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21.发明公开公开(公告)号：US20230384312A1
公开(公告)日：2023-11-30
申请号：US18249830
申请日：2021-10-22
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , CENTRE HOSPITALIER UNIVERSITAIRE D'ANGERS , UNIVERSITE D'ANGERS , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
IPC分类号： G01N33/574
CPC分类号： G01N33/57438 , G01N33/57484 , G01N2333/988
摘要： A method of predicting the risk of recurrence in a subject undergoing treatment for, or having undergone treatment for, clear cell renal cell carcinoma (ccRCC), by comparing the level of extracellular vesicles, preferably microvesicles, expressing carbonic anhydrase 9 (CA9+ MVs) in a sample from the subject with a reference level. Also, a method of diagnosing ccRCC or identifying a risk of developing ccRCC, by comparing the level of CA9+ MVs in a sample from the subject with a reference level.
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22.发明公开公开(公告)号：US20230330440A1
公开(公告)日：2023-10-19
申请号：US18044645
申请日：2021-09-09
申请人： SORBONNE UNIVERSITE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
发明人： Serge PICAUD , Sara CADONI , José-Alain SAHEL , Mickaël TANTER , Charlie DEMENE
CPC分类号： A61N7/00 , C12N15/86 , A61N2007/0026 , C12N2750/14143 , A61N2007/0095
摘要： Devices and methods for reversibly stimulating neuronal cells in a subject. The devices include a module for generating ultrasounds at 4 MHz or more to stimulate neuronal cells expressing mechanosensitive channels with the ultrasounds. The methods include expressing mechanosensitive channels into neuronal cells and exposing the cells to ultrasounds at 4 MHz or more. Also, the use of the methods or devices for visual restoration in a subject.
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23.发明公开公开(公告)号：US20230253118A1
公开(公告)日：2023-08-10
申请号：US18004710
申请日：2021-07-12
发明人： Delphine SAUCE , Martin LARSEN
CPC分类号： G16H50/30 , G01N33/5308
摘要： An in vitro method of classifying a subject suspected to suffer from an acute event including the steps of: determining neopterin concentration in a biological sample obtained from the subject, comparing the concentration with a predetermined reference neopterin concentration, and assigning the subject to a risk group based on the comparison of the neopterin concentration with the predetermined reference neopterin concentration.
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公开(公告)号：US20230233553A1
公开(公告)日：2023-07-27
申请号：US18003783
申请日：2021-06-28
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , FONDATION IMAGINE , Université Paris Cité , Assistance Publique-Hôpitaux de Paris (APHP) , University of Connecticut
IPC分类号： A61K31/496 , A61K38/22 , A61P19/08
CPC分类号： A61K31/496 , A61K38/2242 , A61P19/08
摘要： Activating mutations in fibroblast growth factor receptor 3 (FGFR3) and inactivating mutations in the natriuretic peptide receptor 2 (NPR2) guanylyl cyclase both result in decreased production of cyclic GMP (cGMP) and severe short stature, causing achondroplasia and acromesomelic dysplasia type Maroteaux, respectively. In attempt to find a new therapeutic approach for FGFR3-related skeletal disease, the inventors showed that a combination of a NPR2 agonist (e.g. BMN-111) and a phosphatase inhibitor (e.g. LB-100) significantly increases the length of the Fgfr3Y367C/+ femurs compared to Fgfr3+/+ femurs and improves the whole growth plate cartilage. The present invention thus relates to the use of a NPR2 agonist (e.g. BMN-111) and a phosphatase inhibitor (e.g. LB-100) for the treatment of FGFR3-related skeletal disease (e.g. achondroplasia).
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公开(公告)号：US20230225698A1
公开(公告)日：2023-07-20
申请号：US17996094
申请日：2021-04-13
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , Centre National de la Recherche Scientifique (CNRS) , Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris
CPC分类号： A61B8/06 , A61B8/488 , A61B8/5223 , A61B8/0883
摘要： The present invention relates to the field of ultrasounds and imagining of the coronary blood flow of the heart. Patients with coronary microvascular dysfunction (CMD) have poor prognostic with significantly higher rates of cardiovascular events, including hospitalization for heart failure, sudden cardiac death, and myocardial infarction (MI). Despite the urgent clinical need, there are no non-ionizing and non-invasive techniques available in clinic to directly visualize the coronary microvasculature and assess the local coronary microvascular system. Flow imaging remains a difficult task to perform in the heart because of the fast movements of this organ. In order to overcome the limitations of actual imaging methods for the coronary blood flow, the inventors proposed an ultrasound ultrafast imaging method that automatically detect the time periods in which the myocardium velocity is low and estimate the coronary flow velocity and the tissue velocity from the same data acquisition.
