公开(公告)号：US09717406B2

公开(公告)日：2017-08-01

申请号：US14757749

申请日：2015-12-22

Applicant: Manish Dinkarrao Kulkarni ,  Manmohan Singh Sidhu

Inventor： Manish Dinkarrao Kulkarni ,  Manmohan Singh Sidhu

IPC: A61B3/14 ,  A61B3/10 ,  A61B3/00 ,  A61B34/00

CPC classification number: A61B3/0083 ,  A61B3/0033 ,  A61B3/0041 ,  A61B3/102 ,  A61B34/25 ,  A61B2560/0431

Abstract: There is a need for robust and portable system, and apparatus for ophthalmology. We propose use of folding apparatus for ocular purposes for the first time. Our system will have a chin-rest (or face-rest or forehead rest) that can be folded so that the ocular device could be transported in a brief-case type casing.

公开(公告)号：US09636410B2

公开(公告)日：2017-05-02

申请号：US14130886

申请日：2012-07-06

Applicant: Luis Brito ,  Michelle Chan ,  Andrew Geall ,  Derek O'Hagan ,  Manmohan Singh

Inventor： Luis Brito ,  Michelle Chan ,  Andrew Geall ,  Derek O'Hagan ,  Manmohan Singh

IPC: A61K47/48 ,  A61K9/107 ,  A61K47/06 ,  A61K47/24 ,  A61K39/12 ,  A61K39/39 ,  A61K39/00

CPC classification number: A61K39/39 ,  A61K9/1075 ,  A61K39/12 ,  A61K39/155 ,  A61K39/245 ,  A61K47/02 ,  A61K47/06 ,  A61K47/12 ,  A61K47/22 ,  A61K47/24 ,  A61K47/26 ,  A61K47/34 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/575 ,  C12N7/00 ,  C12N2710/16134 ,  C12N2710/16171 ,  C12N2710/16734 ,  C12N2710/16771 ,  C12N2760/18534 ,  C12N2760/18571 ,  C12N2770/36134 ,  C12N2770/36143 ,  C12N2840/203 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/412

Abstract: This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.

公开(公告)号：US09393215B2

公开(公告)日：2016-07-19

申请号：US12095655

申请日：2006-12-01

Applicant: Janet R. Wendorf ,  Manmohan Singh ,  Derek T. O'Hagan

Inventor： Janet R. Wendorf ,  Manmohan Singh ,  Derek T. O'Hagan

IPC: A61K9/14 ,  A61K39/00 ,  A61K39/002 ,  A61K39/09 ,  A61K39/095 ,  A61K39/10 ,  A61K39/12 ,  A61K39/13 ,  A61K39/145 ,  A61K39/165 ,  A61K39/20 ,  A61K39/21 ,  A61K39/25 ,  A61K39/29 ,  A61K39/385 ,  A61K31/04 ,  A61K31/10 ,  A61K31/12 ,  A61K33/00 ,  A61K35/00 ,  A61K9/51 ,  A61K39/39

CPC classification number: A61K9/5153 ,  A61K39/39 ,  A61K2039/55555 ,  Y02A50/466

Abstract: Disclosed herein are sterile-filtered lyophilized nanoparticle compositions which contain at least one biodegradable polymer, at least one surfactant, at least one cryoprotective agent and at least one antigen. Also disclosed are methods of making and using such compositions and kits supplying such compositions.

Abstract translation: 本文公开了含有至少一种生物可降解聚合物，至少一种表面活性剂，至少一种冷冻保护剂和至少一种抗原的无菌过滤的冻干纳米颗粒组合物。 还公开了制备和使用这些组合物和提供这种组合物的试剂盒的方法。

公开(公告)号：US09192661B2

公开(公告)日：2015-11-24

申请号：US13808245

申请日：2011-06-07

Applicant: Siddhartha Jain ,  Derek O'Hagan ,  Manmohan Singh

Inventor： Siddhartha Jain ,  Derek O'Hagan ,  Manmohan Singh

IPC: A61K39/385 ,  A61K9/16 ,  A61K9/51 ,  A61K39/155 ,  C12N15/86 ,  C12N15/88 ,  A61K39/12 ,  A61K39/00

CPC classification number: A61K39/385 ,  A61K9/1617 ,  A61K9/1647 ,  A61K9/5123 ,  A61K9/5153 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/55555 ,  A61K2039/622 ,  A61P31/14 ,  C12N15/86 ,  C12N15/88 ,  C12N2760/18534 ,  C12N2770/36143

Abstract: Particle compositions comprising adsorbed RNA replicons as well as methods of making and using the same are described.

