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    Compositions and methods of mutant Nogo-66 domain proteins
    21.
    发明申请
    Compositions and methods of mutant Nogo-66 domain proteins 审中-公开
    突变Nogo-66结构域蛋白的组成和方法

    公开(公告)号：US20070026463A1

    公开(公告)日：2007-02-01

    申请号：US11495061

    申请日：2006-07-28

    Applicant: Yuhong Xie ,  Brian Bates ,  Janet Paulsen

    Inventor： Yuhong Xie ,  Brian Bates ,  Janet Paulsen

    IPC: C40B30/06 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

    CPC classification number: G01N33/566 ,  C07K14/47 ,  C07K2319/61 ,  G01N2333/475 ,  G01N2500/02

    Abstract: To facilitate the study of Nogo-66 interaction with its neuronal receptors, and to explore therapeutic opportunities, the present invention provides mutant human Nogo-66 domain-based proteins that do not aggregate during isolation or purification procedures, and methods for using these proteins. Aggregates of Nogo-66 domain containing proteins do not effectively or efficiently bind to the NgR1 receptor, and therefore limit the utility of Nogo-66 domain-based reagents. To overcome aggregation problems, the invention provides proteins that comprise a mutant human Nogo-66 domain, wherein the cysteine at position 47 of the wild-type human Nogo-66 domain is mutated. The invention also provides for various Nogo-66 domain fusion reporter proteins that are able to bind to NgR1, and therefore can be used in high-throughput assays to identify drug candidate compounds that can block binding of the Nogo-66 domain to NgR1, indicating that these compounds may be potential therapeutic agents for neurodegenerative diseases and neuronal repair.

    Abstract translation: 为了促进Nogo-66与其神经元受体的相互作用的研究，并且为了探索治疗机会，本发明提供了在分离或纯化过程中不聚合的突变型人Nogo-66结构域的蛋白质，以及使用这些蛋白质的方法。 含有Nogo-66结构域的蛋白质的聚集体不能有效或有效地结合NgR1受体，因此限制了Nogo-66结构域的试剂的效用。 为了克服聚集问题，本发明提供了包含突变人Nogo-66结构域的蛋白质，其中野生型人Nogo-66结构域的位置47处的半胱氨酸被突变。 本发明还提供了能够结合NgR1的各种Nogo-66结构域融合报道蛋白，因此可用于高通量测定以鉴定可阻断Nogo-66结构域与NgR1结合的药物候选化合物，表明 这些化合物可能是神经变性疾病和神经元修复的潜在治疗剂。

    Method and a medical closure system for sealing a puncture
    22.
    发明申请
    Method and a medical closure system for sealing a puncture 审中-公开
    用于密封穿刺的方法和医疗闭合系统

    公开(公告)号：US20060229670A1

    公开(公告)日：2006-10-12

    申请号：US11396377

    申请日：2006-03-30

    Applicant: Brian Bates

    Inventor： Brian Bates

    IPC: A61B17/08

    CPC classification number: A61B17/0057 ,  A61B2017/00004 ,  A61B2017/00637 ,  A61B2017/00654 ,  A61B2017/00672

    Abstract: The invention is generally directed to a method for sealing a puncture through a wall of a blood vessel or wall of a body cavity. The invention is also directed to a medical closure system including a closure member, an occlusive material or a composition of occlusive materials.

    Abstract translation: 本发明一般涉及通过血管的壁或体腔的壁密封穿刺的方法。 本发明还涉及包括封闭构件，封闭材料或闭塞材料组合物的医疗闭合系统。

    Coated implantable medical device
    23.
    发明申请
    Coated implantable medical device 审中-公开
    涂层可植入医疗器械

    公开(公告)号：US20060195176A1

    公开(公告)日：2006-08-31

    申请号：US11410354

    申请日：2006-04-25

    Applicant: Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  Thomas Kozma ,  William Voorhees

    Inventor： Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  Thomas Kozma ,  William Voorhees

    IPC: A61F2/82

    CPC classification number: A61L33/022 ,  A61F2/0077 ,  A61F2/02 ,  A61F2/06 ,  A61F2/24 ,  A61F2/82 ,  A61F2/91 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  A61N5/1002 ,  C08L65/04

    Abstract: Bioactive-coated medical devices are provided, including coated vascular stents. The medical device coating can include a coating layer posited over at least a portion of the medical device surface, and can include a butyl methacrylate polymer or an ethylene-vinyl acetate copolymer in combination with a bioactive material that can function as both an immunosuppressive agent and an antiproliferative agent. Optionally, multilayer coatings can further include an adhesion promoting layer comprising parylene positioned between the coating layer and the medical device surface, a porous layer comprising butyl methacrylate positioned over at least a portion of the coating layer, or both. The coating layer preferably comprises between about 0.5 and 2.0 μg/mm2 of the bioactive material on the outer surface of the medical device. The bioactive material can be absorbed into the coating layer, which can have a thickness of between about 0.5 μm to about 5 μm.

