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    MICROORGANISMS AND METHODS FOR CONVERSION OF SYNGAS AND OTHER CARBON SOURCES TO USEFUL PRODUCTS
    195.
    发明申请
    MICROORGANISMS AND METHODS FOR CONVERSION OF SYNGAS AND OTHER CARBON SOURCES TO USEFUL PRODUCTS 审中-公开
    将有关产品转化为基质和其他碳源的微生物和方法

    公开(公告)号：US20140147900A1

    公开(公告)日：2014-05-29

    申请号：US13920927

    申请日：2013-06-18

    Applicant: Genomatica, Inc.

    Inventor： John D. Trawick ,  Mark J. Burk ,  Anthony P. Burgard

    IPC: C12P7/18

    CPC classification number: C12P7/18 ,  C12N9/0006 ,  C12N9/10 ,  C12N9/1029 ,  C12N9/88 ,  C12N15/52 ,  C12P7/04 ,  C12P7/42

    Abstract: A non-naturally occurring microbial organism having an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway includes at least one exogenous nucleic acid encoding an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway enzyme expressed in a sufficient amount to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol. The aforementioned organisms are cultured to produce isopropanol, 4-hydroxybutryate, or 1,4-butanediol.

    Abstract translation: 具有异丙醇，4-羟基丁酸酯或1,4-丁二醇途径的非天然存在的微生物包括至少一种编码以足够量表达的异丙醇，4-羟基丁酸酯或1,4-丁二醇途径酶的外源核酸 产生异丙醇，4-羟基丁酸酯或1,4-丁二醇。 培养上述生物体以产生异丙醇，4-羟基丁酸酯或1,4-丁二醇。

    METHODS AND ORGANISMS FOR THE GROWTH-COUPLED PRODUCTION OF 1,4-BUTANEDIOL
    196.
    发明申请
    METHODS AND ORGANISMS FOR THE GROWTH-COUPLED PRODUCTION OF 1,4-BUTANEDIOL 审中-公开
    用于1,4-丁二醇的生长联合生产的方法和有机体

    公开(公告)号：US20140030780A1

    公开(公告)日：2014-01-30

    申请号：US13914422

    申请日：2013-06-10

    Applicant: Anthony P. BURGARD ,  Stephen J. Van Dien ,  Mark J. Burk

    Inventor： Anthony P. BURGARD ,  Stephen J. Van Dien ,  Mark J. Burk

    IPC: C12P7/18

    CPC classification number: C12P7/18 ,  B01D3/002 ,  C12N9/0006

    Abstract: The invention provides a non-naturally occurring microorganism comprising one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory to coupling 1,4-butanediol production to growth of the microorganism when the gene disruption reduces an activity of the enzyme, whereby the one or more gene disruptions confers stable growth-coupled production of 1,4-butanediol onto the non-naturally occurring microorganism. The microorganism can further comprise a gene encoding an enzyme in a 1,4-butanediol (BDO) biosynthetic pathway. The invention additionally relates to methods of using microorganisms to produce BDO.

    Abstract translation: 本发明提供了包含一种或多种基因破坏的非天然存在的微生物，所述一个或多个基因破坏发生在编码需要将1,4-丁二醇生产偶联以生产微生物的酶的基因发生在基因破坏时降低活性 该酶，其中一个或多个基因破坏赋予非天然存在的微生物上1,4-丁二醇稳定的生长偶联产生。 微生物还可以包含编码1,4-丁二醇（BDO）生物合成途径中的酶的基因。 本发明还涉及使用微生物来生产BDO的方法。

    Methods for increasing product yields
    197.
    发明授权
    Methods for increasing product yields 有权
    提高产品产量的方法

    公开(公告)号：US08637286B2

    公开(公告)日：2014-01-28

    申请号：US13011818

    申请日：2011-01-21

    Applicant: Anthony P. Burgard ,  Robin E. Osterhout ,  Jun Sun ,  Priti Pharkya

    Inventor： Anthony P. Burgard ,  Robin E. Osterhout ,  Jun Sun ,  Priti Pharkya

    IPC: C12N9/00 ,  C12N1/20

    CPC classification number: C12P7/42 ,  C12N9/0008 ,  C12N9/0095 ,  C12P7/04 ,  C12P7/16 ,  C12P7/18 ,  C12P7/52 ,  Y02E50/10

    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includes culturing this organism for a sufficient period of time to produce a product.

    Abstract translation: 非天然存在的微生物体包括具有还原性TCA或Wood-Ljungdahl途径的微生物生物体，其中至少一种编码这些途径酶的外源核酸以足够的量表达以增强通过乙酰辅酶A的碳通量。 通过乙酰辅酶A增强碳通量的方法包括在条件和足够的时间段内培养这些非天然存在的微生物，以产生具有乙酰辅酶A作为结构单元的产物。 另一种非天然存在的微生物生物体包括至少一种编码以足够量表达的酶的外源核酸，以增强在一氧化碳或氢气存在下还原当量的可用性，从而通过碳水化合物 - 碳原料。 在一氧化碳或氢气存在下增强还原当量的可用性的方法包括在足够的时间内培养该生物体以产生产物。

    METHODS FOR INCREASING PRODUCT YIELDS
    198.
    发明申请
    METHODS FOR INCREASING PRODUCT YIELDS 审中-公开
    增加产品线的方法

    公开(公告)号：US20140011249A1

    公开(公告)日：2014-01-09

    申请号：US13889056

    申请日：2013-05-07

    Applicant: Genomatica, Inc.

