公开(公告)号：US20230173018A1

公开(公告)日：2023-06-08

申请号：US18106009

申请日：2023-02-06

Applicant: RAMOT AT TEL AVIV UNIVERSITY LTD.

Inventor： Micha FRIDMAN ,  Qais Z JABER ,  Judith BERMAN

IPC: A61K38/12 ,  A61P31/10 ,  C12Q1/18

CPC classification number: A61K38/12 ,  A61P31/10 ,  C12Q1/18

Abstract: Provided herein are caspofungin derivatives having anti-fungal activity and methods of using same for treating fungal infection. Further provided are methods and kits for determining responsiveness to an anti-fungal activity of an echinocandin compound.

公开(公告)号：US11666656B2

公开(公告)日：2023-06-06

申请号：US16079123

申请日：2017-02-24

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Ronit Satchi-Fainaro ,  Evgeni Pisarevsky ,  Anat Eldar-Boock ,  Dikla Ben-Shushan ,  Yana Epshtein ,  Anna Scomparin

IPC: A61K47/65 ,  A61K9/51 ,  A61P35/00 ,  A61K47/64 ,  A61K47/59 ,  A61P35/04 ,  A61K31/4184 ,  A61K31/506 ,  A61K31/4745

CPC classification number: A61K47/65 ,  A61K9/5153 ,  A61K31/4184 ,  A61K31/506 ,  A61K47/59 ,  A61K47/645 ,  A61P35/00 ,  A61P35/04 ,  A61K31/4745 ,  A61K2300/00

Abstract: Polymeric conjugates comprising a polymeric matrix having associated therewith an agent that down-regulates an activity or expression of a polypeptide associated with onset or progression of melanoma, and optionally and preferably, an additional agent that acts in synergy with said agent, are provided. Synthetic methodologies for preparing these conjugates and uses thereof in treating melanoma and other cancerous diseases are also provided.

公开(公告)号：US11649475B2

公开(公告)日：2023-05-16

申请号：US17058623

申请日：2019-05-24

Applicant: NEMIS Technologies AG ,  Ramot at Tel-Aviv University Ltd.

Inventor： Doron Shabat ,  Michal Eli Roth-Konforti ,  Nir Hananya ,  Ori Green ,  Urs Spitz ,  Lukas Wick ,  Julian Ihssen ,  Raffael Vorberg ,  Riccardo Cribiu ,  Zuzana Babjakovà ,  Chunyan Yao

IPC: C07D321/00 ,  C07D407/04 ,  C12Q1/10 ,  C12Q1/04 ,  C12Q1/14 ,  C12Q1/22 ,  C12Q1/44 ,  C12Q1/54 ,  G01N21/76

CPC classification number: C12Q1/10 ,  C07D321/00 ,  C07D407/04 ,  C12Q1/04 ,  C12Q1/14 ,  C12Q1/22 ,  C12Q1/44 ,  C12Q1/54 ,  G01N21/76

Abstract: Dioxetane compounds represented by Formula I below, and methods of using the dioxetane compounds in the detection of presence or absence, quantification, and identification of microorganisms including bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, and fungi by means of chemiluminescence.

公开(公告)号：US11648260B2

公开(公告)日：2023-05-16

申请号：US17042441

申请日：2019-03-27

Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LIMITED ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Shulamit Levenberg ,  Shaowei Guo ,  Daniel Offen ,  Nisim Perets

IPC: C07H21/02 ,  C07H21/04 ,  A61K31/713 ,  A61K35/28 ,  A61K38/51 ,  C12N15/113 ,  A61K9/50 ,  C12N15/11 ,  A61K9/127

CPC classification number: A61K31/713 ,  A61K9/5068 ,  A61K35/28 ,  A61K38/51 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1137 ,  A61K9/127 ,  C12N2310/14 ,  C12N2310/3515 ,  C12N2310/531 ,  C12N2320/32

Abstract: The present invention provides pharmaceutical compositions comprising membrane vesicles, including extracellular vesicles including those referred to as exosomes, loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor. Methods of treating neurological diseases, disorders or conditions using the extracellular vesicles are provided. Isolated extracellular vesicles loaded with an exogenous Phosphatase and tensin homolog (PTEN) inhibitor are provided as well.

