COMPOSITIONS AND METHODS FOR MODULATING CELL-CELL FUSION VIA INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS
    192.
    发明申请
    COMPOSITIONS AND METHODS FOR MODULATING CELL-CELL FUSION VIA INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS 审中-公开
    通过中介型钙激活钾通道调节细胞融合的组合物和方法

    公开(公告)号:US20110300152A1

    公开(公告)日:2011-12-08

    申请号:US13128290

    申请日:2009-11-10

    CPC classification number: C07K14/705

    Abstract: Compositions and methods are provided for modulating cell-cell fusion by using agents that modulate expression, activity, or function of intermediate-conductance calcium-activated potassium (SK4) channel. In some embodiments, the compositions and methods of the invention provide for inhibition of multi-nucleated osteoclastogenesis and cell-cell fusion, especially cell fusion involving macrophages. In such embodiments, the compositions can comprise inhibitory nucleic acids, monoclonal antibodies or small molecule inhibitors of the SK4 channels and find use in preventing and/or treating various diseases or disorders including bone loss, autoimmune and inflammatory diseases or disorders, implant and transplant rejection, and cancer metastasis. In other embodiments, the compositions and methods of the invention provide for activation of cell-cell fusion. Also provided are methods to screen for SK4 channel modulators (inhibitors or activators) that modulate cell-cell fusion, particularly macrophage cell fusion.

    Abstract translation: 提供了通过使用调节中间电导钙激活钾(SK4)通道的表达,活性或功能的试剂来调节细胞 - 细胞融合的组合物和方法。 在一些实施方案中,本发明的组合物和方法提供了抑制多核破骨细胞发生和细胞 - 细胞融合,特别是涉及巨噬细胞的细胞融合。 在这样的实施方案中,组合物可以包含SK4通道的抑制性核酸,单克隆抗体或小分子抑制剂,并且可用于预防和/或治疗各种疾病或病症,包括骨丢失,自身免疫和炎性疾病或病症,植入物和移植排斥 ,和癌转移。 在其它实施方案中,本发明的组合物和方法提供细胞 - 细胞融合的活化。 还提供了筛选调节细胞融合,特别是巨噬细胞融合的SK4通道调节剂(抑制剂或活化剂)的方法。

    Method and System for User Equipment Location Determination on a Wireless Transmission System
    193.
    发明申请
    Method and System for User Equipment Location Determination on a Wireless Transmission System 有权
    无线传输系统用户设备位置确定方法与系统

    公开(公告)号:US20110286349A1

    公开(公告)日:2011-11-24

    申请号:US13147272

    申请日:2010-02-05

    CPC classification number: G01S5/10 H04L5/0007 H04W4/02 H04W24/10 H04W64/00

    Abstract: Neighbor cell hearability can be improved by including an additional reference signal that can be detected at a low sensitivity and a low signal-to-noise ratio, by introducing non-unity frequency reuse for the signals used for a time difference of arrival (TDOA) measurement, e.g., orthogonality of signals transmitted from the serving cell sites and the various neighbor cell sites. The new reference signal, called the TDOA-RS, is proposed to improve the hearability of neighbor cells in a cellular network that deploys 3GPP EU-TRAN (LTE) system, and the TDOA-RS can be transmitted in any resource blocks (RB) for POSCH and/or MBSFN subframe, regardless of whether the latter is on a carrier supporting both PMCH and POSCH or not. Besides the additional TDOA-RS reference signal, an additional synchronization signal (TDOA-sync) may also be included to improve the hearability of neighbor cells.

    Abstract translation: 通过对于用于到达时差(TDOA)的信号引入非单位频率重用,可以通过包括可以在低灵敏度和低信噪比下检测的附加参考信号来提高邻近小区的可听性, 测量,例如从服务小区站点和各个相邻小区站点发送的信号的正交性。 提出了称为TDOA-RS的新参考信号,以提高部署3GPP EU-TRAN(LTE)系统的蜂窝网络中相邻小区的可听性,并且可以在任何资源块(RB)中传输TDOA-RS, 用于POSCH和/或MBSFN子帧,而不管后者是否在支持PMCH和POSCH的载波上。 除了附加的TDOA-RS参考信号之外,还可以包括附加同步信号(TDOA-sync)以提高相邻小区的可听性。

    METHOD AND APPARATUS FOR EXCHANGING MEDIA SERVICE QUERIES
    194.
    发明申请
    METHOD AND APPARATUS FOR EXCHANGING MEDIA SERVICE QUERIES 有权
    交换媒体服务查询的方法和装置

