公开(公告)号：US20110024331A1

公开(公告)日：2011-02-03

申请号：US12533180

申请日：2009-07-31

Applicant: Sunil Srinivasa Murthy ,  Aaron Joseph Dulgar-Tulloch ,  James William Bray ,  Shankar Chandrasekaran ,  Arvind Kumar Tiwari

Inventor： Sunil Srinivasa Murthy ,  Aaron Joseph Dulgar-Tulloch ,  James William Bray ,  Shankar Chandrasekaran ,  Arvind Kumar Tiwari

IPC: B03C1/01

CPC classification number: B03C1/288 ,  B03C1/0332 ,  B03C1/0335 ,  B03C2201/18 ,  B03C2201/26

Abstract: The present application discloses a process for the high throughput separation of at least one distinct biological material from a sample using magnetic tags and a magnetic separation set up capable of processing at least about 106 units/second. A magnetic field gradient is used to deflect target material bearing a magnet tag from one laminar flow stream to another so that the magnetically tagged target material exits a separation chamber via a different outlet than the rest of the sample. The process is applicable to isolating several distinct biological materials by directing each via magnetic deflection to its own unique outlet. The application also discloses a system for performing the process and a kit that includes the system and the magnetic tags.

Abstract translation: 本申请公开了一种使用磁性标签和至少能够处理至少约106单位/秒的磁分离装置从至少一种不同的生物材料与样品分离高通量的方法。 使用磁场梯度将具有磁性标签的目标材料从一个层流流转移到另一层，使得磁标记的靶材料通过与样品其余部分不同的出口离开分离室。 该方法适用于通过将每个通过磁偏转指向其自己的独特出口来分离几种不同的生物材料。 本申请还公开了一种用于执行该过程的系统和包括该系统和磁性标签的套件。

公开(公告)号：US20110017600A1

公开(公告)日：2011-01-27

申请号：US12841760

申请日：2010-07-22

Applicant: Thomas R. Larson

Inventor： Thomas R. Larson

IPC: B03C5/02

CPC classification number: B03C1/32 ,  B01D21/26 ,  B03C1/02 ,  B03C1/023 ,  B03C1/0335 ,  B03C1/035 ,  B03C1/30 ,  B03C5/02 ,  B03C2201/18 ,  E21B21/065

Abstract: The present invention discloses a system for separating minerals in drilling fluid based primarily on density. The separator creates and maintains a slurry with a controllable density for separating minerals from drill cuttings. The density if controlled through the use of an electrode array. The separator comprises a primary separation chamber containing the dense slurry, and a multiple number of secondary separation chambers used to separate cuttings from the drilling fluid. The invention also contains inlet hardware allowing the mixed mineral suspension to enter the first separation chamber, and hardware allowing the three outlet (separated) streams to exit the device. One of the three outlet streams carries the minerals that have a density greater than the user selectable density set point, while the second carries the minerals that have a density less than the density set point, and the third carries clean drilling fluid.

Abstract translation: 本发明公开了一种基于密度分离钻井液中矿物的分离系统。 分离器产生并保持具有可控密度的浆料，用于将矿物与钻屑分离。 密度如果通过使用电极阵列进行控制。 分离器包括含有致密浆料的主分离室和用于将切屑与钻井液分离的多个次级分离室。 本发明还包含允许混合矿物悬浮液进入第一分离室的入口硬件以及允许三个出口（分离的）流离开设备的硬件。 三个出口流中的一个携带具有大于用户可选密度设定点的密度的矿物，而第二个输送具有小于密度设定点的密度的矿物，并且第三个携带清洁的钻井液。

公开(公告)号：US20100326909A1

公开(公告)日：2010-12-30

申请号：US12464153

申请日：2009-05-12

Applicant: Michael Vogeser

Inventor： Michael Vogeser

IPC: B01D15/42 ,  G01N33/00 ,  B03C1/00

CPC classification number: B03C1/015 ,  B01L2200/0647 ,  B03C1/288 ,  B03C2201/18 ,  G01N30/08 ,  G01N2030/085 ,  G01N2030/8813 ,  G01N2446/20

Abstract: Described are a device and a method for the manipulation of a liquid sample material in which magnetic microparticles are suspended whereby the microparticles have a functionalized surface and an analyte is bound to the surface. The sample material is introduced into a device with a liquid system through an injection device (50) and in a first mobile phase the sample material is carried to an extractor (90). In a section (97) of the extractor (90) the microparticles are immobilized by means of a magnetic field of a controllable means (96) and separated from the remaining sample material. By switching over of a switching unit (110) a second mobile phase (75) is carried to the extractor (90) and the second mobile phase (75) detaches the adsorbed analyte from the surface of the microparticles. The second mobile phase (75) with the dissolved analyte(s) can be analyzed by way of chromatographic separation (130) and subsequent detection (140).

