公开(公告)号：US10111706B2

公开(公告)日：2018-10-30

申请号：US15220186

申请日：2016-07-26

申请人： MEDLUMICS S.L.

发明人： Eduardo Margallo Balbás ,  José Luis Rubio Guivernau ,  Santiago Jiménez Valero ,  Alejandro Barriga Rivera ,  Justo Contreras Bermejo ,  Juan Lloret Soler ,  Juan Sancho Durá

IPC分类号： A61B18/14 ,  A61B5/00 ,  A61B18/00 ,  A61B17/00 ,  A61B90/00

摘要： Systems and methods for performing RF ablation while monitoring the procedure using low coherence interferometry (LCI) data are described. A catheter includes a distal section, a proximal section, a multiplexer, and a sheath coupled between the distal section and the proximal section. The distal section includes several interconnected optical ports configured to transmit exposure radiation toward a sample and receive radiation that have been reflected or scattered from the sample. The interconnected optical ports are formed on a substrate having rigid sections and flexible sections arranged around the distal section. A holder maintains the interconnected optical elements in a fixed spatial relationship.

公开(公告)号：US09976844B2

公开(公告)日：2018-05-22

申请号：US15014148

申请日：2016-02-03

申请人： MEDLUMICS S.L.

发明人： Juan Lloret Soler ,  Juan Sancho Durá ,  José Luis Rubio Guivernau ,  Eduardo Margallo Balbás ,  William Kennedy Landles ,  Andrés Cifuentes ,  Blair Ungar ,  Kirill Zinoviev

IPC分类号： G01B9/02 ,  A61B5/00 ,  G02B6/30 ,  G02B6/27 ,  G02B6/32 ,  G02B6/42 ,  G02B26/08 ,  G02B6/293

CPC分类号： G01B9/02051 ,  A61B5/0066 ,  A61B2562/0233 ,  A61B2562/228 ,  G01B9/02091 ,  G02B6/2766 ,  G02B6/29346 ,  G02B6/30 ,  G02B6/32 ,  G02B6/4221 ,  G02B6/4226 ,  G02B6/4251 ,  G02B6/4269 ,  G02B6/4271 ,  G02B6/4284 ,  G02B26/0833

摘要： A chip package includes a housing, one or more electrical connections coupled to an exterior of the housing, a photonic integrated circuit, and a scanning unit. Both the photonic integrated circuit and the scanning unit are disposed within the housing. The photonic integrated circuit has at least one waveguide designed to guide a beam of light. The scanning unit is designed to laterally scan the beam of light across a focal plane outside of the housing. The scanning unit is aligned with the photonic integrated circuit such that the beam of light is coupled between the photonic integrated circuit and the scanning unit.

公开(公告)号：US20160038031A1

公开(公告)日：2016-02-11

申请号：US14820255

申请日：2015-08-06

申请人： Medlumics S.L.

发明人： Eduardo Margallo Balbás ,  Alejandro Barriga Rivera ,  José Luis Rubio Guivernau ,  Santiago Jiménez Valero ,  Juan Lloret Soler

IPC分类号： A61B5/00 ,  A61B18/18 ,  A61B1/07 ,  A61M25/09 ,  A61B1/00

CPC分类号： A61B5/0084 ,  A61B1/00009 ,  A61B1/00045 ,  A61B1/00087 ,  A61B1/00096 ,  A61B1/0016 ,  A61B1/07 ,  A61B5/0066 ,  A61B5/02007 ,  A61B5/6851 ,  A61B5/6852 ,  A61B5/6886 ,  A61B17/00 ,  A61B18/18 ,  A61B2017/22038 ,  A61B2017/22094 ,  A61B2018/0041 ,  A61B2018/00982 ,  A61B2562/0266 ,  A61M25/09 ,  A61M2025/09183

摘要： Systems and methods for controlling a guide with the aid of optical coherence tomography (OCT) data are described. A guide wire includes at least one optical fiber, a flexible substrate, and one or more optical elements. The at least one optical fiber transmits a source beam of radiation. The flexible substrate includes a plurality of waveguides. At least one of the plurality of waveguides transmits one or more beams of radiation away from the guide wire, and at least one of the plurality of waveguides receives one or more beams of scattered radiation that have been reflected or scattered from a sample. The multiplexer generates the one or more beams of exposure radiation from the source beam of radiation. The one or more optical elements at least one of focus and steer the one or more beams of radiation.

