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公开(公告)号：US20160169926A1
公开(公告)日：2016-06-16
申请号：US14960719
申请日：2015-12-07
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christian Marty , Beat Rene Widmer , Markus Jeziorski
CPC classification number: G01N35/1011 , G01N35/0099 , G01N35/04 , G01N35/1081 , G01N2035/00089 , G01N2035/00287 , G01N2035/00326 , G01N2035/0403 , G01N2035/0427 , G01N2035/1051
Abstract: A device for container storing is presented. The device comprises storage with at least one storing level including a pipetting storing level for fluid pipetting. Each storing level has storing positions having a container holder to detachably hold at least one container. A handler is movable with respect to the storage for transferring containers with respect to the storing positions. A storing position of the pipetting storing level includes a flat spring to bias a container against the container holder. The flat spring has a through hole to provide a pipette access to a lid of the container. A system for pipetting is also presented, comprising the device and a pipettor movable with respect to the pipetting storing level with at least one pipette for pipetting contained in a container stored in the pipetting storing level. The pipette has a pipette tip to penetrate a lid of the container.
Abstract translation: 提出了一种用于容器存储的装置。 该装置包括具有至少一个存储水平的存储，包括用于流体吸移的移液存储水平。 每个存储水平具有存储位置，其具有可拆卸地保持至少一个容器的容器保持器。 处理器相对于用于相对于存储位置传送容器的存储器是可移动的。 移液存储位置的存储位置包括用于将容器偏压抵靠容器保持器的扁平弹簧。 平板弹簧具有一个通孔，以提供一个移液管进入容器的盖子。 还提供了一种用于移液的系统，其包括该装置和移液器，该吸移管可相对于移液存储水平移动，至少一个用于移液管的移液管容纳在存储在移液存储水平的容器中。 移液器具有移液管尖以穿透容器的盖子。
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222.发明授权公开(公告)号：US09364185B2
公开(公告)日：2016-06-14
申请号：US14155954
申请日：2014-01-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Raymond A. Strickland
CPC classification number: A61B5/74 , H04L1/0007 , H04L1/0061 , H04W4/70 , H04W4/80
Abstract: A method performed by a medical device for transmitting data packets includes: removing select data fields from a data packet defined in accordance with IEEE standard 11073 to form a modified data packet; determining a length of the modified data packet; determining whether the length of the modified data packet is greater than a predetermined maximum length of data packets under the Bluetooth low energy protocol, as defined in Bluetooth Core Specification version 4.0 or higher; when the length of the modified data packet is greater than the predetermined maximum length of data packets defined under the Bluetooth low energy protocol, partitioning the modified data packet into a plurality of individual data packets, wherein each of the individual data packets includes a portion of the modified data packet; and transmitting the individual data packets via an antenna in accordance with the Bluetooth low energy protocol.
Abstract translation: 由用于发送数据分组的医疗装置执行的方法包括：从根据IEEE标准11073定义的数据分组中移除选择数据字段以形成修改的数据分组; 确定修改的数据分组的长度; 确定修改的数据分组的长度是否大于蓝牙低功耗协议下的数据分组的预定最大长度，如蓝牙核心规范版本4.0或更高版本中所定义的; 当修改的数据分组的长度大于在蓝牙低能量协议下定义的数据分组的预定最大长度时，将修改的数据分组划分成多个单独的数据分组，其中每个单独的数据分组包括 修改后的数据包; 以及根据蓝牙低能量协议通过天线发送各个数据分组。
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公开(公告)号：US20160161521A1
公开(公告)日：2016-06-09
申请号：US14909782
申请日：2014-06-27
Inventor： Susumu SAKAIRI , Katsuhiro KAMBARA , Stephan SATTLER , Reinhold KRAEMER
CPC classification number: G01N35/1002 , B01L3/50825 , G01N35/00663 , G01N35/025 , G01N2035/00287 , G01N2035/00673 , G01N2035/0405 , G01N2035/0443
Abstract: An automatic analyzer provided with a roller and a reagent container shoulder presser at the position where an operator inserts a reagent container into the automatic analyzer. The reagent container is pushed while the lid of the reagent container is made to touch the upper side of the roller and the shoulder presser is made to touch the shoulder of the reagent container, and the application of upward force to the lid causes the lid of the reagent container to be half open, after which the reagent container is inserted in the analyzer.
Abstract translation: 一种在操作者将试剂容器插入自动分析装置的位置处设置有辊和试剂容器肩压脚的自动分析装置。 在使试剂容器的盖接触到辊的上侧并使肩压接触试剂容器的肩部的同时推动试剂容器，并且向盖施加向上的力使盖 试剂容器半开，然后将试剂容器插入分析器中。
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公开(公告)号：US09333296B2
公开(公告)日：2016-05-10
申请号：US14562881
申请日：2014-12-08
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Ofer Arnold , Illai J Gescheit , Avraham Neta
CPC classification number: A61M5/158 , A61M5/1415 , A61M5/14244 , A61M5/5086 , A61M2005/1416 , A61M2005/1585 , A61M2005/1586 , A61M2005/1588
Abstract: An inserter and methods of using embodiments of the inserter are described. The inserter includes a housing having a cannula assembly and an insertion mechanism. Two buttons are located on the inserter and are concomitantly actionable for actuation of the insertion mechanism, wherein the insertion mechanism is configured to place a cannula assembly in a well that is disposed on the cradle. The inserter also includes a first parts and second part, whereby the first part includes a handle and the second part comprises the entire insertion mechanism, whereby the first and second part are connected via an indentation.
