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153 条记录 (耗时 0.025 秒)

    Blocking protein fractions, recovery methods and products
    13.
    发明授权
    Blocking protein fractions, recovery methods and products 失效
    阻断蛋白质馏分，回收方法和产品

    公开(公告)号：US4196121A

    公开(公告)日：1980-04-01

    申请号：US880547

    申请日：1978-02-23

    申请人： Lawrence Burton ,  Frank Friedman

    发明人： Lawrence Burton ,  Frank Friedman

    IPC分类号： A23J1/06 ,  A61K35/14

    CPC分类号： A61K38/1709 ,  A23J1/06 ,  Y10S530/829

    摘要： A process is provided for the isolation of two protein fractions herein termed the "blocking protein fractions" or "Blocker I" and "Blocker II," from mammalian blood. The process comprises a series of centrifugal separations of blood fractions under conditions which maintain the integrity of the desired material as it existed in vivo. These blocking protein fractions are new materials and they constitute another aspect of the invention. Isolated Blocker I and Blocker II, which are natural proteins or derivatives thereof, are useful to prevent tissue implant rejection, and as standards for the determination of the tumor remission activity of other materials isolated from blood.

    摘要翻译： 提供了一种从哺乳动物血液中分离本文称为“阻断蛋白质级分”或“阻断剂I”和“阻断剂II”的两种蛋白质组分的方法。 该方法包括在保持所需材料在体内存在的完整性的条件下的血液级分的一系列离心分离。 这些阻断蛋白质级分是新材料，它们构成本发明的另一方面。 作为天然蛋白质或其衍生物的分离的阻断剂I和阻断剂II可用于防止组织植入物排斥，以及用于确定从血液中分离的其它材料的肿瘤缓解活性的标准。

    Anti-antihemocytic serum and a method for the preparation thereof
    14.
    发明授权
    Anti-antihemocytic serum and a method for the preparation thereof 失效
    抗抗血细胞血清及其制备方法

    公开(公告)号：US4134885A

    公开(公告)日：1979-01-16

    申请号：US865489

    申请日：1977-12-29

    申请人： Juozas B. Valjukas ,  Marionas A. Babyanskas ,  Pyatras A. Zayanchkauskas ,  Yanina I. Zhukauskene

    发明人： Juozas B. Valjukas ,  Marionas A. Babyanskas ,  Pyatras A. Zayanchkauskas ,  Yanina I. Zhukauskene

    IPC分类号： A01N63/02 ,  A61K39/00 ,  C07K16/18 ,  A23J1/06

    CPC分类号： A01N63/02 ,  C07K16/18 ,  A61K39/00 ,  Y10S530/806 ,  Y10S530/83 ,  Y10S530/858

    摘要： The anti-antihemocytic serum comprises water-soluble proteins in a physiological solution isolated from cells of the bodies of insects immunized by a single injection in a dose of 0.25 .mu.l to 2.0 .mu.l for every insect with the anti-hemocytic serum produced from the plasma of the blood of an animal immunized with a suspension of hemocytes from cells of the bodies of the given species of insects. The titre of hemocytoagglutinins of the anti-antihemocytic serum is 1:256 to 1:1024. The method for the preparation of anti-antihemocytic serum resides in immunizing the given species of insects with antihemocytic serum, produced from the plasma of the blood of an animal immunized with a suspension of hemocytes from cells of the bodies of insects, by means of a single injection in a dose of 0.25 to 2.0 .mu.l for every insect, removing the hemolymph and the alimentary tract from insects in 24 hours, homogenizing the remaining cells of the bodies of insects and diluting them with a physiological solution, isolating proteins from cells of the bodies of insects by breaking the integrity of cells, and isolating the fluid from the resultant mixture separating it from the indissoluble portion of cells of the bodies of insects, obtaining the target product.

    摘要翻译： 抗 - 抗血细胞血清包含生理溶液中的水溶性蛋白质，所述生理溶液从每只从每只昆虫产生的抗血细胞血清的每只昆虫以单次注射免疫的昆虫体细胞分离，其剂量为0.25-1.0μl 使用来自给定昆虫种类的细胞的血细胞悬浮液免疫的动物血液的血浆。 抗血细胞血清的血细胞凝集素滴度为1:256至1:1024。 用于制备抗抗血细胞血清的方法是用由抗体血清形成的给定种类的昆虫进行免疫，所述抗细胞血清由用来自昆虫体的细胞的血细胞悬浮液免疫的动物血液的血浆产生，借助于 单次注射每只昆虫的0.25至2.0μl的剂量，在24小时内从昆虫中除去血淋巴和消化道，均匀化昆虫体的剩余细胞并用生理溶液稀释，从细胞中分离蛋白 通过破坏细胞的完整性，并从所得混合物中分离出与昆虫体的细胞不溶部分分离的昆虫体，获得目标产物。

