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公开(公告)号：US5653684A
公开(公告)日：1997-08-05
申请号：US452637
申请日：1995-05-25
CPC分类号： A61F2/90 , A61B18/1492 , A61M29/02 , A61B2017/00504 , A61B2018/00214 , A61B2018/00422 , A61F2002/9511 , A61F2220/0008
摘要： A catheter for use in angioplasty and other medical procedures is disclosed. The catheter features a flexible-wire mesh tip movably attached at a distal end of the catheter, the tip being expandable from a contracted position which it is first in when the catheter is deployed inside the lumen of a vessel, to stretch open the lumen and eliminate a flow obstruction therein, such as is caused by plaque deposits; the tip subsequently being returnable to its contracted position inside the catheter when the catheter is withdrawn from the lumen of the vessel. Radio frequency energy may additionally be used to weld the source of the flow obstruction to the wall of the lumen leaving a conduit of sufficiently expanded diameter to allow resumption of normal flow in the vessel.
摘要翻译： 公开了用于血管成形术和其他医疗程序的导管。 导管具有可移动地附接在导管的远端处的柔性丝网，尖端可从收缩位置扩展，当收缩位置首先在导管部署在血管腔内时，拉伸开口腔， 消除其中的流动阻塞，如由斑块沉积造成的; 当导管从容器的内腔中取出时，尖端随后可返回到导管内的收缩位置。 另外可以使用射频能量将流动阻塞的源焊接到管腔的壁，留下具有足够扩张的直径的导管，以允许在容器中恢复正常的流动。
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公开(公告)号：US5599325A
公开(公告)日：1997-02-04
申请号：US350779
申请日：1994-12-07
CPC分类号： A61M25/0045 , A61L29/049 , A61L29/06 , A61L29/18 , A61M25/005 , A61M2025/0098 , A61M25/0069
摘要： A diagnostic catheter comprises an inner layer of substantially unmodified polyamide over which is a reinforcing means and an outer layer of polymer having a hardness of 50 Shore D to 70 Shore D, along with a suitable radiopaque filler. Affixed either directly to the end of the above tubular body or to a stem member secured to that tubular body is a soft-tip formed from a blend of PEBA whose hardness is such that the catheter can be Considered as having an atraumatic tip. The resulting catheter exhibits excellent torque and column strength characteristics while providing a relatively large diameter lumen for a given outside diameter.
摘要翻译： 诊断导管包括基本上未改性的聚酰胺的内层，其上是硬化度为50肖氏D至70肖氏D的加强装置和聚合物外层，以及合适的不透射线填料。 直接连接到上述管状体的端部或固定到该管状体的杆构件是由PEBA的混合物形成的软尖端，其硬度使得导管可以被认为具有无创伤的尖端。 所得到的导管表现出优异的扭矩和柱强度特性，同时为给定的外径提供相对较大直径的腔。
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公开(公告)号：US5591226A
公开(公告)日：1997-01-07
申请号：US377069
申请日：1995-01-23
CPC分类号： A61F2/90 , A61B17/11 , A61F2/064 , A61F2/07 , A61M1/3655 , A61B2017/1107 , A61F2/848 , A61F2002/072 , A61F2002/075 , A61F2002/8486 , A61F2210/0076 , A61F2220/0016 , A61F2220/0075 , A61M39/0247
摘要： A percutaneous stent-graft is disclosed for restoring blood flow between vessels. The stent-graft has a body implantable device and first and second peel-away retaining elements. Also disclosed are methods for deploying a stent-graft.
摘要翻译： 公开了一种用于恢复血管之间的血流的经皮支架移植物。 支架移植物具有主体可植入装置和第一和第二剥离保持元件。 还公开了用于展开支架移植物的方法。
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公开(公告)号：US5587125A
公开(公告)日：1996-12-24
申请号：US290075
申请日：1994-08-15
CPC分类号： A61M25/1029 , A61M2025/1075 , A61M2025/1084
摘要： A non-coextrusion process for making multi-layer angioplasty balloons involves pre-forming separate parisons and then concentrically disposing the plural parisons to form a composite parison which is then subjected to a blow-molding process. The resulting balloon can have its properties tailored by appropriate selection of the particular plastics to be used for the multiple parisons.
