公开(公告)号：US20200271630A1

公开(公告)日：2020-08-27

申请号：US16797599

申请日：2020-02-21

申请人： Henan Polytechnic University

发明人： Lizhi CUI ,  Xuhui PU ,  Xinwei LI ,  Keping WANG ,  Yi YANG ,  Bingfeng LI ,  Qiongxia YU ,  Junqi YANG ,  Fuzhong WANG ,  Shumin FEI

IPC分类号： G01N30/88 ,  G01N30/36

摘要： The present invention relates to a quick quantitative analysis method and analyzer for mixture concentration information. A quick quantitative analysis method for a mixture based on spectral information includes: collecting a sample of a mixture solution, and injecting into a DAD to obtain DAD data; then, calculating a spectral library by a quick qualitative analysis method based on a vector error algorithm to obtain a spectral error vector; determining a spectral curve of a component included in the data corresponding to the sample, according to a value of the error vector; and calculating a content flag value of each component in the sample and concentration information of each substance.

公开(公告)号：US20200096486A1

公开(公告)日：2020-03-26

申请号：US16691927

申请日：2019-11-22

申请人： SHIMADZU CORPORATION

发明人： Nobuhiro HANAFUSA ,  Kazuhiro SUZUKI

IPC分类号： G01N30/24 ,  G01N35/02 ,  G01N30/88 ,  G01N35/00 ,  G01N1/10 ,  G01N35/04 ,  G01N27/62 ,  G01N30/36

摘要： The present invention provides a processing device with a high degree of flexibility in setting of preprocessing and which is capable of increasing the preprocessing efficiency, and an analysis system provided with the same. Setting receiving means (84d) receives, for each sample, setting of a plurality of types of preprocessing and a parameter for each preprocessing. A preprocessing execution section (84e) controls a plurality of preprocessing sections and a transport arm (24) so that a plurality of types of preprocessing set for each of different samples is performed simultaneously in parallel. The preprocessing execution section (84e) performs control in such a way that preprocessing is not to be performed on different samples at the same preprocessing section at the same.

公开(公告)号：US20190367509A1

公开(公告)日：2019-12-05

申请号：US16456714

申请日：2019-06-28

申请人： F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.

发明人： Elena BRASOLA ,  Filippo Tomasi ,  Loris Peruzzi

IPC分类号： C07D471/04 ,  B01D11/02 ,  C07B63/00 ,  C07D413/14 ,  G01N30/36 ,  G01N30/72 ,  C07D413/04

摘要： Object of the present invention are dimer impurities of the active ingredient Apixaban, analytical methods for identifying and/or quantifying them and a synthetic method for removing or limiting said impurities from Apixaban and synthetic precursors thereof.

公开(公告)号：US10451049B2

公开(公告)日：2019-10-22

申请号：US15061214

申请日：2016-03-04

申请人： SHIMADZU CORPORATION

发明人： Shintaro Yamamoto

IPC分类号： F04B39/06 ,  G01N30/32 ,  F04B15/06 ,  G01N30/30 ,  F04B15/08 ,  G01N30/36

摘要： A liquid carbon dioxide delivery pump with a pump head including a pump chamber and a refrigerant channel different from a channel passing through the pump chamber, a circulation channel for refrigerant, a refrigerant pump arranged on the circulation channel, the refrigerant pump for causing the refrigerant to circulate through the circulation channel, and a cooling section arranged on the circulation channel, at a position away from the pump head, the cooling section being configured to cool the refrigerant passing through the circulation channel. The liquid carbon dioxide delivery pump further has a temperature sensor for detecting an ambient temperature of the pump head or a temperature of the pump head, and a refrigerant pump control section for adjusting, based on a detection signal of the temperature sensor, a flow rate of the refrigerant pump such that liquid carbon dioxide flowing through the pump head at a specific temperature.

公开(公告)号：US20190262745A1

公开(公告)日：2019-08-29

申请号：US16282626

申请日：2019-02-22

申请人： SILCOTEK CORP.

发明人： Jesse BISCHOF ,  Lucas D. PATTERSON ,  Gary BARONE ,  Min YUAN ,  David A. SMITH

IPC分类号： B01D15/38 ,  G01N30/36 ,  B01D15/22

摘要： Liquid chromatography techniques are disclosed. Specifically, the liquid chromatography technique includes providing a liquid chromatography system having a coated metallic fluid-contacting element, and transporting a fluid to contact the coated metallic fluid-contacting element. Conditions for the transporting of the fluid are selected from the group consisting of the temperature of the fluid being greater than 150° C., pressure urging the fluid being greater than 60 MPa, the fluid having a protein-containing analyte incompatible with one or both of titanium and polyether ether ketone, the fluid having a chelating agent incompatible with the one or both of the titanium or the polyether ether ketone, and combinations thereof.

公开(公告)号：US20190178859A1

公开(公告)日：2019-06-13

申请号：US16275849

申请日：2019-02-14

申请人： Genentech, Inc.