Abstract translation: 描述插入器和使用插入器的实施例的方法。 插入器包括具有套管组件和插入机构的壳体。 两个按钮位于插入器上并且同时可操作地用于致动插入机构，其中插入机构构造成将插管组件放置在布置在托架上的孔中。 插入器还包括第一部分和第二部分，由此第一部分包括手柄，并且第二部分包括整个插入机构，由此第一部分和第二部分经由凹陷连接。
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公开(公告)号：US09316642B2
公开(公告)日：2016-04-19
申请号：US14335022
申请日：2014-07-18
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Elke Faatz , Peter Schaarschmidt , Urban Schmitt , Christian Scholz
IPC: A61K39/02 , A61K39/00 , G01N33/53 , G01N33/571 , C07K14/20
CPC classification number: G01N33/571 , C07K14/20 , C07K2319/00 , G01N2333/20 , G01N2469/20
Abstract: The invention concerns soluble variants of Treponema pallidum antigen 47 (TpN47 antigen) comprising at least domain B, or at least domains A and B, optionally domain D of the complete TpN47 protein molecule with the proviso that all antigens lack domain C (amino acid residues 224 to 351) of TpN47. The Tpn47 antigens can be fused to a chaperone. Moreover, the invention covers DNA encoding the antigens, a method of producing these antigens as well as the use of these antigens in an immunodiagnostic assay for the detection of antibodies against Treponema pallidum in an isolated sample.
Abstract translation: 本发明涉及包含至少结构域B或者至少结构域A和B，完全TpN47蛋白质分子的任选结构域D的梅毒螺旋体抗原47（TpN47抗原）的可溶性变体，条件是所有抗原缺失结构域C（氨基酸残基 224〜351）TpN47。 Tpn47抗原可以融合到伴侣。 此外，本发明涵盖编码抗原的DNA，制备这些抗原的方法以及在免疫诊断测定中使用这些抗原来检测分离样品中针对梅毒螺旋体的抗体。
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Patent Agency Ranking
公开(公告)号：US20160101422A1
公开(公告)日：2016-04-14
申请号：US14872471
申请日：2015-10-01
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Armin Bucher , Thomas Guggisberg , Stephan Sattler , Martin Halter
IPC: B01L9/00
CPC classification number: B01L9/543 , B01L2200/025 , B01L2300/0809 , B01L2300/0858
Abstract: A rack for holding assay tips with improved stacking is provided. The rack has guiding elements arranged near opposing edges of at least two substantially orthogonal side walls of the peripheral wall of the rack configured to provide an early alignment of the rack with a similar rack, such that assay tips received in the rack nest into the assay tips received in the similar rack when the racks are stacked.
Abstract translation: 提供了一种用于保持具有改进的堆叠的测定头的机架。 齿条具有布置在齿条周壁的至少两个基本上正交的侧壁的相对边缘附近的引导元件，其被配置为提供齿条与类似齿条的早期对准，使得容纳在齿条中的测定尖端嵌入测定 当机架堆叠时，在类似机架中收到的提示。
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227.发明申请MODULE FOR A LABORATORY SAMPLE DISTRIBUTION SYSTEM, LABORATORY SAMPLE DISTRIBUTION SYSTEM AND LABORATORY AUTOMATION SYSTEM 有权实验室样品分配系统模块，实验室样品分配系统和实验室自动化系统公开(公告)号：US20160097786A1
公开(公告)日：2016-04-07
申请号：US14865822
申请日：2015-09-25
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michal Malinowski , Henny Volz , Christian Riether
CPC classification number: G01N35/04 , B65G54/02 , B65G2201/0261 , G01N35/00 , G01N2035/00326 , G01N2035/0477
Abstract: A module for a laboratory sample distribution system, a laboratory sample distribution system comprising such modules, and a laboratory automation system comprising such a laboratory sample distribution system are presented. A magnetic coupling enhancer is provided in order to increase magnetic coupling between adjacent modules.
