treatment liquid is improved with a device which causes the breathing gas and/or the liquid to oscillate. The device may be a breathing gas generator which generates different frequencies to cause the breathing gas and treatment liquid to oscillate at appropriate frequencies. The device may be a vibrator unit which is applied to the chest to cause the treatment liquid to oscillate. The device may be a magnetic field generator for generating a magnetic field across the lungs and setting electrically conductive components in the treatment liquid in motion.