Abstract translation: 描述了用于操纵其中悬浮磁性微粒的液体样品材料的装置和方法，由此微粒具有官能化表面并且分析物结合到表面。 将样品材料通过注射装置（50）引入具有液体系统的装置中，并且在第一流动相中将样品材料运送到提取器（90）。 在提取器（90）的部分（97）中，微粒通过可控制装置（96）的磁场被固定，并与剩余的样品材料分离。 通过切换开关单元（110），将第二流动相（75）运送到提取器（90），并且第二流动相（75）将吸附的分析物从微粒表面分离。 可以通过色谱分离（130）和随后的检测（140）分析具有溶解的分析物的第二流动相（75）。

公开(公告)号：US20100307981A1

公开(公告)日：2010-12-09

申请号：US12676376

申请日：2008-09-19

Applicant: Ralf Himmelreich ,  Thomas Rothmann

Inventor： Ralf Himmelreich ,  Thomas Rothmann

IPC: B03C1/02 ,  B03C1/28

CPC classification number: B03C1/286 ,  B03C1/01 ,  B03C2201/18

Abstract: The present invention relates to a device and a method for treating liquids with magnetic particles, wherein at least one further central element which ensures collection and homogenization of the particles is additionally provided.

Abstract translation: 本发明涉及一种用于用磁性颗粒处理液体的装置和方法，其中还提供了确保颗粒收集和均质化的至少一个另外的中心元件。

公开(公告)号：US20100291712A1

公开(公告)日：2010-11-18

申请号：US12328228

申请日：2008-12-04

Applicant: Michael Vogeser

Inventor： Michael Vogeser

IPC: G01N33/553 ,  B03C1/30 ,  B01D15/08 ,  G01N1/34 ,  G01N21/00 ,  G01N27/26

CPC classification number: G01N30/08 ,  B03C1/015 ,  B03C1/288 ,  B03C2201/18 ,  G01N2030/085 ,  G01N2030/8813 ,  G01N2446/20

Abstract: The invention concerns a device and a method for the manipulation of a liquid sample material in which magnetic microparticles are suspended whereby the microparticles have a functionalized surface and an analyte is bound to the surface. The sample material is introduced into a device with a liquid system through an injection device (50) and in a first mobile phase the sample material is carried to an extractor (90). In a first section (97a) of the extractor (90) the microparticles are immobilized by means of a magnetic field of a controllable device (96) and separated from the remaining sample material. By switching over of a switching unit (110) a second mobile phase (75) is carried to the extractor (90) and the second mobile phase (75) detaches the adsorbed analyte from the surface of the microparticles. In a second section (97b) of the extractor (90) the microparticles are immobilized and the second mobile phase (75) with the dissolved analyte(s) can be analyzed by way of chromatographic separation (130) and subsequent detection (140).

Abstract translation: 本发明涉及用于操纵其中悬浮磁性微粒的液体样品材料的装置和方法，由此微粒具有官能化表面并且分析物结合到表面。 将样品材料通过注射装置（50）引入具有液体系统的装置中，并且在第一流动相中将样品材料运送到提取器（90）。 在提取器（90）的第一部分（97a）中，微粒通过可控设备（96）的磁场被固定，并与剩余的样品材料分离。 通过切换开关单元（110），将第二流动相（75）运送到提取器（90），并且第二流动相（75）将吸附的分析物从微粒表面分离。 在提取器（90）的第二部分（97b）中，微粒被固定，并且可以通过色谱分离（130）和随后的检测（140）分析具有溶解的分析物的第二流动相（75）。

