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191.发明授权Method of fabricating an implantable medical device using gel extrusion and charge induced orientation 有权使用凝胶挤出和电荷诱导取向制造可植入医疗器械的方法公开(公告)号：US09023262B2
公开(公告)日：2015-05-05
申请号：US13873097
申请日：2013-04-29
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Bin Huang , David C. Gale
CPC classification number: A61L31/00 , A61F2/82 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , B29C47/0026 , B29C47/8835 , B29C47/887 , B29C47/8895
Abstract: The invention provides a method of manufacturing a polymeric implantable medical device using gel extrusion of high molecular weight polymers or charge-induced orientation to avoid heat degradation of the polymer that might occur during conventional heat extrusion.
Abstract translation: 本发明提供了使用高分子量聚合物或电荷诱导取向的凝胶挤出制造聚合物可植入医疗装置的方法，以避免在常规热挤压期间可能发生的聚合物的热降解。
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公开(公告)号：US08998679B2
公开(公告)日：2015-04-07
申请号：US14280471
申请日：2014-05-16
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Bin Huang , David C. Gale , Daniel Castro , Timothy A. Limon
CPC classification number: A61F2/82 , A61F2/91 , A61L2400/18 , C08J7/02
Abstract: Methods of treating the polymeric surfaces of a stent with a fluid including a solvent for the surface polymer are disclosed.
Abstract translation: 公开了一种用包括用于表面聚合物的溶剂的流体处理支架的聚合物表面的方法。
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公开(公告)号：US20150094616A1
公开(公告)日：2015-04-02
申请号：US14499856
申请日：2014-09-29
Applicant: Abbott Cardiovascular Systems, Inc.
Inventor： John A. Simpson , Jeffrey F. Dooley
IPC: A61M25/09
CPC classification number: A61M25/09 , A61M2025/09108 , A61M2025/09133 , A61M2025/0915 , A61M2025/09175 , Y10T29/49
Abstract: Guide wires including a guide wire tip portion including a distal tip portion and a proximal tip portion, where the tip portion includes a circular cross-section and substantially constant diameter along both a linear elastic distal tip portion and a superelastic proximal tip portion. Methods for manufacture include providing a superelastic wire (e.g., nitinol) including a length so as to define both a distal tip portion and a proximal tip portion. The distal tip portion is cold worked, without imparting significant cold work to the proximal tip portion, to provide linear elastic properties within the distal tip portion, while the proximal tip portion maintains superelastic properties. The tip portion is ground or otherwise reduced in cross-sectional thickness after cold working of the distal tip portion, so as to provide a circular cross-section having a desired substantially constant diameter along both the distal tip portion and the proximal tip portion.
Abstract translation: 引导线，其包括包括远侧末端部分和近端部分的导丝末端部分，其中所述尖端部分包括具有圆形横截面且沿直线弹性远端尖端部分和超弹性近端部部分具有基本上恒定的直径。 制造方法包括提供包括长度的超弹性线（例如镍钛诺），以便限定远侧末端部分和近端部分。 远侧末端部分被冷加工，而不会对近侧尖端部分施加显着的冷作用，以在远侧末端部分内提供线性弹性特性，而近侧尖端部分保持超弹性。 在远端部分的冷加工之后，尖端部分被研磨或以其它方式减小横截面厚度，以便提供沿着远侧末端部分和近端部分具有期望的基本上恒定的直径的圆形横截面。
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公开(公告)号：US08992817B2
公开(公告)日：2015-03-31
申请号：US13709765
申请日：2012-12-10
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Barbara E. Stamberg
CPC classification number: A61B17/12109 , A61B17/00008 , A61B17/12031 , A61B17/12045 , A61B17/12136 , A61B2017/00526 , A61B2017/00889 , A61B2017/00893 , A61B2017/12127 , A61L29/04 , A61L29/14 , A61L29/148 , A61L29/16 , A61L2400/12 , A61M25/10 , A61M25/1029 , A61M2025/105 , D01D5/0007 , D01D5/0023 , D01D5/0076
Abstract: The disclosed subject matter describes systems and methods of electrospinning a fiber for a variety of applications. An exemplary embodiment includes a medical device application for delivering a therapeutic agent, such as a sclerosing agent, to the walls of a blood vessel to perform sclerotherapy. A method of fabricating a medical balloon comprises charging a polymer material with an electric voltage, dispensing the charged polymeric material through a nozzle, collecting the charged polymeric material on a grounded mandrel, wherein the mandrel includes a tubular body having a plurality of openings extending through the tubular body, and forming an electrospun medical balloon defined by a body having a varied thickness.
