公开(公告)号：US20120202994A1

公开(公告)日：2012-08-09

申请号：US13447498

申请日：2012-04-16

Applicant: Carsten Friese ,  Andreas Kirschning ,  Jürgen Wichelhaus ,  Sascha Volkan Ceylau

Inventor： Carsten Friese ,  Andreas Kirschning ,  Jürgen Wichelhaus ,  Sascha Volkan Ceylau

IPC: C07C45/61 ,  C07C67/297 ,  C07D277/56 ,  C07C201/12 ,  C07C37/00 ,  C07C51/38 ,  C07C67/303 ,  C07C209/36 ,  C07C41/30 ,  C07D295/073

CPC classification number: B01J19/12 ,  B01J8/42 ,  B01J2208/0038 ,  B01J2208/00433 ,  B01J2208/00513 ,  B01J2219/00139 ,  C07B61/00 ,  C07C37/055 ,  C07C41/30 ,  C07C45/69 ,  C07C67/03 ,  C07C67/303 ,  C07C205/60 ,  C07C209/36 ,  C07D277/56 ,  C07D295/073 ,  H05B6/106 ,  H05B6/108 ,  C07C49/796 ,  C07C69/618 ,  C07C69/612 ,  C07C211/46 ,  C07C43/215 ,  C07C39/225

Abstract: The invention relates to a method for carrying out a chemical reaction for producing a target compound by heating in a reactor a reaction medium containing at least one first reactant, such that a chemical bond inside the first reactant or between the first and a second reactant is formed or modified. The reaction medium is brought into contact with a solid heating medium that can be warmed by electromagnetic induction and that is inside the reactor and is surrounded by the reaction medium. Said heating medium is heated by electromagnetic induction with the aid of an inductor and the target bond is formed from the first reactant or from the first and a second reactant and said target bond is separated from the heating medium.

Abstract translation: 本发明涉及一种通过在反应器中加热含有至少一种第一反应物的反应介质进行化学反应的方法，使得第一反应物内或第一和第二反应物之间的化学键为 形成或修改。 使反应介质与可通过电磁感应加热并且在反应器内部并被反应介质包围的固体加热介质接触。 所述加热介质借助于电感器通过电磁感应加热，并且目标键由第一反应物或第一和第二反应物形成，并且所述靶键与加热介质分离。

公开(公告)号：US20120130092A1

公开(公告)日：2012-05-24

申请号：US13312150

申请日：2011-12-06

Applicant: Teruhiko Ishikawa ,  Seiki Saito ,  Takayuki Kudoh ,  Kotaro Suto ,  Hironori Nishiuchi ,  Makoto Okada ,  Masatoshi Taniguchi

Inventor： Teruhiko Ishikawa ,  Seiki Saito ,  Takayuki Kudoh ,  Kotaro Suto ,  Hironori Nishiuchi ,  Makoto Okada ,  Masatoshi Taniguchi

IPC: C07D493/04 ,  C07C205/50 ,  C07D407/04 ,  C07D317/30 ,  C07D317/32 ,  C07C205/55 ,  C07C201/12

CPC classification number: C07D317/30 ,  C07C205/50 ,  C07C205/55 ,  C07C2601/16 ,  C07D317/32 ,  C07D493/04

Abstract: It is possible to produce oseltamivir safely and stably in large quantities by using as a starting material tartaric acid, mannitol or arabinose, via dihydroxyhexenoic acid ester of the formula (4c). (wherein R1, R2 and R6 are same or different and are each alkyl, aryl, substituted aryl, aralkyl, substituted aralkyl or aromatic heterocyclic group, and R1 and R2 are not methyl simultaneously)

Abstract translation: 通过使用式（4c）的二羟基己酸酯作为原料酒石酸，甘露糖醇或阿拉伯糖，可以大量安全稳定地生产奥司他韦。 （其中R 1，R 2和R 6相同或不同，各自为烷基，芳基，取代的芳基，芳烷基，取代的芳烷基或芳族杂环基，并且R 1和R 2不同时为甲基）

公开(公告)号：US20120108818A1

公开(公告)日：2012-05-03

申请号：US13146141

申请日：2010-01-26

Applicant: Birger Hagberg ,  Lars Eklund

Inventor： Birger Hagberg ,  Lars Eklund

IPC: B01J19/12 ,  C07D211/90 ,  C07C201/12 ,  C07C51/353

CPC classification number: B01J19/126 ,  B01J2219/1215 ,  B01J2219/1227 ,  H05B6/806

Abstract: The present invention relates to a microwave apparatus, a method or use of the apparatus and a method of carrying out chemical reactions on a continuous basis with the apparatus, wherein the apparatus is particularly suitable for microwave-assisted organic synthesis.