摘要翻译： 描述了借助于光学相干断层扫描（OCT）数据来控制指南的系统和方法。 引导线包括至少一个光纤，柔性基板和一个或多个光学元件。 所述至少一个光纤传输辐射源。 柔性基板包括多个波导。 所述多个波导中的至少一个将一个或多个辐射束从所述导丝传播，并且所述多个波导中的至少一个波导接收已经从样本反射或散射的一个或多个散射辐射束。 多路复用器产生来自辐射源的一束或多束曝光辐射。 所述一个或多个光学元件至少一个焦点并引导所述一个或多个辐射束。

公开(公告)号：US12011218B2

公开(公告)日：2024-06-18

申请号：US17746798

申请日：2022-05-17

申请人： Medlumics S.L.

发明人： Juan Sancho Durá ,  Sara Mas Gómez ,  David Gonzalez ,  Matthieu Duperron ,  Carlos Sanz Moreno ,  Jorge Jimenez ,  Alexandre Romoscanu

IPC分类号： A61B18/18 ,  A61M25/00 ,  G02B6/26 ,  A61B17/00 ,  A61B18/00

CPC分类号： A61B18/18 ,  A61M25/0012 ,  A61M25/005 ,  G02B6/262 ,  A61B2017/00292 ,  A61B2018/00577 ,  A61B2018/1807 ,  A61M2025/0096

摘要： Described herein are methods, devices, and support structures for assembling optical fibers in catheter tips and facilitating alignment and structural support. A method for assembling a plurality of optical fibers and lenses in a support structure for an ablation catheter includes providing a support structure with a proximal end, a body, and a distal end, the distal end including a plurality of alignment orifices or slits. A plurality of optical fibers are threaded through the alignment orifices or slits, such that each optical fiber is threaded through a corresponding alignment orifice or slit. An adhesive material is applied at each alignment orifice or slit to secure the optical fibers, and the plurality of optical fibers are then cleaved at the distal end to remove portions of the fibers extending out of the distal end. Finally, a lens is attached to each of the ends of the plurality of optical fibers.

公开(公告)号：US20230404696A1

公开(公告)日：2023-12-21

申请号：US18205951

申请日：2023-06-05

申请人： Medlumics S.L.

发明人： Juan SANCHO ,  David HERRANZ ,  Christophe BAILLEUL ,  James GREENE

IPC分类号： A61B90/00 ,  A61B18/14

CPC分类号： A61B90/06 ,  A61B2090/061 ,  A61B18/1492

摘要： Described herein are systems, methods for detecting gaps between lesions formed in tissue during ablation. A system includes a catheter that has proximal section, a distal section, and a shaft coupled between the proximal section and the distal section. A plurality of optical fibers are located within the catheter and are coupled to a computing device. The computing device includes a memory and a processor configured to receive, from the optical fibers, optical measurement data of a portion of tissue during or after an ablation, identify one or more optical properties of the portion of tissue by analyzing the optical measurement data, and detect a presence or an absence of a gap between one or more lesions formed in the portion of tissue based on the one or more optical properties.

公开(公告)号：US20230029805A1

公开(公告)日：2023-02-02

申请号：US17746798

申请日：2022-05-17

申请人： Medlumics S.L.

发明人： Juan SANCHO DURÁ ,  Sara MAS GÒMEZ ,  David GONZALEZ ,  Matthieu DUPERRON ,  Carlos SANZ MORENO ,  Jorge JIMENEZ ,  Alexandre ROMOSCANU

IPC分类号： A61B18/18 ,  G02B6/26 ,  A61M25/00

摘要： Described herein are methods, devices, and support structures for assembling optical fibers in catheter tips and facilitating alignment and structural support. A method for assembling a plurality of optical fibers and lenses in a support structure for an ablation catheter includes providing a support structure with a proximal end, a body, and a distal end, the distal end including a plurality of alignment orifices or slits. A plurality of optical fibers are threaded through the alignment orifices or slits, such that each optical fiber is threaded through a corresponding alignment orifice or slit. An adhesive material is applied at each alignment orifice or slit to secure the optical fibers, and the plurality of optical fibers are then cleaved at the distal end to remove portions of the fibers extending out of the distal end. Finally, a lens is attached to each of the ends of the plurality of optical fibers.

公开(公告)号：US11517199B2

公开(公告)日：2022-12-06

申请号：US16277863

申请日：2019-02-15

申请人： Medlumics S.L.