    公开(公告)号:US20110276557A1

    公开(公告)日:2011-11-10

    申请号:US13138093

    申请日:2009-12-23

    CPC classification number: G06F17/30038 G06F17/30277 G06F17/30398

    Abstract: A user accessing a media service desires to find out more information about the media service by formulating a query, by operation of an input device, where a region of interest of said media service is selected by the user. The query is submitted to other users who are defined by various tiers defined by different types of criteria. The users belonging to such tiers respond back to the query with new information, which is rendered on the media device being used by the user. Such responses are then rendered on the media device of the user. Optionally, a computer assistance mode is operated where keywords are extracted from said communications between users, and such keywords a used to obtain additional results from a resource such as a search engine.

    Abstract translation: 访问媒体服务的用户期望通过操作输入设备,通过用户选择所述媒体服务的感兴趣区域来制定查询来查找关于媒体服务的更多信息。 该查询被提交给由不同类型的标准定义的各个层定义的其他用户。 属于这些层的用户利用在用户使用的媒体设备上呈现的新信息来回应该查询。 然后将这样的响应呈现在用户的媒体设备上。 可选地,运行计算机辅助模式,其中从用户之间的所述通信中提取关键字,并且这种关键字a用于从诸如搜索引擎的资源获得附加结果。

    Method and system for transmitting in TDM mode
    195.
    发明授权
    Method and system for transmitting in TDM mode 有权
    用于TDM模式传输的方法和系统

    公开(公告)号:US08050294B2

    公开(公告)日:2011-11-01

    申请号:US12515799

    申请日:2007-11-21

    CPC classification number: H04J3/1605 H04J3/062 H04J3/12 H04L49/901

    Abstract: A method for transmitting data in TDM mode is provided to solve the problem in the prior art that the data processing between a transmitter side and a receiver side could not be real time and the delay time during data transmitting would be longer. The method comprises: packaging TIME DIVISION MULTIPLEXING (TDM) frame head information and data to be sent into a TDM frame at a transmitter side, and transmitting the TDM frame to a receiver side; receiving the TDM frame at the receiver side. With the solution according to the present invention, it is possible to perform real time data processing between the transmitter side and the receiver side and shorten the delay time during data transmitting.

    Abstract translation: 提供了一种以TDM模式发送数据的方法,以解决现有技术中发射机侧和接收机侧之间的数据处理不能实时且数据发送期间的延迟时间更长的问题。 该方法包括:将时分多路复用(TDM)帧头信息和要发送到发送机侧的TDM帧的数据进行包装,并将TDM帧发送到接收机侧; 在接收机侧接收TDM帧。 利用根据本发明的解决方案,可以在发送机侧和接收机侧之间执行实时数据处理,并缩短数据发送期间的延迟时间。

    METHODS FOR OBTAINING TERMINAL MULTICASTS STATUS
    196.
    发明申请
    METHODS FOR OBTAINING TERMINAL MULTICASTS STATUS 失效
    用于获取终端多态性状态的方法

    公开(公告)号:US20110213868A1

    公开(公告)日:2011-09-01

    申请号:US12737095

    申请日:2009-06-05

    CPC classification number: H04L12/185

    Abstract: The present invention provides a method for sending a message to a network device with a specific MAC address, in an IP network implementing a interne group management protocol IGMP, comprising: sending, by a network terminal, to the network device, a multicast group management status message including a destination address set as the specific MAC address.

    Abstract translation: 本发明提供了一种在实现国际组织管理协议IGMP的IP网络中向具有特定MAC地址的网络设备发送消息的方法,包括:由网络终端向网络设备发送组播组管理 状态消息,包括设置为特定MAC地址的目的地址。

    Hierarchical stochastic analysis process optimization for integrated circuit design and manufacture
    197.
    发明授权
    Hierarchical stochastic analysis process optimization for integrated circuit design and manufacture 失效
    集成电路设计制造的分层随机分析过程优化

    公开(公告)号:US08005660B2

    公开(公告)日:2011-08-23

    申请号:US11823601

    申请日:2007-06-27

    Abstract: An Integrated Circuit Design tool incorporating a Stochastic Analysis Process (“SAP”) is described. The SAP can be applied on many levels of circuit components including transistor devices, logic gate devices, and System-on-Chip or chip designs. The SAP replaces the large number of traditional Monte Carlo simulations with operations using a small number of sampling points or corners. The SAP is a hierarchical approach using a model fitting process to generate a model that can be used with any number of performance metrics to generate performance variation predictions along with corresponding statistical information (e.g., mean, three-sigma probability, etc.). A hierarchical SAP process breaks an overall circuit into a plurality of subcircuits and performs circuit simulation and SAP analysis steps on each subcircuit. An integration and reduction process combines the analysis results of each subcircuit, and a final SPICE/SAP process provides a model for the overall circuit based on the subcircuits.

