公开(公告)号：US20160251317A1

公开(公告)日：2016-09-01

申请号：US15148168

申请日：2016-05-06

Applicant: MERIAL INC.

Inventor： Charles Q. Meng

IPC: C07D235/28 ,  A61K45/06 ,  A61K31/277 ,  A61K31/4184

CPC classification number: C07D235/28 ,  A61K31/277 ,  A61K31/4184 ,  A61K45/06 ,  C07D235/08 ,  C07D235/10 ,  C07D235/18 ,  C07D405/04 ,  C07D405/10 ,  C07D409/04 ,  C07D409/10

Abstract: The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one benzimidazole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.

公开(公告)号：US20160199477A1

公开(公告)日：2016-07-14

申请号：US14991003

申请日：2016-01-08

Applicant: Merial Inc.

Inventor： Russell F. Bey ,  Paulraj Kirubakaran Lawrence ,  Randy R. Simonson

IPC: A61K39/102

CPC classification number: A61K39/102 ,  A61K2039/522 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/285 ,  C12N1/36

Abstract: The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.

Abstract translation: 本发明提供减毒的血液流行性感冒菌株，其在动物中引起血红蛋白溶血性免疫应答，包含所述菌株的组合物，针对血蓝单胞菌疫苗接种的方法，以及用于此类方法和组合物的试剂盒。 本发明还提供了多价疫苗，当以有效量向易感“运送发热”或牛呼吸道疾病的动物施用时提供保护性免疫。

公开(公告)号：US20160185726A1

公开(公告)日：2016-06-30

申请号：US14981847

申请日：2015-12-28

Applicant: MERIAL, INC.

Inventor： Charles Q. Meng ,  Alan Long ,  Scot Huber ,  Srinivas Reddy Gurrala ,  Douglas Edward Wilkinson ,  Gregory Pacofsky

IPC: C07D215/38 ,  A61K31/495 ,  A61K31/496 ,  C07D307/81 ,  C07C233/56 ,  A61K31/167 ,  C07D401/12 ,  C07D263/58 ,  C07D211/58 ,  C07D277/64 ,  C07D277/82 ,  C07D471/08 ,  C07D213/74 ,  C07D333/66 ,  C07D333/60 ,  A61K31/47 ,  A61K31/4995 ,  A61K31/472 ,  C07D295/16

CPC classification number: C07D215/38 ,  A61K31/167 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/472 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4995 ,  A61K45/06 ,  C07C233/56 ,  C07C235/16 ,  C07C2601/14 ,  C07D211/58 ,  C07D213/74 ,  C07D215/42 ,  C07D217/06 ,  C07D241/04 ,  C07D263/58 ,  C07D277/64 ,  C07D277/82 ,  C07D295/15 ,  C07D295/16 ,  C07D295/185 ,  C07D295/215 ,  C07D307/14 ,  C07D307/81 ,  C07D307/82 ,  C07D333/60 ,  C07D333/66 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/08 ,  Y02A50/423

Abstract: The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.

Abstract translation: 本发明涉及以下式（I）的新型驱肠剂化合物：其中Y和Z独立地为双环碳环或双环杂环基，或Y或Z中的一个为双环碳环或双环杂环基，Y中的另一个为 或Z是烷基，烯基，炔基，环烷基，苯基，杂环基或杂芳基，变量X1，X2，X3，X4，X5，X6，X7和X8如本文所定义。 本发明还提供包含本发明的驱肠剂化合物的兽用组合物及其用于治疗和预防动物寄生虫感染的用途。

公开(公告)号：US20160143285A1

公开(公告)日：2016-05-26

申请号：US15009996

申请日：2016-01-29

Applicant: MERIAL INC.

Inventor： Mark David Soll ,  Diane Larsen ,  Susan Mancini Cady ,  Peter Cheifetz ,  Izabela Galeska ,  Saijun Gong

IPC: A01N43/80

Abstract: This invention relates to veterinary compositions for treating and/or preventing fleas or ticks infection or infestation in an animal comprising an isoxazoline active agent of Formula (II): or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

公开(公告)号：US20160051519A1

公开(公告)日：2016-02-25

申请号：US14930690

申请日：2015-11-03

Applicant: MERIAL, INC.

