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    Compositions and methods of mutant Nogo-66 domain proteins
    1.
    发明申请
    Compositions and methods of mutant Nogo-66 domain proteins 审中-公开
    突变Nogo-66结构域蛋白的组成和方法

    公开(公告)号：US20070026463A1

    公开(公告)日：2007-02-01

    申请号：US11495061

    申请日：2006-07-28

    申请人： Yuhong Xie ,  Brian Bates ,  Janet Paulsen

    发明人： Yuhong Xie ,  Brian Bates ,  Janet Paulsen

    IPC分类号： C40B30/06 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705

    CPC分类号： G01N33/566 ,  C07K14/47 ,  C07K2319/61 ,  G01N2333/475 ,  G01N2500/02

    摘要： To facilitate the study of Nogo-66 interaction with its neuronal receptors, and to explore therapeutic opportunities, the present invention provides mutant human Nogo-66 domain-based proteins that do not aggregate during isolation or purification procedures, and methods for using these proteins. Aggregates of Nogo-66 domain containing proteins do not effectively or efficiently bind to the NgR1 receptor, and therefore limit the utility of Nogo-66 domain-based reagents. To overcome aggregation problems, the invention provides proteins that comprise a mutant human Nogo-66 domain, wherein the cysteine at position 47 of the wild-type human Nogo-66 domain is mutated. The invention also provides for various Nogo-66 domain fusion reporter proteins that are able to bind to NgR1, and therefore can be used in high-throughput assays to identify drug candidate compounds that can block binding of the Nogo-66 domain to NgR1, indicating that these compounds may be potential therapeutic agents for neurodegenerative diseases and neuronal repair.

    摘要翻译： 为了促进Nogo-66与其神经元受体的相互作用的研究，并且为了探索治疗机会，本发明提供了在分离或纯化过程中不聚合的突变型人Nogo-66结构域的蛋白质，以及使用这些蛋白质的方法。 含有Nogo-66结构域的蛋白质的聚集体不能有效或有效地结合NgR1受体，因此限制了Nogo-66结构域的试剂的效用。 为了克服聚集问题，本发明提供了包含突变人Nogo-66结构域的蛋白质，其中野生型人Nogo-66结构域的位置47处的半胱氨酸被突变。 本发明还提供了能够结合NgR1的各种Nogo-66结构域融合报道蛋白，因此可用于高通量测定以鉴定可阻断Nogo-66结构域与NgR1结合的药物候选化合物，表明 这些化合物可能是神经变性疾病和神经元修复的潜在治疗剂。

    G-protein coupled receptor and uses therefor
    3.
    发明申请
    G-protein coupled receptor and uses therefor 审中-公开
    G蛋白偶联受体及其用途

    公开(公告)号：US20070031860A1

    公开(公告)日：2007-02-08

    申请号：US11396960

    申请日：2006-04-03

    申请人： Maria Blatcher ,  Brian Bates ,  Janet Paulsen

    发明人： Maria Blatcher ,  Brian Bates ,  Janet Paulsen

    IPC分类号： C12Q1/68 ,  G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

    CPC分类号： C07K14/70571 ,  A01K2217/075

    摘要： The present invention is based on the identification of a G-protein coupled receptor (GPCR) that is expressed predominantly in the brain and placenta and nucleic acid molecules that encoded the GPCR, which is referred to herein as the hCAR protein and hCAR gene respectively (for human Constitutively Active Receptor). Based on this identification, the present invention provides: (1) isolated hCAR protein; (2) isolated nucleic acid molecules that encode an hCAR protein; (3) antibodies that selectively bind to the hCAR protein; (4) methods of isolating allelic variants of the hCAR protein and gene; (5) methods of identifying cells and tissues that express the hCAR protein/gene; (6) methods of identifying agents and cellular compounds that bind to the hCAR protein; (7) methods of identifying agents that modulate the expression of the hCAR gene; and (8) methods of modulating the activity of the hCAR protein in a cell or organism.

    摘要翻译： 本发明基于主要在脑和胎盘中表达的G蛋白偶联受体（GPCR）的鉴定和编码GPCR的核酸分子（分别在本文中称为hCAR蛋白和hCAR基因） 对于人类组成型活性受体）。 基于该鉴定，本发明提供：（1）分离的hCAR蛋白; （2）编码hCAR蛋白的分离的核酸分子; （3）选择性结合hCAR蛋白的抗体; （4）分离hCAR蛋白和基因的等位基因变体的方法; （5）鉴定表达hCAR蛋白/基因的细胞和组织的方法; （6）鉴定与hCAR蛋白结合的试剂和细胞化合物的方法; （7）鉴定调节hCAR基因表达的试剂的方法; 和（8）调节细胞或生物体中hCAR蛋白活性的方法。

    Interactive system and method for boxing and martial arts
    7.
    发明授权
    Interactive system and method for boxing and martial arts 有权
    拳击和武术的交互系统和方法

