公开(公告)号：US20110311540A1

公开(公告)日：2011-12-22

申请号：US13117051

申请日：2011-05-26

Applicant: David Botstein ,  Robert L. Cohen ,  Audrey D. Goddard ,  Austin L. Gurney ,  Kenneth J. Hillan ,  David A. Lawrence ,  Arnold J. Levine ,  Diane Pennica ,  Margaret Ann Roy ,  William I. Wood

Inventor： David Botstein ,  Robert L. Cohen ,  Audrey D. Goddard ,  Austin L. Gurney ,  Kenneth J. Hillan ,  David A. Lawrence ,  Arnold J. Levine ,  Diane Pennica ,  Margaret Ann Roy ,  William I. Wood

IPC: A61K39/395 ,  C07K16/46 ,  A61P35/00 ,  C07K16/22

CPC classification number: C07K14/47 ,  C07K14/475 ,  C07K16/18 ,  C07K16/22 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/73 ,  C07K2317/74 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.

Abstract translation: 提供了Wnt-1诱导的分泌蛋白（WISP），其基因至少被Wnt-1诱导。 还提供了编码那些多肽的核酸分子，以及包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体，以及用于产生多肽的方法。

公开(公告)号：US20110171238A1

公开(公告)日：2011-07-14

申请号：US12944519

申请日：2010-11-11

Applicant: Diane Pennica ,  Victoria Smith ,  William I. Wood

Inventor： Diane Pennica ,  Victoria Smith ,  William I. Wood

IPC: A61K39/395 ,  C12N5/09 ,  A61P35/00

CPC classification number: C12N15/1034 ,  A61K38/1709 ,  A61K2039/505 ,  C07K14/47 ,  C07K2319/00 ,  C12N15/85 ,  G01N33/574 ,  A61K2300/00

Abstract: The present invention is directed to novel polypeptides having sequence similarity to Stra6, a murine retinoic acid responsive protein, and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Abstract translation: 本发明涉及与Stra6，鼠视黄酸反应性蛋白质以及编码这些多肽的核酸分子具有序列相似性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20100221249A1

公开(公告)日：2010-09-02

申请号：US12648425

申请日：2009-12-29

Applicant: DAVID BOTSTEIN ,  ROBERT L. COHEN ,  AUDREY D. GODDARD ,  AUSTIN L. GURNEY ,  KENNETH J. HILLAN ,  DAVID A. LAWRENCE ,  ARNOLD J. LEVINE ,  DIANE PENNICA ,  MARGARET ANN ROY ,  WILLIAM I. WOOD

Inventor： DAVID BOTSTEIN ,  ROBERT L. COHEN ,  AUDREY D. GODDARD ,  AUSTIN L. GURNEY ,  KENNETH J. HILLAN ,  DAVID A. LAWRENCE ,  ARNOLD J. LEVINE ,  DIANE PENNICA ,  MARGARET ANN ROY ,  WILLIAM I. WOOD

IPC: A61K39/395 ,  A61P35/00

CPC classification number: C07K14/47 ,  C07K14/475 ,  C07K16/18 ,  C07K16/22 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/73 ,  C07K2317/74 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.

Abstract translation: 提供了Wnt-1诱导的分泌蛋白（WISP），其基因至少被Wnt-1诱导。 还提供了编码那些多肽的核酸分子，以及包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体，以及用于产生多肽的方法。

公开(公告)号：USH2181H1

公开(公告)日：2007-02-06

申请号：US07663244

申请日：1991-02-28

Applicant: Arthur D. Levinson ,  Diane Pennica ,  William J. Kohr ,  Gordon A. Vehar ,  David V. Goeddel ,  Elizabeth M. Yelverton ,  Christian C. Simonsen

Inventor： Arthur D. Levinson ,  Diane Pennica ,  William J. Kohr ,  Gordon A. Vehar ,  David V. Goeddel ,  Elizabeth M. Yelverton ,  Christian C. Simonsen

IPC: C12N15/09

Abstract: A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild-type DHFR with methotrexate.

