中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

324 records (took 0.03 seconds)

    EXTERNAL STANDARD REFERENCE SYSTEM OF TYPE INSERTED INTO COIL OF HUMAN MAGNETIC RESONANCE IMAGING EQUIPMENT
    243.
    发明申请
    EXTERNAL STANDARD REFERENCE SYSTEM OF TYPE INSERTED INTO COIL OF HUMAN MAGNETIC RESONANCE IMAGING EQUIPMENT 审中-公开
    人造磁共振成像设备线圈插入式外部标准参考系

    公开(公告)号：US20170049354A1

    公开(公告)日：2017-02-23

    申请号：US14872805

    申请日：2015-10-01

    Applicant: The Catholic University of Korea Industry-Academic Cooperation Foundation

    Inventor： Bo-Young Choe ,  Kyu-Ho Song ,  Do-Wan Lee

    IPC: A61B5/055 ,  A61B5/00 ,  G01R35/00 ,  G01R33/48 ,  G01R33/46

    CPC classification number: A61B5/055 ,  A61B5/0042 ,  G01R33/46 ,  G01R33/58 ,  G01R35/00

    Abstract: The present invention relates to an external standard reference system of a type inserted into the coil of a human magnetic resonance imaging equipment, and more specifically, to a system capable of analyzing metabolic components (quantity of metabolites) in a human body without an error and a limited range using an external standard reference analysis method, in order to enhance accuracy of diagnosis by utilizing magnetic resonance spectroscopy of the human magnetic resonance imaging equipment. A system for evaluating performance of magnetic resonance spectroscopy includes an outer container for inserting an RF coil and provided with a plurality of holes; a plurality of inner containers arranged to be inserted into the plurality of holes respectively and capable of being filled with metabolites different from each other in at least a type or a concentration; and a frame for fixing a head of an object arranged inside the outer container.

    Abstract translation: 本发明涉及插入到人体磁共振成像设备的线圈中的类型的外部标准参考系统，更具体地，涉及能够分析人体内的代谢成分（代谢物的数量）而没有错误的系统，以及 使用外部标准参考分析方法的有限范围，以通过使用人类磁共振成像设备的磁共振光谱来增强诊断的准确性。 用于评估磁共振波谱性能的系统包括用于插入RF线圈并设置有多个孔的外容器; 多个内容器，分别插入到多个孔中并能够以至少一种或多种浓度填充彼此不同的代谢物; 以及用于固定布置在外部容器内的物体的头部的框架。

    METHOD OF MANUFACTURING SCAFFOLD FOR TREATMENT OF TOOTH EXTRACTION SOCKET AND IMPLANTATION OF DENTAL IMPLANT
    244.
    发明申请
    METHOD OF MANUFACTURING SCAFFOLD FOR TREATMENT OF TOOTH EXTRACTION SOCKET AND IMPLANTATION OF DENTAL IMPLANT 审中-公开
    牙科植入物的处理方法及牙植入植入方法

    公开(公告)号：US20170007374A1

    公开(公告)日：2017-01-12

    申请号：US15123165

    申请日：2016-07-07

    Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

    Inventor： Sang Hwa LEE

    IPC: A61C8/00 ,  A61C1/08 ,  A61C13/00 ,  A61B6/03 ,  A61B6/14

    CPC classification number: A61C13/0019 ,  A61B6/032 ,  A61B6/14 ,  A61C8/0036 ,  A61C13/0004 ,  B29C64/106 ,  B29C64/112 ,  B29C64/386

    Abstract: Provided is a technique of allowing a dental implant to be stably placed after extraction, to be accurately placed in a tooth extraction socket, and to be stably placed in the tooth extraction socket according to implantation position and angle. A method of manufacturing a scaffold for treatment of a tooth extraction socket and implantation of a dental implant includes receiving dental implantation information of dental CT data which is previously input via a terminal of a manager; manufacturing, by using a three-dimensional (3D) printer, a 3D model comprising alveolar bones and teeth, which are distinguished therebetween, based on a medical image file that is a medical image file (DICOM file) of the dental CT data; performing virtual tooth-extraction by removing, from the manufactured 3D model, a region corresponding to a tooth in a tooth-extraction target area; and manufacturing, by using the 3D printer, a scaffold to be placed in an actual tooth extraction socket according to a shape of a tooth extraction socket that exists in the manufactured 3D model as a result of the virtual tooth-extraction, wherein, when the scaffold is manufactured, image data of the scaffold is amended to allow a guide hole for implanting the dental implant to be formed in the scaffold based on the dental implantation information.