公开(公告)号：US20100288705A1

公开(公告)日：2010-11-18

申请号：US12778219

申请日：2010-05-12

Applicant: Ralf Griebel

Inventor： Ralf Griebel

IPC: B03C1/02

CPC classification number: B03C1/286 ,  B03C1/0332 ,  B03C2201/18 ,  G01N35/0098 ,  G01N35/10

Abstract: A rod assembly for the extraction of magnetizable particles from solutions is described. The rod assembly includes at least one guide element. A rod element is insertable into the at least one guide element and moveable in a direction substantially parallel to the at least one guide element. A magnet element is moveable to a distal magnet element position; wherein the distal magnet element position is located on a distal end section of the at least one guide element; wherein the at least one guide element includes an opening at a distal end. A method for the extraction of magnetizable particles from solutions is also described, as well as a magnet element for the extraction of magnetizable particles from solutions.

Abstract translation: 描述了用于从溶液中提取可磁化颗粒的棒组件。 杆组件包括至少一个引导元件。 杆元件可插入到至少一个引导元件中并且可在基本上平行于至少一个引导元件的方向上移动。 磁铁元件可移动到远端磁铁元件位置; 其中所述远端磁体元件位置位于所述至少一个引导元件的远端部分上; 其中所述至少一个引导元件包括在远端的开口。 还描述了从溶液中提取可磁化颗粒的方法，以及用于从溶液中提取可磁化颗粒的磁体元件。

公开(公告)号：US20100284864A1

公开(公告)日：2010-11-11

申请号：US12294509

申请日：2007-03-21

Applicant: Tobias Holenstein ,  Rolf Schneebeli ,  Renato Belz

Inventor： Tobias Holenstein ,  Rolf Schneebeli ,  Renato Belz

IPC: B03C1/12 ,  B01L9/00

CPC classification number: B03C1/02 ,  B01L3/5085 ,  B01L9/543 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/12 ,  B03C1/288 ,  B03C2201/18 ,  G01N35/0098

Abstract: An apparatus for separating magnetic particles from a liquid which contains said particles, said liquid being contained in an elongated vessel (11) having a length axis (12), said vessel being arranged in a vessel holder (13) with its length axis (12) in a substantially vertical position, said vessel (11) having a bottom and a tapered cross-section that diminishes towards the bottom of the vessel and a side wall (14) which has an outer surface which forms an angle with the length axis (12) of said vessel (11). This apparatus comprises a magnet (15) having a plane outer surface (16) and being adapted for being moved by transport means (17) along a motion path (25), said magnet (15) and said transport means (17) being so arranged with respect to said vessel (11) that over a portion of said motion path (25) said plane outer surface (16) of said magnet is in contact with a portion of said outer surface of said side wall (14) of said vessel (11), and transport means (17) for moving said magnet (15) between a first predetermined position and a second predetermined position along said motion path (25).

Abstract translation: 一种用于从包含所述颗粒的液体中分离磁性颗粒的装置，所述液体包含在具有长度轴线（12）的细长容器（11）中，所述容器布置在容器保持器（13）中，其长度轴线（12 ），所述容器（11）具有朝向容器底部减小的底部和锥形横截面，以及具有与长度轴形成角度的外表面的侧壁（14） 12）。 该装置包括具有平面外表面（16）并且适于由运输装置（17）沿着运动路径（25）移动的磁体（15），所述磁体（15）和所述传送装置（17）是如此 相对于所述容器（11）布置在所述运动路径（25）的一部分上，所述磁体的所述平面外表面（16）与所述容器的所述侧壁（14）的所述外表面的一部分接触 （11）和用于沿着所述运动路径（25）在所述第一预定位置和第二预定位置之间移动所述磁体（15）的传送装置（17）。

公开(公告)号：US07829026B2

公开(公告)日：2010-11-09

申请号：US12019386

申请日：2008-01-24

Applicant: Chih-Hsien Su ,  Chao-Hung Kao ,  Yuh-Jiuan Lin

Inventor： Chih-Hsien Su ,  Chao-Hung Kao ,  Yuh-Jiuan Lin

IPC: B01L99/10 ,  G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC classification number: G01N35/0098 ,  B01L9/06 ,  B03C1/0332 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/26 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255

Abstract: A magnetic separation device, comprising: at least a test tube base, for receiving at least a test tube; and a magnetic member, pivotally connected to the at least one test tube base and capable of generating a magnetic force. With the aforesaid device, the test tube being received in the test tube base can be moved toward/away from the magnetic member while the magnetic member and the test tube base are driven to rotate about a pivotal end connecting the two, and thereby, the strength of the magnetic force applied on a mixture containing in the test tube by the magnetic member is varied accordingly.