Abstract translation: 描述包含吸附的RNA复制子的颗粒组合物以及其制备和使用方法。

公开(公告)号：US09045470B2

公开(公告)日：2015-06-02

申请号：US12874153

申请日：2010-09-01

Applicant: Tom Yao Hsiang Wu ,  Yongkai Li ,  Alex Cortez ,  Kathy Yue ,  Xiaoyue Zhang ,  Manmohan Singh ,  David Skibinski

Inventor： Tom Yao Hsiang Wu ,  Yongkai Li ,  Alex Cortez ,  Kathy Yue ,  Xiaoyue Zhang ,  Manmohan Singh ,  David Skibinski

IPC: A01N61/00 ,  A61K31/00 ,  A01N57/00 ,  A61K31/675 ,  C07D471/04

CPC classification number: C07F9/6561 ,  C07D471/04

Abstract: The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.

Abstract translation: 本发明提供了一类新颖的化合物，免疫原性组合物和包含这些化合物的药物组合物以及使用这些化合物治疗或预防与Toll样受体7相关的疾病或病症的方法。一方面，该化合物可用作增强的佐剂 疫苗的有效性。

公开(公告)号：US20140112950A1

公开(公告)日：2014-04-24

申请号：US14002700

申请日：2012-03-02

Applicant: Manmohan Singh ,  Barbara Baudner ,  David Skibinski

Inventor： Manmohan Singh ,  Barbara Baudner ,  David Skibinski

IPC: A61K39/00

CPC classification number: A61K39/0018 ,  A61K31/4375 ,  A61K31/66 ,  A61K33/06 ,  A61K39/102 ,  A61K39/116 ,  A61K39/12 ,  A61K39/295 ,  A61K39/39 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N2730/10134 ,  C12N2770/32634 ,  Y02A50/466 ,  A61K2300/00

Abstract: Combination vaccine compositions as well as methods for their manufacture have a relatively low amount of antigen and/or a relatively low amount of aluminium, but they can nevertheless have immunogenicity which is comparable to combination vaccines with a relatively high amount of antigen and/or a relatively high amount of aluminium. Aluminium-free combination vaccine compositions are also provided e.g. compositions which are adjuvanted with an oil-in-water emulsion adjuvant.

Abstract translation: 组合疫苗组合物及其制备方法具有相对低量的抗原和/或相对低量的铝，但是它们仍可具有免疫原性，其可与具有相对高量抗原和/或 相对较高的铝量。 也提供了无铝组合疫苗组合物，例如， 用水包油乳剂佐剂佐剂化的组合物。

公开(公告)号：US20140083283A1

公开(公告)日：2014-03-27

申请号：US13608979

申请日：2012-09-10

Applicant: Dan W. Pratt ,  Manmohan Singh Chawla

Inventor： Dan W. Pratt ,  Manmohan Singh Chawla

IPC: E21B43/117

CPC classification number: E21B43/117 ,  F42B1/028 ,  F42D3/00

Abstract: A perforating system has a perforating module comprising a unitary body of explosive. The explosive is contained within a non-explosive casing, or liner, having formed indentations and a cover thereover. The indentations, which will transform into explosively formed penetrators (EFP's) upon detonation, have a perimeter shape that allows for improved packing density, e.g., a hexagonal perimeter, which results in relatively little “dead space” wherein no perforating penetrators are generated. In operation, the module provides a relatively dense shot pattern and substantially reduced amount of post-detonation debris that could clog the perforations and/or require remedial clean-up or repeat perforation.