    Abstract translation: 提供了一种允许牙科植入物在提取后稳定放置的技术，以精确地放置在拔牙插座中，并且根据植入位置和角度稳定地放置在拔牙插座中。 一种用于处理牙齿拔出插座和植入牙科植入物的支架的方法包括接收先前通过管理者的终端输入的牙科CT数据的牙齿植入信息; 基于作为牙科CT数据的医学图像文件（DICOM文件）的医学图像文件，通过使用三维（3D）打印机制造包括牙槽骨和牙齿的3D模型，其在其间进行区分; 通过从制造的3D模型中移除与拔牙目标区域中的牙齿相对应的区域来执行虚拟拔牙; 并且通过使用3D打印机，根据虚拟拔牙的结果，根据制造的3D模型中存在的拔牙套筒的形状，将脚手架放置在实际的拔牙座中，其中，当 脚手架被制造，脚手架的图像数据被修改为允许基于牙齿植入信息将用于植入待形成牙科植入物的引导孔植入到支架中。

    MTOR/STAT3 SIGNAL INHIBITOR-TREATED MESENCHYMAL STEM CELL HAVING IMMUNOMODULATORY ACTIVITY, AND CELL THERAPY COMPOSITION COMPRISING SAME, FOR PREVENTING OR TREATING IMMUNE DISORDERS
    245.
    发明申请
    MTOR/STAT3 SIGNAL INHIBITOR-TREATED MESENCHYMAL STEM CELL HAVING IMMUNOMODULATORY ACTIVITY, AND CELL THERAPY COMPOSITION COMPRISING SAME, FOR PREVENTING OR TREATING IMMUNE DISORDERS 审中-公开
    具有免疫调节活性的MTOR / STAT3信号抑制剂治疗的细胞干细胞和包含其的细胞治疗组合物，用于预防或治疗免疫障碍

    公开(公告)号：US20160289640A1

    公开(公告)日：2016-10-06

    申请号：US14912391

    申请日：2014-08-14

    Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

    Inventor： Chul Woo YANG ,  Mi-La CHO ,  Sung-Hwan PARK ,  Eun Kyung KIM ,  Byung Ha CHUNG ,  Kyoung-Woon KIM ,  Seon-Yeong LEE ,  Sung-Hee LEE ,  Eun Ji YANG ,  Jeong-hee JEONG ,  Min Jung PARK ,  Seok-Jung KIM ,  Eun-Jung LEE ,  Su-Jin MOON

    IPC: C12N5/0775 ,  A61K38/17 ,  A61K35/28 ,  C07K14/715

    CPC classification number: C12N5/0667 ,  A61K35/28 ,  A61K38/177 ,  C07K14/7158 ,  C12N5/0665 ,  C12N2501/04

    Abstract: The present invention relates to a mesenchymal stem cell having immunomodulatory activity and a preparation method therefor and, more specifically, to: a rapamycin-treated mesenchymal stem cell having immunomodulatory activity, which expresses any one or more cell surface factors selected from the group consisting of CCR1, CCR2, CCR3, CCR4, CCR7, CCR9 and CXCR4; a cell therapy composition comprising the mesenchymal stem cell, for preventing or treating immune disorders; and a preparation method for the mesenchymal stem cell having immunomodulatory activity. The rapamycin-treated mesenchymal stem cell having immunomodulatory activity, according to the present invention, has increased expression of IDO, TGF-β and IL-10 which are factors having immunomodulatory activity, has decreased expression of Phospho-mTOR, Rictor and Ractor which are signal transduction factors of mTOR, and has increased expression, in the cell, of autophagic inducer Beclin1, ATG5, ATG7, LC3I or LCII. If this cell is used as a cell therapy in individuals having immune disorders, it is possible to effectively treat immune disorders.

