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1.发明授权Method of producing a polyether antibiotic from actinomadura fibrosa sp. nov. NRRL 18348 and actinomadura sp. NRRL 18880 失效从放线菌纤维菌中生产聚醚抗生素的方法 nov。 NRRL 18348和放线菌属 NRRL 18880
公开(公告)号：US5278053A
公开(公告)日：1994-01-11
申请号：US760640
申请日：1991-09-16
申请人： LaVerne D. Boeck
发明人： LaVerne D. Boeck
CPC分类号： C07D493/10 , C12P17/181 , Y10S435/825
摘要： Improved processes for producing a polyether antibiotic compound represented by A82810 comprising: (1) cultivating Actinomadura fibrosa sp. nov. NRRL 18348 or Actinomadura sp. NRRL 18880, (2) feeding acid hydrolyzed casein at a rate from about 2.50-7.50 gm/L/day, (3) feeding glucose at a rate from about 2.50-7.50 gm/L/day, and (4) feeding propionate at a rate from about 0.50-1.5 gm/L/day to the appropriate culture medium during fermentation, are provided.
摘要翻译： 用于生产由A82810代表的聚醚抗生素化合物的改进方法包括：（1）培养放线菌（Actinomadura fibrosa sp。 nov。 NRRL 18348或Actinomadura sp。 NRRL 18880，（2）以约2.50-7.50gm / L /天的速率喂食酸水解酪蛋白，（3）以约2.50-7.50gm / L /天的速率喂食葡萄糖，和（4）将丙酸盐 提供了在发酵期间从约0.50-1.5gm / L /天到合适培养基的速率。
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2.发明授权Insecticide and miticide A83543 compounds and their method of production by fermentation 失效杀虫剂和杀螨剂A83543化合物及其发酵方法
公开(公告)号：US5496931A
公开(公告)日：1996-03-05
申请号：US406760
申请日：1995-03-17
申请人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
发明人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
CPC分类号： C07H17/08 , C12N1/20 , C12P1/06 , C12P19/62 , Y10S435/822
摘要： Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A983543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ecto-parasiticidal combinations, compositions and methods are provided.
摘要翻译： 包含主要组分A83543A和A83543D以及次要组分A83543B，A83543C，A83543E，A983543F，A83543G，A83543H和A83543J的发酵产物A83543由新近描述的种类，多孢裂孢酵母（Saccharopolyspora spinosa）生产。 A83543组分及其酸加成盐（A83543化合物）可用作杀虫剂，特别是鳞翅目和双翅目物种。 提供杀虫剂，杀螨剂或除虫杀虫剂组合，组合物和方法。
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公开(公告)号：US4336333A
公开(公告)日：1982-06-22
申请号：US243283
申请日：1981-03-13
CPC分类号： C07H19/06 , C12P19/385 , C12R1/52 , Y10S435/893
摘要： Tunicamycin is produced by the cultivation of Streptomyces chartreusis Calhoun and Johnson, 1956, NRRL 12338. Methods of recovering tunicamycin and for separating and isolating individual factors A.sub.1, A.sub.2, B.sub.1, B.sub.2, C.sub.1, C.sub.2, D.sub.1 and D.sub.2 from tunicamycin complex are described.
摘要翻译： 描述了通过培养链霉菌（Streptomyces chartreusis Calhoun）和约翰逊（Johnson），1956年，NRRL 12338生产突变霉素的方法。回收衣霉素并从衣霉素复合物中分离和分离各个因子A1，A2，B1，B2，C1，C2，D1和D2的方法。
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公开(公告)号：US4683204A
公开(公告)日：1987-07-28
申请号：US658977
申请日：1984-10-09
申请人： LaVerne D. Boeck
发明人： LaVerne D. Boeck
CPC分类号： C07H19/01 , A23K20/195 , C12P19/445 , C12P19/60 , C12R1/03 , Y10S435/825
摘要： Improved fermentation process for producing the polyether antibiotic A80190 which comprises cultivating a new strain of Actinomodura Oligospora, NRRL 15878, and the biologically purified culture of this microorganism are provided.
摘要翻译： 提供了用于生产聚醚抗生素A80190的改进的发酵方法，其包括培养新的放线杆菌寡核苷酸NRRL 15878和该微生物的生物纯化培养物。
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公开(公告)号：US4563442A
公开(公告)日：1986-01-07
申请号：US653259
申请日：1984-09-24
IPC分类号： C07G11/00 , A23K20/195 , A61K38/00 , A61P31/04 , C07K9/00 , C07K14/195 , C07K14/41 , C12P19/60 , C12P21/04 , C12R1/045 , A61K37/00 , A61K35/00
CPC分类号： C12R1/045 , A23K20/195 , C07K9/008 , Y10S930/19 , Y10S930/27
摘要： New glycopeptide antibiotics of the formula: ##STR1## wherein W is the remaining portion of a glycopeptide antibiotic selected from actaplanin factors B.sub.1, B.sub.2, B.sub.3, C.sub.1, C.sub.2, C.sub.3, D.sub.1, D.sub.2, E.sub.1, G, K, L, M, N, O and actaplanin .psi.aglycone, and salts thereof, particularly the pharmaceutically acceptable salts, are useful new antibiotics are active against gram-positive bacteria and increase feed-efficiency utilization and enhance milk production in ruminants.