Abstract translation: 本发明涉及一种微波设备，该设备的方法或用途以及与设备连续进行化学反应的方法，其中该设备特别适用于微波辅助有机合成。

公开(公告)号：US20120065411A1

公开(公告)日：2012-03-15

申请号：US13321754

申请日：2010-05-26

Applicant: Gerhard Kretzschmar ,  Volker Kraft ,  Thomas Olpp ,  Kai Rossen

Inventor： Gerhard Kretzschmar ,  Volker Kraft ,  Thomas Olpp ,  Kai Rossen

IPC: C07D307/80 ,  C07C205/45 ,  C07C201/12 ,  C07C205/43

CPC classification number: C07D307/80 ,  C07C205/45

Abstract: A process for the production of 2-alkyl-3-aroyl-5-nitrobenzofurans by acylation of 2-(2-hydroxy-5-nitrophenyl)-1-aryl-ethanones and subsequent treatment of the esters with combinations of bases and proton acids or Lewis acids. This process can be used for the production of Dronedarone. Furthermore, novel intermediates for the manufacture of Dronedarone are provided.

Abstract translation: 通过2-（2-羟基-5-硝基苯基）-1-芳基乙酰胺的酰化生产2-烷基-3-芳酰基-5-硝基苯并呋喃的方法，随后用碱和质子酸的组合处理酯 或路易斯酸。 该方法可用于生产决奈达隆。 此外，还提供了制备决奈达隆的新型中间体。

公开(公告)号：US20110237836A1

公开(公告)日：2011-09-29

申请号：US12373164

申请日：2007-07-12

Applicant: Alexander Straub

Inventor： Alexander Straub

IPC: C07C209/36 ,  C07C205/06 ,  C07C201/12

CPC classification number: C07C205/06 ,  C07C205/11 ,  C07C205/12 ,  C07C205/34 ,  C07C209/32 ,  C07C209/70 ,  C07C211/52 ,  C07C2601/02 ,  C07C211/45 ,  C07C211/46

Abstract: The present invention relates to a process for preparing nitrobenzene derivatives and aniline derivatives, which are of significance as intermediates for fungicidally active alkylanilides.

Abstract translation: 本发明涉及硝基苯衍生物和苯胺衍生物的制备方法，它们作为杀真菌活性烷基苯胺的中间体是重要的。

公开(公告)号：US20110178302A1

公开(公告)日：2011-07-21

申请号：US13054458

申请日：2009-07-13

Applicant: Nagichettiar Satyamurthy ,  Jorge R. Barrio

Inventor： Nagichettiar Satyamurthy ,  Jorge R. Barrio

IPC: C07D241/08 ,  C07C17/20 ,  C07C45/63 ,  C07C67/307 ,  C07C253/30 ,  C07C201/12 ,  C07D213/61 ,  C07D277/66 ,  C07D263/18 ,  C07C227/16 ,  C07D233/32

CPC classification number: C07B59/00 ,  C07C17/093 ,  C07C45/63 ,  C07C201/12 ,  C07C223/02 ,  C07C229/36 ,  C07C251/24 ,  C07C253/30 ,  C07C271/22 ,  C07D233/32 ,  C07D263/14 ,  C07D263/18 ,  C07D277/66 ,  C07C25/18 ,  C07C25/13 ,  C07C47/55 ,  C07C49/807 ,  C07C255/50 ,  C07C205/12

Abstract: Iodylbenzene derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are used as precursors in aromatic nucleophilic substitution reactions. The iodyl group (IO2) is regiospecifically substituted by nucleophilic fluoride to provide the corresponding fluoroaryl derivatives. No-carrier-added [F-18]fluoride ion derived from anhydrous [F-18](F/Kryptofix, [F-18]CsF or a quaternary ammonium fluoride (e.g., Me4NF, Et4NF, n-Bu4NF, (PhCH2)4NF) exclusively substitutes the iodyl moiety in these derivatives and provides high specific activity F-18 labeled fluoroaryl analogs. Iodyl derivatives of a benzothiazole analog and 6-iodyl-L-dopa derivatives have been synthesized as precursors and have been used in the preparation of no-carrier-added [F-18]fluorobenzothiazole as well as 6-[F-18]fluoro-L-dopa.