Abstract translation: 射孔系统具有包括一体的爆炸物的穿孔模块。 爆炸物包含在不爆炸的外壳或内衬中，其上形成有凹痕和盖。 在爆炸时将变成爆炸形成的穿透器（EFP）的凹陷具有允许改进的填充密度（例如六边形周长）的周边形状，这导致相对较少的“死空间”，其中不产生穿孔穿透器。 在操作中，模块提供相对致密的喷射模式，并且显着减少了可能堵塞穿孔的后爆炸碎片的数量和/或需要补救清理或重复穿孔。

公开(公告)号：US20130195898A1

公开(公告)日：2013-08-01

申请号：US13621174

申请日：2012-09-15

Applicant: Derek O'Hagan ,  Gary S. Ott ,  John Donnelly ,  Jina Kazzaz ,  Mildred Ugozzoli ,  Manmohan Singh ,  John Barackman

Inventor： Derek O'Hagan ,  Gary S. Ott ,  John Donnelly ,  Jina Kazzaz ,  Mildred Ugozzoli ,  Manmohan Singh ,  John Barackman

IPC: A61K39/39

CPC classification number: A61K39/39 ,  A61K9/1075 ,  A61K9/167 ,  A61K39/0208 ,  A61K39/21 ,  A61K39/245 ,  A61K39/29 ,  Y02A50/411 ,  Y02A50/471

Abstract: Microparticles with adsorbent surfaces, methods of making such microparticles, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(α-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like, and are formed using cationic, anionic, or nonionic detergents. The surface of the microparticles efficiently adsorb biologically active macromolecules, such as DNA, polypeptides, antigens, and adjuvants. Also provided are compositions of an oil droplet emulsion having a metabolizable oil and an emulsifying agent. Immunogenic compositions having an immunostimulating amount of an antigenic substance, and an immunostimulating amount of an adjuvant composition are also provided. Methods of stimulating an immune response, methods of immunizing a host animal against a viral, bacterial, or parasitic infection, and methods of increasing a Th1 immune response in a host animal by administering to the animal an immunogenic composition of the microparticles, and/or microemulsions of the invention, are also provided.

公开(公告)号：US08431160B2

公开(公告)日：2013-04-30

申请号：US11710250

申请日：2007-02-24

Applicant: Derek O'Hagan ,  Manmohan Singh ,  Janet Wendorf ,  Jina Kazzaz ,  Padma Malyala

Inventor： Derek O'Hagan ,  Manmohan Singh ,  Janet Wendorf ,  Jina Kazzaz ,  Padma Malyala

IPC: A61K9/14 ,  A61K39/00 ,  A61K39/39 ,  A61K39/12 ,  A61K39/02 ,  A61K39/002 ,  A61K39/21 ,  A61K39/29 ,  A61K39/145 ,  A61K39/10 ,  A61K39/05 ,  A61K39/08 ,  A61P37/04

CPC classification number: A61K9/1652 ,  A61K39/095 ,  A61K39/385 ,  A61K39/39 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/6093

Abstract: Immunogenic compositions are described herein which comprise microparticles that further comprise a biodegradable polymer. The microparticle compositions also comprise a cationic polysaccharide and an immunological species selected from an antigen, an immunological adjuvant and a combination thereof. Also described are methods of making such compositions and methods of administering such compositions. Methods of modulating the release rate of immunological species from microparticles are also described. These methods comprise varying the ratio of the cationic polysaccharide relative to the biodegradable polymer within the microparticles.

公开(公告)号：US20120237546A1

公开(公告)日：2012-09-20

申请号：US13394036

申请日：2010-09-01

Applicant: Manmohan Singh ,  David Skibinski ,  Simona Cianetti ,  Francesco Doro ,  Siddhartha Jain

Inventor： Manmohan Singh ,  David Skibinski ,  Simona Cianetti ,  Francesco Doro ,  Siddhartha Jain

IPC: A61K39/00 ,  A61K39/095 ,  A61K39/12 ,  A61P37/04 ,  A61P31/04 ,  A61P31/12 ,  A61P31/14 ,  A61K39/02 ,  A61K39/155

CPC classification number: A61K39/39 ,  A61K31/4375 ,  A61K31/66 ,  A61K33/08 ,  A61K33/42 ,  A61K39/095 ,  A61K45/06 ,  A61K2039/55505 ,  A61K2039/55511 ,  Y02A50/386 ,  Y02A50/41 ,  A61K2300/00

Abstract: The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 7. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.

Abstract translation: 本发明提供了一类新颖的化合物，免疫原性组合物和包含这些化合物的药物组合物以及使用这些化合物治疗或预防与Toll样受体7相关的疾病或病症的方法。一方面，该化合物可用作增强的佐剂 疫苗的有效性。