Abstract translation: 所公开的主题描述了用于各种应用的静电纺丝的系统和方法。 示例性实施例包括用于将诸如硬化剂的治疗剂递送到血管的壁以执行硬化疗法的医疗装置应用。 一种制造医用气囊的方法包括用电压对聚合物材料进行充电，通过喷嘴分配带电的聚合物材料，在接地的心轴上收集带电的聚合物材料，其中心轴包括管状体，其具有延伸穿过的多个开口 并且形成由具有不同厚度的主体限定的电纺医疗气囊。
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公开(公告)号：US20150083272A1
公开(公告)日：2015-03-26
申请号：US14557057
申请日：2014-12-01
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： STEPHEN D. PACETTI
IPC: B65B3/00 , A61K31/573 , A61K31/436
CPC classification number: B65B3/003 , A61F2/91 , A61F2250/0068 , A61K31/436 , A61K31/573 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2300/602
Abstract: A method of loading a composition into a structural element of a stent, where the structural element is defined by a lumen and at least one opening to access the lumen. The composition may comprise a therapeutic agent, and wherein at a temperature of 30° C. and at one atmosphere, the composition may be in a solid state or semi-solid state.
Abstract translation: 一种将组合物装载到支架的结构元件中的方法，其中结构元件由腔和至少一个开口限定，以进入内腔。 组合物可以包含治疗剂，并且其中在30℃的温度和一个大气压下，组合物可以是固态或半固体状态。
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Patent Agency Ranking
公开(公告)号：US20150081000A1
公开(公告)日：2015-03-19
申请号：US14484943
申请日：2014-09-12
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Syed Faiyaz Ahmed Hossainy , John E. Papp , Joel Harrington
CPC classification number: A61L31/148 , A61F2/88 , A61F2/90 , A61F2/966 , A61F2002/826 , A61F2002/9517 , A61F2250/0018 , A61F2250/0031 , A61F2250/0039 , A61F2250/0067 , A61L31/128 , C08L67/04
Abstract: A braided polymeric scaffold, made at least in part from a bioresorbable material is deployed on a catheter that uses a push-pull mechanism to deploy the scaffold. A drug coating is disposed on the scaffold. A plurality of scaffold segments on a catheter is also disclosed.
Abstract translation: 至少部分由生物可吸收材料制成的编织聚合物支架部署在使用推拉机构部署支架的导管上。 药物涂层设置在支架上。 还公开了导管上的多个支架段。
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197.发明申请METHODS FOR INCREASING A RETENTION FORCE BETWEEN A POLYMERIC SCAFFOLD AND A DELIVERY BALLOON 审中-公开增加聚合物和交付气泡之间的保持力的方法公开(公告)号：US20150059960A1
公开(公告)日：2015-03-05
申请号：US14535246
申请日：2014-11-06
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Lily Ayo Roberts , Sean A. McNiven , Kathleen Yan , Boyd V. Knott , Jeremy B. Beer , Mark C. Johnson
CPC classification number: B29B11/04 , A61F2/2436 , A61F2/915 , A61F2/958 , A61F2002/9522 , A61F2002/9583 , A61F2250/0067 , A61L31/00 , B29C55/24 , B29C65/66 , B29C65/7817 , B29C66/532 , B29C66/63 , B29C66/71 , B29C66/73117 , B29C66/73791 , B29C66/91411 , B29C66/91421 , B29C66/91945 , B29C66/92445 , B29C66/9292 , B29C66/92921 , B29C66/949 , B29C67/0014 , B29C2793/0009 , B29K2101/00 , B29L2028/00 , B29L2031/7534 , B29L2031/7543 , B29K2067/046 , B29K2067/043
Abstract: A medical device-includes a scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes inflating the delivery balloon during a diameter reduction to improve scaffold retention and maintaining an inflated balloon during the diameter reduction and prior and subsequent dwell periods.
