公开(公告)号：US4407946A

公开(公告)日：1983-10-04

申请号：US313849

申请日：1981-10-22

Applicant: David P. Labeda ,  John H. E. J. Martin ,  Joseph J. Goodman

Inventor： David P. Labeda ,  John H. E. J. Martin ,  Joseph J. Goodman

IPC: C07H17/04 ,  C07H19/01 ,  C12N1/20 ,  C12P19/60 ,  C12R1/03 ,  C12P1/04

CPC classification number: C07H19/01 ,  C12P19/60 ,  C12R1/03 ,  Y10S435/825 ,  Y10S435/875

Abstract: This invention relates to a novel process for the production of antibiotic X-14868A using the novel microorganism Antinomadura yumaense sp. nov.

Abstract translation: 本发明涉及使用新型微生物Antinomadura yumaense sp。生产抗生素X-14868A的新方法。 nov。

公开(公告)号：US5432193A

公开(公告)日：1995-07-11

申请号：US61373

申请日：1993-05-14

Applicant: Guy T. Carter ,  Gerhard Schlingmann ,  David P. Labeda ,  Joseph J. Goodman

Inventor： Guy T. Carter ,  Gerhard Schlingmann ,  David P. Labeda ,  Joseph J. Goodman

IPC: C07D407/14 ,  C07H19/01 ,  A61K31/35

CPC classification number: C07D407/14 ,  C07H19/01

Abstract: This invention relates to antibiotic LL-D37187.alpha. derived from the microorganism Streptomyces which is useful as an antibacterial agent.

Abstract translation: 本发明涉及可用作抗菌剂的来自微生物链霉菌的抗生素LL-D37187α。

公开(公告)号：US4626503A

公开(公告)日：1986-12-02

申请号：US701831

申请日：1985-02-14

Applicant: May D. Lee ,  Amedeo A. Fantini ,  David P. Labeda ,  William M. Maiese ,  Raymond T. Testa ,  Donald B. Borders

Inventor： May D. Lee ,  Amedeo A. Fantini ,  David P. Labeda ,  William M. Maiese ,  Raymond T. Testa ,  Donald B. Borders

IPC: C07H17/04 ,  C12P1/06 ,  C12P19/60 ,  C12N1/20 ,  C07G11/00 ,  A01N25/26

CPC classification number: C07H17/04 ,  C12P1/06 ,  C12P19/60 ,  C12R1/465

Abstract: Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194.beta..sub.3, LL-D49194.gamma., LL-D49194.delta., LL-D49194.epsilon., LL-D49194.xi., LL-D49194.eta., LL-D49194.omega., LL-D49194.omega..sub.2 and LL-D49194.omega..sub.3.

Abstract translation: 抗肿瘤剂LL-D49194α1，LL-D49194β1，LL-D49194β2，LL-D49194β3，LL-D49194γ，LL-D49194δ，LL-D49194ε，LL-D49194 xi，LL-D49194 eta ，LL-D49194欧米加，LL-D49194 omega2和LL-D49194ω3。

公开(公告)号：US4503044A

公开(公告)日：1985-03-05

申请号：US488496

申请日：1983-04-25

Applicant: May D. Lee ,  Donald B. Borders ,  David P. Labeda ,  Amedeo A. Fantini ,  Raymond T. Testa

Inventor： May D. Lee ,  Donald B. Borders ,  David P. Labeda ,  Amedeo A. Fantini ,  Raymond T. Testa

IPC: C07G11/00 ,  A61K35/74 ,  A61K38/00 ,  A61P31/04 ,  A61P35/00 ,  C07K5/06 ,  C12P1/04 ,  C12R1/01 ,  A61K37/00 ,  C07C103/52

CPC classification number: C07K5/06026 ,  C12R1/01 ,  A61K38/00

Abstract: This disclosure describes a new antibacterial and anti-tumor agent designated LL-D05139 .beta., produced in a microbiological fermentation under controlled conditions using a new genus Glycomyces harbinensis gen. nov., sp. nov., and mutants thereof.

Abstract translation: 本公开描述了一种名为LL-D05139β的新型抗细菌剂和抗肿瘤剂，其在微生物发酵下，在控制条件下使用新的Glycomyces harbinensis gen。 诺夫山脉 nov。及其突变体。

公开(公告)号：US07247650B2

公开(公告)日：2007-07-24

申请号：US11065934

申请日：2005-02-25

Applicant: Mia Haruna Yoshino Summers ,  Edmund Idris Graziani ,  Margaret M. Leighton ,  Kevin Pong ,  Roger Alan Kele ,  David P. Labeda

Inventor： Mia Haruna Yoshino Summers ,  Edmund Idris Graziani ,  Margaret M. Leighton ,  Kevin Pong ,  Roger Alan Kele ,  David P. Labeda

IPC: C07D498/18 ,  A61K31/407

CPC classification number: C07D498/18

Abstract: This invention relates, in part, to macrolide compounds, actinomycete strains for producing them, and pharmaceutical compositions containing them.