    Inventor： Anthony P. BURGARD ,  Robin E. Osterhout ,  Jun Sun ,  Priti Pharkya

    IPC: C12P7/42 ,  C12P7/04 ,  C12P7/18

    CPC classification number: C12P7/42 ,  C12N9/0008 ,  C12N9/0095 ,  C12P7/04 ,  C12P7/16 ,  C12P7/18 ,  C12P7/52 ,  Y02E50/10

    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through acetyl-CoA. A method for enhancing carbon flux through acetyl-CoA includes culturing theses non-naturally occurring microbial organisms under conditions and for a sufficient period of time to produce a product having acetyl-CoA as a building block. Another non-naturally occurring microbial organism includes at least one exogenous nucleic acid encoding an enzyme expressed in a sufficient amount to enhance the availability of reducing equivalents in the presence of carbon monoxide or hydrogen, thereby increasing the yield of redox-limited products via carbohydrate-based carbon feedstock. A method for enhancing the availability of reducing equivalents in the presence of carbon monoxide or hydrogen includes culturing this organism for a sufficient period of time to produce a product.

    Abstract translation: 非天然存在的微生物体包括具有还原性TCA或Wood-Ljungdahl途径的微生物生物体，其中至少一种编码这些途径酶的外源核酸以足够的量表达以增强通过乙酰辅酶A的碳通量。 通过乙酰辅酶A增强碳通量的方法包括在条件和足够的时间段内培养这些非天然存在的微生物，以产生具有乙酰辅酶A作为结构单元的产物。 另一种非天然存在的微生物生物体包括至少一种编码以足够量表达的酶的外源核酸，以增强在一氧化碳或氢气存在下还原当量的可用性，从而通过碳水化合物 - 碳原料。 在一氧化碳或氢气存在下增强还原当量的可用性的方法包括在足够的时间内培养该生物体以产生产物。

    Microorganisms for the production of adipic acid and other compounds
    199.
    发明授权
    Microorganisms for the production of adipic acid and other compounds 有权
    用于生产己二酸等化合物的微生物

    公开(公告)号：US08592189B2

    公开(公告)日：2013-11-26

    申请号：US13525129

    申请日：2012-06-15

    Applicant: Anthony P. Burgard ,  Priti Pharkya ,  Robin E. Osterhout

    Inventor： Anthony P. Burgard ,  Priti Pharkya ,  Robin E. Osterhout

    IPC: C12P7/44 ,  C12N1/20

    CPC classification number: C12N15/52 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/1096 ,  C12N9/80 ,  C12N9/88 ,  C12P7/44 ,  C12P7/46 ,  C12P7/62 ,  C12P13/001 ,  C12P13/005 ,  C12P13/02 ,  C12P17/10 ,  C12Y101/01035 ,  C12Y102/0101 ,  C12Y103/01031 ,  C12Y206/01 ,  C12Y402/01

    Abstract: The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in the respective adipate, 6-aminocaproic acid or caprolactam pathway. The invention additionally provides a method for producing adipate, 6-aminocaproic acid or caprolactam. The method can include culturing an adipate, 6-aminocaproic acid or caprolactam producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an adipate, 6-aminocaproic acid or caprolactam pathway enzyme in a sufficient amount to produce the respective product, under conditions and for a sufficient period of time to produce adipate, 6-aminocaproic acid or caprolactam.

    Abstract translation: 本发明提供了具有己二酸，6-氨基己酸或己内酰胺途径的非天然存在的微生物。 微生物生物体含有至少一种编码相应己二酸，6-氨基己酸或己内酰胺途径中的酶的外源核酸。 本发明另外提供了生产己二酸，6-氨基己酸或己内酰胺的方法。 该方法可以包括培养己二酸，6-氨基己酸或己内酰胺生产微生物，其中微生物生物体表达至少一种编码己二酸，6-氨基己酸或己内酰胺途径酶的外源核酸，其量足以产生相应的产物 在条件下和足够的时间内生产己二酸，6-氨基己酸或己内酰胺。

    Methods and organisms for the growth-coupled production of 1,4-butanediol
    200.
    发明授权
    Methods and organisms for the growth-coupled production of 1,4-butanediol 有权
    用于1,4-丁二醇生长偶联生产的方法和生物

    公开(公告)号：US08470582B2

    公开(公告)日：2013-06-25

    申请号：US13065303

    申请日：2011-03-18

    Applicant: Anthony P. Burgard ,  Stephen J. Van Dien ,  Mark J. Burk

    Inventor： Anthony P. Burgard ,  Stephen J. Van Dien ,  Mark J. Burk

    IPC: C12N1/20

    CPC classification number: C12P7/18 ,  B01D3/002 ,  C12N9/0006

    Abstract: The invention provides a non-naturally occurring microorganism comprising one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory to coupling 1,4-butanediol production to growth of the microorganism when the gene disruption reduces an activity of the enzyme, whereby the one or more gene disruptions confers stable growth-coupled production of 1,4-butanediol onto the non-naturally occurring microorganism. The microorganism can further comprise a gene encoding an enzyme in a 1,4-butanediol (BDO) biosynthetic pathway. The invention additionally relates to methods of using microorganisms to produce BDO.

    Abstract translation: 本发明提供了包含一种或多种基因破坏的非天然存在的微生物，所述一个或多个基因破坏发生在编码需要将1,4-丁二醇生产偶联以生产微生物的酶的基因发生在基因破坏时降低活性 该酶，其中一个或多个基因破坏赋予非天然存在的微生物上1,4-丁二醇稳定的生长偶联产生。 微生物还可以包含编码1,4-丁二醇（BDO）生物合成途径中的酶的基因。 本发明还涉及使用微生物来生产BDO的方法。

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