公开(公告)号：US20150338349A1

公开(公告)日：2015-11-26

申请号：US14282364

申请日：2014-05-20

Applicant: Roche Diagnostics Operations Inc.

Inventor： Robert E. Carter ,  Matthew C. Sauers

IPC: G01N21/77 ,  F21V33/00

CPC classification number: G01N21/77 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/157 ,  A61B2560/0468 ,  F21V33/0068 ,  F21W2131/20 ,  G01N27/3272 ,  G01N27/3273 ,  G01N33/48707 ,  G01N33/48785 ,  G01N33/49 ,  Y10T436/144444

Abstract: A handheld medical device is configured to illuminate a test strip inserted therein and may include a housing having a port configured to receive a test strip. A circuit board may be mounted inside the housing. A measurement module may be mounted to the circuit board and may be cooperatively operable with the test strip inserted into the port to measure a sample of fluid residing on the test strip. The circuit board faces an opposing top surface of the test strip inserted into the port. A light source may be mounted on the circuit board and operable to emit light substantially perpendicular to the opposing top surface of the test strip inserted into the port. The light source may project the light along an optical axis substantially perpendicular to the opposing top surface of the test strip and illuminate an area surrounding a dosing end of the test strip.

Abstract translation: 手持医疗设备被配置为照亮插入其中的测试条，并且可以包括具有被配置为接收测试条的端口的壳体。 电路板可以安装在壳体内。 测量模块可以安装到电路板上，并且可以与插入端口中的测试条可协同操作，以测量驻留在测试条上的流体样本。 电路板面向插入端口的测试条的相对顶面。 光源可以安装在电路板上并且可操作地发射基本垂直于插入端口的测试条的相对顶表面的光。 光源可以沿着基本上垂直于测试条的相对顶表面的光轴投影光，并照亮测试条的计量端周围的区域。

公开(公告)号：US20150300974A1

公开(公告)日：2015-10-22

申请号：US14625997

申请日：2015-02-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin T. Gerber ,  Eric Diebold

IPC: G01N27/30 ,  G01N27/327

CPC classification number: G01N27/307 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B2562/0295 ,  C12Q1/54 ,  G01N27/327 ,  G01N27/3272 ,  G01N27/3273 ,  G01N27/416 ,  G01N33/492 ,  G01N33/66

Abstract: Systems and methods for multiple analyte analysis are provided. In one embodiment, a method includes determining concentrations of first and second analytes in a sample. The first and second analytes may be, for example, glucose and hydroxybutyrate. In this form, an indication related to the measured concentration of hydroxybutyrate is provided in response to determining that the concentration of hydroxybutyrate is above a predetermined value. In a further aspect of this form, a quantitative indication representative of the measured glucose concentration is automatically provided regardless of the value of the measured glucose concentration. In another embodiment, a system includes a meter configured to interact with a test element to assess first and second analytes in a sample. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description and drawings.

Abstract translation: 提供了多个分析物分析的系统和方法。 在一个实施方案中，一种方法包括确定样品中第一和第二分析物的浓度。 第一和第二分析物可以是例如葡萄糖和羟基丁酸酯。 在这种形式中，响应于确定羟基丁酸酯的浓度高于预定值而提供与所测量的羟基丁酸酯浓度相关的指示。 在该形式的另一方面，自动提供代表测量的葡萄糖浓度的定量指示，而与所测量的葡萄糖浓度的值无关。 在另一个实施方案中，系统包括配置成与测试元件相互作用以评估样品中的第一和第二分析物的仪表。 进一步的实施例，形式，对象，特征，优点，方面和优点将从描述和附图中变得显而易见。

公开(公告)号：US09163286B2

公开(公告)日：2015-10-20

申请号：US14169993

申请日：2014-01-31

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Thomas Metzler ,  Tobias Haslinger ,  Annette Peceny ,  Harald Sobek

IPC: C12P19/34 ,  C12Q1/68 ,  C12N9/12

CPC classification number: C12Q1/686 ,  C12N9/1252 ,  C12Q1/6876

Abstract: The present invention provides methods to obtain dry compositions of reaction compounds that maintain the biological activity of the compounds upon re-solubilization after a certain storage time. Preferably, the dry composition comprises a polymerase, and the dry composition is usable for polymerase chain reaction (PCR) amplification after re-solubilization.

