中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

247 records (took 0.018 seconds)

    System for measuring membrane permeation
    11.
    发明申请
    System for measuring membrane permeation 审中-公开
    膜渗透测量系统

    公开(公告)号：US20040142341A1

    公开(公告)日：2004-07-22

    申请号：US10475888

    申请日：2004-03-17

    Inventor： Johannes Schmitt ,  Joachim Noller

    IPC: C12Q001/68 ,  C08G063/48 ,  C08G063/91 ,  B32B005/16

    CPC classification number: G01N33/5432 ,  Y10T428/2991

    Abstract: The invention relates to a system, which can be used for measuring membrane permeation in substances. Said system comprises, essentially, porous particles with an inner surface formed within the pores, and another outer surface. Essentially, only the outer surface is fully covered by a lipid layer, said lipid layer extending over the openings of the pores on the outer surface. Preferably, an intermediate layer is arranged between the outer surface and the lipid layer. Said intermediate layer is embodied, more particularly, in the form a polymer network.

    Abstract translation: 本发明涉及一种可用于测量物质中膜渗透性的系统。 所述系统基本上包括在孔内形成有内表面的多孔颗粒和另一外表面。 基本上，只有外表面被脂质层完全覆盖，所述脂质层在外表面上的孔的开口上延伸。 优选地，在外表面和脂质层之间布置中间层。 所述中间层更具体地体现为聚合物网络的形式。

    Inhibition of xenoreactive antibodies
    12.
    发明申请
    Inhibition of xenoreactive antibodies 审中-公开
    抑制异反应性抗体

    公开(公告)号：US20040141944A1

    公开(公告)日：2004-07-22

    申请号：US10402845

    申请日：2003-03-28

    Inventor： Alexander Schwarz ,  Guerard W. Byrne ,  Thomas A. Davis ,  Lisa E. Diamond ,  John S. Logan

    IPC: A61K039/00 ,  C08G063/48 ,  C08G063/91

    CPC classification number: C07K16/00 ,  A61K39/001 ,  A61K47/59 ,  A61K47/60 ,  A61K47/61 ,  A61K47/645 ,  A61K2039/6093

    Abstract: One aspect of the present invention relates to methods and compositions for attenuating xenograft rejection by administering, to an animal receiving the xenograft, an amount of a polymer-derivatized xenoantigen (hereinafter nullxenopolymernull) effective for inhibiting or lessening the severity of hyperacute rejection response (HAR), or other immunological response to the graft, that is dependent on the presence of the xenoantigen on the grafted tissues or cells. In certain embodiments, the xenopolymer is administered in an amount sufficient to neutralize host antibodies (nullxenoreactive antibodiesnull or nullXNAnull) immunoreactive with the xenoantigen. The xenopolymer may additionally, or alternatively, be used as a tolerogen (or anergen) for the xenoantigen, e.g., able to suppress, to some degree, the production/secretion of XNAs by the immune system of the host.

    Abstract translation: 本发明的一个方面涉及通过向接受异种移植物的动物施用一定量的有效抑制或减轻超急性排斥反应严重性的聚合物衍生的异种抗原（以下称为“异戊烯”）来减弱异种移植排斥的方法和组合物 （HAR）或其他对移植物的免疫应答，这取决于移植组织或细胞上异种抗原的存在。 在某些实施方案中，以足以中和与异种抗原免疫反应的宿主抗体（“异反应性抗体”或“XNA”）的量施用异种聚合物。 异源聚合物可以另外地或替代地用作异种抗原的耐受原（或过敏原），例如能够在一定程度上抑制宿主的免疫系统产生/分泌XNA。

    Reagents and methods for solid phase synthesis and display
    13.
    发明申请
    Reagents and methods for solid phase synthesis and display 审中-公开
    用于固相合成和显示的试剂和方法

    公开(公告)号：US20040106728A1

    公开(公告)日：2004-06-03

    申请号：US10619799

    申请日：2003-07-14

    Applicant: Affymetrix, Inc.