Inventor： Mark D. Soll ,  Joseph K. Rosentel, JR. ,  James Pate ,  Natalya Shub ,  Monica Tejwani-Motwani ,  Carol Belansky

IPC: A61K31/42 ,  A61K31/4402 ,  A61K45/06 ,  A61K31/215 ,  A61K31/415 ,  A61K38/15 ,  A61K31/22 ,  A61K31/44

CPC classification number: A61K31/42 ,  A01N43/40 ,  A01N43/80 ,  A01N49/00 ,  A61K9/0017 ,  A61K9/06 ,  A61K31/215 ,  A61K31/22 ,  A61K31/231 ,  A61K31/366 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4745 ,  A61K31/7048 ,  A61K38/15 ,  A61K45/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/26 ,  A61K2300/00

Abstract: This invention relates to topical compositions for combating ectoparasites and endoparasites in animals, comprising at least one isoxazoline active agent and a pharmaceutically acceptable carrier, optionally in combination with one or more additional active agents. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

公开(公告)号：US09249102B2

公开(公告)日：2016-02-02

申请号：US14083879

申请日：2013-11-19

Applicant: MERIAL INC.

Inventor： Charles Q. Meng ,  Alan Long ,  Srinivas Reddy Gurrala ,  Douglas Edward Wilkinson

IPC: A61K31/497 ,  C07D401/00 ,  C07D215/38 ,  A61K31/167 ,  A61K31/4704 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4995 ,  A61K45/06 ,  C07D241/04 ,  C07D277/64 ,  C07D307/81 ,  C07D401/06 ,  C07D401/12 ,  C07D417/06 ,  C07D471/08 ,  C07D403/12 ,  C07D213/74 ,  C07D215/42 ,  C07D217/06 ,  C07D333/66 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D263/58 ,  C07D277/82 ,  C07D295/15 ,  C07D295/185 ,  C07D295/215 ,  C07D307/14 ,  C07D307/82 ,  C07C233/56 ,  C07C235/16

CPC classification number: C07D215/38 ,  A61K31/167 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/472 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4995 ,  A61K45/06 ,  C07C233/56 ,  C07C235/16 ,  C07C2601/14 ,  C07D211/58 ,  C07D213/74 ,  C07D215/42 ,  C07D217/06 ,  C07D241/04 ,  C07D263/58 ,  C07D277/64 ,  C07D277/82 ,  C07D295/15 ,  C07D295/16 ,  C07D295/185 ,  C07D295/215 ,  C07D307/14 ,  C07D307/81 ,  C07D307/82 ,  C07D333/60 ,  C07D333/66 ,  C07D401/06 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12 ,  C07D471/08

Abstract: The present invention relates to novel anthelmintic compounds of formula (I) below: wherein Y and Z are independently a bicyclic carbocyclic or a bicyclic heterocyclic group, or one of Y or Z is a bicyclic carbocyclic or a bicyclic heterocyclic group and the other of Y or Z is alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, heterocyclyl or heteroaryl, and variables X1, X2, X3, X4, X5, X6, X7 and X8 are as defined herein. The invention also provides for veterinary compositions comprising the anthelmintic compounds of the invention, and their uses for the treatment and prevention of parasitic infections in animals.

Abstract translation: 本发明涉及以下式（I）的新型驱肠剂化合物：其中Y和Z独立地为双环碳环或双环杂环基，或Y或Z中的一个为双环碳环或双环杂环基，Y中的另一个为 或Z是烷基，烯基，炔基，环烷基，苯基，杂环基或杂芳基，变量X1，X2，X3，X4，X5，X6，X7和X8如本文所定义。 本发明还提供包含本发明的驱肠剂化合物的兽用组合物及其用于治疗和预防动物寄生虫感染的用途。

公开(公告)号：US20160008457A1

公开(公告)日：2016-01-14

申请号：US14798132

申请日：2015-07-13

Applicant: MERIAL, INC.