Abstract translation: 本发明提供了获得干燥组合物的方法，所述反应化合物在一定的储存时间后再溶解时维持化合物的生物活性。 优选地，干组合物包含聚合酶，并且干组合物可用于再溶解后的聚合酶链反应（PCR）扩增。

公开(公告)号：US20150233945A1

公开(公告)日：2015-08-20

申请号：US14705299

申请日：2015-05-06

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dirk Block ,  Julian Braz ,  Hans-Peter Brunner ,  James Creeden ,  Hans-Juergen Loyda ,  Ursula-Henrike Wienhues-Thelen ,  Christian Zaugg

IPC: G01N33/68

CPC classification number: G01N33/6887 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/58 ,  G01N2800/325 ,  G01N2800/52

Abstract: The present invention relates to a method for guiding heart failure treatment in a subject suffering from heart failure. The method is based on the determination of the amount of a BNP-type peptide and a cardiac troponin in a sample from said subject. Further envisaged by the present invention are kits and devices adapted to carry out the present invention. The present invention also relates to a system for guiding heart failure treatment in a subject suffering from heart failure as disclosed herein and to reagents and kits used in performing the methods disclosed herein.

Abstract translation: 本发明涉及一种在患有心力衰竭的受试者中引导心力衰竭治疗的方法。 该方法基于来自所述受试者的样品中BNP型肽和心肌肌钙蛋白的量的测定。 本发明进一步设想的是适用于实施本发明的试剂盒和装置。 本发明还涉及用于指导本文公开的患有心力衰竭的受试者的心力衰竭治疗的系统以及用于执行本文公开的方法的试剂和试剂盒。

公开(公告)号：US20150226694A1

公开(公告)日：2015-08-13

申请号：US14695528

申请日：2015-04-24

Applicant: Roche Diagnostics Operations, Inc. ,  Roche Operations Ltd.

Inventor： Christopher D. Wilsey

IPC: G01N27/327

CPC classification number: G01N27/3275 ,  C12Q1/006 ,  G01N27/3272

Abstract: The concentration of glucose in a blood sample is determined by methods utilizing test strips having a sample receiving cavity having a volume from about 0.3 μl to less than 1 μl and determining the glucose concentration within a time period from about 3.5 seconds to about 8 seconds.

Abstract translation: 血液样品中葡萄糖的浓度通过利用具有样品接收空腔的体积从约0.3μl至小于1μl的测试条的方法确定，并在约3.5秒至约8秒的时间段内测定葡萄糖浓度。

公开(公告)号：US20150226693A1

公开(公告)日：2015-08-13

申请号：US14695433

申请日：2015-04-24

Applicant: Roche Diagnostics Operations, Inc. ,  Roche Operations Ltd.

Inventor： Christopher D. Wilsey

IPC: G01N27/327

CPC classification number: G01N27/3272 ,  C12Q1/001 ,  C12Q1/006 ,  G01N27/307 ,  G01N27/3273 ,  G01N27/3275

Abstract: Analytes in a liquid sample are determined by methods utilizing sample volumes from about 0.3 μl to less than 1 μl and test times from about 3.5 to about 6 seconds after detection of the sample. The methods are preferably performed using small test strips including a sample receiving chamber filled with the sample by capillary action.

Abstract translation: 液体样品中的分析物通过使用样品体积从约0.3μl至小于1μl的方法和检测样品后约3.5至约6秒的测试时间来确定。 该方法优选使用包括通过毛细管作用填充样品的样品接收室的小测试条进行。

公开(公告)号：US20150224497A1

公开(公告)日：2015-08-13

申请号：US14174874

申请日：2014-02-07

Applicant: Beckton, Dickinson and Company ,  Roche Diagnostics Operations, Inc.