    Inventor： Glenn H. McGall ,  Anthony D. Barone ,  Martin Diggelmann

    IPC: C08G063/48 ,  C08G063/91 ,  C07F009/02

    CPC classification number: C07F9/2408 ,  B01J2219/00722 ,  B01J2219/00725 ,  C07D493/10 ,  C07H21/00 ,  C40B40/06 ,  C40B40/10

    Abstract: New compounds, compositions and methods which find application in solid phase synthesis including the preparation of high-density arrays of diverse polymer sequences such as diverse peptides and oligonucleotides as well as in preparation of arrays of small ligand molecules. The compounds of the present invention are those which are typically referred to as linking groups, linkers or spacers and include unsymmetrical disulfide linking groups, and 1,3-diol derivatives capable of providing a triggered release of an attached compound from a solid support under mild conditions. Additional new compounds are labels which can be incorporated into either the 3null or 5null terminus of a DNA oligomer.

    Abstract translation: 可用于固相合成的新化合物，组合物和方法，包括制备不同聚合物序列的高密度阵列，例如多种肽和寡核苷酸，以及制备小配体分子的阵列。 本发明的化合物是通常称为连接基团，接头或间隔基并且包括不对称二硫键连接基团的化合物，以及能够在温和的条件下从固体支持物引发附着化合物的触发释放的1,3-二醇衍生物 条件。 另外的新化合物是可掺入DNA寡聚体的3'或5'末端的标记。

    Intracellular delivery system for protein phosphatases
    14.
    发明申请
    Intracellular delivery system for protein phosphatases 审中-公开
    蛋白磷酸酶的细胞内递送系统

    公开(公告)号：US20040101941A1

    公开(公告)日：2004-05-27

    申请号：US10343094

    申请日：2003-07-07

    Inventor： Sara Lavi ,  Roni Sutchi-Painaro

    IPC: C12N009/16 ,  C08G063/48 ,  C08G063/91

    CPC classification number: C12N11/08 ,  A61K38/00 ,  A61K47/65 ,  C12N9/16 ,  C12Y301/03016

    Abstract: The subject invention relates to a polymer-based intracellular delivery system for protein phosphatases. This delivery system can be used to deliver protein phosphatases for any disease or disorder in which it is desirable to elevate protein phosphatase activity, particularly for tumor therapy. Novel protein phosphatases are also disclosed.

    Abstract translation: 本发明涉及蛋白磷酸酶的基于聚合物的细胞内递送系统。 该递送系统可用于递送蛋白质磷酸酶用于任何疾病或病症，其中期望提高蛋白质磷酸酶活性，特别是用于肿瘤治疗。 还公开了新的蛋白磷酸酶。

    Biocompatible polymer for fixing biological ligands
    15.
    发明申请
    Biocompatible polymer for fixing biological ligands 审中-公开
    用于固定生物配体的生物相容性聚合物

    公开(公告)号：US20040091451A1

    公开(公告)日：2004-05-13

    申请号：US10296889

    申请日：2003-01-27

    Inventor： Marie-Therese Charreyre ,  Franck D'Agosto ,  Arnaud Favier ,  Christian Pichot ,  Bernad Mandrand

    IPC: A61K031/765 ,  C08G063/48 ,  C08G063/91

    CPC classification number: C08L53/00 ,  C08F293/005

    Abstract: The invention concerns a biocompatible polymer having a mole weight more than 50000 g/mole, preferably 90000 g/mole for fixing biological ligands comprising at least a first linear segment consisting of a hydrophobic homopolymer derived from polymerisation of a hydrophobic monomer A; a second linear segment consisting of a hydrophilic polymer derived from copolymerisation of a monomer B bearing a reactive function X and a hydrophilic monomer C not bearing any reactive function, said second segment being covalently bound to one end of the first segment. The invention also concerns a biological polymer-ligand-conjugate, a device for capturing a target molecule comprising a solid support whereon is immobilised a biological polymer-ligand conjugate and methods for preparing said polymer. The invention is mainly applicable in the field of diagnosis.