发明人： Eduardo Margallo Balbás ,  Alejandro Barriga Rivera ,  José Luis Rubio Guivernau ,  Santiago Jiménez Valero ,  Juan Lloret Soler

IPC分类号： A61B5/00 ,  A61B17/00 ,  A61B5/02 ,  A61M25/09 ,  A61B1/00 ,  A61B1/07 ,  A61B18/18 ,  A61B17/22 ,  A61B18/00

摘要： Embodiments for crossing an occlusion by controlling a guide with the aid of optical coherence tomography (OCT) data are described. Embodiments include transmitting one or more beams of radiation via one or more waveguides on a flexible substrate within a guide wire. One or more beams of scattered or reflected radiation may be received from a sample via one or more waveguides. Depth-resolved optical data of the sample may be generated based on the received beams of scattered or reflected radiation. The depth-resolved data may be used for determining at least one of a distance between the guide wire and a wall of the artery and a distance between the guide wire and an occlusion within the artery. A position of the guide wire within the artery may then be controlled based on the determined distance or distances.

公开(公告)号：US20210212755A1

公开(公告)日：2021-07-15

申请号：US17148506

申请日：2021-01-13

申请人： Medlumics S.L.

发明人： Jorge JIMENEZ ,  David HERRANZ ,  James GREENE ,  Michael NAGY ,  Tyler PANIAN ,  Juan SANCHO ,  Matthieu DUPERRON

IPC分类号： A61B18/14 ,  A61B18/12

摘要： Described herein is a system including a catheter, an optical circuit, a pulsed field ablation energy source, and a processing device. The catheter includes a proximal section, a distal section, and a shaft coupled between the proximal section and the distal section. The optical circuit is configured to transport light at least partially from the proximal section to the distal section and back. The pulsed field ablation energy source is coupled to the catheter and configured to transmit pulsed electrical signals to a tissue sample. The processing device is configured to analyze one or more optical signals received from the optical circuit to determine changes in polarization or phase retardation of light reflected or scattered by the tissue sample, and determine changes in a birefringence of the tissue sample based on the changes in polarization or phase retardation.

公开(公告)号：US20210077181A1

公开(公告)日：2021-03-18

申请号：US16950499

申请日：2020-11-17

申请人： MEDLUMICS S.L.

发明人： Eduardo Margallo Balbás ,  José Luis Rubio Guivernau ,  Santiago Jiménez Valero ,  Alejandro Barriga Rivera ,  Justo Contreras Bermejo ,  Juan Lloret Soler

IPC分类号： A61B18/14 ,  A61B5/00 ,  A61B5/053 ,  A61B18/24

摘要： Systems and methods for performing RF ablation while monitoring the procedure using low coherence interferometry (LCI) data are described. A catheter includes a distal section, a proximal section, a multiplexer, and a sheath coupled between the distal section and the proximal section. The distal section includes one or more electrodes configured to apply RF energy to a portion of a sample in contact with the electrode. The distal section also includes a plurality of optical elements configured to transmit one or more beams of exposure radiation away from the distal section of the catheter. The proximal section includes an optical source configured to generate a source beam of radiation and a detector configured to generate depth-resolved optical data. The multiplexer is configured to generate the one or more beams of exposure radiation from the source beam of radiation.

公开(公告)号：US10820806B2

公开(公告)日：2020-11-03

申请号：US16222284

申请日：2018-12-17

申请人： Medlumics S.L.

发明人： Matthieu Duperron ,  Juan Sancho Durá ,  José Luis Rubio Guivernau ,  Sara María Más Gómez

IPC分类号： A61B5/00 ,  G02B6/122 ,  G02B6/126 ,  G02B6/024 ,  A61B90/00 ,  G02B6/12 ,  A61B90/30 ,  G01B9/02

摘要： A medical instrument is described that includes an optical source, an optical fiber, and a waveguide patterned upon a substrate. The optical fiber receives radiation from the optical source and includes a first segment and a second segment. The second segment is rotated about an optical axis relative to the first segment. The waveguide receives radiation from the optical source and guides a beam of radiation. The waveguide includes a first waveguide segment designed to impart a first differential group delay on the beam of radiation and a second waveguide segment designed to impart a second differential group delay on the beam of radiation. A sum of the first differential group delay and the second differential group delay is substantially zero.