摘要翻译： 新型糖肽抗生素，其结构式如下：其中W是选自actaplanin因子B1，B2，B3，C1，C2，C3，D1，D2，E1，G，K，L，M的糖肽抗生素的剩余部分， N，O和actaplanin psi糖苷配基及其盐，特别是其药学上可接受的盐是有用的新型抗生素对革兰氏阳性细菌具有活性，并增加饲料效率的利用并提高反刍动物中的牛奶生产。
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公开(公告)号：US4558008A
公开(公告)日：1985-12-10
申请号：US561008
申请日：1983-12-13
CPC分类号： C12R1/365 , C07K9/008 , Y10S435/872 , Y10S930/19 , Y10S930/27
摘要： The novel glycopeptide antibiotic A-51568B is produced by submerged, aerobic fermentation of Nocardia orientalis NRRL 15232. A-51568B demonstrates antibiotic activity against gram-positive bacteria.
摘要翻译： 新型糖肽抗生素A-51568B是通过东方诺卡氏菌NRRL 15232的淹没好氧发酵生产的.A-51568B显示对革兰氏阳性菌的抗生素活性。
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公开(公告)号：US4009262A
公开(公告)日：1977-02-22
申请号：US569712
申请日：1975-04-21
申请人： LaVerne D. Boeck , David H. Berg
发明人： LaVerne D. Boeck , David H. Berg
CPC分类号： C07G11/00
摘要： Recovery of an antibiotic selected from the group consisting of antibiotic A-28086 factor A, antibiotic A-28086 factor B, antibiotic A-28086 factor D, and salinomycin by acidifying the fermentation broth in which said antibiotic is produced to about pH 2.0-4.0 and separating the antibiotic with the culture solids.
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公开(公告)号：US5571901A
公开(公告)日：1996-11-05
申请号：US479500
申请日：1995-06-07
申请人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
发明人： LaVerne D. Boeck , Hang Chio , Tom E. Eaton , Otis W. Godfrey, Jr. , Karl H. Michel , Walter M. Nakatsukasa , Raymond C. Yao
CPC分类号： C07H17/08 , C12N1/20 , C12P1/06 , C12P19/62 , Y10S435/822
摘要： Fermentation product A83543, comprising major components A83543A and A83543D and minor components A83543B, A83543C, A83543E, A83543F, A83543G, A83543H and A83543J, is produced by a newly described species, Saccharopolyspora spinosa. The A83543 components and their acid-addition salts (A83543 compounds) are useful as insecticides, particularly against Lepidoptera and Diptera species. Insecticidal, miticidal or ectoparasiticidal combinations, compositions and methods are provided.
摘要翻译： 包含主要成分A83543A和A83543D以及次要成分A83543B，A83543C，A83543E，A83543F，A83543G，A83543H和A83543J的发酵产品A83543由新描述的种类，酿酒酵母（Saccharopolyspora spinosa）生产。 A83543组分及其酸加成盐（A83543化合物）可用作杀虫剂，特别是鳞翅目和双翅目物种。 提供杀虫，杀螨或外寄生疫苗组合，组合物和方法。
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公开(公告)号：US4663282A
公开(公告)日：1987-05-05
申请号：US729785
申请日：1985-05-02
申请人： LaVerne D. Boeck , Gladys M. Clem , Charles L. Hershberger , Marie T. Anderson , Karl H. Michel
发明人： LaVerne D. Boeck , Gladys M. Clem , Charles L. Hershberger , Marie T. Anderson , Karl H. Michel
CPC分类号： C12R1/045 , A23K20/195 , C07K9/008 , Y10S435/827
摘要： New glycopeptide antibiotic CUC/CSV which has the formula: ##STR1## wherein R is L-ristosaminyl;R.sub.1 is the disaccharide mannosyl-glucosyl; andR.sub.2 and R.sub.3 are mannosyl, and its salts, particularly the pharmaceutically acceptable salts, are useful new antibiotics are active against gram-positive bacteria and increase feed-efficiency utilization and enhance milk production in ruminants.
摘要翻译： 新型糖肽抗生素CUC / CSV，其具有下式：其中R为L-赖氨酰胺基; R1是二糖甘露糖基 - 葡糖基; R2和R3是甘露糖基，其盐，特别是药学上可接受的盐是有用的，新的抗生素对革兰氏阳性细菌具有活性，并增加了饲料效率的利用，提高了反刍动物的产奶量。
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公开(公告)号：US4560509A
公开(公告)日：1985-12-24
申请号：US552549
申请日：1983-11-16
IPC分类号： A61K31/395 , A61K35/74 , A61P31/04 , C07D498/08 , C12N1/20 , C12P1/02 , C12P7/24 , C12P17/18 , C12R1/465 , C07D491/08
CPC分类号： C07D498/08 , C12P17/189 , C12R1/465 , Y10S435/886
摘要： A new antibiotic of the rifamycin class, A39079 factor S-1, which has the structure ##STR1## is an effective broad-spectrum antibiotic and increases feed-utilization efficiency in animals.
摘要翻译： 利福霉素类的新抗生素A39079因子S-1具有结构“IMAGE”，是一种有效的广谱抗生素，提高动物饲料利用效率。
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