Inventor： Frederic Furrer ,  Hans-Peter Wahl

IPC: B01L3/00 ,  G01N35/10

CPC classification number: B01L3/50825 ,  B01L2200/0689 ,  B01L2300/042 ,  B01L2300/043 ,  B01L2300/044 ,  B01L2300/049 ,  B01L2300/0858 ,  B01L2300/123 ,  B01L2400/0611 ,  B01L2400/0638 ,  B01L2400/0683 ,  G01N35/10

Abstract: A sample collection tube is disclosed for collecting a body fluid sample. The tube includes a closure arranged at an open end to close the open end and a partially evacuated inner space. The closure also includes a base portion connected to the sidewall and a cap portion coupled to the base portion, where the cap portion has an elastomeric material that is pierceable from outside of the tube for collecting a sample into the partially evacuated inner space and where the cap portion can be pivotable with respect to the sidewall such as to make the inner space accessible for withdrawing an aliquot of the sample. Alternatively, the cap portion can be separable from the base portion to make the inner space accessible and the base portion can include a self-resealable valve adapted to allow access of a pipetting unit into the inner space when the cap portion is separated and adapted to re-seal after withdrawal of the pipetting unit. Also disclosed is a work cell for handling sample collection tubes.

Abstract translation: 公开了用于收集体液样品的采样管。 管包括设置在开口端的封闭件，以封闭开口端和部分抽空的内部空间。 闭合件还包括连接到侧壁的基座部分和联接到基座部分的帽部分，其中帽部分具有可从管的外部刺穿的弹性体材料，用于将样品收集到部分抽空的内部空间中，并且其中 帽部分可以相对于侧壁可枢转，以便使得内部空间可接近以取出样品的等分试样。 或者，盖部分可以与基部分离，以使得内部空间可接近，并且基部部分可以包括自重新密封的阀，其适于在盖部被分离并适应于允许移动单元进入内部空间时 拔出后重新密封。 还公开了用于处理样品采集管的工作室。

公开(公告)号：US20150196258A1

公开(公告)日：2015-07-16

申请号：US14155954

申请日：2014-01-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Raymond A. Strickland

IPC: A61B5/00 ,  H04L1/00 ,  H04W4/00

CPC classification number: A61B5/74 ,  H04L1/0007 ,  H04L1/0061 ,  H04W4/70 ,  H04W4/80

Abstract: A method performed by a medical device for transmitting data packets includes: removing select data fields from a data packet defined in accordance with IEEE standard 11073 to form a modified data packet; determining a length of the modified data packet; determining whether the length of the modified data packet is greater than a predetermined maximum length of data packets under the Bluetooth low energy protocol, as defined in Bluetooth Core Specification version 4.0 or higher; when the length of the modified data packet is greater than the predetermined maximum length of data packets defined under the Bluetooth low energy protocol, partitioning the modified data packet into a plurality of individual data packets, wherein each of the individual data packets includes a portion of the modified data packet; and transmitting the individual data packets via an antenna in accordance with the Bluetooth low energy protocol.

Abstract translation: 由用于发送数据分组的医疗装置执行的方法包括：从根据IEEE标准11073定义的数据分组中移除选择数据字段以形成修改的数据分组; 确定修改的数据分组的长度; 确定修改的数据分组的长度是否大于蓝牙低功耗协议下的数据分组的预定最大长度，如蓝牙核心规范版本4.0或更高版本中所定义的; 当修改的数据分组的长度大于在蓝牙低能量协议下定义的数据分组的预定最大长度时，将修改的数据分组划分成多个单独的数据分组，其中每个单独的数据分组包括 修改后的数据包; 以及根据蓝牙低能量协议通过天线发送各个数据分组。

公开(公告)号：US09076120B2

公开(公告)日：2015-07-07

申请号：US14055266

申请日：2013-10-16

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Martin Burri ,  Andreas Eberhart ,  Akihiro Tanji

