公开(公告)号：US6157960A

公开(公告)日：2000-12-05

申请号：US852263

申请日：1997-05-07

Applicant: David Louis Kaminsky ,  Richard Adam King ,  Zhiyong Li

Inventor： David Louis Kaminsky ,  Richard Adam King ,  Zhiyong Li

IPC: G06F15/16 ,  G06F9/44 ,  G06F9/46

CPC classification number: G06F9/546 ,  G06F9/548

Abstract: The automatic object distribution of the present invention allows object oriented programs to be run as distributed programs without any explicit networking code, and without using an interface definition language (IDL). The present invention allows programmers to experiment with different distributions without complicating the programming task. It accomplishes this by generating two proxies that allow method calls written for local invocation to be invoked over a network. These dynamically-generated proxies allow calls to flow across a network as if they were local.

Abstract translation: 本发明的自动对象分发允许面向对象的程序作为分布式程序运行而不需要任何明确的联网代码，并且不使用接口定义语言（IDL）。 本发明允许程序员在不使编程任务复杂化的情况下对不同的分布进行实验。 它通过生成两个代理来实现，该代理允许通过网络调用为本地调用编写的方法调用。 这些动态生成的代理允许呼叫流过网络，就像它们是本地的。

公开(公告)号：US10342852B2

公开(公告)日：2019-07-09

申请号：US15729420

申请日：2017-10-10

Applicant: Chaoyu Miao ,  Zhiyong Li ,  Pei Wang

Inventor： Chaoyu Miao ,  Zhiyong Li ,  Pei Wang

IPC: A61K38/19 ,  C07K14/52 ,  A61K38/22 ,  A23L33/17 ,  A61K39/00 ,  C07K14/475

Abstract: The present invention provides an application of Metrnl protein in preparing a hypolipidemic, hypoglycemic medicine or dietary supplement. The present invention further provides a method for preparing a mouse with fat-specific overexpression of Metrnl.

公开(公告)号：US20180030102A1

公开(公告)日：2018-02-01

申请号：US15729420

申请日：2017-10-10

Applicant: Chaoyu Miao ,  Zhiyong Li ,  Pei Wang

Inventor： Chaoyu Miao ,  Zhiyong Li ,  Pei Wang

IPC: C07K14/475 ,  A61K38/22 ,  A61K39/00

CPC classification number: A61K38/19 ,  A23L33/17 ,  A23V2002/00 ,  A61K39/00 ,  C07K14/475 ,  C07K14/52

Abstract: The present invention provides an application of Metrnl protein in preparing a hypolipidemic, hypoglycemic medicine or dietary supplement. The present invention further provides a method for preparing a mouse with fat-specific overexpression of Metrnl.

公开(公告)号：US09638625B2

公开(公告)日：2017-05-02

申请号：US14345277

申请日：2011-10-27

Applicant: Ansoon Kim ,  Zhiyong Li ,  Wei Wu

Inventor： Ansoon Kim ,  Zhiyong Li ,  Wei Wu

IPC: G01J3/44 ,  G01N21/05 ,  G01N21/65 ,  G01N21/552 ,  G01N33/49 ,  G01N1/40 ,  B82Y20/00

CPC classification number: G01N21/05 ,  B82Y20/00 ,  G01N21/554 ,  G01N21/658 ,  G01N33/491 ,  G01N2001/4088 ,  G01N2021/651

Abstract: An apparatus for filtering species in a fluid includes a body having a first side and a second side, a first set of nano-fingers positioned on the body near the first side, a second set of nano-fingers positioned on the body closer to the second side than the first set of nano-fingers, wherein the nano-fingers in the second set of nano-fingers are arranged on the body at a relatively more densely than the nano-fingers in the first set of nano-fingers, and a cover positioned over the first set of nano-fingers and the second set of nano-fingers to form a channel with the body within which the first and second sets of nano-fingers are positioned.

