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公开(公告)号：US20160279163A1
公开(公告)日：2016-09-29
申请号：US15172209
申请日：2016-06-03
Applicant: CytoSorbents Corporation
Inventor： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Robert H. Bartlett , Humayra Begum Ali
IPC: A61K31/745 , A61K9/00 , A61K47/48
CPC classification number: A61K31/745 , A61K9/0053 , A61K9/16 , A61K9/50 , A61K31/74 , A61K31/75 , A61K47/58 , B01J20/261 , B01J20/28004 , B01J20/28073 , B01J20/28076 , B01J20/3064 , C08F212/36 , C08J9/26 , C08J2201/0444 , C08J2207/10 , C08J2325/02 , Y02A50/406 , Y02A50/411
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
Abstract translation: 本发明涉及从患有或处于炎症风险的患者处理全身，局部或局部炎症的方法，其包括施用治疗有效剂量的吸附所述患者中的炎性介质的吸附剂。 在一些优选实施方案中，吸附剂是生物相容性有机聚合物。
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公开(公告)号：US20150335576A1
公开(公告)日：2015-11-26
申请号：US14410901
申请日：2013-06-28
Applicant: Cytosorbents Corporation
Inventor： Phillip P. Chan , Vincent J. Capponi , Thomas D. Golobish , Humayra Begum Ali
CPC classification number: A61M1/3679 , A61K9/16 , A61K31/765 , A61M2202/0057 , A61M2202/0405 , A61M2202/0413 , A61M2202/0415 , A61M2202/0423 , A61M2202/0464 , A61M2202/0466 , A61M2202/049 , A61M2202/0492 , A61M2202/0496 , A61M2202/20 , A61M2202/203 , A61M2202/206 , B01J20/261 , B01J20/28069 , B01J20/28078 , C08F299/00 , C08J9/26 , C08J2201/0444 , C08J2207/10 , C08J2353/00
Abstract: Provided herein are materials and methods of reducing contamination in a biological substance or treating contamination in a subject by one or more toxins comprising contacting the biological substance with an effective amount of a sorbent capable of sorbing the toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and sorbing the toxin. Also provided are kits to reduce contamination by one or more toxins in a biological substance comprising a sorbent capable of sorbing a toxin, wherein the sorbent comprises a plurality of pores ranging from 50 Å to 40,000 Å with a pore volume of 0.5 cc/g to 5.0 cc/g and a size of 0.05 mm to 2 cm and a vessel to store said sorbent when not in use together with packaging for same.
Abstract translation: 本文提供的是减少生物物质中的污染物或通过一种或多种毒素治疗受试者污染物的材料和方法，包括使生物物质与有效量的能够吸附毒素的吸附剂接触，其中吸附剂包括多个孔 范围从50埃到40,000埃，孔体积为0.5cc / g至5.0cc / g，尺寸为0.05mm至2cm，并吸附毒素。 还提供了用于减少包含能够吸附毒素的吸附剂的生物物质中的一种或多种毒素污染的试剂盒，其中所述吸附剂包括多孔孔径为50〜40,000埃，孔体积为0.5cc / g至 5.0cc / g和0.05mm至2cm的尺寸，以及当不与其一起使用的包装一起存储所述吸附剂的容器。
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公开(公告)号：US20230310693A1
公开(公告)日：2023-10-05
申请号：US18022018
申请日：2021-08-19
Applicant: CYTOSORBENTS CORPORATION
Inventor： Phillip P. CHAN , Ophir ORTIZ , Thomas D. Golobish , Vincent J. CAPPONI , Wei-Tai Young
CPC classification number: A61L15/44 , A61L15/425 , A61L15/38 , A61L2300/254 , A61L2300/43 , A61L2300/402 , A61L2300/414
Abstract: The invention concerns methods for the selective, topical or trans dermal delivery or removal of one or more substances to, or from, respectively, the skin or surface of a human or animal subject, via the topical or transdermal application of a porous, polymeric composition capable of releasing or sorbing (adsorbing and/or absorbing) said substances, wherein said porous polymer is a particulate material, with particles having an average diameter in the range of approximately 0.1 microns to approximately 0.5 centimeters, and having a plurality of pores with an average pore diameter in a range of approximately 50 Angstroms to approximately 40,000 Angstroms.