    Abstract translation: 本发明涉及具有免疫调节活性的间充质干细胞及其制备方法，更具体地涉及：具有免疫调节活性的雷帕霉素治疗的间充质干细胞，其表达任何一种或多种选自以下的细胞表面因子： CCR1，CCR2，CCR3，CCR4，CCR7，CCR9和CXCR4; 包含间充质干细胞用于预防或治疗免疫疾病的细胞疗法组合物; 以及具有免疫调节活性的间充质干细胞的制备方法。 根据本发明的具有免疫调节活性的雷帕霉素处理的间充质干细胞具有增加作为具有免疫调节活性的因子的IDO，TGF-β和IL-10的表达，具有降低的磷酸化mTOR，Rictor和Ractor的表达， mTOR的信号转导因子，并且在自噬诱导物Beclin1，ATG5，ATG7，LC3I或LCII的细胞中表达增加。 如果该细胞在具有免疫障碍的个体中用作细胞疗法，则有可能有效治疗免疫疾病。

    REDUCING OR NON-REDUCING POLYNUCLEOTIDE POLYMER FOR DRUG DELIVERY AND METHOD FOR PREPARING SAME
    247.
    发明申请
    REDUCING OR NON-REDUCING POLYNUCLEOTIDE POLYMER FOR DRUG DELIVERY AND METHOD FOR PREPARING SAME 审中-公开
    用于药物递送的还原性或非还原性多核苷酸聚合物及其制备方法

    公开(公告)号：US20160193150A1

    公开(公告)日：2016-07-07

    申请号：US14899558

    申请日：2014-06-20

    Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  UTAH-INHA DDS & ADVANCED THERAPEUTICS RESEARCH CENTER

    Inventor： Han Chang KANG ,  You Han BAE ,  Ha Na CHO

    IPC: A61K9/16 ,  A61K48/00 ,  C07H21/00

    CPC classification number: A61K9/1641 ,  A61K47/593 ,  A61K48/0041 ,  C07H21/00

    Abstract: The present invention relates to a reducing or non-reducing polynucleotide polymer for drug delivery and a method for preparing same, and provides a reducing or non-reducing polymer synthesized by using nucleotides, a method for preparing same, and a polymer composition for drug delivery containing the reducing or non-reducing polymer. The present invention relates to a drug delivery carrier for delivering proteins or peptides to a targeted area through electrostatic attraction, by obtaining a negatively (−) charged polymer by using nucleotides to synthesize the reducing or non-reducing polymer, which is easily breakable due to disulfide bonds, and then bonding the negatively (−) charged polymer with a positively (+) charged protein or peptide, wherein a polymer derived from a non-viral drug delivery carrier containing the novel reducing or non-reducing polymer is capable of effectively enabling escape of a drug, delivered by means of proton buffering activity, from an endosome to other organelles in a cell.

    Abstract translation: 本发明涉及用于药物递送的还原性或非还原性多核苷酸聚合物及其制备方法，并提供通过使用核苷酸合成的还原性或非还原性聚合物，其制备方法和用于药物递送的聚合物组合物 含有还原性或非还原性聚合物。 本发明涉及通过静电吸引将蛋白质或肽递送至目标区域的药物递送载体，通过使用核苷酸通过使用核苷酸合成还原性或非还原性聚合物获得负（ - ）带电聚合物，其由于 然后将带负电荷的（ - ）带电聚合物与正（+）带电荷的蛋白质或肽结合，其中衍生自含有新型还原或非还原性聚合物的非病毒药物递送载体的聚合物能够有效地实现 通过质子缓冲活性递送的药物从细胞内的内体到其他细胞器的逃逸。