    Method of producing intravenously injectable gamma globulin
    15.
    发明授权
    Method of producing intravenously injectable gamma globulin 失效
    产生静脉注射的γ球蛋白的方法

    公开(公告)号：US4124576A

    公开(公告)日：1978-11-07

    申请号：US747063

    申请日：1976-12-03

    申请人： Myer L. Coval

    发明人： Myer L. Coval

    IPC分类号： A61K39/395 ,  A61K38/00 ,  C07K16/06 ,  A23J1/06 ,  A61K37/06

    CPC分类号： C07K16/06 ,  A61K38/00 ,  Y10S530/831 ,  Y10S530/851

    摘要： An improved process is provided for the preparation of a gamma globulin suitable for intravenous administration from the readily available Fraction II or II + III plasma protein paste or from the corresponding fractions originating from placental extracts. The Fraction II or II + III paste is extracted with water at a pH of 4.9 to 6.0 and impurities are fractionally precipitated by addition of polyethylene glycol to 4% of wt./vol. and then 6% vol. ethanol. The desired gamma globulin is then precipitated at a pH 8.0 by addition of polyethylene glycol to 12% wt./vol.

    摘要翻译： 提供了一种改进的方法，用于制备适合于从容易获得的级分II或II + III血浆蛋白糊剂或源自胎盘提取物的相应级分静脉内施用的γ球蛋白。 将级分II或II + III糊料在pH为4.9至6.0的水中提取，并通过加入聚乙二醇将重量/体积的4重量％分散沉淀出杂质。 然后6％vol。 乙醇。 然后将所需的γ球蛋白在pH8.0下通过加入聚乙二醇至12％wt /

    Amidated immune globulins and process for preparing them
    16.
    发明授权
    Amidated immune globulins and process for preparing them 失效
    免疫球蛋白及其制备方法

    公开(公告)号：US4118379A

    公开(公告)日：1978-10-03

    申请号：US770181

    申请日：1977-02-18

    申请人： Rudolf Schmidtberger

    发明人： Rudolf Schmidtberger

    IPC分类号： A61K38/00 ,  C07K16/06 ,  A23J1/06

    CPC分类号： C07K16/06 ,  A61K38/00 ,  Y10S530/83

    摘要： The invention relates to modified immune globulins, a process for preparing them by treating immune globulins in a slightly acidic to neutral solution with a molar excess of a primary amine and a carbodiimide or salts thereof and pharmaceutical compositions containing modified immune globulins.

    摘要翻译： 本发明涉及修饰的免疫球蛋白，其通过用摩尔过量的伯胺和碳二亚胺或其盐处理轻微酸性至中性溶液中的免疫球蛋白和含有修饰的免疫球蛋白的药物组合物来制备它们的方法。

    Cyanocobalamin derivatives
    17.
    发明授权
    Cyanocobalamin derivatives 失效
    氰基卡马林衍生物

    公开(公告)号：US4082738A

    公开(公告)日：1978-04-04

    申请号：US689280

    申请日：1976-05-24

    申请人： Gordon Dean Niswender ,  James M. Hudson

    发明人： Gordon Dean Niswender ,  James M. Hudson

    IPC分类号： C07H23/00 ,  G01N33/82 ,  A23J1/08 ,  A23J1/06

    CPC分类号： C07H23/00 ,  G01N33/82 ,  Y10S436/823 ,  Y10S530/806 ,  Y10S530/807

    摘要： The present invention is concerned with novel derivatives of cyanocobalamin (vitamin B.sub.12), especially of the monocarboxylic acid hydrolysates thereof, by which (1) an antigenic conjugate thereof with a protein is obtainable and (2) a readily iodinatable aromatic ring can be introduced while retaining in each instance, the essential constitution of cyanocobalamin to such an extent that (a) the antigenic protein conjugate, when introduced into the blood stream of a vertebrate, causes the formation of an antibody which is specific to the cyanocobalamin portion of the conjugate and (b) unmodified cyanocobalamin and the second-mentioned derivative when tagged or labeled with radioactive-iodine competitively bind on the aforementioned antibody. Thus, the present invention provides cyanocobalamin derivatives which are quite useful in radioimmunoassay (RIA) of vitamin B.sub.12.