公开(公告)号：US20230123617A1

公开(公告)日：2023-04-20

申请号：US18085700

申请日：2022-12-21

Applicant: Ichilov Tech Ltd. ,  Ramot at Tel-Aviv University Ltd. ,  The Royal Institution For The Advancement Of Learning/McGill University

Inventor： Talma HENDLER ,  Neomi SINGER ,  Robert ZATORRE ,  Alain DAGHER ,  Marcel FARRES-FRANCH

IPC: A61B5/375 ,  A61B5/38 ,  A61B5/372 ,  G16H20/30 ,  G01R33/48

Abstract: A neurofeedback method, including: recording electrical signals from at least one brain region of a subject, wherein changes in the recorded electrical signals over time indicate changes in an activity level of the at least one brain region; providing an audio signal having a perceived quality based on the recorded electrical signals and according to an activity level of the at least one brain region; delivering the audio signal to the subject during said recording.

公开(公告)号：US11610650B2

公开(公告)日：2023-03-21

申请号：US14723875

申请日：2015-05-28

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Tamir Tuller ,  Hadas Zur

IPC: C12N15/79 ,  G16B30/00 ,  G16B35/00 ,  G16C20/60 ,  C12N15/10 ,  G06F17/00 ,  G06F17/10 ,  G06F17/15 ,  G06F17/17

Abstract: Methods of designing a polynucleotide sequence for expressing a polypeptide-of-interest in a cell are provided. Also provided are artificial transcript sequences generated according to the present teachings. Further provided are methods of estimating the adaptiveness of a transcript sequence encoding a polypeptide-of-interest to a gene expression machinery in a cell.

公开(公告)号：US20230085269A1

公开(公告)日：2023-03-16

申请号：US17800345

申请日：2021-03-11

Applicant: BIOMODIFYING, LLC ,  Ramot at Tel-Aviv University Ltd.

Inventor： Daniel Rubinstein ,  Daniel Wreschner

IPC: C07K16/30 ,  C12N15/63 ,  A61K47/64

Abstract: The present invention provides isolated monoclonal antibodies which bind to the MUC1 SEA domain. The invention also concerns the use of these antibodies in therapeutic and diagnostic methods.

公开(公告)号：US20230033494A1

公开(公告)日：2023-02-02

申请号：US17785904

申请日：2020-12-16

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Noam Eliaz ,  David Svetlizky ,  Julie Schoenung ,  Enrique J. Lavernia ,  Yizhang Zhou ,  Baolong Zheng

IPC: B22F10/25 ,  C22C21/06 ,  B33Y70/00 ,  B33Y10/00 ,  B33Y50/02

Abstract: A method for forming a 2-dimensional pattern or 3-dimensional object using an aluminum (Al) 5xxx series alloy includes providing a feedstock that includes the Al 5xxx alloy. The method further includes depositing, using an additive manufacturing process, the feedstock under thermal conditions that permit formation of the pattern or object. The method further includes adjusting a parameter of the additive manufacturing process during the depositing.

公开(公告)号：US11565091B2

公开(公告)日：2023-01-31

申请号：US16461383

申请日：2017-11-16

Applicant: Ramot at Tel-Aviv University Ltd. ,  Tel HaShomer Medical Research Infrastructure and Services Ltd. ,  Hadasit Medical Research Services and Development Ltd.

Inventor： Ofer Barnea ,  Omer Doron

IPC: A61M27/00 ,  A61M25/10 ,  A61M25/00 ,  A61B5/03 ,  A61M60/122 ,  A61M60/268

Abstract: A method for influencing cerebral perfusion in a patient by modifying a volume of a volume adaptor introduced into a cerebral ventricle of the patient, the method comprising identifying a timing of a cerebral blood inflow and/or outflow in a cardiac activity of the patient, modifying a volume of the volume adaptor in synchronization to the identified timing of the cerebral blood flow, to an amount sufficient to modify an intracranial pressure in the cerebral ventricle, such that a flow of the cerebral blood flow is enhanced. In some exemplary embodiments of the invention, the inflation duration of the volume adapter is short relative to the cardiac cycle.

公开(公告)号：US20230026437A1

公开(公告)日：2023-01-26

申请号：US17783276

申请日：2020-12-08

Applicant: THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION ,  Ramot at Tel-Aviv University Ltd.

Inventor： Dror MINZ ,  Shmuel Haim CARMELI ,  Anuj RANA ,  Bogdan BELGORODSKY ,  Rakeshkumar Manojkumar JAIN ,  Eddie Joseph CYTRYN

IPC: A01N63/22 ,  A01N37/10 ,  A01N35/02 ,  A01N31/02 ,  A01P3/00 ,  A01P5/00 ,  A01P1/00

Abstract: The present disclosure relates to bacteria and bacteria-associated volatile organic compounds, and to their use in agriculture.