Abstract translation: 在芳香环上使用由电子给体取代的取代基和吸电子基团作为芳族亲核取代反应的前体。 碘基（IO2）被亲核氟化物区域性取代，以提供相应的氟代芳基衍生物。 F-18]（F / Kryptofix，[F-18] CsF或季铵氟化物（如Me4NF，Et4NF，n-Bu4NF，（PhCH2））的无载体添加[F-18] 4NF）仅代替这些衍生物中的碘基部分，并提供高比活性F-18标记的氟代芳基类似物。苯并噻唑类似物和6-碘代-L-多巴衍生物的碘代衍生物已被合成为前体，并已用于制备 无载体添加的[F-18]氟代苯并噻唑以及6- [F-18]氟-L-多巴。

公开(公告)号：US20110144382A1

公开(公告)日：2011-06-16

申请号：US12969264

申请日：2010-12-15

Applicant: Qinghua Yin ,  Xiwang Qi

Inventor： Qinghua Yin ,  Xiwang Qi

IPC: B01J23/42 ,  B01J23/00 ,  B01J23/46 ,  B01J21/02 ,  B01J37/00 ,  C07C201/12 ,  C07C209/36 ,  C07C67/00 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: B01J23/8926 ,  B01J23/42 ,  B01J35/0013 ,  B01J37/00 ,  B01J37/009 ,  B01J37/0211 ,  B01J37/32 ,  B01J37/349 ,  B28B23/0087 ,  B32B7/12 ,  B32B37/14 ,  B82Y30/00 ,  B82Y40/00

Abstract: A catalyst comprising a plurality of support nanoparticles and a plurality of catalytic nanoparticles. At least one catalytic nanoparticle is bonded to each support nanoparticle. The catalytic particles have a size and a concentration, wherein a first configuration of the size and the concentration of the catalytic nanoparticles enables a first catalysis result and a second configuration of the size and the concentration of the catalytic nanoparticles enables a second catalysis result, with the first and second configurations having a different size or concentration, and the first and second catalysis results being different. In some embodiments, the first catalysis result is a selective reduction of a first selected functional group without reducing one or more other functional groups, and the second catalysis result is a selective reduction of a second selected functional group without reducing one or more other functional groups.

Abstract translation: 包含多个载体纳米颗粒和多个催化纳米颗粒的催化剂。 至少一种催化纳米颗粒结合到每个载体纳米颗粒上。 催化颗粒具有尺寸和浓度，其中催化纳米颗粒的尺寸和浓度的第一配置使得能够实现第一催化结果，并且催化纳米颗粒的尺寸和浓度的第二配置使得能够产生第二催化结果， 第一和第二构型具有不同的尺寸或浓度，第一和第二催化结果不同。 在一些实施方案中，第一催化结果是选择性还原第一选择的官能团而不减少一个或多个其它官能团，并且第二催化结果是选择性还原第二选择的官能团而不减少一个或多个其它官能团 。

公开(公告)号：US20100331566A1

公开(公告)日：2010-12-30

申请号：US12823937

申请日：2010-06-25

Applicant: Leslie S. Jimenez ,  Ahalya Ramanathan

Inventor： Leslie S. Jimenez ,  Ahalya Ramanathan

IPC: C07C253/30 ,  C07C201/12 ,  C07C231/12 ,  C07C41/24 ,  C07C37/00 ,  C07C45/65 ,  C07C209/74 ,  C07C205/06 ,  C07C233/07 ,  C07C43/205 ,  C07C39/06 ,  C07C49/563 ,  C07C211/52 ,  C07C255/50

CPC classification number: C07C37/00 ,  C07B31/00 ,  C07C41/24 ,  C07C45/65 ,  C07C201/12 ,  C07C209/74 ,  C07C231/12 ,  C07C253/30 ,  C07C39/06 ,  C07C43/205 ,  C07C49/825 ,  C07C205/57 ,  C07C211/52 ,  C07C233/15 ,  C07C255/50

Abstract: The invention provides synthetic methods that utilize bromo or chloro substituents as blocking groups during the functionalization of aromatic rings, as well as compounds that are prepared from such methods.