IPC: G06F19/00 ,  G06Q30/00 ,  G06Q90/00 ,  G06Q10/08 ,  B01L9/06 ,  B01L99/00 ,  G01N35/00

CPC classification number: G01N35/00732 ,  B01L9/06 ,  B01L99/00 ,  B01L2300/024 ,  G01N2035/00782 ,  G01N2035/00801 ,  G01N2035/00831 ,  G01N2035/00851 ,  G06Q10/087

Abstract: A system and method for locating sample vessels are presented. The system comprises a holder having an array of positions for holding sample vessels. An information tag is attached to the holder for storing and/or retrieving machine-readable information related to the positions of sample vessels with respect to the array of positions. The system further comprises a handheld device capable of reading information on the information tag. The handheld device has an input for inputting information related to a to-be-located sample vessel and an output for outputting a position of the to-be-located sample vessel with respect to the array of positions based on information stored in the information tag. The method comprises inputting information related to a to-be-located sample vessel into the handheld device, reading information stored in the holder's information tag with the handheld device; and outputting a position of the to-be-located sample vessel.

Abstract translation: 提出了一种用于定位样品容器的系统和方法。 该系统包括具有用于保持样品容器的位置阵列的保持器。 一个信息标签连接到保持器，用于存储和/或检索与样品容器相对于位置阵列相关的位置的机器可读信息。 该系统还包括能够读取关于信息标签的信息的手持设备。 手持装置具有用于输入与要定位的取样容器相关的信息的输入端和用于基于存储在信息标签中的信息输出相对于位置阵列的待定位样品容器的位置的输出 。 该方法包括将与待定位的采样容器相关的信息输入到手持设备中，用手持设备读取存储在保持器的信息标签中的信息; 并输出待定位的样品容器的位置。

公开(公告)号：US20150185230A1

公开(公告)日：2015-07-02

申请号：US14644695

申请日：2015-03-11

Applicant: Roche Diagnostics Operations, Inc

Inventor： Dirk Block ,  Roberto Latini ,  Serge Masson ,  Ursula-Henrike Wienhues-Thelen ,  Christian Zaugg

IPC: G01N33/68 ,  A61B5/055 ,  A61B8/08

CPC classification number: G01N33/6887 ,  A61B5/055 ,  A61B8/0883 ,  G01N33/82 ,  G01N2333/4703 ,  G01N2333/4706 ,  G01N2333/4712 ,  G01N2333/50 ,  G01N2333/78 ,  G01N2800/32 ,  G01N2800/329 ,  G01N2800/50

Abstract: The present invention relates to a method for assessing whether a subject shall be subjected to an imaging based diagnostic assessment. The method is based on the determination of the amount(s) of a cardiac Troponin and/or Fibroblast Growth Factor 23 (FGF-23) in a sample from the subject, and on the comparison of the, thus, determined amount(s) with a reference amount (reference amounts). The present invention also relates to a system for performing an assessment whether a subject shall be subjected to an imaging based diagnostic assessment and to reagents and kits used in performing the methods disclosed herein. Moreover, the present invention is directed to a method for predicting the risk of mortality and/or of a cardiovascular event. Also encompassed is a method for diagnosing an early stage of LVH in a subject having a preserved left ventricular ejection.

Abstract translation: 本发明涉及一种用于评估受试者是否应进行基于成像的诊断评估的方法。 该方法基于来自受试者的样品中心肌肌钙蛋白和/或成纤维细胞生长因子23（FGF-23）的量的测定，以及因此确定的量（s） 具有参考量（参考量）。 本发明还涉及一种用于执行评估受试者是否应进行基于成像的诊断评估的系统以及用于执行本文所公开的方法的试剂和试剂盒。 此外，本发明涉及一种用于预测死亡风险和/或心血管事件风险的方法。 还包括用于诊断具有保留的左心室射血的受试者的LVH的早期阶段的方法。