Abstract translation: 一种磁分离装置，包括：用于至少接收试管的至少一个试管底座; 以及磁性构件，枢转地连接到所述至少一个试管基座并且能够产生磁力。 利用上述装置，容纳在试管基座中的试管可以朝向/远离磁性构件移动，同时驱动磁性构件和试管基座围绕连接两者的枢转端旋转，从而， 相应地改变施加在包含在试管中的混合物的磁力的磁力的强度。

公开(公告)号：US20100252436A1

公开(公告)日：2010-10-07

申请号：US12746730

申请日：2008-11-19

Applicant: Je-Kyun Park ,  Joo-Hun Kang ,  Sung-Young Choi ,  Won-Hye Lee

Inventor： Je-Kyun Park ,  Joo-Hun Kang ,  Sung-Young Choi ,  Won-Hye Lee

IPC: B03C1/00 ,  B03C1/32

CPC classification number: B03C1/32 ,  B01L3/502761 ,  B03C1/288 ,  B03C2201/18 ,  Y10T436/25375

Abstract: The present invention relates to a method of separating fine particles by measuring the magnetic susceptibilities thereof using isomagnetophoresis. In a system for separating fine particles using isomagnetophoresis according to the present invention, fluids having different magnetic susceptibilities and fine particles to be measured are introduced into a microfluidic channel to form a magnetic susceptibility gradient, a strong magnetic field is applied to the channel to control the behavior of the introduced fine particles, thus moving the fine particles to respective positions at which the fluids having magnetic susceptibilities identical to those thereof is present. According to the present invention, fine particles having a fine difference in magnetic susceptibility can be separated from each other by measuring the magnetic susceptibilities thereof.

Abstract translation: 本发明涉及通过使用等离子体渗透法测定其磁敏度来分离细颗粒的方法。 在根据本发明的使用等离子体蒸气分离细颗粒的系统中，将具有不同磁化率的流体和要测量的细颗粒的流体引入微流体通道中以形成磁化率梯度，将强磁场施加到通道以控制 引入的细颗粒的行为，从而将细颗粒移动到具有与其相同的磁化率的流体的各个位置。 根据本发明，可以通过测量其磁化率来分离具有微小磁化率​​差的细颗粒。

公开(公告)号：US07807454B2

公开(公告)日：2010-10-05

申请号：US11583989

申请日：2006-10-18

Applicant: Sang-Hyun Oh ,  Amarendra Kumar Singh ,  Yanting Zhang ,  Dharmakirthi Nawarathna ,  Unyoung Kim ,  Patrick Sean Daugherty ,  Hyongsok Soh ,  Brian Scott Ferguson

Inventor： Sang-Hyun Oh ,  Amarendra Kumar Singh ,  Yanting Zhang ,  Dharmakirthi Nawarathna ,  Unyoung Kim ,  Patrick Sean Daugherty ,  Hyongsok Soh ,  Brian Scott Ferguson

IPC: G01N33/553

CPC classification number: B01L3/502776 ,  B01L3/502761 ,  B01L2200/0636 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2300/0864 ,  B01L2400/043 ,  B03C1/32 ,  B03C2201/18

Abstract: A microfluidic device may employ one or more sorting stations for separating target species from other species in a sample. The separation is driven by magnetophoresis. A sorting station generally includes separate buffer and sample streams. A magnetic field gradient applied to the sorting station deflects the flow path of magnetic particles (which selectively label the target species) from a sample stream into a buffer stream. The buffer stream leaving the sorting station is used to detect or further process purified target species labeled with the magnetic particles.

Abstract translation: 微流体装置可以采用一个或多个分选站，用于将样品中的目标物种与其他物种分离。 分离由磁电泳驱动。 分选站通常包括单独的缓冲器和采样流。 施加到分选站的磁场梯度将磁性粒子（其选择性地标记目标物种）的流动路径偏转成缓冲液流。 离开分选站的缓冲液流用于检测或进一步处理用磁性颗粒标记的纯化目标物种。