公开(公告)号：US09588048B2

公开(公告)日：2017-03-07

申请号：US14118801

申请日：2011-05-20

Applicant: Ansoon Kim ,  Zhiyong Li

Inventor： Ansoon Kim ,  Zhiyong Li

IPC: G01N21/65 ,  G01J3/44 ,  B82Y15/00

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/44

Abstract: A surface enhanced Raman spectroscopy (SERS) sensor, system and method employ nanorods and independent nanoparticles that interact. The sensor includes at least two spaced apart nanorods attached at first ends to a substrate and an independent nanoparticle. Second ends of the nanorods are movable into close proximity to one another and include a Raman active surface. The nanoparticle has a functionalized surface that includes a Raman signal generator. An interaction between the nanoparticle and the nanorod second ends in close proximity is detectable. The system includes the SERS sensor, an illumination source and a Raman signal detector. The method includes illuminating the interaction of the nanoparticle and the nanorods with an analyte, and detecting an effect on a Raman signal caused by the analyte.

Abstract translation: 表面增强拉曼光谱（SERS）传感器，系统和方法采用纳米棒和独立纳米粒子相互作用。 传感器包括至少两个间隔开的纳米棒，其在第一端附着到基底和独立的纳米颗粒。 纳米棒的第二端可以彼此靠近移动并且包括拉曼活性表面。 纳米颗粒具有包括拉曼信号发生器的官能化表面。 纳米颗粒和纳米棒第二末端之间的相互作用是可以接近的。 该系统包括SERS传感器，照明源和拉曼信号检测器。 该方法包括用分析物照射纳米颗粒和纳米棒的相互作用，并检测由分析物引起的对拉曼信号的影响。

公开(公告)号：US09212997B2

公开(公告)日：2015-12-15

申请号：US14405334

申请日：2012-07-29

Applicant: Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Huei Pei Kuo ,  Steven Barcelo ,  Zhang-Lin Zhou

Inventor： Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Huei Pei Kuo ,  Steven Barcelo ,  Zhang-Lin Zhou

IPC: G01J3/44 ,  G01N21/65 ,  B82Y15/00

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/4412 ,  G01N2021/651 ,  G01N2201/06113 ,  Y10S977/902

Abstract: A scattering spectroscopy nanosensor includes a nanoscale-patterned sensing substrate to produce an optical scattering response signal indicative of a presence of an analyte when interrogated by an optical stimulus. The scattering spectroscopy nanosensor further includes a protective covering to cover and protect the nanoscale-patterned sensing substrate. The protective covering is to be selectably removed by exposure to an optical beam incident on the protective covering. The protective covering is to prevent the analyte from interacting with the nanoscale-patterned sensing substrate prior to being removed.

Abstract translation: 散射光谱纳米传感器包括纳米级图案化的感测衬底，以产生指示当通过光学刺激询问的分析物存在时的光学散射响应信号。 散射光谱纳米传感器还包括覆盖并保护纳米级图案化感测基板的保护覆盖层。 通过暴露在入射到保护罩上的光束可选地去除保护罩。 保护性覆盖物是在去除之前防止分析物与纳米级图案化的感测基板相互作用。

公开(公告)号：US20150330902A1

公开(公告)日：2015-11-19

申请号：US14377524

申请日：2012-02-08

Applicant: Devin Alexander Mourey ,  James William Stasiak ,  James Elmer Abbott, Jr. ,  Zhiyong Li

Inventor： Devin Alexander Mourey ,  James William Stasiak ,  James Elmer Abbott, Jr. ,  Zhiyong Li

IPC: G01N21/65

CPC classification number: G01N21/658 ,  G01N2201/06113 ,  G01N2201/068

Abstract: Molecule sensing apparatus. The apparatus has first and second chambers, an input port extending into the first chamber, a fluid channel extending from the first chamber to the second chamber, and a surface-enhanced substrate in the second chamber.

