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    Method for detecting bacteria in urine and for treating rheumatoid arthritis, essential hypertension and other diseases associated with bacteriuria
    15.
    发明授权
    Method for detecting bacteria in urine and for treating rheumatoid arthritis, essential hypertension and other diseases associated with bacteriuria 失效
    用于检测尿中细菌和治疗类风湿性关节炎，原发性高血压和其他与菌尿有关的疾病的方法

    公开(公告)号：US4673637A

    公开(公告)日：1987-06-16

    申请号：US603088

    申请日：1984-04-23

    申请人： Edward S. Hyman

    发明人： Edward S. Hyman

    IPC分类号： C12Q1/04 ,  G01N33/564 ,  G01N33/569 ,  G01N1/00

    CPC分类号： C12Q1/04 ,  G01N33/564 ,  G01N33/56911 ,  G01N2800/102 ,  Y10S435/825 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

    摘要： A novel method of urine specimen preparation comprising intense centrifugation and a lipid wash mitigates or prevents loss of bacteria-containing sediment prior to examination. Modifications of the method facilitate examination of urines with interfering constituents such as glucose, phosphates, and soluble and insoluble proteins. By this method, bacteria have been found in the urine of patients suffering from rheumatoid arthritis and essential hypertension. These bacteria were not detected in standard urine preparations. Administration of antibiotic agents effective against the bacteria detected, such as clindamycin, destroyed these bacteria and provided therapeutic relief.

    摘要翻译： 包括强离心和脂质洗涤在内的尿标本制备的新方法减轻或防止在检查之前含有细菌的沉淀物的损失。 该方法的改进便于用诸如葡萄糖，磷酸盐和可溶性和不溶性蛋白质的干扰成分检测尿。 通过这种方法，在患有类风湿性关节炎和原发性高血压的患者的尿液中发现细菌。 这些细菌在标准尿液制剂中未检出。 施用有效对抗细菌的抗生素，如克林霉素，破坏了这些细菌并提供了治疗救济。

    Antiviral antibiotic BU-4344V
    19.
    发明授权
    Antiviral antibiotic BU-4344V 失效
    抗病毒抗生素BU-4344V

    公开(公告)号：US5256548A

    公开(公告)日：1993-10-26

    申请号：US874775

    申请日：1992-04-27

    申请人： Masahisa Oka ,  Koji Tomita ,  Osamu Tenmyo ,  Nobuaki Naruse

    发明人： Masahisa Oka ,  Koji Tomita ,  Osamu Tenmyo ,  Nobuaki Naruse

    IPC分类号： C07K7/06 ,  C12P21/04 ,  C07K7/54 ,  C12N1/12 ,  C12R1/03

    CPC分类号： C12R1/03 ,  C07K7/06 ,  Y10S435/825

    摘要： There is provided a new antiviral antibiotic designated herein as BU-4344V which is produced by fermentation of a BU-4344V-producing strain of a new microorganism, Actinomadura parvosata subsp. kistnae ATCC No. 55076. Antibiotic BU-4344V is recovered and purified from the fermentation broth by use of extraction, chromatography, and crystallization techniques. BU-4344V has been found to have some antibacterial activity and inhibits the growth of viruses, including influenza virus type A.

    摘要翻译： 提供了本文命名为BU-4344V的新的抗病毒抗生素，其通过发酵新生微生物（Actinomadura parvosata subsp。）的BU-4344V生产菌株而产生。 kistnae ATCC No.50576.通过使用提取，色谱和结晶技术从发酵液中回收和纯化抗生素BU-4344V。 已经发现BU-4344V具有一些抗菌活性并抑制病毒的生长，包括A型流感病毒。