公开(公告)号：US07005499B1

公开(公告)日：2006-02-28

申请号：US09715418

申请日：2000-11-16

Applicant: David A. Lewin ,  Diane Pennica ,  Luca Rastelli ,  Bruce Taillon

Inventor： David A. Lewin ,  Diane Pennica ,  Luca Rastelli ,  Bruce Taillon

IPC: C07K14/47

CPC classification number: C07K14/52 ,  A61K38/00

Abstract: The present invention provides novel polypeptides, termed FCTRX polypeptides, as well as polynucleotides encoding FCTRX polypeptides and antibodies that immunospecifically bind to an FCTRX or a derivative, variant, mutant, or fragment of an FCTRX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FCTRX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.

Abstract translation: 本发明提供了称为FCTRX多肽的新型多肽，以及编码FCTRX多肽的多核苷酸和免疫特异性结合FCTRX或FCTRX多肽，多核苷酸或抗体的衍生物，变体，突变体或片段的抗体。 本发明还提供了FCTRX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

公开(公告)号：US06387657B1

公开(公告)日：2002-05-14

申请号：US09182145

申请日：1998-10-29

Applicant: David A. Botstein ,  Robert L. Cohen ,  Audrey D. Goddard ,  Austin L. Gurney ,  Kenneth J. Hillan ,  David A. Lawrence ,  Arnold J. Levine ,  Diane Pennica ,  Margaret Ann Roy ,  William I. Wood

Inventor： David A. Botstein ,  Robert L. Cohen ,  Audrey D. Goddard ,  Austin L. Gurney ,  Kenneth J. Hillan ,  David A. Lawrence ,  Arnold J. Levine ,  Diane Pennica ,  Margaret Ann Roy ,  William I. Wood

IPC: C12N1512

CPC classification number: C07K14/47 ,  C07K14/475 ,  C07K16/18 ,  C07K16/22 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/73 ,  C07K2317/74 ,  C12Q1/6886 ,  C12Q2600/136

Abstract: Wnt-1-Induced Secreted Proteins (WISPs) are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides, and methods for producing the polypeptides.

Abstract translation: 提供了Wnt-1诱导的分泌蛋白（WISP），其基因至少被Wnt-1诱导。 还提供了编码那些多肽的核酸分子，以及包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的多肽的嵌合多肽分子，与多肽结合的抗体，以及用于产生多肽的方法。

公开(公告)号：US06284247B1

公开(公告)日：2001-09-04

申请号：US09105681

申请日：1998-06-26

Applicant: David V. Goeddel ,  William J. Kohr ,  Diane Pennica ,  Gordon A. Vehar

Inventor： David V. Goeddel ,  William J. Kohr ,  Diane Pennica ,  Gordon A. Vehar

IPC: A61K3848

CPC classification number: C12N15/71 ,  A61K38/00 ,  C12N9/003 ,  C12N9/6459 ,  C12Y304/21069

Abstract: Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with which it is ordinarily associated in its native cellular environment. Methods, expression vehicles and various host cells useful in its production are also disclosed.

Abstract translation: 使用重组DNA技术以有用的量产生人组织纤溶酶原激活物（t-PA）。 因此，所公开的发明使得能够生产没有其天然细胞环境中通常相关的污染物的t-PA。 还公开了可用于其生产的方法，表达载体和各种宿主细胞。

公开(公告)号：US5849574A

公开(公告)日：1998-12-15

申请号：US450874

申请日：1995-05-26

Applicant: Arthur D. Levinson ,  Diane Pennica ,  William J. Kohr ,  Gordon A. Vehar ,  David V. Goeddel ,  Elizabeth M. Yelverton ,  Christian C. Simonsen

Inventor： Arthur D. Levinson ,  Diane Pennica ,  William J. Kohr ,  Gordon A. Vehar ,  David V. Goeddel ,  Elizabeth M. Yelverton ,  Christian C. Simonsen