    COMPOSITION FOR TREATING EPSTEIN-BARR VIRUS INFECTION, COMPRISING EPSTEIN-BARR VIRUS MICRO RNA INHIBITOR
    248.
    发明申请
    COMPOSITION FOR TREATING EPSTEIN-BARR VIRUS INFECTION, COMPRISING EPSTEIN-BARR VIRUS MICRO RNA INHIBITOR 审中-公开
    用于治疗EPSTEIN-BARR病毒感染的组合物，包含EPSTEIN-BARR病毒微RNA抑制剂

    公开(公告)号：US20150329865A1

    公开(公告)日：2015-11-19

    申请号：US14702463

    申请日：2015-05-01

    Applicant: The Catholic University of Korea Industry-Academic Cooperation Foundation

    Inventor： Suk Kyeong LEE ,  Yu-Jin Jung ,  Hoyun Choi ,  Hyoji Kim

    IPC: C12N15/113 ,  C12N7/00 ,  C12Q1/70

    CPC classification number: C12N7/00 ,  C12N15/1133 ,  C12N2310/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/3231 ,  C12N2710/16211 ,  C12N2710/16263 ,  C12Q1/701 ,  C12Q1/705 ,  C12Q2600/136 ,  C12Q2600/158

    Abstract: Provided is a composition comprising an Epstein-Barr virus microRNA inhibitor for treating Epstein-Barr virus infection, and a method using Epstein-Barr virus microRNA for screening a therapeutic agent for treating Epstein-Barr virus infection. The provided composition enables one to induce the lytic cycle of EBV such that EBV-infected cells are destroyed by a host immune system. Therefore, the composition can be effectively used for the prevention or treatment of diseases, including various cancers, caused by EBV infection. Moreover, the provided method enables one to screen a therapeutic agent having excellent antiviral effect for treating Epstein-Barr virus infection by inducing Epstein-Barr virus lytic cycle.

    Abstract translation: 提供了包含用于治疗爱泼斯坦 - 巴尔病毒感染的爱泼斯坦 - 巴尔病毒微RNA抑制剂的组合物，以及使用爱泼斯坦 - 巴尔病毒微小RNA筛选用于治疗爱泼斯坦 - 巴尔病毒感染的治疗剂的方法。 所提供的组合物使得能够诱导EBV的裂解循环，使得EBV感染的细胞被宿主免疫系统破坏。 因此，该组合物可有效地用于预防或治疗由EBV感染引起的疾病，包括各种癌症。 此外，所提供的方法使得能够通过诱导爱泼斯坦 - 巴尔病毒裂解循环来筛选具有优异的抗病毒效果的治疗剂来治疗爱泼斯坦 - 巴尔病毒感染。

    Antiviral compositions comprising ethanol extract of Tetracera scandens and use thereof
    249.
    发明授权
    Antiviral compositions comprising ethanol extract of Tetracera scandens and use thereof 有权
    抗病毒组合物，其包含四氯化comprising的乙醇提取物及其用途

    公开(公告)号：US09084758B2

    公开(公告)日：2015-07-21

    申请号：US14467610

    申请日：2014-08-25

    Applicant: The Catholic University of Korea Industry-Academic Cooperation Foundation

    Inventor： Ji Chang You

    IPC: A01N65/00 ,  A61K36/185 ,  A61K36/00

    CPC classification number: A61K36/185 ,  A61K36/00 ,  A61K2236/00

    Abstract: A composition for preventing or treating a viral infection, which includes an ethanol extract of Tetracera scandens as an effective component, is provided. The composition exhibits low toxicity and few side effects and effectively inhibits reverse transcriptase activities to suppress synthesis of DNA, and thus can be useful in preventing or treating infections caused by various kinds of RNA viruses.

    Abstract translation: 提供了一种用于预防或治疗病毒感染的组合物，其包括作为有效成分的四氯化钪的乙醇提取物。 该组合物的毒性低，副作用小，有效抑制逆转录酶活性抑制DNA的合成，因此可用于预防或治疗由各种RNA病毒引起的感染。

Patent Agency Ranking