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公开(公告)号：US20210401874A1
公开(公告)日：2021-12-30
申请号：US17341912
申请日：2021-06-08
Applicant: CytoSorbents Corporation
Inventor： Thomas Golobish , Maryann Gruda , Tamaz Guliashvili , Pamela O'Sullivan , Andrew Scheirer , Vi Dan , Wei-Tai Young , Vincent Capponi , Phillip Chan
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
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公开(公告)号：US20210330697A1
公开(公告)日：2021-10-28
申请号：US17229265
申请日：2021-04-13
Applicant: CytoSorbents Corporation
Inventor： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Humayra Begum Ali
IPC: A61K31/745 , A61K31/74 , A61K31/75 , A61K9/00 , A61K9/16 , A61K9/50 , B01J20/26 , B01J20/28 , B01J20/30 , C08F212/36 , C08J9/26 , A61K47/58
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
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Patent Agency Ranking
26.发明授权公开(公告)号：US11065600B2
公开(公告)日：2021-07-20
申请号：US16303232
申请日：2017-05-18
Applicant: CYTOSORBENTS CORPORATION
Inventor： Tamaz Guliashvili , Thomas Golobish , Maryann Gruda , Pamela O'Sullivan , Andrew Scheirer , Vincent Capponi , Phillip Chan , Wei-Tai Young
IPC: A61K31/745 , B01J20/00 , B01J20/26 , B01D15/34 , B01J20/28 , B01J20/32 , A61K9/00 , A61M1/36 , B01D15/12
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.
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公开(公告)号：US20190282608A1
公开(公告)日：2019-09-19
申请号：US16424747
申请日：2019-05-29
Applicant: Cytosorbents Corporation
Inventor： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Humayra Begum Ali
IPC: A61K31/745 , A61K47/58 , A61K31/75 , A61K9/00 , C08J9/26 , C08F212/36 , B01J20/28 , A61K9/16 , B01J20/26 , B01J20/30 , A61K31/74 , A61K9/50
Abstract: The present invention concerns methods of administering a therapeutically effective dose of a sorbent for an inflammatory mediator to a patient where the inflammatory mediator is one or more of enzymes, cytokines, prostaglandins, eicosanoids, leukotrienes, kinins, complement, coagulation factors, endotoxins, enterotoxins, lipopolysaccharide, cell fragments, bile salts, fatty acids, phospholipids, interferon and immunomodulatory antibodies, biologics or drugs.
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公开(公告)号：US10314859B2
公开(公告)日：2019-06-11
申请号：US15886978
申请日：2018-02-02
Applicant: Cytosorbents Corporation
Inventor： Humayra Begum Ali , Thomas D. Golobish , Vincent J. Capponi , Phillip P. Chan , Wei Tai Young , Andrew Robert Scheirer
IPC: A61M31/00 , A61K31/74 , A61K31/765 , A61P1/06 , A61P1/04 , A61P1/00 , A61K9/00 , A61K31/79 , A61K31/75
Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).
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29.发明申请公开(公告)号：US20190060545A1
公开(公告)日：2019-02-28
申请号：US16082376
申请日：2017-02-17
Applicant: CYTOSORBENTS CORPORATION
Inventor： Maryann GRUDA , Pamela O'SULLIVAN , Tamaz GULIASHVILI , Andrew SCHEIRER , Thomas GOLOBISH , Vincent CAPPONI , Phillip CHAN
Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer sorbent with a plurality of pores, said polymer designed to adsorb pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules. Also disclosed herein are methods for reducing contamination in a biological substance, or treating contamination in a subject, by one or more pathogen-associated molecular pattern molecules and damage-associated molecular pattern molecules, by contacting the biological substance with an effective amount of sorbent capable of sorbing the toxin.
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公开(公告)号：US10034894B2
公开(公告)日：2018-07-31
申请号：US15635517
申请日：2017-06-28
Applicant: CytoSorbents Corporation
Inventor： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Humayra Begum Ali
IPC: A61K31/745 , A61K9/16 , A61K9/50 , C08J9/26 , B01J20/26 , B01J20/30 , A61K9/00 , B01J20/28 , C08F212/36 , A61K31/74 , A61K31/75 , A61K47/58
CPC classification number: A61K31/745 , A61K9/0053 , A61K9/16 , A61K9/50 , A61K31/74 , A61K31/75 , A61K47/58 , B01J20/261 , B01J20/28004 , B01J20/28073 , B01J20/28076 , B01J20/3064 , C08F212/36 , C08J9/26 , C08J2201/0444 , C08J2207/10 , C08J2325/02 , Y02A50/406 , Y02A50/411
Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
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