摘要翻译： 用于制备多层血管成形术气球的非共挤出方法包括预先形成分离的型坯，然后同心地布置多个型坯以形成复合型坯，然后将其进行吹塑过程。 所得到的气球可以通过适当选择用于多个型坯的特定塑料来调整其性能。
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25.发明授权Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel commingled with at least one other, dissimilar polymer hydrogel 失效含有聚氨酯 - 尿素聚合物水凝胶的湿滑粘结水凝胶涂层的方法，该水凝胶与至少一种其它不同的聚合物水凝胶
公开(公告)号：US5576072A
公开(公告)日：1996-11-19
申请号：US382459
申请日：1995-02-01
申请人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
发明人： Fritz Hostettler , David Rhum , Michael R. Forman , Michael N. Helmus , Ni Ding
IPC分类号： A61L29/04 , A61L29/08 , B05D7/00 , B05D7/02 , C08G18/10 , C08G18/48 , C08G18/75 , C09D175/04 , B05D3/00 , B29C71/02 , C04B41/00 , H05H1/00
CPC分类号： B05D7/54 , A61L29/049 , A61L29/085 , B05D7/02 , C08G18/10 , C08G18/4833 , C08G18/4837 , C08G18/755 , C08G18/758 , C09D175/04 , C08G2210/00 , Y10T428/31551
摘要： A process for preparing coating compositions of a commingled hydrogel of a polyurethane-polyurea polymer hydrogel and at least one other polymer hydrogel of a polymer different from polyurethane-polyurea; a process for making materials composed of a polymeric plastic or rubber substrate or a metallic substrate, with a coating of the commingled hydrogel thereon; and a process for making medical devices with a coating of the commingled hydrogel thereon, are disclosed. The coating compositions tenaciously adhere to the substrate materials and medical devices to which they are applied due to bonding of a tie coat to a reactive substrate surface and due to the commingling of the two hydrogel components. The coating compositions and coated materials and medical devices are non-toxic and biocompatible, making them ideally suited for use in applications such as for catheters, catheter balloons and stents. In such applications, the coating compositions, coated materials, and coated medical devices made therefrom demonstrate low coefficients of friction in contact with body fluids, especially blood, as well as a high degree of wear permanence over prolonged use. The commingled hydrogel coatings are capable of being dried to facilitate storage of the devices to which they have been applied, and can be instantly reactivated for later use by exposure to water.
摘要翻译： 制备聚氨酯 - 聚脲聚合物水凝胶的混合水凝胶和不同于聚氨酯 - 聚脲的聚合物的至少一种其它聚合物水凝胶的涂料组合物的方法; 制造由聚合物塑料或橡胶基材或金属基材组成的材料的方法，其上混合水凝胶的涂层; 并公开了在其上制造混合水凝胶涂层的医疗装置的方法。 涂层组合物由于粘结涂层与反应性基底表面的结合以及由于两种水凝胶组分的混合而顽固地粘附到其所施加的基底材料和医疗装置上。 涂料组合物和涂覆材料和医疗装置是无毒的和生物相容的，使得它们非常适用于诸如导管，导管气囊和支架的应用。 在这样的应用中，由其制成的涂料组合物，涂覆的材料和涂覆的医疗装置显示出与体液，特别是血液接触的低摩擦系数，以及长期使用时的高度的耐磨性。 混合的水凝胶涂层能够被干燥以便于其已被施加到的装置的储存，并且可以立即重新激活以供将来通过暴露于水中使用。
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公开(公告)号：US5531685A
公开(公告)日：1996-07-02
申请号：US284076
申请日：1994-08-01
CPC分类号： A61M25/0158
摘要： An apparatus includes a flexible tubular member containing a shape-memory tube formed to include a lumen extending along the central axis of the tubular member. A liner sleeve extends through the lumen of the shape-memory tube and lies inside the tubular member. A control system selectively heats the shape-memory tube to its activated state causing the shape-memory tube to move toward a predetermined shape if it is different than its present configuration. Whether the shape-memory tube moves or not, it will increase significantly in stiffness, both axial and bending to help retain, hold, or wedge the apparatus in place in a selected body cavity while catheters or other objects are passed through a lumen in the liner sleeve.
摘要翻译： 一种装置包括柔性管状构件，其包含形状记忆管，该形状记忆管形成为包括沿管状构件的中心轴延伸的内腔。 衬套套筒延伸穿过形状记忆管的内腔并位于管状构件的内部。 控制系统选择性地将形状记忆管加热至其激活状态，导致形状记忆管如果不同于其当前配置则朝预定形状移动。 无论形状记忆管是否移动，它将在刚度（轴向和弯曲）方面显着增加，以帮助将装置保持，保持或楔入所选体腔内的适当位置，同时导管或其它物体通过内窥镜 衬套。
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公开(公告)号：US5505699A
公开(公告)日：1996-04-09
申请号：US217306
申请日：1994-03-24
CPC分类号： A61M25/104 , A61M2025/0186 , A61M2025/09141 , A61M2025/1015 , A61M2025/1093
摘要： This invention relates to an angioplasty device that is formed from a hollow metallic tube, a balloon affixed adjacent the distal end of the tube and being in fluid communication with the lumen of the tube, a flexible distal segment connected to the distal end of the tube and a removable hub connected adjacent to the proximal end of the tube. The tube is preferably formed from a superelastic material such as nickel-titanium alloy. This invention also relates to various methods of using this angioplasty device.