Abstract translation: 提供了用于实验室样品分配系统的模块，包括这种模块的实验室样品分配系统以及包括这样的实验室样品分配系统的实验室自动化系统。 提供磁耦合增强器以增加相邻模块之间的磁耦合。
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公开(公告)号：US20160091482A1
公开(公告)日：2016-03-31
申请号：US14963576
申请日：2015-12-09
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Klaus Andreas Bauer-Espindola , Carina Horn , Michael Marquant , Christine Nortmeyer , Volker Unkrig
CPC classification number: G01N33/492 , G01N21/6428 , G01N21/78 , G01N21/8483 , G01N27/02 , G01N27/12 , G01N27/3274 , G01N2021/7786
Abstract: A method for detecting at least one analyte in a body fluid is disclosed comprising performing an optical measurement, wherein at least one test chemical is contacts the body fluid. The test chemical is an optical test chemical adapted to perform at least one detection reaction, wherein at least one optically detectable property is changed due to the detection reaction to provide at least one optical measurement value. At least one impedance measurement is generated wherein at least one alternating electrical signal is applied to the body fluid via the impedance measurement electrodes and at least one answer signal is recorded, and at least one impedance measurement value is generated. At least one evaluation step is performed wherein at least one evaluation algorithm is used, and the optical measurement value and the impedance measurement value are used for determining a concentration of the analyte in the body fluid.
Abstract translation: 公开了一种用于检测体液中的至少一种分析物的方法，包括执行光学测量，其中至少一种测试化学品接触体液。 测试化学品是适于执行至少一个检测反应的光学测试化学品，其中由于检测反应而改变至少一种可光学检测的性质以提供至少一种光学测量值。 产生至少一个阻抗测量，其中经由阻抗测量电极将至少一个交流电信号施加到体液，并记录至少一个应答信号，并且产生至少一个阻抗测量值。 执行至少一个评估步骤，其中使用至少一个评估算法，并且使用光学测量值和阻抗测量值来确定体液中分析物的浓度。
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公开(公告)号：US20160089867A1
公开(公告)日：2016-03-31
申请号：US14962519
申请日：2015-12-08
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Kurt Klonig , Marc Moldt , Christine Nortmeyer
CPC classification number: B32B37/12 , B32B38/0008 , G01N21/6428 , G01N27/3272
Abstract: A method and a production device for producing a test element are disclosed. The method comprises providing in a transport step a continuous substrate tape, wherein the tape is transported in a transport direction parallel to a direction of extension of the continuous substrate tape; applying in an adhesive application step at least one continuous adhesive strip, wherein the strip is applied to the continuous substrate tape with a liquid adhesive and a slot coating process, and wherein the continuous adhesive strip is oriented parallel to the transport direction; applying in a cover element application step at least one cover element, wherein the at least one cover element is applied to the continuous adhesive strip, thereby securing the cover element to the continuous substrate tape; and individualizing in an individualization step the continuous substrate tape, wherein the tape is individualized into single test elements.
Abstract translation: 公开了一种用于制造测试元件的方法和生产装置。 该方法包括在输送步骤中提供连续的基底带，其中所述带沿平行于所述连续基底带的延伸方向的输送方向输送; 在粘合剂施加步骤中施加至少一个连续的粘合剂条，其中所述条带用液体粘合剂和狭缝涂布工艺施加到连续的基材带上，并且其中连续的粘合带平行于输送方向取向; 在覆盖元件施加步骤中施加至少一个覆盖元件，其中所述至少一个覆盖元件施加到所述连续的粘合剂条上，从而将所述覆盖元件固定到所述连续的基底带上; 并且在个体化步骤中个性化连续基材带，其中胶带被个体化成单个测试元件。
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公开(公告)号：US20160076068A1
公开(公告)日：2016-03-17
申请号：US14950443
申请日：2015-11-24
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Alfred Engel , Michael Greif , Christine Jung , Sebastian Malik , Rainer Mueller , Harald Sobek , Bernhard Suppmann , Marco Thomann
CPC classification number: C12P19/18 , C12N9/1081 , C12P19/02 , C12P19/44 , C12P21/005
Abstract: The present disclosure is directed to the use of certain glycosyltransferase variants having N-terminal truncation deletions. Contrary to previous findings certain truncations were found to exhibit sialidase enzymatic activity, particularly a variant of human sialyltransferase (hST6Gal-I) with a truncation deletion involving the first 89 N-terminal amino acids of the respective wild-type polypeptide. A fundamental finding documented in the present disclosure is that there exists a variant of this enzyme which is capable of catalyzing transfer of a glycosyl moiety as well as hydrolysis thereof. Thus, disclosed is a specific exemplary variant of mammalian glycosyltransferase, nucleic acids encoding the same, methods and means for recombinantly producing the variant of mammalian glycosyltransferase and use thereof, particularly for sialylating in a quantitatively controlled manner terminal acceptor groups of glycan moieties being part of glycoproteins such as immunoglobulins.
Abstract translation: 本公开涉及使用具有N-末端截短缺失的某些糖基转移酶变体。 发现某些截短表现出唾液酸酶酶活性，特别是具有涉及相应野生型多肽的前89个N-末端氨基酸的截短缺失的人唾液酸转移酶（hST6Gal-1）的变体。 在本公开文献中记载的基本发现是存在能够催化糖基部分的转移以及其水解的酶的变体。 因此，公开了哺乳动物糖基转移酶的特定示例性变体，编码哺乳动物糖基转移酶的核酸，用于重组产生哺乳动物糖基转移酶变体的方法和手段及其用途，特别是以定量控制的方式唾液酸化作为部分的聚糖部分的末端受体基团 糖蛋白如免疫球蛋白。
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