    Abstract translation: 描述了结合随机分析过程(“SAP”)的集成电路设计工具。 SAP可以应用于许多级别的电路组件,包括晶体管器件,逻辑门器件和片上系统或芯片设计。 SAP通过使用少量采样点或角落的操作替代了大量传统的蒙特卡罗模拟。 SAP是使用模型拟合过程生成可以与任何数量的性能度量一起使用以产生性能变化预测以及相应的统计信息(例如,平均三西格玛概率等)的模型的分层方法。 分层SAP流程将整个电路分解成多个子电路,并在每个子电路上执行电路仿真和SAP分析步骤。 集成和减少流程结合了每个子电路的分析结果,最终的SPICE / SAP流程为基于子电路的整个电路提供了一个模型。

    Multicast mesh routing protocol
    198.
    发明授权
    Multicast mesh routing protocol 有权
    组播网状路由协议

    公开(公告)号:US07961646B2

    公开(公告)日:2011-06-14

    申请号:US11919099

    申请日:2005-04-25

    Abstract: A method for a node to select a route to join a multicast group in a wireless mesh network, including establishing the route between the node and the multicast group using media access control addresses is described. A method for determining a multicast group leader of the multicast group of a wireless mesh network using media access control addresses is also described.

    Abstract translation: 描述了节点选择在无线网状网络中加入组播组的路由的方法,包括使用媒体接入控制地址建立节点与组播组之间的路由。 还描述了使用媒体访问控制地址来确定无线网状网络的多播组的多播组组长的方法。

    METHOD AND APPARATUS FOR FEC ENCODING AND DECODING
    199.
    发明申请
    METHOD AND APPARATUS FOR FEC ENCODING AND DECODING 有权
    FEC编码和解码的方法和装置

    公开(公告)号:US20110099449A1

    公开(公告)日:2011-04-28

    申请号:US12734536

    申请日:2008-11-04

    Abstract: A method for Forward Error Correction (FEC) encoding in a transmitter, the method comprising: receiving a data stream from a data source; generating a first Forward Error Correction data for respective data block with a first block size of the data stream; and generating a second Forward Error Correction data for respective data block with a second block size of the data stream, wherein the second block size is different with the first block size and wherein the data blocks of the first block size form the data stream, and the data blocks with the second block size form the data stream.

    Abstract translation: 一种在发射机中进行前向纠错(FEC)编码的方法,所述方法包括:从数据源接收数据流; 为所述数据流的第一块大小生成相应数据块的第一前向纠错数据; 以及生成具有所述数据流的第二块大小的相应数据块的第二前向纠错数据,其中所述第二块大小与所述第一块大小不同,并且其中所述第一块大小的数据块形成所述数据流,以及 具有第二块大小的数据块形成数据流。

    System and Method for Supporting Multi-User Antenna Beamforming in a Cellular Network
    200.
    发明申请
    System and Method for Supporting Multi-User Antenna Beamforming in a Cellular Network 有权
    在蜂窝网络中支持多用户天线波束成形的系统和方法

    公开(公告)号:US20110081943A1

    公开(公告)日:2011-04-07

    申请号:US12997061

    申请日:2009-06-24

    CPC classification number: H04W52/58 H04W52/346 H04W52/42 H04W72/046

    Abstract: The present invention is a method and system for supporting a beamforming antenna system in a multiple user mobile broadband communication network including a process for setting and adjusting the magnitude and phase of the signal to user equipment from each antenna. Namely, the present invention supports the communication of power signal values or levels to user equipment in a manner that keeps pace with the rapid variations of the power levels that occur in the dynamic scheduling of transmissions on the cell site. The present invention satisfies this need for an improved signal strength signaling to user equipment for the situation where multiple users are located on the cell site.

    Abstract translation: 本发明是一种用于在多用户移动宽带通信网络中支持波束成形天线系统的方法和系统,包括用于从每个天线设置和调整到用户设备的信号的幅度和相位的过程。 也就是说,本发明支持以与在小区站点上的传输的动态调度中发生的功率电平的快速变化相一致的方式来向用户设备通信电力信号值或电平。 本发明满足了对于多个用户位于小区站点上的情况,对用户设备的改进的信号强度信令的满足。

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