摘要翻译： 本发明涉及一种由中空金属管形成的血管成形术装置，邻近管的远端固定并与管的内腔流体连通的球囊，连接到管的远端的柔性远端段 以及与管的近端相邻连接的可移除的轮毂。 该管优选由诸如镍 - 钛合金的超弹性材料形成。 本发明还涉及使用该血管成形术装置的各种方法。
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公开(公告)号：US5501759A
公开(公告)日：1996-03-26
申请号：US304413
申请日：1994-09-12
申请人： Michael R. Forman
发明人： Michael R. Forman
CPC分类号： A61M25/1034 , B29C65/1622 , B29C65/1635 , B29C65/1654 , B29C65/1664 , B29C65/1667 , B29C65/1683 , B29C65/1687 , B29C65/68 , B29C66/1122 , B29C66/3452 , B29C66/53241 , B29C66/5344 , B29C66/63 , B29C66/65 , B29C66/652 , B29C66/73921 , B29C66/80 , A61M2025/1031 , A61M25/0009 , B29C2035/0822 , B29C65/1616 , B29C65/1619 , B29C65/1661 , B29C66/71 , B29K2995/0049 , B29K2995/0069 , B29L2022/022 , B29L2031/7542 , B29L2031/7543
摘要： A process for assembling a balloon catheter involves selectively concentrating laser energy along an annular fusion bond site at contiguous surface portions of a length of catheter tubing and a shaft or neck portion of a dilatation balloon. The laser energy wavelength, and the polymeric materials of the balloon and catheter, are matched for high absorption of the laser energy to minimize conductive heat transfer in axial directions away from the bond site. This minimizes crystallization and stiffening in regions near the bond site, permitting fusion bonds to be located close to the proximal and distal cones of the dilatation balloon while preserving the soft, pliant quality of the cones. The disclosure further is directed to an embodiment of a balloon catheter assembled according to the process.
摘要翻译： 一种用于组装气囊导管的方法包括选择性地将激光能量沿着一定长度的导管管线和扩张球囊的轴或颈部部分的连续表面部分处的环形熔合部位集中。 激光能量波长以及球囊和导管的聚合物材料匹配，以激光能量的高吸收，以最小化离开粘结部位的轴向方向的传导热传递。 这使得结合位置附近的区域的结晶化和硬化最小化，允许熔融粘合位置靠近扩张球囊的近端和远端锥体，同时保持锥体的柔软，质地良好的质量。 本发明进一步涉及根据该方法组装的球囊导管的实施例。
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公开(公告)号：US5404886A
公开(公告)日：1995-04-11
申请号：US61083
申请日：1993-05-14
申请人： Jeffrey D. Vance
发明人： Jeffrey D. Vance
CPC分类号： A61M25/0905
摘要： A guidewire for guiding and exchanging body insertable catheters includes a body insertable guide section and an exchange section, both formed of flexible wire. In one embodiment, a pin connector at the distal end of the exchange section includes a truncated conical head, a shank, and a groove between the head and the shank. A socket connector is attached to the proximal end of the guide section. Four indentations are formed in the socket connector, spaced apart angularly 90.degree. from one another. The maximum diameter of the conical head is greater than the distance between opposed nodules, as the pin connector is insertable into the, it temporarily elastically deforms the socket as the head moves past the nodules. The nodules become captured within the groove, to allow rotation of the exchange section relative to the guide section while preventing any substantial axial relative movement of the sections. The exchange section can be disconnected from the guide section by withdrawing the pin connector proximally, again elastically deforming the socket as the head passes the nodules. The connectors permit repeated connections and disconnections, so the guidewire sections are reusable. In another embodiment, the pin connector has a cylindrical head and a narrower recess adjacent the head, and an indentation is formed in the socket connector with a gradually inclined wall that terminates in a steeply inclined edge.
摘要翻译： 用于引导和更换主体可插入导管的导丝线包括由柔性线形成的主体可插入引导部分和交换部分。 在一个实施例中，在交换部分的远端处的销连接器包括截头锥形头部，柄部以及头部和柄部之间的凹槽。 插座连接器附接到引导部分的近端。 在插座连接器中形成四个凹口，彼此间隔成90°角。 锥形头部的最大直径大于相对的结节之间的距离，因为销连接器可插入，当头部移动通过结节时，它使套管暂时弹性变形。 结节被捕获在凹槽内，以允许交换部分相对于引导部分旋转，同时防止部分的任何实质的轴向相对运动。 交换部分可以通过将销连接器向近端拔出而与引导部分断开，当头部通过结节时，再次使插座弹性变形。 连接器允许重复连接和断开连接，因此导线部分是可重复使用的。 在另一个实施例中，销连接器具有圆柱形头部和邻近头部的较窄凹槽，并且凹口在插座连接器中形成为具有终止于陡峭倾斜边缘的逐渐倾斜的壁。
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公开(公告)号：US5368567A
公开(公告)日：1994-11-29
申请号：US104422
申请日：1993-08-09
申请人： Jeffrey A. Lee
发明人： Jeffrey A. Lee
CPC分类号： A61M25/104 , A61M2025/0183 , A61M2025/1079
摘要： This disclosure is directed to the design of a dilatation catheter having two or more associated fluidcarrying tubes, the operative or distal end of one of which supplies fluid to inflate an expansible balloon and the operable or distal end of the other of which supplies an injectable dye or contrast enhancing fluid adjacent the proximal end of the balloon.
摘要翻译： 本公开涉及具有两个或更多个相关联的流体输送管的扩张导管的设计，其中一个的操作或远端提供流体以膨胀可膨胀气囊，另一个的可操作或远端提供可注射染料 或邻近气囊近端的对比度增强液体。
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