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公开(公告)号：US20100255463A1
公开(公告)日：2010-10-07
申请号：US11648184
申请日：2006-12-29
申请人： Susan Harsin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Harsin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
CPC分类号： C12Q1/6869 , C12Q2565/101 , C12Q2565/301 , C12Q2537/143
摘要： A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.
摘要翻译： 公开了一种测序方法，其允许单个DNA或RNA分子或其部分直接和基本实时地进行测序。 该方法涉及工程化具有原子和/或分子标签的聚合酶和/或dNTP，其具有由检测系统监测的可检测性质。
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22.发明申请ENZYMATIC NUCLEIC ACID SYNTHESIS: METHODS FOR DIRECT DETECTION OF TAGGED MONOMERS 审中-公开酶促核酸合成：用于直接检测标记单体的方法公开(公告)号：US20100216122A1
公开(公告)日：2010-08-26
申请号：US12352353
申请日：2009-01-12
申请人： Susan H. Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan H. Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C07H19/06 , C07H19/10 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12Q1/6806 , C12Q1/6853 , C12Q2525/101 , C12Q2565/301 , C12Q2533/101 , C12Q2525/113
摘要： Nucleotide triphosphate probes containing a molecular and/or atomic tag on a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed.
摘要翻译： 在γ和/或bgr上含有分子和/或原子标签的核苷酸三磷酸探针; 公开了具有可检测性质的磷酸基和/或碱基部分，以及在测序反应和各种测定中使用标记的核苷酸的试剂盒和方法。 此外，公开了磷酸盐和聚磷酸盐分子保真改性剂。
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公开(公告)号：US20070275395A1
公开(公告)日：2007-11-29
申请号：US11648856
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q2565/101 , C12Q2565/301 , C12Q2537/143
摘要： A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.
摘要翻译： 公开了一种测序方法，其允许单个DNA或RNA分子或其部分直接和基本实时地进行测序。 该方法涉及工程化具有原子和/或分子标签的聚合酶和/或dNTP，其具有由检测系统监测的可检测特性。
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公开(公告)号：US20070184475A1
公开(公告)日：2007-08-09
申请号：US11648713
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
CPC分类号： C12Q1/6869 , C12Q2565/101 , C12Q2565/301 , C12Q2537/143
摘要： A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.
摘要翻译： 公开了一种测序方法，其允许单个DNA或RNA分子或其部分直接和基本实时地进行测序。 该方法涉及工程化具有原子和/或分子标签的聚合酶和/或dNTP，其具有由检测系统监测的可检测特性。
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公开(公告)号：US20070172866A1
公开(公告)日：2007-07-26
申请号：US11648182
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
CPC分类号： C12Q1/6869 , C12Q2565/101 , C12Q2537/157 , C12Q2535/122 , C12Q2565/301 , C12Q2537/143 , C12Q2521/319
摘要： A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.
摘要翻译： 公开了一种测序方法，其允许单个DNA或RNA分子或其部分直接和基本实时地进行测序。 该方法涉及工程化具有原子和/或分子标签的聚合酶和/或dNTP，其具有由检测系统监测的可检测特性。
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公开(公告)号：US20070172865A1
公开(公告)日：2007-07-26
申请号：US11648174
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
CPC分类号： C12Q1/6869 , C12Q2565/101 , C12Q2565/301 , C12Q2537/143
摘要： A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.
摘要翻译： 公开了一种测序方法，其允许单个DNA或RNA分子或其部分直接和基本实时地进行测序。 该方法涉及工程化具有原子和/或分子标签的聚合酶和/或dNTP，其具有由检测系统监测的可检测特性。
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公开(公告)号：US20060088946A1
公开(公告)日：2006-04-27
申请号：US11257566
申请日：2005-10-25
申请人： Richard Willson , Paul Ruchhoeft
发明人： Richard Willson , Paul Ruchhoeft
IPC分类号： C12Q1/68 , G01N33/551
CPC分类号： G01N33/54373 , B82Y5/00 , C12Q1/6837 , Y10S436/805 , Y10S977/701 , Y10S977/702 , Y10S977/704 , Y10S977/705 , Y10S977/773 , Y10S977/774 , Y10S977/834 , Y10S977/92 , C12Q2563/155
摘要： Labels and methods of producing labels for use in clinical, analytical and pharmaceutical development assays are provided. Labels may comprise shape-encoded particles which may be coupled to ligands such as DNA, RNA and antibodies, where different shapes are used to identify which ligand(s) are present. Labels may also comprise reflectors, including retroreflectors and retroreflectors susceptible to analyte-dependent assembly for efficient homogeneous assays.
摘要翻译： 提供了生产用于临床，分析和药物开发测定的标签的标签和方法。 标签可以包括可以与诸如DNA，RNA和抗体的配体偶联的形状编码的颗粒，其中使用不同的形状来鉴定哪些配体存在。 标签还可以包括反射器，包括对分析物依赖性装配易于进行有效均匀测定的后向反射器和后向反射器。
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公开(公告)号：US20190237094A1
公开(公告)日：2019-08-01
申请号：US16380869
申请日：2019-04-10
摘要： A system for intelligent acoustic monitoring. The system includes a microphone to capture environmental acoustic data and a processor coupled to the microphone. The processor is configured to receive and perform acoustic analysis on the captured acoustic data to generate an acoustic signature, based on a result of the acoustic analysis, identify an event indicated by the acoustic signature, and perform a remedial action based on the identified event.
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公开(公告)号：US20110059436A1
公开(公告)日：2011-03-10
申请号：US12419660
申请日：2009-04-07
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
CPC分类号： C12Q1/6869 , C12Q2565/101 , C12Q2565/301 , C12Q2537/143
摘要： A sequencing methodology is disclosed that allows a single DNA or RNA molecule or portion thereof to be sequenced directly and in substantially real time. The methodology involves engineering a polymerase and/or dNTPs with atomic and/or molecular tags that have a detectable property that is monitored by a detection system.
摘要翻译： 公开了一种测序方法，其允许单个DNA或RNA分子或其部分直接和基本实时地进行测序。 该方法涉及工程化具有原子和/或分子标签的聚合酶和/或dNTP，其具有由检测系统监测的可检测特性。
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30.发明申请Enzymatic nucleic acid synthesis: methods for inhibiting pyrophosphorolysis during sequencing synthesis 审中-公开酶学核酸合成：测序合成期间抑制焦磷酸分解的方法公开(公告)号：US20070172869A1
公开(公告)日：2007-07-26
申请号：US11648723
申请日：2006-12-29
申请人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
发明人： Susan Hardin , Xiaolian Gao , James Briggs , Richard Willson , Shiao-Chun Tu
CPC分类号： C12Q1/6869 , C07H19/06 , C07H19/10 , C07H19/20 , C12N9/1241 , C12N9/1252 , C12Q1/6806 , C12Q1/6853 , C12Q2525/101 , C12Q2565/301 , C12Q2533/101 , C12Q2525/113
摘要： Nucleotide triphosphate probes containing a molecular and/or atomic tag on a γ and/or β phosphate group and/or a base moiety having a detectable property are disclosed, and kits and method for using the tagged nucleotides in sequencing reactions and various assay. Also, phosphate and polyphosphate molecular fidelity altering agents are disclosed.
摘要翻译： 公开了在γ和/或β磷酸基团和/或具有可检测性质的碱基部分上含有分子和/或原子标签的核苷酸三磷酸探针，以及在测序反应和各种测定中使用标记的核苷酸的试剂盒和方法。 此外，公开了磷酸盐和聚磷酸盐分子保真改性剂。
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