Abstract translation: 分子感测装置。 该装置具有第一和第二腔室，延伸到第一腔室中的输入端口，从第一腔室延伸到第二腔室的流体通道，以及在第二腔室中的表面增强基底。

公开(公告)号：US20150065390A1

公开(公告)日：2015-03-05

申请号：US14394295

申请日：2012-04-20

Applicant: Alexandre M. Bratkovski ,  Zhiyong Li ,  Wei Wu ,  Min Hu ,  R. Stanley Williams ,  Ansoon Kim

Inventor： Alexandre M. Bratkovski ,  Zhiyong Li ,  Wei Wu ,  Min Hu ,  R. Stanley Williams ,  Ansoon Kim

IPC: G01N21/65 ,  G01N35/00 ,  B01L3/00

CPC classification number: G01N21/658 ,  B01L3/5088 ,  B01L2300/0627 ,  B01L2300/0819 ,  B01L2300/161 ,  G01N21/648 ,  G01N35/00009 ,  G01N2035/00019

Abstract: Examples of integrated sensors are disclosed herein. An example of an integrated sensor includes a substrate and a sensing member formed on a surface of the substrate. The sensing member includes collapsible signal amplifying structures and an area surrounding the collapsible signal amplifying structures that enables self-positioning of droplets exposed thereto toward the collapsible signal amplifying structures.

Abstract translation: 本文公开了集成传感器的示例。 集成传感器的示例包括形成在基板的表面上的基板和感测构件。 感测构件包括可折叠信号放大结构和围绕可折叠信号放大结构的区域，其使得能够将暴露于其的液滴自动定位到可折叠信号放大结构。

公开(公告)号：US08810788B2

公开(公告)日：2014-08-19

申请号：US13254897

申请日：2009-03-13

Applicant: Zhiyong Li ,  Min Hu

Inventor： Zhiyong Li ,  Min Hu

IPC: G01J3/44 ,  G01N21/65 ,  G01N21/55

CPC classification number: G01N21/554 ,  B82Y30/00 ,  G01N21/553 ,  G01N21/658

Abstract: Broad band structures for surface enhanced Raman spectroscopy are disclosed herein. Each embodiment of the structure is made up of a metal layer, and a dielectric layer established on at least a portion of the metal layer. The dielectric layer has a controlled thickness that varies from at least one portion of the dielectric layer to at least another portion of the dielectric layer. Nanostructures are established on the dielectric layer at least at the portion and the other portion, the nanostructures thus being configured to exhibit variable plasmon resonances.

Abstract translation: 本文公开了用于表面增强拉曼光谱的宽带结构。 结构的每个实施例由金属层和建立在金属层的至少一部分上的电介质层组成。 电介质层具有从电介质层的至少一部分到电介质层的至少另一部分变化的受控厚度。 至少在部分和另一部分，在电介质层上建立纳米结构，因此纳米结构被构造成表现出可变的等离子体共振。

公开(公告)号：US08808645B2

公开(公告)日：2014-08-19

申请号：US13281232

申请日：2011-10-25

Applicant: Warren Jackson ,  Zhiyong Li

Inventor： Warren Jackson ,  Zhiyong Li

IPC: B01D35/00 ,  B01D41/00 ,  B01D63/00 ,  C02F1/44 ,  B01D24/00 ,  B01D39/00 ,  B01D61/42 ,  A61M37/00

CPC classification number: G01N21/658 ,  B29D11/0074

Abstract: Molecular filters are disclosed herein. An example of the molecular filter includes a rolled substrate having an interior surface and opposed ends that are substantially orthogonal to the interior surface. The rolled substrate defines a layer and a fluid flow path extending from one of the opposed ends to another of the opposed ends. A template is positioned on the interior surface of the rolled substrate. The template includes a matrix, and molecule template locations formed in the matrix.

Abstract translation: 本文公开了分子过滤器。 分子过滤器的一个实例包括具有内表面和基本上正交于内表面的相对端的轧制衬底。 卷绕的基板限定了从相对端中的一个延伸到相对端中的另一个的层和流体流动路径。 模板位于轧制衬底的内表面上。 模板包括在矩阵中形成的矩阵和分子模板位置。