IPC: C12N9/06 ,  C12N9/72 ,  C12N15/58 ,  C12N15/85

CPC classification number: C12N9/0028 ,  C12N15/85 ,  C12N9/6459 ,  C12Y304/21069 ,  C12N2800/108 ,  C12N2830/00 ,  C12N2830/55

Abstract: A method for producing tissue plasminogen activator (t-PA) in eukaryotic host cells is disclosed. Enhanced levels of t-PA production are obtained by co-amplification of the t-PA gene through treatment of cultures transformed with mutant or wild type DHFR with methotrexate.

Abstract translation: 公开了一种在真核宿主细胞中产生组织纤溶酶原激活物（t-PA）的方法。 通过用甲氨蝶呤处理用突变体或野生型DHFR转化的培养物共同扩增t-PA基因，获得增强的t-PA产生水平。

公开(公告)号：US5723585A

公开(公告)日：1998-03-03

申请号：US443130

申请日：1995-05-17

Applicant: Joffre Baker ,  Kenneth Chien ,  Kathleen King ,  Diane Pennica ,  William Wood

Inventor： Joffre Baker ,  Kenneth Chien ,  Kathleen King ,  Diane Pennica ,  William Wood

IPC: G01N33/53 ,  A61K38/00 ,  C07K14/52 ,  C07K16/24 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12N15/19 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/68 ,  C07K1/22 ,  A61K38/36 ,  C07K14/00 ,  C07K14/47

CPC classification number: C12Q1/025 ,  C07K14/52 ,  G01N33/6872 ,  A01K2217/05 ,  A61K38/00 ,  G01N2500/00 ,  Y10S930/14

Abstract: Isolated CHF, isolated DNA encoding CHF, recombinant or synthetic methods of preparing CHF, and a method of purifying CHF are disclosed. These CHF molecules are shown to influence hypertrophic activity and neurological activity. Accordingly, these compounds or their antagonists may be used for treatment of heart failure, arrhythmic disorders, inotropic disorders, and neurological disorders.

Abstract translation: 公开了分离的CHF，编码CHF的分离的DNA，重组或合成CHF制备方法和纯化CHF的方法。 显示这些CHF分子影响增生活性和神经活性。 因此，这些化合物或其拮抗剂可用于治疗心力衰竭，心律不齐症，肌力障碍和神经障碍。

公开(公告)号：US20100093628A1

公开(公告)日：2010-04-15

申请号：US12537888

申请日：2009-08-07

Applicant: Luc DESNOYER ,  Ellen H. FILVAROFF ,  Diane PENNICA

Inventor： Luc DESNOYER ,  Ellen H. FILVAROFF ,  Diane PENNICA

IPC: A61K38/17 ,  C12N5/00 ,  A61P19/00

CPC classification number: C07K14/475 ,  A61K38/00 ,  C07K14/47

Abstract: The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or degenerative cartilagenous disorders, including arthritis, comprising the administration of WISP polypeptide. Optionally, the administration may be in combination with one or more cartilage agents (e.g., peptide growth factor, catabolism antagonist, osteo-, synovial, anti-inflammatory factor). Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of WISP polypeptide in combination with standard surgical techniques. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of chondrocytes previously treated with an effective amount of WISP polypeptide.

Abstract translation: 本发明涉及软骨的治疗和修复方法，包括损伤的软骨或包括关节炎在内的退行性软骨疾病，包括施用WISP多肽。 任选地，给药可以与一种或多种软骨剂（例如肽生长因子，分解代谢拮抗剂，骨，滑膜，抗炎因子）组合。 或者，该方法提供了由损伤或退行性软骨障碍损伤的软骨的治疗和修复，包括与标准手术技术组合施用WISP多肽。 或者，该方法提供对由损伤或退行性软骨障碍损伤的软骨的治疗和修复，包括施用有效量的WISP多肽以前治疗的软骨细胞。