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157 条记录 (耗时 0.034 秒)

    Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation
    26.
    发明授权
    Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation 有权
    编码参与体内平衡和适应的蛋白质的谷氨酸棒杆菌基因

    公开(公告)号：US06831165B1

    公开(公告)日：2004-12-14

    申请号：US09602777

    申请日：2000-06-23

    申请人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer

    发明人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer

    IPC分类号： C07H2104

    CPC分类号： C12Q1/689 ,  C07K14/34 ,  C07K2319/00 ,  C12N9/00 ,  C12N9/18 ,  C12P13/04

    摘要： Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated HA proteins, mutated HA proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of HA genes in this organism.

    摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型HA蛋白质的分离的核酸分子，命名为HA核酸分子。 本发明还提供反义核酸分子，含有HA核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供分离的HA蛋白，突变的HA蛋白，融合蛋白，抗原肽以及用于基于该生物体中HA基因的遗传工程改进谷氨酸棒球菌产生所需化合物的方法。

    Method for the production of glutaconate
    29.
    发明授权
    Method for the production of glutaconate 有权
    生产戊二酸的方法

    公开(公告)号：US08778645B2

    公开(公告)日：2014-07-15

    申请号：US13144616

    申请日：2010-01-15

    申请人： Oskar Zelder ,  Wolfgang Buckel ,  Ivana Djurdjevic

    发明人： Oskar Zelder ,  Wolfgang Buckel ,  Ivana Djurdjevic

    IPC分类号： C12P21/06 ,  C12P7/44 ,  C12N9/00 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04

    CPC分类号： C12P7/44 ,  C12N9/0006 ,  C12N9/13 ,  C12N9/88 ,  C12P7/50

    摘要： The present invention relates to a novel method for the biocatalytic production of unsaturated dicarboxylic acids by cultivating a recombinant microorganism co-expressing a glutaconate CoA-transferase and a 2-hydroxyglutaryl-CoA dehydratase system. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as a method of preparing polyamide or polyester copolymers making use of said dicarboxylic acids as obtained by said biocatalytic production method.

    摘要翻译： 本发明涉及通过培养共表达戊二酸CoA转移酶和2-羟基戊二酰辅酶A脱水酶系统的重组微生物来生物催化生产不饱和二羧酸的新方法。 本发明还涉及适用于制备这种宿主的相应的重组宿主，重组载体，表达盒和核酸以及通过所述生物催化生产方法获得的制备使用所述二羧酸的聚酰胺或聚酯共聚物的方法。

    Method for producing methionine using a microorganism with reduced expression activity of a negative regulator of methionine biosynthesis
    30.
    发明授权
    Method for producing methionine using a microorganism with reduced expression activity of a negative regulator of methionine biosynthesis 有权
    使用具有降低甲硫氨酸生物合成负调节子的表达活性的微生物生产甲硫氨酸的方法

    公开(公告)号：US08389251B2

    公开(公告)日：2013-03-05

    申请号：US13018119

    申请日：2011-01-31

    申请人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer ,  Stefan Haefner ,  Corrinna Klopprogge

    发明人： Markus Pompejus ,  Burkhard Kröger ,  Hartwig Schröder ,  Oskar Zelder ,  Gregor Haberhauer ,  Stefan Haefner ,  Corrinna Klopprogge

    IPC分类号： C12P13/12 ,  C12N15/74

    CPC分类号： C07K14/34

    摘要： Isolated nucleic acid molecules, designated MR nucleic acid molecules, which encode novel MR proteins from Corynebacterium glutamicum are described which are involved in biosynthesis of a fine chemical, e.g., methionine biosynthesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MR nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides methods of producing methionine from microorganisms, e.g., C. glutamicum, which involve culturing recombinant microorganisms which overexpress or underexpress at least one MR molecule of the invention under conditions such that methionine is produced. Also featured are methods of producing a fine chemical, e.g., methionine, which involve culturing recombinant microorganisms having selected MR genes deleted or mutated under conditions such that the fine chemical, e.g., methionine, is produced.

    摘要翻译： 描述了编码来自谷氨酸棒杆菌的新型MR蛋白质的分离的核酸分子，称为MR核酸分子，其涉及精细化学品的生物合成，例如甲硫氨酸生物合成。 本发明还提供反义核酸分子，含有MR核酸分子的重组表达载体和已经引入表达载体的宿主细胞。 本发明还提供了从微生物例如谷氨酸棒杆菌制备甲硫氨酸的方法，其涉及在产生甲硫氨酸的条件下培养过表达或低表达本发明的至少一种MR分子的重组微生物。 还特征在于生产精细化学品的方法，例如甲硫氨酸，其涉及在产生精细化学物质例如甲硫氨酸的条件下培养具有选择的MR基因缺失或突变的重组微生物。