Inventor： Srivishnupriya Anbalagan ,  Emily Collin ,  Benjamin Matthew Hause

IPC: A61K39/215 ,  C12N7/00

CPC classification number: A61K39/215 ,  A61K39/225 ,  A61K2039/5252 ,  C12N7/00 ,  C12N2770/18034 ,  C12N2770/18071 ,  C12N2770/20021 ,  C12N2770/20034

Abstract: The present invention encompasses porcine epidemic diarrhea virus (PEDV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing inactivated PEDV. The invention also encompasses epitopes or immunogens which can be used to protect porcine animals against PEDV.

Abstract translation: 本发明包括猪流行性腹泻病毒（PEDV）疫苗或组合物。 疫苗或组合物可以是含有灭活的PEDV的疫苗或组合物。 本发明还包括可用于保护猪动物免受PEDV的表位或免疫原。

公开(公告)号：US20160000896A1

公开(公告)日：2016-01-07

申请号：US14851457

申请日：2015-09-11

Applicant: Merial Inc.

Inventor： Nicolas Pierre Yves Carboulec ,  Rene Labatut ,  Lionel Gerentes

IPC: A61K39/02

CPC classification number: A61K39/099 ,  A61K39/0225 ,  A61K39/0241 ,  A61K2039/521 ,  A61K2039/552

Abstract: The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.

Abstract translation: 本发明涉及用于灭活微生物和病毒的高压装置，同时保留其免疫原性并用于制备和产生可从原核生物或真核生物产生的包涵体的可溶性，分解，重折叠或活性免疫原性或治疗性蛋白质。 本发明包括用于灭活致病生物体的高压方法，以及使用灭活病原体生产疫苗组合物的方法。 高温灭活的微生物比化学灭活的微生物更安全，更具免疫原性。 类似地，与更重聚集的蛋白质相比，溶解的蛋白质具有优异的性质，包括减少的非特异性免疫反应。

公开(公告)号：US20150328307A1

公开(公告)日：2015-11-19

申请号：US14716481

申请日：2015-05-19

Applicant: MERIAL, INC.

Inventor： Paulraj Lawrence ,  Russell Bey

IPC: A61K39/225 ,  C12N7/00

CPC classification number: A61K39/215 ,  A61K39/225 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/14041 ,  C12N2770/20034

Abstract: The present invention encompasses porcine epidemic diarrhea virus (PEDV) vaccines or compositions. The vaccine or composition may be a vaccine or composition containing PEDV antigens. The invention also encompasses recombinant vectors encoding and expressing PEDV antigens, epitopes or immunogens which can be used to protect porcine animals against PEDV.

Abstract translation: 本发明包括猪流行性腹泻病毒（PEDV）疫苗或组合物。 疫苗或组合物可以是含有PEDV抗原的疫苗或组合物。 本发明还包括编码和表达可用于保护猪动物抵抗PEDV的PEDV抗原，表位或免疫原的重组载体。

公开(公告)号：US20150183785A1

公开(公告)日：2015-07-02

申请号：US14658668

申请日：2015-03-16

Applicant: MERIAL, INC.

Inventor： Loic Patrick Le Hir de Fallois ,  Hyoung Ik Lee ,  Douglas Edward Wilkinson ,  Brent Christopher Beck

IPC: C07D471/04 ,  A01N43/90

CPC classification number: C07D471/04 ,  A01N43/80 ,  A01N43/90 ,  A61K31/365 ,  A61K31/437 ,  A61K31/495 ,  A61K38/05 ,  A61K45/06 ,  C07K5/06 ,  A61K2300/00

Abstract: The present invention relates to novel dihydroazole of formula (I) and salts thereof: Wherein R1, A1, A2, G, X and Y are as defined in the description, compositions thereof, processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.

Abstract translation: 本发明涉及式（I）的新型二氢唑及其盐：其中R1，A1，A2，G，X和Y如说明书中所定义，其组成，其制备方法及其用于预防或治疗寄生虫 感染或感染动物和农药。