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公开(公告)号：US20230215572A1
公开(公告)日：2023-07-06
申请号：US17611997
申请日：2020-05-29
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES , UNIVERSITE PARIS-SACLAY , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -
发明人： Irène BUVAT
CPC分类号： G16H50/30 , G06T7/0014 , G16H20/10 , G06T2207/10104 , G06T2207/30096
摘要： The present invention relates to a method for assisting with lymphoma prognosis. The prognosis of therapeutic response of patients with lymphoma is difficult. Based on a study of advanced stage DLBCL patients, the inventors showed that medical imaging such as 18F-FDG-PET/CT can provide a prognostic radiomic signature combining metrics reflecting tumor dissemination and tumor burden. In another aspect, the invention relates to a computer software comprising instructions to implement at least a part of a method according to the invention. In yet another aspect, the invention relates to a computer-readable non-transient recording medium on which a software is registered to implement a method according to the invention.
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27.发明公开公开(公告)号：US20230207300A1
公开(公告)日：2023-06-29
申请号：US17926730
申请日：2021-05-20
申请人： UNIVERSITE DE LILLE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)
发明人： Isabelle SALZET , Julien FRANCK , Michel SALZET , Flore HERVE
IPC分类号： H01J49/04 , H01J49/26 , G01N33/497 , H01J49/10
CPC分类号： H01J49/049 , G01N33/497 , H01J49/26 , H01J49/105
摘要： A system and method for analyzing volatile organic compounds (VOCs) adsorbed on an adsorbent membrane, by low-temperature plasma and mass spectrometry (LTP-MS). The system includes a receptacle for receiving the adsorbent membrane, a low-temperature plasma ionizer configured to emit a plasma stream in a plasma emission direction, thereby ionizing the VOCs adsorbed by the membrane and forming a VOC-laden ionized gas, and a mass spectrometer for analyzing the ionized VOCs.
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公开(公告)号：US20230173155A1
公开(公告)日：2023-06-08
申请号：US17997763
申请日：2021-04-30
申请人： MEXBRAIN , UNIVERSITE CLAUDE BERNARD LYON 1 , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS - , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , INSTITUT GUSTAVE ROUSSY , VETAGRO-SUP INSTITUT D'ENSEIGNEMENT SUPÉRIEUR ET DE RECHERCHE
发明人： Marco NATUZZI , Thomas BRICHART , Fabien ROSSETTI , Matteo MARTINI , François LUX , Olivier TILLEMENT , Jean-Luc PERFETTINI , Vanessa LOUZIER , Jeanne-Marie BONNET-GARIN , Jean-Yves AYOUB
IPC分类号： A61M1/16
CPC分类号： A61M1/1621 , A61M1/1654
摘要： The present invention relates to the field of medical devices, more particularly the field of devices for extracting circulating molecules from the blood of a mammal, and their therapeutic uses, in particular in treating sepsis, cytokine release syndrome and/or any other form of systemic inflammatory response or cytokine shock, caused by bacterial, parasitic, fungal or viral infections, in particular caused by a viral infection, for example coronaviruses with human respiratory tract tropism.
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29.发明公开公开(公告)号：US20230172919A1
公开(公告)日：2023-06-08
申请号：US17913268
申请日：2021-03-26
申请人： SORBONNE UNIVERSITE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： A61K31/4439 , A61K9/00 , A61P27/02 , A61K45/06 , A61K31/155
CPC分类号： A61K31/4439 , A61K9/0019 , A61K9/0048 , A61K31/155 , A61K45/06 , A61P27/02
摘要： An insulin sensitizer for use in the prevention and/or treatment of the damages caused by retinal detachment, and in particular for preventing or treating the loss of vision induced by retinal detachment. Also, a composition including the insulin sensitizer for use in the prevention and/or treatment of the damages caused by retinal detachment and a device including the composition.
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30.发明公开公开(公告)号：US20230142731A1
公开(公告)日：2023-05-11
申请号：US17862622
申请日：2022-07-12
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , GENETHON , SORBONNE UNIVERSITÉ , UNIVERSITÉ DE PARIS , SPARK THERAPEUTICS, INC.
发明人： Sébastien LACROIX-DESMAZES , Federico MINGOZZI , Jordan DIMITROV , Christian LEBORGNE , Sean ARMOUR
IPC分类号： A61K48/00 , C12N9/24 , C12N15/113 , C12N15/86 , A61K38/48 , C12N9/64 , C12N15/861
CPC分类号： A61K48/005 , C12N9/2402 , C12N15/113 , C12N15/86 , A61K38/4873 , C12N9/6475 , C12N15/861 , C12N2310/11 , C12N2310/141 , C12N2750/14143 , C12Y302/01 , C12Y304/22 , C12Y304/2201 , G01N33/6854
摘要： Disclosed herein are methods for treating patients that may develop or already have pre-existing gene therapy neutralizing antibodies by administering a protease that cleaves peptide bonds present in immunoglobulins or by administering a glycosidase that cleaves carbohydrate residues present on immunoglobulins, or other similar enzymatic cleavage of immunoglobulins in vivo. Also disclosed are methods for utilizing IdeS and other immunoglobulin G-degrading enzyme polypeptides for gene therapy treatment of a disease in a patient in need thereof.
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