发明人： Mary MONTTI ,  Richard L. BEARDSLEY ,  Michael S. CHINN

IPC分类号： G01N30/96 ,  G01N30/36

摘要： The invention provides methods for quantifying a non-ionic surfactant in a composition comprising a polypeptide and the non-ionic surfactant, where the quantification exhibits reduced interference between the non-ionic surfactant and the polypeptide. Also provided are methods where the composition further includes N-acetyl tryptophan, and the quantification exhibits reduced interference between the non-ionic surfactant, the polypeptide, and N-acetyl tryptophan.

公开(公告)号：US20190170709A1

公开(公告)日：2019-06-06

申请号：US16269559

申请日：2019-02-06

申请人： Longyuan Mei ,  Longzhi Mei ,  Longyu Mei

发明人： Longyuan Mei ,  Longzhi Mei ,  Longyu Mei

IPC分类号： G01N30/36 ,  G01N30/32

摘要： A pressure system for liquid chromatography allows multiple fluid lines to be driven in parallel by a single pump. A fluid pressure medium supply provides fluid pressure to the system. The fluid pressure medium supply is connected to a plurality of fluid transfer pipes, each with a flow limiter. The fluid pressure medium supply is configured to provided more flow than the flow limiters combined, and excess flow is either diverted with a pressure limiter or reduced with a pressure adjuster, or both. Further layers of pressure and flow control may be added with additional pressure limiters and/or pressure adjusters and flow limiters connected together. In some cases, multiple lines containing different fluids may be driven by the same pressure source through the use of flexible fluid delivery inner containers, each within a rigid container that is pressurized by the pressure source.

公开(公告)号：US10254255B2

公开(公告)日：2019-04-09

申请号：US14429529

申请日：2013-09-18

申请人： Waters Technologies Corporation

发明人： Robert A. Jencks ,  Mark W. Moeller

IPC分类号： G01N30/34 ,  G01N30/36 ,  F16K11/07 ,  F16K11/074

摘要： Exemplary embodiments are directed to a rotary selector valve that includes a valve body that includes a rotor and a stator. The stator includes a first port for flow of a first flow material and a second port for flow of a second flow material. The rotor includes a groove for flow of at least one of the first flow material and the second flow material. The rotor includes a vent groove disposed between the first port and the second port for venting at least a portion of at least one of the first flow material and the second flow material to an exterior of the valve body. Exemplary methods of operating a rotary selector valve and CO2-based chromatography flow systems including a rotary selector valve are also provided.

公开(公告)号：US09945762B2

公开(公告)日：2018-04-17

申请号：US14586882

申请日：2014-12-30

申请人： AGILENT TECHNOLOGIES, INC.

发明人： Edwin E. Wikfors ,  Brian A. Bidlingmeyer ,  Klaus Witt

IPC分类号： G01N30/06 ,  G01N1/28 ,  G01N30/20 ,  G01N30/36 ,  G01N30/34

CPC分类号： G01N1/28 ,  G01N30/20 ,  G01N30/36 ,  G01N2030/202 ,  G01N2030/207 ,  G01N2030/342

摘要： A method and a system for introducing a sample into a mobile phase of a chromatography system is provided. The method includes initially directing the mobile phase directly into a separation unit of the chromatography system, bypassing a sample loop, the mobile phase including a combined solvent, metered from a pressurized first solvent and a second solvent; loading the sample into the sample loop, while the mobile phase continues to be directed directly into the separation unit; pressurizing the sample in the sample loop with the pressurized first solvent, while the mobile phase continues to be directed directly into the separation unit; and switching the sample loop into the mobile phase, thereby introducing the pressurized sample to the separation unit.

公开(公告)号：US09435773B2

公开(公告)日：2016-09-06

申请号：US13375884

申请日：2009-06-03

申请人： Bernd Glatz ,  Wolfgang Kretz

发明人： Bernd Glatz ,  Wolfgang Kretz

IPC分类号： G01N30/20 ,  G01N30/32 ,  G01N30/36 ,  G01N30/02

CPC分类号： G01N30/20 ,  G01N30/32 ,  G01N30/36 ,  G01N2030/027 ,  G01N2030/207

摘要： A sample injector (200) for use in a fluid separation system (10) for separating compounds of a fluidic sample in a mobile phase, the sample injector (200) comprising a switchable valve (202), a sample loop (204) in fluid communication with the valve (202) and configured for receiving the fluidic sample, a metering device (206) in fluid communication with the sample loop (204) and configured for introducing a metered amount of the fluidic sample on the sample loop (204), and a control unit (208) configured for controlling switching of the valve (202) to transfer the sample loop (204) between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device (206) during the intermediate state to at least partially equilibrate a pressure difference in the sample loop (204) between the low pressure state and the high pressure state.

摘要翻译： 一种用于流体分离系统（10）的样品注射器（200），用于分离流动相中的流体样品的化合物，样品注射器（200）包括可切换阀（202），流体中的样品环（204） 与所述阀（202）的连通并且被配置为接收流体样品;计量装置（206），其与所述样品环（204）流体连通并且被配置用于将计量量的所述流体样品引入所述样品环（204）上， 以及控制单元（208），其被配置为用于控制所述阀（202）的切换以经由中间状态在低压状态和高压状态之间传送所述样品回路（204），并且用于在所述中间状态期间控制所述计量装置（206） 中间状态以至少部分平衡低压状态和高压状态之间的样品回路（204）中的压力差。