    Abstract translation: 提供生物活性涂层医疗器械，包括涂层血管支架。 医疗器械涂层可以包括位于医疗器械表面的至少一部分上的涂层，并且可以包括甲基丙烯酸丁酯聚合物或乙烯 - 乙酸乙烯酯共聚物与可以用作免疫抑制剂和生物活性物质的生物活性材料 抗增生剂。 任选地，多层涂层还可以包括粘合促进层，其包括定位在涂层和医疗器件表面之间的聚对二甲苯，包含位于涂层的至少一部分上的甲基丙烯酸丁酯的多孔层，或两者。 涂层优选包含在医疗装置的外表面上的生物活性材料的约0.5和2.0杯/平方毫米之间。 生物活性材料可以被吸收到涂层中，其可以具有在约0.5μm至约5μm之间的厚度。

    Implantable bioabsorbable valve support frame
    25.
    发明申请
    Implantable bioabsorbable valve support frame 审中-公开
    植入式生物可吸收阀支架

    公开(公告)号：US20050267560A1

    公开(公告)日：2005-12-01

    申请号：US11136039

    申请日：2005-05-23

    Applicant: Brian Bates

    Inventor： Brian Bates

    IPC: A61F2/02 ,  A61F2/06 ,  A61F2/24 ,  A61L31/02 ,  A61L31/14

    CPC classification number: A61F2/2475 ,  A61F2/2418 ,  A61F2210/0004 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0023 ,  A61F2230/0026 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2230/0095

    Abstract: Medical devices for implantation within a body vessel comprising a frame formed at least in part from a metallic bioabsorbable material are provided. The devices can be pushed from a delivery catheter into the lumen of a duct or vessel and may include one or more barbs for anchoring purposes. A full or partial covering of fabric or other flexible material, or a bioabsorbable material, including a collagen-based material such as small intestinal submucosa (SIS), may be attached to the frame to form an occlusion device, a graft, or an implantable, intraluminal valve such as for correcting incompetent venous valves.

    Abstract translation: 提供用于植入体内容器的医疗装置，其包括至少部分地由金属生物可吸收材料形成的框架。 装置可以从输送导管推入管道或容器的内腔中，并且可以包括用于锚定目的的一个或多个倒钩。 织物或其他柔性材料或包括基于胶原的材料如小肠粘膜下层（SIS）的生物可吸收材料的全部或部分覆盖物可以附接到框架上以形成闭塞装置，移植物或植入物 ，腔内瓣膜如纠正无力静脉瓣膜。

    APPARATUS AND PROCESS FOR PRODUCING COATINGS
    28.
    发明申请
    APPARATUS AND PROCESS FOR PRODUCING COATINGS 有权

    公开(公告)号：US20210017664A1

    公开(公告)日：2021-01-21

    申请号：US16933387

    申请日：2020-07-20

    Applicant: Ying Zhang ,  Brian Bates ,  Jason Witman

    Inventor： Ying Zhang ,  Brian Bates ,  Jason Witman

    IPC: C25D17/04 ,  C25D15/02 ,  C25D17/06

    Abstract: An apparatus is disclosed for applying a coating to a desired object including a rotatable container having at least one container wall. An electrolyte can be retained within the container, the at least one container wall made of a material that does not allow the electrolyte to pass through the at least one container wall of the container. An anode can be positioned within the container. The apparatus can include a mount for securing the desired object such that a surface of the desired object is exposed to the electrolyte. A controller can be in electrical communication with the anode and the mount, wherein when power is supplied from the controller to the anode and the mount, particles in the electrolyte are deposited on the desired object forming a composite coating.

    Filter media retainer assembly
    29.
    发明授权
    Filter media retainer assembly 有权
    过滤介质固定器组件

    公开(公告)号：US08871093B2

    公开(公告)日：2014-10-28

    申请号：US13349185

    申请日：2012-01-12

    Applicant: Christopher J. Ball ,  Brian Bates

    Inventor： Christopher J. Ball ,  Brian Bates

    IPC: B01D24/22 ,  B01D24/46 ,  B01D24/24

    CPC classification number: B01D24/22 ,  B01D24/24 ,  B01D24/4631 ,  G06Q50/22 ,  H04N7/18

    Abstract: A filter system for filtering a liquid containing particles including a single media retainer plate having a top and bottom surface, and defining at least one hopper-shaped compartment having a sloped wall defining a slot spanning the top and bottom surfaces is disclosed. The plate also includes at least one baffle extending from the bottom surface and filter media disposed on the top surface. During a filtering operation of the filter system, the filter media captures the particles, such as dirt, from the liquid as the liquid passes through the filter media to an underdrain system. During a backwash operation of the filter system, the baffle is adapted to direct a backwash fluid in a vertical direction through the slot so that the backwash fluid actuates the filter media to scour the top surface of the plate and prevent the build-up of biological scaling on the plate.

    Abstract translation: 公开了一种过滤系统，用于过滤含有颗粒的液体，包括具有顶部和底部表面的单个介质保持板，并且限定了至少一个具有限定跨越顶部和底部表面的槽的倾斜壁的料斗形隔室。 板还包括从底表面延伸的至少一个挡板和设置在顶表面上的过滤介质。 在过滤系统的过滤操作期间，当液体通过过滤介质时，过滤介质从液体中捕获诸如污物的颗粒，从而将液体通过过滤介质。 在过滤系统的回洗操作期间，挡板适于将反洗流体沿垂直方向引导通过狭槽，使得反冲洗流体致动过滤介质以冲洗板的顶表面并防止生物体的积聚 在板上缩放。

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