Abstract translation: 本发明提供了在芳环官能化期间利用溴或氯取代基作为封闭基团的合成方法以及由这些方法制备的化合物。

公开(公告)号：US20050256343A1

公开(公告)日：2005-11-17

申请号：US10520725

申请日：2003-07-09

Applicant: Eric Fache ,  Sebastien Righini

Inventor： Eric Fache ,  Sebastien Righini

IPC: C07C201/12 ,  C07C21/12 ,  C07C201/16 ,  C07C205/22

CPC classification number: C07C201/16 ,  C07C205/22

Abstract: The invention relates to a method of preparing a high-purity nitrophenol and, more specifically, p-nitrophenol from a nitrohalobenzene. The inventive method comprises the following steps: (a) hydrolysis of a nitrohalobenzene compound by reacting said compound with a base; (b) acidification in order to produce the nitrophenol compound from the salt thereof by means of an acid treatment; (c) crystallisation of the nitrophenol compound obtained; and (d) separation of the product obtained. The invention is characterised in that it also comprises at least the following steps: (e) concentration of the reaction medium after hydrolysis (a) and before acidification (b); and (f) liquid/liquid decantation after acidification (b) and before crystallisation (c), which is intended to eliminate the water phase obtained after acidification (b).

Abstract translation: 本发明涉及一种从硝基卤苯制备高纯度硝基苯酚，更具体地说是对硝基苯酚的方法。 本发明的方法包括以下步骤：（a）通过使所述化合物与碱反应来水解硝基卤苯化合物; （b）酸化以通过酸处理从其盐生产硝基苯酚化合物; （c）获得的硝基苯酚化合物的结晶; 和（d）所得产物的分离。 本发明的特征在于其还包括至少以下步骤：（e）水解（a）和酸化（b）之前浓缩反应介质; 和（f）在酸化（b）和结晶（c）之前的液体/液体倾析，其旨在消除酸化后获得的水相（b）。

公开(公告)号：US06919456B2

公开(公告)日：2005-07-19

申请号：US10452082

申请日：2003-05-30

Applicant: Barry M. Trost ,  Hisanaka Ito

Inventor： Barry M. Trost ,  Hisanaka Ito

IPC: B01J23/06 ,  B01J31/18 ,  C07B53/00 ,  C07C45/64 ,  C07C45/72 ,  C07C45/74 ,  C07C201/12 ,  C07C205/03 ,  C07C205/04 ,  C07C205/15 ,  C07C205/16 ,  C07C205/30 ,  C07C205/32 ,  C07D207/09 ,  C07D211/36 ,  C07D207/40 ,  C07D405/00

CPC classification number: C07C45/64 ,  B01J23/06 ,  B01J31/1805 ,  B01J31/182 ,  B01J2231/342 ,  B01J2231/345 ,  B01J2231/40 ,  B01J2531/20 ,  B01J2531/22 ,  B01J2531/23 ,  B01J2531/26 ,  B01J2531/27 ,  C07B53/00 ,  C07B2200/07 ,  C07C45/72 ,  C07C45/74 ,  C07C201/12 ,  C07C201/14 ,  C07C269/06 ,  C07C2601/14 ,  C07D207/09 ,  C07C49/83 ,  C07C271/16 ,  C07C205/15 ,  C07C205/16 ,  C07C205/30 ,  C07C205/32 ,  C07C205/14 ,  C07C205/26

Abstract: Methods and compositions are provided for the direct catalytic asymmetric aldol reaction of aldehydes with donor molecules selected from ketones and nitroalkyl compounds. The reactions employ as catalyst a Group 2A or Group 2B metal complex of a ligand of formula I, as defined further herein.

Abstract translation: 提供方法和组合物用于醛与选自酮和硝基烷基化合物的供体分子的直接催化不对称醛醇缩合反应。 该反应使用如本文进一步定义的式I配体的2A族或2B族金属络合物作为催化剂。