    公开(公告)号：US08337366B2

    公开(公告)日：2012-12-25

    申请号：US13234110

    申请日：2011-09-15

    申请人： Terry G. Jones ,  Redza Shah ,  Jeffrey Eversmann ,  Nathan Sewell ,  Brian Bates ,  Joshua Eversmann

    发明人： Terry G. Jones ,  Redza Shah ,  Jeffrey Eversmann ,  Nathan Sewell ,  Brian Bates ,  Joshua Eversmann

    IPC分类号： A63B71/00 ,  A63B69/34

    CPC分类号： A63B69/201 ,  A63B24/0062 ,  A63B69/004 ,  A63B69/32 ,  A63B2024/0037 ,  A63B2220/53 ,  A63B2244/10 ,  A63B2244/102 ,  G09B19/0038

    摘要： A boxing or martial arts training and exercise device may include punching pads locationally displaced on a frame. Respective pads may be positioned in support on the frame for punching and kicking. Each pad can communicatively connect to one or more impact sensor. Each impact sensor can communicatively connect to a control unit. The control unit may be communicatively connected to a display. The impact sensor detects strikes to the pad. The impact sensor includes an accelerometer and a signal processor. The control unit includes an aggregator for receiving and logging strike metrics. The control unit directs sequences in the display according to a routine, and delivers indicators of strike metrics. The control unit includes a user interface for selection among sequences, as well as for selection of various menu items. A video of a human instructor or an animated avatar is viewable in a display.

    摘要翻译： 拳击或武术训练和锻炼装置可以包括位于框架上位置的冲压垫。 相应的垫可以被定位在框架上用于冲压和踢脚。 每个垫可以通信地连接到一个或多个冲击传感器。 每个冲击传感器可以通信地连接到控制单元。 控制单元可以通信地连接到显示器。 撞击传感器检测到撞击垫。 冲击传感器包括加速度计和信号处理器。 控制单元包括用于接收和记录打击度量的聚合器。 控制单元根据例程指示显示中的序列，并提供罢工指标的指标。 控制单元包括用于在序列之间进行选择的用户界面，以及用于选择各种菜单项。 人类教练或动画头像的视频可在显示器中观看。

    Coated implantable medical device
    10.
    发明申请
    Coated implantable medical device 有权
    涂层可植入医疗器械

    公开(公告)号：US20070050010A1

    公开(公告)日：2007-03-01

    申请号：US11515395

    申请日：2006-09-01

    申请人： Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  David Grewe ,  Darin Schaeffer

    发明人： Brian Bates ,  Anthony Ragheb ,  Neal Fearnot ,  William Voorhees ,  Thomas Kozma ,  David Grewe ,  Darin Schaeffer

    IPC分类号： A61F2/86 ,  A61F2/06

    CPC分类号： A61F2/91 ,  A61F2/24 ,  A61F2/82 ,  A61F2/885 ,  A61F2250/0068 ,  A61K51/1282 ,  A61L27/306 ,  A61L27/54 ,  A61L29/085 ,  A61L29/106 ,  A61L29/16 ,  A61L31/088 ,  A61L31/10 ,  A61L31/16 ,  A61L33/022 ,  A61L2300/256 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61N5/1002 ,  C08L65/04

    摘要： A coated implantable medical device 10 includes a structure 12 adapted for introduction into the vascular system, esophagus, trachea, colon, biliary tract, or urinary tract; at least one coating layer 16 posited on one surface of the structure; and at least one layer 18 of a bioactive material posited on at least a portion of the coating layer 16, wherein the coating layer 16 provides for the controlled release of the bioactive material from the coating layer. In addition, at least one porous layer 20 can be posited over the bioactive material layer 18, wherein the porous layer includes a polymer and provides for the controlled release of the bioactive material therethrough. Preferably, the structure 12 is a coronary stent. The porous layer 20 includes a polymer applied preferably by vapor or plasma deposition and provides for a controlled release of the bioactive material. It is particularly preferred that the polymer is a polyamide, parylene or a parylene derivative, which is deposited without solvents, heat or catalysts, and merely by condensation of a monomer vapor.

    摘要翻译： 涂覆的可植入医疗装置10包括适于引入到血管系统，食道，气管，结肠，胆道或尿道中的结构12; 至少一个涂层16位于该结构的一个表面上; 和至少一层生物活性物质的层18位于涂层16的至少一部分上，其中涂层16提供生物活性材料从涂层的受控释放。 此外，至少一个多孔层20可以放置在生物活性材料层18上方，其中多孔层包括聚合物并提供生物活性材料通过其控制释放。 优选地，结构12是冠状动脉支架。 多孔层20包括优选通过蒸气或等离子体沉积施加的聚合物，并提供生物活性材料的受控释放。 特别优选的是，聚合物是聚酰胺，聚对二甲苯或聚对二甲苯衍生物，它们不经溶剂，热或催化剂沉积，并且仅通过单体蒸气的冷凝而沉积。