    Abstract translation: 本发明涉及摩尔重量大于50000克/摩尔，优选90000克/摩尔的生物相容性聚合物，用于固定生物配体，其包含至少一种由衍生自疏水性单体A的聚合的疏水性均聚物组成的第一线性区段; 第二线性区段由亲水性聚合物组成，所述亲水性聚合物衍生自携带反应性官能团X的单体B与不具有任何反应性功能的亲水性单体C的共聚，所述第二区段共价结合到第一区段的一端。 本发明还涉及生物聚合物 - 配体 - 缀合物，用于捕获包含其中固定有生物聚合物 - 配体缀合物的固体支持物的靶分子的装置和用于制备所述聚合物的方法。 本发明主要适用于诊断领域。

    Biomimetic systems consisting of lipid membranes bound to a substrate
    18.
    发明申请
    Biomimetic systems consisting of lipid membranes bound to a substrate 审中-公开
    由与膜结合的脂质膜组成的生物模拟系统

    公开(公告)号：US20040023304A1

    公开(公告)日：2004-02-05

    申请号：US10443659

    申请日：2003-05-22

    Inventor： Schiller Stefan ,  Naumann Renate ,  Knoll Wolfgang

    IPC: G01N033/53 ,  C08G063/91 ,  C08G063/48

    CPC classification number: B82Y10/00 ,  C07D339/04 ,  C07F9/10 ,  C08G65/334 ,  C08L2203/02 ,  G01N33/54353 ,  G01N33/5438 ,  G01N2610/00 ,  G06N3/002

    Abstract: The invention concerns lipids functionalized with a hydrophilic linker which contain a tethering group for binding to a surface. The invention also concerns self-assembled monolayers of lipids on substrates in particular on ultrasmooth gold substrates. The lipids and the lipid monolayers or bilayers containing these lipids can be used to produce biomimetic supported membrane systems. After the optional incorporation of functional molecules such as membrane-associated proteins, these systems can be used for applications such as model systems for examining biological membranes, screening methods, sensors and bioelectronic devices such as biocomputers.

    Abstract translation: 本发明涉及用亲水接头官能化的脂质，其包含用于结合表面的束缚基团。 本发明还涉及基质上特别是在超光滑金底物上的脂质的自组装单层。 含有这些脂质的脂质和脂质单层或双层可用于产生仿生支持的膜系统。 在功能分子如膜相关蛋白的任选引入之后，这些系统可用于诸如用于检查生物膜的模型系统，筛选方法，传感器和诸如生物计算机的生物电子装置之类的应用。

    Perfluoropolyethers comprising repeating units obtained from oxidation of perfluorodioxoles
    19.
    发明申请
    Perfluoropolyethers comprising repeating units obtained from oxidation of perfluorodioxoles 失效
    全氟聚醚包含由全氟二氧杂环己烯氧化获得的重复单元

    公开(公告)号：US20030232922A1

    公开(公告)日：2003-12-18

    申请号：US10458308

    申请日：2003-06-11

    Applicant: SOLVAY SOLEXIS S.p.A.

    Inventor： Giuseppe Marchionni ,  Ugo De Patto

    IPC: C08G063/48 ,  C08G063/91 ,  C07D317/44

    CPC classification number: C08G65/007 ,  C08G65/322 ,  C08G2650/10

    Abstract: Perfluoropolyethers obtained by oxidation of perfluorodioxoles of formula (I) 1 wherein RfnullnullF, null(O)yCnF2nnull1 with ynull0, 1 and nnull1, 2, 3, 4, 5, and with WnullnullF, nullCnF2nnull1, optionally in the presence of tetrafluoroethylene and/or hexafluoropropene, and subsequent reduction of the obtained peroxidic perfluoropolyethers.

    Abstract translation: 通过氧化式（I）的全氟二氧杂环己烷得到的全氟聚醚，其中Rf = -F， - （O）yCnF 2 n + 1，其中y = 0,1和n = 1,2,3,4,5，并且W = -F， -C n F 2n + 1，任选在四氟乙烯和/或六氟丙烯的存在下，随后还原所得的过氧化全氟聚醚。

Patent Agency Ranking