Abstract translation: 一种医疗装置 - 包括卷曲到具有膨胀气囊的导管的支架。 支架通过包括在直径减小期间使输送气囊膨胀的方法卷曲到气囊，以改善支架保持并在直径减小期间和之前和随后的停留期间保持充气气囊。
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公开(公告)号：US20150057743A1
公开(公告)日：2015-02-26
申请号：US14528235
申请日：2014-10-30
Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.
Inventor： Diem Uyen Ta , David Chi , Svava Maria Altadottir , Bjorn Svensson
IPC: A61F2/82
CPC classification number: A61F2/82 , A61F2/91 , A61F2/915 , A61F2002/91508 , A61F2002/91525 , A61F2002/91558 , A61F2002/91575 , A61F2230/0013 , A61F2250/0029
Abstract: An expandable stent for implanting in a body lumen, such as a coronary artery, peripheral artery, or other body lumen. In one aspect, the stent includes a butterfly pattern to which connecting links are attached. In another aspect, the stent embodies a non-directional structure. One embodiment is a stent in which one or both ends are more flexible than the center portion. Also, the stent may have a non-uniform drug coating. Another embodiment relates to a stent having ends that are more radiopaque than the center portion.
Abstract translation: 用于植入体腔（例如冠状动脉，外周动脉或其他体腔）的可扩张支架。 在一个方面，支架包括连接连接件的蝶形图案。 另一方面，支架体现了非方向性结构。 一个实施例是其中一端或两端比中心部分更柔性的支架。 此外，支架可能具有不均匀的药物涂层。 另一实施例涉及具有比中心部分更不透射线的端部的支架。
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199.发明申请METHOD TO MINIMIZE MOLECULAR WEIGHT DROP OF POLY(L-LACTIDE) STENT DURING PROCESSING 审中-公开在加工过程中最小化聚（L-LACTIDE）STENT分子量降低的方法公开(公告)号：US20150054202A1
公开(公告)日：2015-02-26
申请号：US14530151
申请日：2014-10-31
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Byron Lambert , Yunbing Wang , James Oberhauser
CPC classification number: B29C47/0076 , A61F2/82 , A61L31/041 , A61L31/06 , A61L31/143 , A61L31/148 , B29D23/20 , B29K2005/00 , B29L2023/20 , B29L2031/753 , C08J3/28 , C08J2367/04 , C08L67/04
Abstract: A method to reduce or minimize the reduction in molecular weight of a stent during processing is disclosed. The stent has a scaffolding including a polymer formulation comprising PLLA and polymandelide. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing.
Abstract translation: 公开了减少或最小化处理期间支架分子量降低的方法。 支架具有包括PLLA和聚扁桃酸酯的聚合物制剂的脚手架。 聚对苯二甲酸丁二醇酯降低加工过程中的分子量下降，特别是在灭菌过程中。 支架支架还可包括一种或多种附加的稳定剂，其另外降低加工过程中的分子量下降。
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200.发明申请公开(公告)号：US20150051690A1
公开(公告)日：2015-02-19
申请号：US14530535
申请日：2014-10-31
Applicant: Abbott Cardiovascular Systems Inc.
Inventor： Krashnankutty Sudhir , Wai-Fung Cheong , Virginia Giddings
CPC classification number: A61L31/148 , A61F2/04 , A61F2/82 , A61F2/91 , A61F2/958 , A61F2/962 , A61F2/966 , A61F2210/0004 , A61F2250/0059 , A61F2250/0082 , A61F2250/009 , A61L31/06 , A61L31/16
Abstract: Methods of treating congenital heart defects in infants and children with bioabsorbable polymer stents are described. The treatments reduce or eliminate the adverse affects of congenital heart defects or may be palliative.
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