Abstract translation: 本发明部分涉及大环内酯类化合物，用于生产它们的放线菌菌株和含有它们的药物组合物。

公开(公告)号：US4970198A

公开(公告)日：1990-11-13

申请号：US9321

申请日：1987-01-30

Applicant: May D. Lee ,  Michael Greenstein ,  David P. Labeda ,  Amedeo A. Fantini

Inventor： May D. Lee ,  Michael Greenstein ,  David P. Labeda ,  Amedeo A. Fantini

IPC: C07H15/203 ,  C12P1/06 ,  C12P19/60

CPC classification number: C07H15/203 ,  C12P1/06 ,  C12P19/60 ,  C12R1/29 ,  Y10S435/867

Abstract: Antibacterial and antitumor agents designated LL-E33288 complex and their production by new strains of Micromonospora echinospora ssp. calichensis NNRL-15839, NRRL-15975 and NRRL-18149, are disclosed.

Abstract translation: 名称为LL-E33288复合物的抗菌剂和抗肿瘤剂及其通过新型小单孢菌属 calichensis NNRL-15839，NRRL-15975和NRRL-18149。

公开(公告)号：US4774184A

公开(公告)日：1988-09-27

申请号：US765418

申请日：1985-08-14

Applicant: Taikwang M. Lee ,  Donald B. Borders ,  Joseph J. Goodman ,  Raymond T. Testa ,  William M. Maiese ,  David P. Labeda

Inventor： Taikwang M. Lee ,  Donald B. Borders ,  Joseph J. Goodman ,  Raymond T. Testa ,  William M. Maiese ,  David P. Labeda

IPC: A23K20/195 ,  C07D491/16 ,  C12P17/18 ,  C12P17/16 ,  C12N1/20 ,  C12R1/03

CPC classification number: C07D491/16 ,  A23K20/195 ,  C12P17/188 ,  C12R1/03 ,  Y10S435/825

Abstract: The invention is a process for the production by fermentation of the antibacterial and antiparasitic agents designated LL-D42067.alpha., to methods for its recovery and concentration from crude solutions and to processes for its purification. The invention includes within its scope the biologically pure culture of the antibiotic.

Abstract translation: 本发明是通过发酵生产名为LL-D42067α的抗细菌剂和抗寄生虫剂的方法，用于从粗溶液中回收和浓缩的方法及其纯化方法。 本发明在其范围内包括抗生素的生物学纯培养。

公开(公告)号：US4578468A

公开(公告)日：1986-03-25

申请号：US593159

申请日：1984-03-26

Applicant: Guy T. Carter ,  Donald B. Borders ,  Joseph J. Goodman ,  David P. Labeda

Inventor： Guy T. Carter ,  Donald B. Borders ,  Joseph J. Goodman ,  David P. Labeda

IPC: A23K20/195 ,  A61K31/47 ,  A61P33/00 ,  A61P33/02 ,  C07D319/00 ,  C07D491/16 ,  C12P17/18 ,  C12R1/03 ,  C07D498/12

CPC classification number: C07D491/16 ,  A23K20/195 ,  C12P17/188 ,  C12R1/03

Abstract: Antibiotic LL-D42067.beta. derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent.

Abstract translation: 抗生素LL-D42067通过有氧发酵得到的微生物Actinomadura madurae亚种simaoensis NRRL 15734，可用作抗菌和抗寄生虫剂。

公开(公告)号：US5223430A

公开(公告)日：1993-06-29

申请号：US783582

申请日：1991-10-28

Applicant: Guy T. Carter ,  Joseph J. Goodman ,  David P. Labeda

Inventor： Guy T. Carter ,  Joseph J. Goodman ,  David P. Labeda

IPC: A23K20/195 ,  C07D498/14 ,  C12P17/18

CPC classification number: C07D498/14 ,  A23K20/195 ,  C12P17/188 ,  C12R1/29 ,  Y10S435/867

Abstract: This disclosure describes novel antibacterial agents designated LL-E10985.alpha., LL-E19085.beta., LL-E19085.gamma., LL-E19085.zeta. and LL-E19085.eta., having the structure: ##STR1## their production by aerobic fermentation of a new subspecies of Micromonospora citrea NRRL 18351 and mutants thereof, and the isolation and purification thereof.

Abstract translation: 本公开描述了称为LL-E10985α，LL-E19085β，LL-E19085γ，LL-E19085ζ和LL-E19085等的新型抗菌剂，具有以下结构：其通过需氧发酵的新亚种小单孢菌 柠檬酸NRRL 18351及其突变体，并进行分离和纯化。

公开(公告)号：US5108912A

公开(公告)日：1992-04-28

申请号：US560415

申请日：1990-09-10

Applicant: May D. Lee ,  Michael Greenstein ,  David P. Labeda ,  Amedeo A. Fantini

Inventor： May D. Lee ,  Michael Greenstein ,  David P. Labeda ,  Amedeo A. Fantini

IPC: C07H15/203 ,  C12P19/60

CPC classification number: C07H15/203 ,  C12P19/60 ,  C12R1/29 ,  Y10S435/867 ,  Y10S435/868

Abstract: Antibacterial and antitumor agents designated LL-E33288 complex and their production by new strains of Micromonospora echinospora spp. calichensis NRRL-15839, NRRL-15975 and NRRL-18149, are disclosed.

Abstract translation: 名称为LL-E33288复合物的抗菌剂和抗肿瘤剂及其通过新型小单孢菌属（Phonoconospora echinospora spp。）生产。 calichensis NRRL-15839，NRRL-15975和NRRL-18149。